Published in Drug Metab Dispos on October 17, 1974
On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. J Exp Med (1977) 0.83
Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite. Environ Health Perspect (1985) 0.77
Diagnosis of pseudomembranous colitis. Br Med J (1978) 5.96
The nuclear lamina is a meshwork of intermediate-type filaments. Nature (1986) 5.69
Determinants of HIV-1 shedding in the genital tract of women. Lancet (2001) 5.10
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci U S A (1974) 2.41
Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin. Pediatrics (1992) 2.14
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450. J Biol Chem (1975) 2.05
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci U S A (1981) 2.04
Plasma membranes of the rat liver. Isolation and enzymatic characterization of a fraction rich in bile canaliculi. J Cell Biol (1969) 1.95
Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation. J Biol Chem (1967) 1.93
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther (1976) 1.87
Metals as regulators of heme metabolism. Science (1977) 1.86
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A (1994) 1.85
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J (1976) 1.84
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem (1982) 1.83
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process. J Biol Chem (1977) 1.83
Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway. Proc Natl Acad Sci U S A (1972) 1.77
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process. J Biol Chem (1968) 1.76
Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia (2005) 1.69
Prevention of cyclical attacks of acute intermittent porphyria with a long-acting agonist of luteinizing hormone-releasing hormone. N Engl J Med (1984) 1.68
The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method. Am J Obstet Gynecol (1970) 1.65
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. Am Rev Respir Dis (1993) 1.62
Porphyria cutanea tarda associated with the acquired immune deficiency syndrome. Am J Hematol (1987) 1.57
Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract. WHS 001 Study Team. AIDS (2000) 1.54
Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range. Biochem Med (1973) 1.53
Variation of human immunodeficiency virus type 1 viral RNA levels in the female genital tract: implications for applying measurements to individual women. J Infect Dis (2001) 1.53
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III. J Biol Chem (1983) 1.50
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. Proc Natl Acad Sci U S A (1973) 1.48
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease. Proc Natl Acad Sci U S A (1974) 1.48
Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension (2001) 1.48
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA (1996) 1.47
Interactions between nutritional factors and drug biotransformations in man. Proc Natl Acad Sci U S A (1976) 1.47
A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding. AIDS (2001) 1.45
Hepatitis associated antigen (HAA) in pregnant women and their newborn infants. Am J Dis Child (1972) 1.45
Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Pediatrics (1998) 1.44
Operative choledochoscopy. Br J Surg (1979) 1.43
Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids. Proc Natl Acad Sci U S A (1967) 1.41
Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites. Proc Natl Acad Sci U S A (1967) 1.41
Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A (1995) 1.41
Coagulase and deoxyribonuclease activities of staphylococci isolated from clinical sources. Appl Microbiol (1972) 1.40
Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis. J Biol Chem (1979) 1.39
Induction of aryl hydrocarbon hydroxylase in human skin. Drug Metab Dispos (1974) 1.39
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol Ther (1979) 1.38
Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin Pharmacol Ther (1977) 1.38
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model. Science (1982) 1.36
Lead and methyl mercury: effects of acute exposure on cytochrome P-450 and the mixed function oxidase system in the liver. J Exp Med (1972) 1.35
Studies of the influence of chloro-substituent sites and conformational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures. Biochem J (1986) 1.35
Biologic actions of some natural steroids on the liver. N Engl J Med (1968) 1.34
The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma. Ann Intern Med (1993) 1.32
Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am J Respir Crit Care Med (1995) 1.31
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci U S A (1987) 1.31
Impact of sexual abuse on the HIV-risk-related behavior of adolescents in intensive psychiatric treatment. Am J Psychiatry (2000) 1.29
Tin: a potent inducer of heme oxygenase in kidney. Science (1976) 1.27
Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin-protoporphyrin. Hepatology (1984) 1.26
On the genetic activity of benzimidazole and thiophanate fungicides on diploid Aspergillus nidulans. Mutat Res (1974) 1.25
Vascular abnormalities in non-insulin-dependent diabetes mellitus identified by arterial waveform analysis. Am J Med (1993) 1.24
Effect of lead and genetic factors on heme biosynthesis in the human red cell. Ann N Y Acad Sci (1975) 1.24
The induction and characterization of secretory IgA antibodies. Adv Exp Med Biol (1974) 1.24
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. J Pharmacol Exp Ther (1984) 1.24
Contingency detection and the contingent organization of behavior in interactions: implications for socioemotional development in infancy. Psychol Bull (1996) 1.24
Control of heme metabolism with synthetic metalloporphyrins. J Clin Invest (1986) 1.23
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone. J Clin Invest (1983) 1.22
Ion channels in the nuclear envelope. Nature (1990) 1.22
Solubilization and partial purification of heme oxygenase from rat liver. J Biol Chem (1977) 1.19
A study of Chilean refugee children in Denmark. Lancet (1985) 1.19
Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level. Biochem Med (1973) 1.19
Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J Biol Chem (1978) 1.19
Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem (2001) 1.19
Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols. Proc Natl Acad Sci U S A (1977) 1.18
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver. Proc Natl Acad Sci U S A (1976) 1.18
Stimulation of mammalian erythropoiesis by 5beta-H steroid metabolites. Proc Natl Acad Sci U S A (1970) 1.17
Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats. Biochem Biophys Res Commun (1973) 1.16
Hormones and the liver. The effect of estrogens, progestins, and pregnancy on hepatic function. Am J Obstet Gynecol (1969) 1.16
Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia. Blood (1983) 1.15
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria. Biochem J (1983) 1.15
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait. J Exp Med (1975) 1.14
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism. Arch Biochem Biophys (1987) 1.14
Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. J Clin Invest (1997) 1.14
Molecular aspects of the inherited porphyrias. J Intern Med (2000) 1.13
The secretory antibody response. Anti-DNP antibodies induced by dinitrophenylated type 3 pneumococcus. Immunol Commun (1974) 1.13
Additive effect of erythropoietin and heme on murine hematopoietic recovery after azidothymidine treatment. Blood (1993) 1.13
Hyperbeta-lipoproteinemia in acute intermittent porphyria; preliminary report. N Engl J Med (1970) 1.12
The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments. J Interferon Cytokine Res (2000) 1.12
Drug metabolism in normal children, lead-poisoned children, and normal adults. Clin Pharmacol Ther (1975) 1.12
Hepatitis-associated antigen in pregnant women. Acta Pathol Microbiol Scand B Microbiol Immunol (1972) 1.12
Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period. J Exp Med (1975) 1.12
Drug metabolism by the human hepatoma cell, Hep G2. Biochem Biophys Res Commun (1987) 1.11
The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase. Ann Clin Res (1976) 1.11
The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells. Proc Natl Acad Sci U S A (1969) 1.11
Diet-hormone interactions: protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci (1987) 1.10
The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system. J Biol Chem (1975) 1.10
Genetic, metabolic, and biochemical aspects of the porphyrias. Adv Hum Genet (1981) 1.10