Published in J Biol Chem on May 25, 1967
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 2.93
The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type. J Cell Biol (1986) 2.50
Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex. Proc Natl Acad Sci U S A (1983) 1.98
Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family. EMBO J (1986) 1.78
Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol (1982) 1.77
The primary inhibitor of plasmin in human plasma. Biochem J (1976) 1.64
Partial amino acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen. Proc Natl Acad Sci U S A (1987) 1.61
Activation of plasminogen to plasmin by a protease associated with the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A (1981) 1.29
Preparation and purification of microplasmin. Proc Natl Acad Sci U S A (1987) 1.26
Basis of antifibrinolytic therapy. J Clin Pathol Suppl (R Coll Pathol) (1980) 1.22
Coevolutionary patterns in plasminogen activation. Proc Natl Acad Sci U S A (2003) 1.22
Secondary-site binding of Glu-plasmin, Lys-plasmin and miniplasmin to fibrin. Biochem J (1981) 1.06
Cell surface remodeling by plasmin: a new function for an old enzyme. J Biomed Biotechnol (2012) 1.04
Nerve growth factor: a protease that can activate plasminogen. Proc Natl Acad Sci U S A (1978) 1.03
Amino-acid sequence of activation cleavage site in plasminogen: homology with "pro" part of prothrombin. Proc Natl Acad Sci U S A (1975) 0.99
Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. J Biol Chem (2012) 0.96
Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity. Breast Cancer Res (2007) 0.96
Rapid formation of an anion-sensitive active site in stoichiometric complexes of streptokinase and human [Glu1]plasminogen. Proc Natl Acad Sci U S A (1986) 0.93
Immunocytochemical demonstration of tissue-type plasminogen activator in endocrine cells of the rat pituitary gland. J Cell Biol (1985) 0.92
Localization of the binding site of tissue-type plasminogen activator to fibrin. J Clin Invest (1986) 0.92
Substrates of the plasminogen activator protease of Yersinia pestis. Adv Exp Med Biol (2012) 0.92
Characterization of PauB, a novel broad-spectrum plasminogen activator from Streptococcus uberis. J Bacteriol (2002) 0.91
New insights into the role of Plg-RKT in macrophage recruitment. Int Rev Cell Mol Biol (2014) 0.89
Functional impact of oxidative posttranslational modifications on fibrinogen and fibrin clots. Free Radic Biol Med (2013) 0.88
Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator. Protein Sci (1998) 0.85
Significance of plasminogen activator inhibitor 2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor 2 with lymph node metastasis. Br J Cancer (1998) 0.84
Regulation of fibrinolysis by non-esterified fatty acids. Biochem J (1994) 0.84
Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site. Proc Natl Acad Sci U S A (1982) 0.83
Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis. Br J Cancer (1999) 0.82
Impact of the Pla Protease Substrate α2-Antiplasmin on the Progression of Primary Pneumonic Plague. Infect Immun (2015) 0.81
EGF increases expression and activity of PAs in preimplantation rat embryos and their implantation rate. Reprod Biol Endocrinol (2007) 0.80
STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization. J Biol Chem (2015) 0.79
Expression of plasminogen activators in preimplantation rat embryos developed in vivo and in vitro. Reprod Biol Endocrinol (2005) 0.78
Identification of molecular forms of plasminogen and plasmin-inhibitor complexes in urokinase-activated human plasma. Biochem J (1984) 0.78
Fibrin-targeted plasminogen activation by plasminogen activator, PadA, from Streptococcus dysgalactiae. Protein Sci (2014) 0.77
Proteolysis of plasminogen activator inhibitor-1 by Yersinia pestis remodulates the host environment to promote virulence. J Thromb Haemost (2016) 0.76
Tissue Specific Promoters in Colorectal Cancer. Dis Markers (2015) 0.76
Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. PLoS One (2012) 0.76
Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin. Proc Natl Acad Sci U S A (1993) 0.76
Thrombin-thrombomodulin inhibits prourokinase-mediated pleural mesothelial cell-dependent fibrinolysis. Thromb Res (2007) 0.76
Biochemistry of the plasmin system. J Clin Pathol Suppl (R Coll Pathol) (1980) 0.75
Effect of desialylation on the biological properties of human plasminogen. Biochem J (1992) 0.75
Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line. Biochem J (1992) 0.75
Coagulation complications following trauma. Mil Med Res (2016) 0.75
