Reverse transcriptase activity of human acute leukaemic cells: purification of the enzyme, response to AMV 70S RNA, and characterization of the DNA product.

PubWeight™: 2.25‹?› | Rank: Top 2%

🔗 View Article (PMID 4117890)

Published in Nat New Biol on November 15, 1972

Authors

M G Sarngadharan, P S Sarin, M S Reitz, R C Gallo

Articles citing this

T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor. Proc Natl Acad Sci U S A (1980) 2.89

The discovery of the first human retrovirus: HTLV-1 and HTLV-2. Retrovirology (2005) 2.62

Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway. J Exp Med (1976) 2.34

Purification, characterization, and comparison of the DNA polymerases from two primate RNA tumor viruses. J Virol (1973) 2.34

Primate RNA tumor virus-like DNA synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells. Proc Natl Acad Sci U S A (1973) 1.79

RNA-directed DNA polymerase and virus-induced leukemia in mice. Proc Natl Acad Sci U S A (1973) 1.57

Mechanism of stimulation of murine type-C RNA tumor virus production by glucocorticoids: post-transcriptional effects. J Virol (1974) 1.36

Purification of avian myeloblastosis virus DNA polymerase by affinity chromatography on polycytidylate-agarose. J Virol (1974) 1.27

Relationship between RNA-directed DNA polymerase (reverse transcriptase) from human acute leukemic blood cells and primate type-C viruses. Proc Natl Acad Sci U S A (1974) 1.27

Type-C RNA virus gene expression in human tissue. J Virol (1974) 1.26

Viral-related information in oncornavirus-lik particles isolated from cultures of marrow cells from leukemic patients in relapse and remission. Proc Natl Acad Sci U S A (1975) 1.20

RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus-producing cells: high- and low-molecular-weight forms with variant biochemical and immunological properties. Proc Natl Acad Sci U S A (1975) 1.13

Particles with characteristics of leukoviruses in cultures of marrow cells from leukemic patients in remission and relapse. Proc Natl Acad Sci U S A (1974) 1.11

Systematics of RNA tumor viruses and virus-like particles of human origin. Proc Natl Acad Sci U S A (1974) 1.05

Purification of RNA-instructed DNA polymerase from human leukemic spleens. Proc Natl Acad Sci U S A (1975) 1.01

Primate type-C virus nucleic acid sequences (woolly monkey and baboon types) in tissues from a patient with acute myelogenous leukemia and in viruses isolated from cultured cells of the same patient. Proc Natl Acad Sci U S A (1976) 1.00

Reverse transcriptase activity: increase in marrow cultures from leukaemic patients in relapse and remission. Br J Cancer (1974) 0.98

Rauscher-leukemia-virus-related sequences in human DNA: presence in some tissues of some patients with hemotopoietic neoplasias and absence in DNA from other tissues. Proc Natl Acad Sci U S A (1977) 0.96

Characterization of a new murine cellular DNA polymerase. Proc Natl Acad Sci U S A (1974) 0.92

Detection and isolation of a new DNA polymerase from human breast tumor cell line HBT-3 by (dT)12-18-cellulose chromatography. Proc Natl Acad Sci U S A (1973) 0.89

Properties of noninfectious and transforming viruses released by Murine sarcoma virus-induced hamster tumor cells. J Virol (1973) 0.89

Human antibodies reactive with purified envelope antigens of primate type C tumor viruses. Proc Natl Acad Sci U S A (1978) 0.88

A historical reflection on the discovery of human retroviruses. Retrovirology (2009) 0.88

Transcription of 70S RNA by DNA polymerases from mammalian RNA viruses. J Virol (1975) 0.87

Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis. Proc Natl Acad Sci U S A (1975) 0.86

Oncornavirus-like particles released from arginine-deprived human lymphoblastoid cell lines. Proc Natl Acad Sci U S A (1975) 0.84

Transformation of cultured human embryonic fibroblasts by oncornavirus-like particles released from a human carcinoma cell line. Proc Natl Acad Sci U S A (1975) 0.83

Antibodies in human sera to oncorna virus-like proteins from normal or leukemia marrow cell cultures. J Exp Med (1976) 0.82

Simultaneous detection of reverse transcriptase and high molecular weight RNA in tissue of patients with Hodgkin's disease and patients with leukemia. Proc Natl Acad Sci U S A (1976) 0.82

Strandedness and complementarity of DNA from long-term RNA-dependent DNA polymerase reactions of Soehner-Dmochowski murine sarcoma virus. J Virol (1973) 0.81

