Published in N Engl J Med on April 26, 1973
An avoidable recurrence of cri du chat syndrome in the next generation. Br Med J (Clin Res Ed) (1983) 1.00
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Allergy-epitomes of progress: seminal fluid allergy. West J Med (1982) 0.75
IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones. Eur J Immunol (1981) 4.11
An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal Biochem (1974) 4.05
Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy Appl Immunol (1970) 3.55
Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science (1972) 3.43
Detection and localization of a lectin on Actinomyces viscosus T14V by monoclonal antibodies. J Immunol (1981) 3.17
Prediction of penicillin allergy by immunological tests. J Allergy (1969) 2.76
Beta-glucoside permeases and phospho beta-glucosidases in Aerobacter aerogenes: relationship with cryptic phospho beta-glucosidases in Enterobacteriaceae. Proc Natl Acad Sci U S A (1968) 2.67
Renal failure and interstitial nephritis due to penicillin and methicillin. N Engl J Med (1968) 2.60
Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type. Science (1970) 2.37
Isolation of heavy and light chains of immunoglobulin from the surfaces of lymphoid cells. J Immunol (1971) 2.35
Partial purification and characterization of a heat-labile enterotoxin of Escherichia coli. Infect Immun (1976) 2.26
Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity (2001) 2.11
Mechanisms underlying binding of immune complexes to macrophages. J Exp Med (1971) 2.00
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A (1990) 1.98
Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation. J Biol Chem (1993) 1.91
Lymphokines: their role in lymphocyte responses. Properties of interleukin 1. Fed Proc (1982) 1.90
The biologic activities of guinea pig antibodies. I. Separation of gamma1 and gamma2 immunoglobulins and their participation in allergic reactions of the immediate type. J Immunol (1970) 1.85
Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J Exp Med (1996) 1.77
Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med (1977) 1.73
Relationship between histocompatibility (H-2) genotype and immune responsiveness to low doses of ovalbumin in the mouse. J Immunol (1970) 1.62
Penicillin allergy and the heterogenous immune responses of man to benzylpenicillin. J Clin Invest (1966) 1.54
Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate. J Immunol (1971) 1.48
Refinements in the automated fluorometric histamine analysis system. J Immunol Methods (1975) 1.47
Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. J Biol Chem (1994) 1.43
H-2-linked genetic control of immune responsiveness to ovalbumin and ovomucoid. J Exp Med (1971) 1.40
Fc (IgG) receptors on rat basophilic leukemia cells. J Immunol (1981) 1.39
Monoclonal antibodies that inhibit IgE binding. J Biol Chem (1986) 1.37
Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signaling. Immunol Today (1992) 1.37
Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products. Proc Natl Acad Sci U S A (1988) 1.36
IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid. Arch Biochem Biophys (1981) 1.34
The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). J Biol Chem (1997) 1.34
Persistent formation of reagins in mice injected with low doses of ovalbuminl. Immunology (1971) 1.33
Immunoglobulin synthesis and secretion. I. Biosynthetic studies of the addition of the carbohydrate moieties. J Cell Biol (1970) 1.32
The use of glucose oxidase as a generator of H 2 O 2 in the enzymatic radioiodination of components of cell surfaces. Cell Immunol (1972) 1.31
Variants of the rat basophilic leukemia cell line for the study of histamine release. Fed Proc (1982) 1.28
Automated histamine analysis for in vitro allergy testing. I. A method utilizing allergen-induced histamine release from whole blood. J Allergy Clin Immunol (1976) 1.27
Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody. J Biol Chem (2000) 1.26
Benzylpenicilloyl specific serum antibodies to penicillin in man. I. Development of a sensitive hemagglutination assay method and haptenic specificities of antibodies. J Immunol (1966) 1.26
Mechanism of action of concanavalin A on human basophils. J Immunol (1975) 1.26
The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor. J Biol Chem (1997) 1.25
Characterization of monoclonal antibodies to fimbria-associated adhesins of Bacteroides loescheii PK1295. Infect Immun (1988) 1.25
Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemia basophils. Biochem Biophys Res Commun (1980) 1.23
Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol Cell Biol (1996) 1.22
Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells. J Immunol (1977) 1.22
Platelet requirement in the interaction of the complement and clotting systems. Nat New Biol (1972) 1.21
Synthesis and intracellular transport of immunoglobulin in secretory and nonsecretory cells. Ann N Y Acad Sci (1971) 1.18
Monoclonal antibody against human interleukin 2 (IL 2). I. Purification of IL 2 for the production of monoclonal antibodies. J Immunol (1982) 1.18
Complement-induced histamine release from human basophils. I. Generation of activity in human serum. J Immunol (1975) 1.17
Mechanism of histamine release by formyl methionine-containing peptides. J Immunol (1977) 1.17