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours. Sci Rep (2016) 0.75
Biophysical Mechanisms Mediating Fibrin Fiber Lysis. Biomed Res Int (2017) 0.75
Kinetics of the reaction of streptokinase-plasmin complex with purified human and mouse alpha 2-macroglobulin. Implications for mechanism. Biochem J (1989) 0.75
The hemostasis system in murine atherosclerosis. Curr Drug Targets (2008) 0.75
Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors. Int J Pept Res Ther (2016) 0.75
Physiology and pathophysiology of the plasminogen system in the kidney. Pflugers Arch (2017) 0.75
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11
Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature (1995) 3.84
Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase. Science (1984) 3.06
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature (1983) 3.01
Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Proc Natl Acad Sci U S A (1983) 2.95
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.93
Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci U S A (1981) 2.74
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci U S A (1982) 2.55
Isolation and oncogenic potential of a novel human src-like gene. Mol Cell Biol (1986) 2.31
Molecular cloning of Moloney murine sarcoma virus: arrangement of virus-related sequences within the normal mouse genome. Proc Natl Acad Sci U S A (1979) 2.27
The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol Cell Biol (1988) 2.22
Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol (1995) 2.15
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci U S A (1991) 2.00
Rat sequences of the Kirsten and Harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor RNA. J Virol (1976) 1.99
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A (1990) 1.98
The transforming gene of Moloney murine sarcoma virus. Nature (1979) 1.98
Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation. Cell (1984) 1.80
The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein. EMBO J (1985) 1.72
Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. Proc Natl Acad Sci U S A (1982) 1.72
fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection. Nature (1986) 1.64
Kinetics of activation of human plasminogen by different activator species at pH 7.4 and 37 degrees C. J Biol Chem (1980) 1.63
Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Cell (1984) 1.61
Acquisition of transforming properties by FYN, a normal SRC-related human gene. Proc Natl Acad Sci U S A (1988) 1.60
Segregation of genetic information for a B-tropic leukemia virus with the structural locus for BALB:virus-1. Proc Natl Acad Sci U S A (1977) 1.57
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. Proc Natl Acad Sci U S A (1986) 1.56
Primary structure of the human fgr proto-oncogene product p55c-fgr. Mol Cell Biol (1988) 1.48
Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. J Virol (1989) 1.47
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (1988) 1.47
In vivo identification of the transforming gene product of simian sarcoma virus. Science (1982) 1.44
Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem (1994) 1.42
Effect of Calcium Chloride on the Preparation of Extracts of H. pertussis. Science (1948) 1.42
Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor. Science (1985) 1.39
A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain. Genes Dev (1991) 1.36
Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies. Int J Cancer (1995) 1.36
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene (1995) 1.35
Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem (1997) 1.32
Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. Proc Natl Acad Sci U S A (1989) 1.32
Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res (1987) 1.30
Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc Natl Acad Sci U S A (1989) 1.29
Classification of probe-based confocal laser endomicroscopy findings in pancreaticobiliary strictures. Endoscopy (2012) 1.25
Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A (1985) 1.22
Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling. J Biol Chem (1993) 1.22
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets. Mol Cell Biol (1990) 1.21
Expression of the PDGF-related transforming protein of simian sarcoma virus in E. coli. Cell (1984) 1.17
Physiological activation of the human fibrinolytic system. Isolation and characterization of human plasminogen variants, Chicago I and Chicago II. J Biol Chem (1979) 1.17
