Nerve growth factor (third of three parts).

Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Proc Natl Acad Sci U S A (1984) 1.32

Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells. Proc Natl Acad Sci U S A (1984) 1.08

Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci (2001) 3.53

Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol (1985) 3.16

The isolation of the mouse nerve growth factor protein in a high molecular weight form. Biochemistry (1967) 3.13

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J Neurosci (1990) 3.00

Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature (1987) 2.98

Subunit structure of a high-molecular-weight form of the nerve growth factor from mouse submaxillary gland. Proc Natl Acad Sci U S A (1967) 2.90

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells. J Biol Chem (1979) 2.90

Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci U S A (1986) 2.80

Characterization and isolation of proteolytically modified nerve growth factor. Biochemistry (1976) 2.76

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell (1999) 2.72

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes. J Neurosci (1996) 2.65

The nerve growth factor: biochemistry, synthesis, and mechanism of action. Annu Rev Neurosci (1980) 2.61

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron (2001) 2.51

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A (1998) 2.32

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol (1997) 2.32

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A (1996) 2.32

Changes in the localization of brain prion proteins during scrapie infection. Neurology (1987) 2.27

Charcot-Marie-Tooth disease type 1A. Association with a spontaneous point mutation in the PMP22 gene. N Engl J Med (1993) 2.19

Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Natl Acad Sci U S A (1989) 2.10

The gene for the peripheral myelin protein PMP-22 is a candidate for Charcot-Marie-Tooth disease type 1A. Nat Genet (1992) 2.08

Crystallization of nerve growth factor from mouse submaxillary glands. Proc Natl Acad Sci U S A (1975) 2.03

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states. Proc Natl Acad Sci U S A (1980) 1.97

Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. Sci Transl Med (2009) 1.94

Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci (2001) 1.90

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells. J Biol Chem (1984) 1.88

Multiple forms of the nerve growth factor protein and its subunits. Biochemistry (1968) 1.87

Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Nucleic Acids Res (1985) 1.84

The nerve growth factor family of receptors. Trends Neurosci (1992) 1.80

Evidence for a recessive PMP22 point mutation in Charcot-Marie-Tooth disease type 1A. Nat Genet (1993) 1.72

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A (2001) 1.72

Retracted Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice. Science (1996) 1.68

PMP22 accumulation in aggresomes: implications for CMT1A pathology. Neurobiol Dis (1999) 1.65

The biology and mechanism of action of nerve growth factor. Annu Rev Biochem (1982) 1.64

Reversible dissociation of the mouse nerve growth factor protein into different subunits. Biochemistry (1968) 1.62

Nerve growth factor in mouse saliva. Rapid isolation procedures for and characterization of 7 S nerve growth factor. J Biol Chem (1978) 1.61

Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF. Neurology (2000) 1.60

Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells. J Cell Biol (1981) 1.58

Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). J Cell Biol (1992) 1.56

Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected]. Neurobiol Dis (1999) 1.54

Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci U S A (1979) 1.54

Trembler mouse carries a point mutation in a myelin gene. Nature (1992) 1.51

Structure of the tubulin dimer. J Biol Chem (1977) 1.50

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J Neurosci (1986) 1.47

Lipoprotein uptake by neuronal growth cones in vitro. Science (1987) 1.47

A discordant sibship analysis between beta-NGF and neurofibromatosis. Am J Hum Genet (1985) 1.44

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron (1994) 1.43

Molecular characteristics of nerve growth factor receptors on PC12 cells. J Biol Chem (1985) 1.43

Properties of the beta nerve growth factor receptor of avian dorsal root ganglia. Proc Natl Acad Sci U S A (1973) 1.42

Nerve growth factor effects and receptors in cultured human neuroblastoma cell lines. J Neurosci Res (1982) 1.42

Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science (1985) 1.41

Properties of the beta-nerve growth factor receptor in development. J Cell Biol (1975) 1.41

A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA. Proc Natl Acad Sci U S A (1997) 1.40

Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. Science (1978) 1.39

Evidence for pro-beta-nerve growth factor, a biosynthetic precursor to beta-nerve growth factor. Proc Natl Acad Sci U S A (1977) 1.39

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization. Proc Natl Acad Sci U S A (1991) 1.38

Sequence determination of the mumps virus HN gene. Virology (1988) 1.38

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron (1992) 1.38

BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus. Neuroscience (2002) 1.36

A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse. Proc Natl Acad Sci U S A (1992) 1.36

Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration. Neurobiol Dis (2000) 1.35

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci (1995) 1.35

Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J (1991) 1.35

Neurotrophins are key mediators of the myelination program in the peripheral nervous system. Proc Natl Acad Sci U S A (2001) 1.33

NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci (2000) 1.33

The Use of an Electrolytic Injector as a "Compensating Device" in Electrophoresis. Science (1949) 1.32

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons. Brain Res (1986) 1.30

Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells. Proc Natl Acad Sci U S A (1988) 1.28

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc Natl Acad Sci U S A (1992) 1.27

Denervated sheath cells secrete a new protein after nerve injury. Proc Natl Acad Sci U S A (1983) 1.27

Regulation of tissue-specific expression of alternative peripheral myelin protein-22 (PMP22) gene transcripts by two promoters. J Biol Chem (1994) 1.26

Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem (1993) 1.25

Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice. Gene Ther (2006) 1.24

The biosynthetic precursor of epidermal growth factor and the mechanism of its processing. Proc Natl Acad Sci U S A (1979) 1.23

Increased nerve-growth-factor beta-chain cross-reacting material in familial dysautonomia. N Engl J Med (1976) 1.23

Protective effects of glycoprotein-specific monoclonal antibodies on the course of experimental mumps virus meningoencephalitis. J Virol (1985) 1.23

Enzymatic activities of mouse nerve growth factor and its subunits. Proc Natl Acad Sci U S A (1968) 1.22

Nerve growth factor signaling in caveolae-like domains at the plasma membrane. J Biol Chem (1999) 1.22

Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene. Proc Natl Acad Sci U S A (1989) 1.22

Cloning and sequencing of the mumps virus fusion protein gene. Virology (1987) 1.20

Effects of phorbol ester tumor promoters and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells. Cancer Res (1982) 1.20

Nerve growth factor rapidly induces ornithine decarboxylase mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci U S A (1985) 1.20

Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat. Neuron (1988) 1.20

Neurons promote the translocation of peripheral myelin protein 22 into myelin. J Neurosci (1997) 1.18

A specific 37,000-dalton protein that accumulates in regenerating but not in nonregenerating mammalian nerves. Science (1985) 1.18

Regulation of nerve growth factor synthesis in mouse submaxillary glands by testosterone. J Neurochem (1975) 1.18

A myelin protein is encoded by the homologue of a growth arrest-specific gene. Proc Natl Acad Sci U S A (1991) 1.17

Effects of insulin, insulin-like growth factor-II and nerve growth factor on neurite outgrowth in cultured human neuroblastoma cells. Brain Res (1984) 1.16

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system. Neuron (1989) 1.15

Proteolytic modification of the beta nerve growth factor protein. Biochemistry (1974) 1.15

Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. J Neurosci (1992) 1.14

Interleukin-6 production by Schwann cells and induction in sciatic nerve injury. J Neurochem (1995) 1.13

Comparison of the arginine esteropeptidases associated with the nerve and epidermal growth factor. J Biol Chem (1976) 1.13

Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor. J Neurochem (1995) 1.13

Subunit interaction and enzymatic activity of mouse 7S nerve growth factor. Biochemistry (1969) 1.12

Nerve growth factor. Adv Protein Chem (1977) 1.12