Published in Lancet on April 20, 1974
Laboratory investigation of diarrhea in travelers to Mexico: evaluation of methods for detecting enterotoxigenic Echerichia coli. J Clin Microbiol (1976) 3.34
Experimental non-O group 1 Vibrio cholerae gastroenteritis in humans. J Clin Invest (1990) 2.33
Non-O1 Vibrio cholerae NRT36S produces a polysaccharide capsule that determines colony morphology, serum resistance, and virulence in mice. Infect Immun (1992) 1.86
Survival and growth of non-cholera vibrios in various foods. J Hyg (Lond) (1979) 0.90
Non-O1 Vibrio cholerae intestinal pathology and invasion in the removable intestinal tie adult rabbit diarrhea model. Infect Immun (1992) 0.89
Behavior of Vibrio cholerae in hot foods. Appl Environ Microbiol (1986) 0.76
The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. N Engl J Med (1978) 15.13
General practitioner's perceptions of the route to evidence based medicine: a questionnaire survey. BMJ (1998) 13.39
Antibodies to ribosomes in chronic active hepatitis. Gastroenterology (1979) 12.78
Randomized versus historical controls for clinical trials. Am J Med (1982) 7.53
Performance indicators for primary care groups: an evidence based approach. BMJ (1998) 6.97
A method for assessing the quality of a randomized control trial. Control Clin Trials (1981) 6.63
Microbial surfaces in relation to pathogenicity. Bacteriol Rev (1977) 5.79
Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med (2000) 5.68
Bias in treatment assignment in controlled clinical trials. N Engl J Med (1983) 4.78
Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ (2010) 4.53
Publication bias and clinical trials. Control Clin Trials (1987) 4.34
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest (1996) 3.74
MR imaging and T2 mapping of femoral cartilage: in vivo determination of the magic angle effect. AJR Am J Roentgenol (2001) 3.69
Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA (1995) 3.48
Giardia and Cryptosporidium join the 'Neglected Diseases Initiative'. Trends Parasitol (2006) 3.34
Future provision of out of hours primary medical care: a survey with two general practitioner research networks. BMJ (1996) 3.34
Evidence favoring the use of anticoagulants in the hospital phase of acute myocardial infarction. N Engl J Med (1977) 3.33
Paediatric intensive care transfers. Anaesthesia (2000) 3.32
Association of adrenocorticosteroid therapy and peptic-ulcer disease. N Engl J Med (1983) 3.04
Appropriateness of use of emergency ambulances. J Accid Emerg Med (1998) 3.02
Rate of regeneration of peripheral nerves in man. J Physiol (1943) 3.02
Transgene-mediated auxin overproduction in Arabidopsis: hypocotyl elongation phenotype and interactions with the hy6-1 hypocotyl elongation and axr1 auxin-resistant mutants. Plant Mol Biol (1995) 3.01
Infection and diabetes: the case for glucose control. Am J Med (1982) 2.90
Is perinatal mortality still a good indicator of perinatal care? Paediatr Perinat Epidemiol (1988) 2.87
Pathogenicity of influenza virus. Microbiol Rev (1980) 2.80
Medical care costs and quality of life after randomization to coronary angioplasty or coronary bypass surgery. Bypass Angioplasty Revascularization Investigation (BARI) Investigators. N Engl J Med (1997) 2.65
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature (1992) 2.61
In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation. J Exp Med (1990) 2.61
A survey of clinical trials of antibiotic prophylaxis in colon surgery: evidence against further use of no-treatment controls. N Engl J Med (1981) 2.59
Cancer in universal and left-sided ulcerative colitis: factors determining risk. Gastroenterology (1979) 2.48
Derivatives of 6-aminopenicillanic acid. XI. Alpha-amino-p-hydroxybenzylpenicillin. J Chem Soc Perkin 1 (1971) 2.39
Genetic engineering of harvest index in tobacco through overexpression of a phytochrome gene. Nat Biotechnol (1996) 2.36
Dipsticks and diagnostic algorithms in urinary tract infection: development and validation, randomised trial, economic analysis, observational cohort and qualitative study. Health Technol Assess (2009) 2.36
Overnight calls in primary care: randomised controlled trial of management using nurse telephone consultation. BMJ (1999) 2.32
Phytochrome and photomorphogenesis in plants. Nature (1970) 2.26
Paradoxical expansion of intracranial tuberculomas during chemotherapy. Lancet (1984) 2.19
Earthquake injuries related to housing in a guatemalan village. Science (1977) 2.18
Clinical governance in primary care groups: the feasibility of deriving evidence-based performance indicators. Qual Health Care (2000) 2.16
Preventive care for patients following myocardial infarction. The Wessex Research Network (WReN). Fam Pract (1997) 2.15
Biochemical challenge of microbial pathogenicity. Bacteriol Rev (1968) 2.14
Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene (2007) 2.14
The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med (1978) 2.05
Women's views about management and cause of urinary tract infection: qualitative interview study. BMJ (2010) 2.03
Cost analysis of nurse telephone consultation in out of hours primary care: evidence from a randomised controlled trial. BMJ (2000) 1.99
Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet (1988) 1.98
Groin hernia repair in Scotland. Br J Surg (2000) 1.93
Food intolerance and the irritable bowel syndrome. Gut (1989) 1.88
Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. J Gen Microbiol (1977) 1.85
Anthrax toxic complex. Fed Proc (1967) 1.84
A comparison of cancer risk in Crohn's disease and ulcerative colitis. Cancer (1981) 1.83