Analysis of the primary translational product and integrated DNA of a new feline sarcoma virus, GR-FeSV. Virology (1983) 1.15
Tissue-specific expression and developmental regulation of the human fgr proto-oncogene. Mol Cell Biol (1989) 1.15
Induction of type-C RNA virus by cycloheximide: increased expression of virus-specific RNA. Proc Natl Acad Sci U S A (1974) 1.12
The role of individual cysteine residues in the structure and function of the v-sis gene product. Science (1987) 1.12
High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations. J Biol Chem (1992) 1.11
The specific mechanism of activation of human plasminogen to plasmin. J Biol Chem (1967) 1.11
Plasminogen and plasmin. Methods Enzymol (1976) 1.11
Wild mouse RNA tumor viruses. A nongenetically transmitted virus group closely related to exogenous leukemia viruses of laboratory mouse strains. J Exp Med (1979) 1.10
Nucleotide sequence of the transforming gene of simian sarcoma virus. Proc Natl Acad Sci U S A (1982) 1.10
Differential association of cellular proteins with family protein-tyrosine kinases. J Biol Chem (1991) 1.10
MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma. Carcinogenesis (1994) 1.10
Cellular regulation of mammalian sarcoma virus expression: a gene regulation model for oncogenesis. Cell (1979) 1.09
Involvement of different exogenous feline leukemia virus subgroups in the generation of independent feline sarcoma virus isolates. Virology (1979) 1.09
Radioimmunoassay of human plasminogen and plasmin. J Lab Clin Med (1969) 1.09
In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product. Proc Natl Acad Sci U S A (1985) 1.07
Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation. J Cell Biol (1989) 1.06
Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors. J Biol Chem (1995) 1.06
Detection of PDGF-2 homodimers in human tumor cells. Oncogene (1987) 1.05
Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes. J Virol (1983) 1.05
Molecular localization of the transforming and secretory properties of PDGF A and PDGF B. Science (1990) 1.05
Functional identification of regulatory elements within the promoter region of platelet-derived growth factor 2. Mol Cell Biol (1989) 1.05
The interaction of streptokinase with human, cat, dog, and rabbit plasminogens. The fragmentation of streptokinase in the equimolar plasminogen-streptokinase complexes. J Biol Chem (1974) 1.03
The isolation and characterization of the S-carboxymethyl beta (light) chain derivative of human plasmin. The localization of the active site on the beta (light) chain. J Biol Chem (1967) 1.03
Decreased platelet number and function and increased fibrinolysis contribute to postoperative bleeding in cardiopulmonary bypass patients. Thromb Haemost (1988) 1.03
Induction of mouse type-C virus by translational inhibitors: evidence for transcriptional derepression of a specific class of endogenous virus. Proc Natl Acad Sci U S A (1976) 1.02
Bile peritonitis secondary to breast cancer metastatic to the gallbladder. Am J Gastroenterol (2000) 1.00
Molecular weight studies on human plasminogen and plasmin at the microgram level. J Biol Chem (1969) 1.00
Primate origin of the cell-derived sequences of simian sarcoma virus. J Virol (1982) 0.98
CHESS: comprehensive health enhancement support system for women with breast cancer. Plast Surg Nurs (1996) 0.97
Glyoxylate aminotransferase in peroxisomes from rat liver and kidney. J Biol Chem (1976) 0.95
Isolation and characterization of the affinity chromatography forms of human Glu- and Lys-plasminogens and plasmins. J Biol Chem (1976) 0.95
Studies on the isolation of the multiple molecular forms of human plasminogen and plasmin by isoelectric focusing methods. J Biol Chem (1972) 0.94
Isolation of a human plasmin-derived, functionally active, light (B) chain capable of forming with streptokinase an equimolar light (B) chain-streptokinase complex with plasminogen activator activity. J Biol Chem (1976) 0.94
In vitro biosynthesis of plasminogen in a cell-free system directed by mRNA fractions isolated from monkey liver. Biochemistry (1984) 0.93
Human plasmin. Methods Enzymol (1981) 0.93
Different mechanisms for morphologic reversion of a clonal population of murine sarcoma virus-transformed nonproducer cells. Virology (1977) 0.93
Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate. Biochem Biophys Res Commun (1992) 0.92
RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain. Oncogene (1996) 0.91
Studies on the active center of human plasmin. Partial amino acid sequence of a peptide containing the active center serine residue. J Biol Chem (1969) 0.91