Published in Science on June 28, 1974
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. Proc Natl Acad Sci U S A (1975) 1.87
Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry (2007) 1.79
The circadian basis of winter depression. Proc Natl Acad Sci U S A (2006) 1.69
Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase. Proc Natl Acad Sci U S A (1975) 1.60
Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J (1998) 1.52
The Glymphatic System: A Beginner's Guide. Neurochem Res (2015) 1.33
Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro. Proc Natl Acad Sci U S A (1980) 1.18
Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). J Exp Med (1989) 1.12
Transcriptional control of circadian hormone synthesis via the CREM feedback loop. Proc Natl Acad Sci U S A (1996) 1.03
Circadian changes in long noncoding RNAs in the pineal gland. Proc Natl Acad Sci U S A (2012) 1.02
Atenolol reduces plasma melatonin concentration in man. Br J Clin Pharmacol (1983) 1.01
Expression of melatonin receptors in arteries involved in thermoregulation. Proc Natl Acad Sci U S A (1990) 1.01
Ontogenesis of a biological clock for serotonin:acetyl coenzyme A N-acetyltransferase in pineal gland of rat. Proc Natl Acad Sci U S A (1975) 0.97
Repetitive transcranial magnetic stimulation activates specific regions in rat brain. Proc Natl Acad Sci U S A (1998) 0.97
Classification of preganglionic neurones projecting into the cat cervical sympathetic trunk. J Physiol (1992) 0.96
Induction of dark-adaptive retinomotor movement (cell elongation) in teleost retinal cones by cyclic adenosine 3','5-monophosphate. J Gen Physiol (1982) 0.94
Physiological mechanisms of thermoregulation in reptiles: a review. J Comp Physiol B (2005) 0.94
Transient receptor potential ion channels control thermoregulatory behaviour in reptiles. PLoS One (2007) 0.93
Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study. J Psychiatry Neurosci (2003) 0.91
Catecholamine-stimulated cyclic GMP accumulation in the rat pineal: apparent presynaptic site of action. Proc Natl Acad Sci U S A (1976) 0.90
Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission. J Neurol Neurosurg Psychiatry (1987) 0.89
Pituitary hormone circadian rhythm alterations in cirrhosis patients with subclinical hepatic encephalopathy. World J Gastroenterol (2008) 0.88
Altered emotional and locomotor responses in mice deficient in the transcription factor CREM. Proc Natl Acad Sci U S A (1999) 0.88
Circadian genomics of the chick pineal gland in vitro. BMC Genomics (2008) 0.87
The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal. Br J Pharmacol (1983) 0.87
Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives. Int J Mol Sci (2013) 0.85
N-acetylserotonin and aging-associated cognitive impairment and depression. Aging Dis (2012) 0.85
Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochem J (2005) 0.85
Diurnal variation of the adenylyl cyclase type 1 in the rat pineal gland. Proc Natl Acad Sci U S A (1996) 0.82
Endocrine mechanisms of seasonal adaptation in small mammals: from early results to present understanding. J Comp Physiol B (2010) 0.82
Melatonin pathway genes and breast cancer risk among Chinese women. Breast Cancer Res Treat (2011) 0.81
Aging and oxygen toxicity: Relation to changes in melatonin. Age (Omaha) (1997) 0.79
Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergic transmission. Br J Clin Pharmacol (1985) 0.79
Heat-stable low molecular weight form of phosphodiesterases from bovine pineal gland. Proc Natl Acad Sci U S A (1978) 0.78
Sexually dimorphic effects of melatonin on brain arginine vasotocin immunoreactivity in green treefrogs (Hyla cinerea). Brain Behav Evol (2012) 0.78
Potential role of melatonin in prevention and treatment of oral carcinoma. Indian J Dent (2014) 0.78
Structures and functions of insect arylalkylamine N-acetyltransferase (iaaNAT); a key enzyme for physiological and behavioral switch in arthropods. Front Physiol (2015) 0.78
Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol (2017) 0.77
Pilot investigation of the circadian plasma melatonin rhythm across the menstrual cycle in a small group of women with premenstrual dysphoric disorder. PLoS One (2012) 0.77
Monoaminergic neuropathology in Alzheimer's disease. Prog Neurobiol (2016) 0.76
Chronotypology and melatonin alterations in minimal hepatic encephalopathy. J Circadian Rhythms (2009) 0.76
Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? Clin Transl Sci (2016) 0.76
Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases. Int J Mol Sci (2017) 0.75
A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc Natl Acad Sci U S A (1980) 4.45
Phospholipid methylation and biological signal transmission. Science (1980) 3.02
A sensitive and specific fluorescence assay for tissue serotonin. Biochem Pharmacol (1965) 2.99