Cytidine 5'-monophospho-N-acetyl neuraminic acid and a low molecular weight factor from human blood cells induce lipopolysaccharide alteration in gonococci when conferring resistance to killing by human serum. Microb Pathog (1988) 1.81
Radioiodine-131 therapy for well-differentiated thyroid cancer--a quantitative radiation dosimetric approach: outcome and validation in 85 patients. J Nucl Med (1992) 1.80
Sialylation of lipopolysaccharide and loss of absorption of bactericidal antibody during conversion of gonococci to serum resistance by cytidine 5'-monophospho-N-acetyl neuraminic acid. Microb Pathog (1989) 1.80
Serum bilirubin: a prognostic factor in primary biliary cirrhosis. Gut (1979) 1.78
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. J Cell Biol (1997) 1.72
Cytidine 5'-monophospho-N-acetylneuraminic acid or a related compound is the low Mr factor from human red blood cells which induces gonococcal resistance to killing by human serum. J Gen Microbiol (1988) 1.72
Evaluation of a ganglioside immunosorbent assay for detection of Escherichia coli heat-labile enterotoxin. J Clin Microbiol (1979) 1.70
1% or less: a community-based nutrition campaign. Public Health Rep (1998) 1.69
Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition. Lancet (1991) 1.67
Quantitation of Salmonella O-antibodies in human sera by enzyme-linked immunosorbent assay (ELISA). Int Arch Allergy Appl Immunol (1975) 1.66
Hydrogenated oils and fats: the presence of chemically-modified fatty acids in human adipose tissue. Am J Clin Nutr (1981) 1.65
Immunogenicity of peptides derived from a fibronectin-binding protein of S. aureus expressed on two different plant viruses. Vaccine (1999) 1.63
Production of virulence-related proteins by Canadian strains of Streptococcus suis capsular type 2. Can J Vet Res (1998) 1.63
Molecular epidemiology of hospital-associated and community-acquired Clostridium difficile infection in a Swedish county. J Clin Microbiol (2004) 1.62
Reliability study of the European appropriateness evaluation protocol. Int J Qual Health Care (1999) 1.59
Comparative ocular pressure elevation by medrysone, fluorometholone, and dexamethasone phosphate. Arch Ophthalmol (1980) 1.59
Genome differences among varicella-zoster virus isolates. J Gen Virol (1983) 1.59
Factors affecting the induction of phenotypically determined serum resistance of Neisseria gonorrhoeae grown in media containing serum or its diffusible components. J Gen Microbiol (1981) 1.58
Acute liver decompensation on withdrawal of cytotoxic chemotherapy and immunosuppressive therapy in hepatitis B carriers. Q J Med (1989) 1.57
Penicillin neurotoxicity. Ann N Y Acad Sci (1967) 1.57
Postoperative pain relief after total hip arthroplasty: a randomized, double-blind comparison between intrathecal morphine and local infiltration analgesia. Br J Anaesth (2013) 1.54
Subtyping of hepatitis-associated antigen (HB-Ag); simplified technique with counterelectrophoresis. J Immunol (1972) 1.54
Sensitivity and specificity of clinical trials. Randomized v historical controls. Arch Intern Med (1983) 1.54
Botulinum toxin A for hyperkinetic facial lines: results of a double-blind, placebo-controlled study. Plast Reconstr Surg (1994) 1.54
Prostaglandin synthesis by rheumatoid synovium and its stimulation by colchicine. Prostaglandins (1975) 1.53
Enterotoxigenic Escherichia coli and other gram-negative bacteria of infantile diarrhea: surface antigens, hemagglutinins, colonization factor antigen, and loss of enterotoxigenicity. J Infect Dis (1980) 1.51
Thirteen-year follow-up of deliberate self-harm, using linked data. Br J Psychiatry (1998) 1.50
Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. J Neurol Neurosurg Psychiatry (2001) 1.50
Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation. Br J Exp Pathol (1969) 1.50
Aspergillus nidulans beta-tubulin genes are unusually divergent. Gene (1987) 1.50
Paradoxical responses during the chemotherapy of tuberculosis. J Infect (1987) 1.49
Tublin: nucleotide binding and enzymic activity. J Mol Biol (1974) 1.46
Induction of phenotypically determined resistance of Neisseria gonorrhoeae to human serum by factors in human serum. J Gen Microbiol (1981) 1.46
Management of hypocalcemic effects of WR2721 administered on a daily times five schedule with cisplatin and radiation therapy. The New York Gynecologic Oncology Group. J Clin Oncol (1993) 1.46
Proximity signal and shade avoidance differences between early and late successional trees. Nature (2001) 1.45
Patterns of neoplasia in Crohn's disease and ulcerative colitis. Cancer (1980) 1.45
A survey of the quality of information leaflets on hayfever available from general practices and community pharmacies. Clin Exp Allergy (2004) 1.44
Increase in parasuicide in Scotland. BMJ (1994) 1.43
The relation of pyrexia and nasal inflammatory response to virus levels in nasal washings of ferrets infected with influenza viruses of differing virulence. Br J Exp Pathol (1977) 1.43
Physician performance in a prepaid health plan: results of the peer review program of the Health Insurance Plan of Greater New York. Med Care (1982) 1.43
Differential ability of colonial types of Neisseria gonorrhoeae to produce infection cutaneous perforated plastic chambers in guinea-pigs and rabbits. J Med Microbiol (1975) 1.42
Adverse reactions to carbamazepine managed by desensitisation. Lancet (1985) 1.42
Cerebrospinal-fluid immunoglobulins in meningitis. Lancet (1973) 1.41
Role of neuraminidase in influenza virus-induced apoptosis. J Gen Virol (1999) 1.41
Family practice research networks. Experiences from 3 countries. J Fam Pract (2000) 1.40
Changes in laws are necessary to allow patients detained under Mental Health Act to vote. BMJ (1997) 1.39