Reverse transcriptase activity per virion for avian myeloblastosis virus and Rauscher murine leukemia virus. J Virol (1976) 0.80

Low frequency of (5'-3') -C-G- connection in 70S RNA from simian sarcoma virus. J Virol (1975) 0.75

Articles by these authors

Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science (1984) 33.32

Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science (1984) 32.33

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science (1995) 17.42

The role of mononuclear phagocytes in HTLV-III/LAV infection. Science (1986) 17.33

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell (1986) 12.74

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature (1977) 12.57

Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science (1984) 11.30

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A (1982) 11.15

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A (1985) 10.71

Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS. Cell (1986) 10.70

Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome. Science (1984) 10.40

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci U S A (1978) 9.59

The trans-activator gene of HTLV-III is essential for virus replication. Nature (1986) 8.65

Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120. Proc Natl Acad Sci U S A (1988) 8.40

A molecular clone of HTLV-III with biological activity. Nature (1985) 8.30

Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc Natl Acad Sci U S A (1986) 8.06

Complete nucleotide sequences of functional clones of the AIDS virus. AIDS Res Hum Retroviruses (1987) 7.85

Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS. Science (1986) 7.81

Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient. Nature (1982) 6.78

Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science (1986) 6.53

Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science (1985) 6.51

Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene. Science (1985) 6.48

Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex. Science (1992) 6.35

Functional and morphologic characterization of human T cells continuously grown in vitro. J Immunol (1977) 6.30

Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions. J Virol (1987) 6.20

The sor gene of HIV-1 is required for efficient virus transmission in vitro. Science (1987) 6.16

Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science (1986) 5.86

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80

The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat Med (1996) 5.46

Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS. Science (1984) 5.43

Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. Science (1985) 5.42

Genomic diversity of human T-lymphotropic virus type III (HTLV-III). Science (1985) 5.33

A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science (1982) 5.30

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA. Proc Natl Acad Sci U S A (1986) 5.18

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11

Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. Proc Natl Acad Sci U S A (1985) 5.10

HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complex. Nature (1985) 5.10

Human T-lymphotropic retroviruses. Nature (1985) 5.04

Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins. J Virol (1987) 5.03

Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media. Proc Natl Acad Sci U S A (1980) 4.91

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A (1984) 4.90

Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (1983) 4.83

Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science (1983) 4.72

Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29). Proc Natl Acad Sci U S A (1982) 4.70

Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoprotein. Proc Natl Acad Sci U S A (1986) 4.68

Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line. Virology (1981) 4.68

Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men. Lancet (1984) 4.68

Isolation and transmission of human retrovirus (human t-cell leukemia virus). Science (1983) 4.67

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. Nature (1990) 4.47

Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. Br Med J (Clin Res Ed) (1984) 4.39

Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia. Nature (1981) 4.38

Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 4.37

Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature (1984) 4.35

Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature (1987) 4.35

Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science (1985) 4.31

Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses. Science (1990) 4.28

Screening test for HTLV-III (AIDS agent) antibodies. Specificity, sensitivity, and applications. JAMA (1985) 4.26

Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes. Proc Natl Acad Sci U S A (1981) 4.24

Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects. Science (1986) 4.17

Restricted expression of human T-cell leukemia--lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology (1983) 4.11

Biochemical and immunological analysis of human immunodeficiency virus gag gene products p17 and p24. J Virol (1988) 4.06

Viral DNA carried by human immunodeficiency virus type 1 virions. J Virol (1992) 3.93

Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas. Science (1983) 3.82

Biologically diverse molecular variants within a single HIV-1 isolate. Nature (1988) 3.80

Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet (1984) 3.77

Chromosomal sublocalization of human c-myb and c-fes cellular onc genes. Nature (1983) 3.77

Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan. Proc Natl Acad Sci U S A (1982) 3.75

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol (1993) 3.68

Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet (1982) 3.67

Human T lymphotropic virus type III infection of human alveolar macrophages. Blood (1986) 3.66

HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science (1984) 3.50

HTLV-III in cells cultured from semen of two patients with AIDS. Science (1984) 3.47

Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication. Proc Natl Acad Sci U S A (1993) 3.45

Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat Med (1997) 3.44

A pathogenic retrovirus (HTLV-III) linked to AIDS. N Engl J Med (1984) 3.41

Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees. J Virol (1990) 3.35

Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor. J Exp Med (1981) 3.30

The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma. N Engl J Med (1996) 3.30

DNA-dependent DNA polymerases I and II from normal human-blood lymphocytes. Proc Natl Acad Sci U S A (1972) 3.27