A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain. Life Sci (1967) 2.84
Inhibition of the extraneuronal accumulation and metabolism of norepinephrine by adrenergic blocking agents. J Pharmacol Exp Ther (1967) 2.76
Chemoattractants stimulate degradation of methylated phospholipids and release of arachidonic acid in rabbit leukocytes. Proc Natl Acad Sci U S A (1979) 2.62
Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J Biol Chem (1966) 2.55
Stress hormones: their interaction and regulation. Science (1984) 2.53
Stimulation of phospholipid methylation, Ca2+ influx, and histamine release by bridging of IgE receptors on rat mast cells. Proc Natl Acad Sci U S A (1980) 2.50
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A (1998) 2.48
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells. Proc Natl Acad Sci U S A (1986) 2.45
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Increase in tyrosine hydroxylase activity after reserpine administration. J Pharmacol Exp Ther (1969) 2.32
Biochemistry of catecholamines. Annu Rev Biochem (1971) 2.22
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. Proc Natl Acad Sci U S A (1987) 2.17
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci (1988) 2.14
Enzymatic methylation of phosphatidylethanolamine increases erythrocyte membrane fluidity. Nature (1978) 2.13
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proc Natl Acad Sci U S A (1993) 2.10
beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling. Proc Natl Acad Sci U S A (1979) 2.04
A sensitive enzymatic assay for dopamine- -hydroxylase. J Pharmacol Exp Ther (1971) 2.03
The physiologic disposition and metabolism of norepinephrine in immunosympathectomized animals. J Pharmacol Exp Ther (1966) 2.03
Enzymatic synthesis and rapid translocation of phosphatidylcholine by two methyltransferases in erythrocyte membranes. Proc Natl Acad Sci U S A (1978) 1.96
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit. Proc Natl Acad Sci U S A (1987) 1.94
Reduced uptake of tritiated noradrenaline in tissues of immunosympathectomized animals. Nature (1965) 1.91
Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. Proc Natl Acad Sci U S A (1978) 1.91
Concanavalin A stimulates phospholipid methylation and phosphatidylserine decarboxylation in rat mast cells. Proc Natl Acad Sci U S A (1979) 1.79
Raipid stimulation of protein carboxymethylation in leukocytes by a chemotatic peptide. Nature (1978) 1.77
Regional and subcellular distribution of protein carboxymethylase in brain and other tissues. J Neurochem (1976) 1.75
Increased tyrosine hydroxylase activity after drug-induced alteration of sympathetic transmission. Nature (1969) 1.72
Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves. Science (1971) 1.68
Methylation reactions in the formation and metabolism of catecholamines and other biogenic amines. Pharmacol Rev (1966) 1.67
Trans-synaptic induction of adrenal tyrosine hydroxylase. J Pharmacol Exp Ther (1969) 1.67
Effect of drugs on the accumulation and metabolism of extraneuronal norepinephrine in the rat heart. J Pharmacol Exp Ther (1967) 1.63
Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase. Proc Natl Acad Sci U S A (1975) 1.60
Noradrenaline: fate and control of its biosynthesis. Science (1971) 1.59
Uptake, storage and metabolism of norepinephrine in tissues of the developing rat. J Pharmacol Exp Ther (1967) 1.58
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents. Pharmacol Biochem Behav (1993) 1.55
Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis. Proc Natl Acad Sci U S A (1980) 1.52
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS Lett (1996) 1.52
Serum dopamine-beta-hydroxylase activity. Circ Res (1971) 1.52
Neurally mediated increase in dopamine-beta-hydroxylase activity. Proc Natl Acad Sci U S A (1970) 1.51
Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes. Science (1979) 1.51
Cephapirin: in vitro antibacterial spectrum. Appl Microbiol (1971) 1.50
Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci U S A (1981) 1.47
Factors affecting the enzymatic formation of O-methylated dihydroxy derivatives. Biochem Pharmacol (1965) 1.45
Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling. Proc Natl Acad Sci U S A (1976) 1.39
Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells. Proc Natl Acad Sci U S A (1981) 1.39
Enhanced release of dopamine- -hydroxylase from sympathetic nerves by calcium and phenoxybenzamine and its reversal by prostaglandins. Proc Natl Acad Sci U S A (1971) 1.37
An enzymatic assay for octopamine and other beta-hydroxylated phenylethylamines. J Pharmacol Exp Ther (1969) 1.37
Enhancement of H-3-norepinephrine uptake in rat tissues by O-methylated metabolites of catecholamines. J Pharmacol Exp Ther (1966) 1.36
Cephapirin: pharmacology in normal human volunteers. J Clin Pharmacol New Drugs (1972) 1.36
Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig). Proc Natl Acad Sci U S A (1972) 1.36
IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid. Arch Biochem Biophys (1981) 1.34
Adrenaline synthesis: control by the pituitary gland and adrenal glucocorticoids. Science (1965) 1.34
Adrenal tyrosine hydroxylase: compensatory increase in activity after chemical sympathectomy. Science (1969) 1.33
Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proc Natl Acad Sci U S A (1988) 1.33
Pituitary gland: enzymic formation of methanol from S-adenosylmethionine. Science (1965) 1.32
Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells. Proc Natl Acad Sci U S A (1980) 1.31
Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc Natl Acad Sci U S A (1994) 1.30
The uptake and storage of H3-norepinephrine in the reserpine-pretreated rat heart. J Pharmacol Exp Ther (1965) 1.30
Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension. Science (1976) 1.29
Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts. Proc Natl Acad Sci U S A (1988) 1.29
Influence of pituitary, thyroid, and adrenal hormones on norepinephrine turnover and metabolism in the rat heart. Circ Res (1968) 1.28
Methyltransferase enzymes in red blood cells. J Pharmacol Exp Ther (1971) 1.28
Corticotropin releasing factor stimulates adrenocorticotropin and beta-endorphin release from AtT-20 mouse pituitary tumor cells. Biochem Biophys Res Commun (1982) 1.28
Variants of the rat basophilic leukemia cell line for the study of histamine release. Fed Proc (1982) 1.28
Dopamine- -hydroxylase: regulation of its synthesis and release from nerve terminals. Pharmacol Rev (1972) 1.27
Inhibition of trans-synaptically increased tyrosine hydroxylase activity by cycloheximide and actinomycin D. Mol Pharmacol (1969) 1.27
Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline. Mol Pharmacol (1973) 1.27
Characterization and substrate specificity of a protein carboxymethylase in the pituitary gland. Proc Natl Acad Sci U S A (1974) 1.26
The accumulation of C14-serotonin in the guinea-pig vas deferens. J Pharmacol Exp Ther (1969) 1.25
The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase. J Pharmacol Exp Ther (1989) 1.25
Endocarditis caused by Lactobacillus plantarum. Ann Intern Med (1973) 1.25
On the mechanism of release of norepinephrine from sympathetic nerves induced by depolarizing agents and sympathomimetic drugs. Mol Pharmacol (1975) 1.23
Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ. Proc Natl Acad Sci U S A (1972) 1.23
Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemia basophils. Biochem Biophys Res Commun (1980) 1.23
Norepinephrine and dopamine content of hypothalamic nuclei of the rat. Brain Res (1974) 1.22
Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proc Natl Acad Sci U S A (1990) 1.20
Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells. Proc Natl Acad Sci U S A (1985) 1.19
Sensitive assay for serotonin N-acetyltransferase activity in rat pineal. Anal Biochem (1972) 1.19
Localisation of phenylethanolamine N-methyl transferase in the rat brain nuclei. Nature (1974) 1.19
Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Proc Natl Acad Sci U S A (1969) 1.18
Catecholamines. N Engl J Med (1972) 1.18
Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. J Pharmacol Exp Ther (1966) 1.18
Catecholamine metabolism in experimental hypertension in the rat. Circ Res (1967) 1.17
Phospholipid metabolism, calcium flux, and the receptor-mediated induction of chemotaxis in rabbit neutrophils. J Cell Biol (1982) 1.17
Octopamine. Nature (1977) 1.16
Reduced plasma dopamine-beta-hydroxylase activity in familial dysautonomia. N Engl J Med (1971) 1.16
Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J Neurochem (1980) 1.16
Daily rhythmic changes in tyrosine transaminase activity of the rat liver. Proc Natl Acad Sci U S A (1967) 1.15
Serum dopamine- -hydroxylase: decrease after chemical sympathectomy. Science (1971) 1.15
Control of circadian change of serotonin N-acetyltransferase activity in the pineal organ by the beta--adrenergic receptor. Proc Natl Acad Sci U S A (1972) 1.14
Pineal gland: 24-hour rhythm in norepinephrine turnover. Science (1974) 1.14
Psychotomimetic N-methylated tryptamines: formation in brain in vivo and in vitro. Science (1972) 1.12
Photic and neural control of the 24-hour norepinephrine rhythm in the rat pineal gland. J Pharmacol Exp Ther (1967) 1.11
A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis. J Biol Chem (1989) 1.11
Benzodiazepine and beta-adrenergic receptor ligands independently stimulate phospholipid methylation. Nature (1980) 1.11
Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line. J Pharmacol Exp Ther (1988) 1.10
Delta-9-tetrahydrocannabinol: localization in body fat. Science (1973) 1.10
Elevated plasma dopamine- -hydroxylase activity in autosomal dominant torsion dystonia. N Engl J Med (1973) 1.10