Minor haptenic determinant-specific reagins of penicillin hypersensitivity in man. Int Arch Allergy Appl Immunol (1969) 1.17
Apparatus for preparative electrophoresis through gels. Anal Biochem (1968) 1.17
New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro. J Med Chem (1986) 1.15
Delayed skin reactions to benzylpenicillin in man. Int Arch Allergy Appl Immunol (1968) 1.15
Monoclonal antibody AA4, which inhibits binding of IgE to high affinity receptors on rat basophilic leukemia cells, binds to novel alpha-galactosyl derivatives of ganglioside GD1b. J Biol Chem (1989) 1.15
Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72. J Biol Chem (1994) 1.15
Immunochemical and functional studies of Actinomyces viscosus T14V type 1 fimbriae with monoclonal and polyclonal antibodies directed against the fimbrial subunit. J Gen Microbiol (1991) 1.14
Immunologic mechanisms of platelet damage. Prog Allergy (1972) 1.13
Sepcific removal of in vivo antibody by extracorporeal circulation over an immunoadsorbent in gel. J Clin Invest (1971) 1.13
The production of hapten-specific reaginic antibodies in the guinea pig. J Immunol (1971) 1.13
Immunoglobulin synthesis and secretion, IV. Sites of incorporation of sugars as determined by subcellular fractionation. Proc Natl Acad Sci U S A (1970) 1.13
Basophil activation by concanavalin A: characteristics of the reaction. J Immunol (1974) 1.13
Studies on the mechanism of binding of immune complexes to phagocytes. Nature (1969) 1.12
Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence. J Biol Chem (1993) 1.12
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med (2000) 1.11
High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations. J Biol Chem (1992) 1.11
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation. J Immunol (1981) 1.10
Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction. J Immunol (1976) 1.10
Effects of compounds which inhibit antigenic release of histamine and phagocytic release of lysosomal enzyme on glucose utilization by leukocytes in humans. Proc Soc Exp Biol Med (1970) 1.10
Ionophore A-23187 induced histamine release from rat mast cells and rat basophil leukemia (RBL-1) cells. J Immunol (1975) 1.09
Proteolytic enzymes from the mouse submaxillary gland. Specificity restricted to arginine residues. Arch Biochem Biophys (1977) 1.08
Binding of monoclonal antibody AA4 to gangliosides on rat basophilic leukemia cells produces changes similar to those seen with Fc epsilon receptor activation. J Cell Biol (1992) 1.07
Correlation of blood eosinophilia with antibody classes. Studies with the penicillin hypersensitivity system. Int Arch Allergy Appl Immunol (1969) 1.07
Specificity of the anamnestic response to a double hapten conjugate in guinea pigs primed with a single hapten. J Immunol (1967) 1.07
Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis. J Immunol (1979) 1.07
Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells. J Immunol (2000) 1.04
Methods of enhancing the frequency of antigen-specific hybridomas. Methods Enzymol (1983) 1.03
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases. Mol Biol Cell (2000) 1.03
Enhancing the frequency of antigen-specific hybridomas. Eur J Immunol (1981) 1.03
Syk-independent tyrosine phosphorylation and association of the protein tyrosine phosphatases SHP-1 and SHP-2 with the high affinity IgE receptor. J Immunol (1997) 1.03
Immunochemical mechanisms of drug allergy. Annu Rev Med (1966) 1.02
Cell surface immunoglobulin. I. Isolation and characterization of immunoglobulin from murine myeloma cells. J Immunol (1972) 1.01
A sensitive hemagglutination assay method for dinitrophenyl-specific antibodies. The effect of antibody binding affinity on titers. J Immunol (1967) 1.01
A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling. EMBO J (1998) 1.01
Increased nerve-growth-stimulating activity in disseminated neurofibromatosis. N Engl J Med (1974) 1.01
Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity. J Immunol (1998) 1.00
Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A (2000) 1.00
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J Biol Chem (1996) 1.00
The effect of esteroproteases from mouse submaxillary gland on the growth of rat hepatoma cells in tissue culture. Exp Cell Res (1969) 0.99
Adherence of rat basophilic leukemia (RBL-2H3) cells to fibronectin-coated surfaces enhances secretion. J Immunol (1992) 0.99
Antigenicity and cross-reactivity of penicillins and cephalosporins. J Infect Dis (1973) 0.99
The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis. Clin Immunol Immunopathol (1987) 0.99
Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcepsilonRI signaling. J Biol Chem (1997) 0.99
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. J Biol Chem (1997) 0.99
Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents. J Immunol (1977) 0.98
Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: reconstitution by hybridization. Proc Natl Acad Sci U S A (1981) 0.98
Destruction of rabbit platelets in the allergic response of sensitized leukocytes. II. Evidence for basophil involvement. J Immunol (1971) 0.98
Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells. Proc Natl Acad Sci U S A (2001) 0.98
Induction of immune response and the role of antibody specificity in drug hypersensitivity-type hemolytic anemias and thrombocytopenias. Semin Hematol (1965) 0.97