Published in Science on September 24, 1982
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci U S A (1987) 1.31
HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage. Bone (2009) 1.13
An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin. J Clin Invest (1984) 1.06
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production. J Clin Invest (1985) 1.05
Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen. J Exp Med (1982) 1.05
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin. Proc Natl Acad Sci U S A (1985) 1.03
Control of heme and cytochrome P-450 metabolism by inorganic metals, organometals and synthetic metalloporphyrins. Environ Health Perspect (1984) 0.96
Hematin-derived anticoagulant. Generation in vitro and in vivo. J Exp Med (1986) 0.87
15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thromb Haemost (2008) 0.86
Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinaemia. Inhibition by zinc-protoporphyrin. Biochem J (1984) 0.85
Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha). J Exp Med (1985) 0.85
Regulation of food intake and body weight by cobalt porphyrins in animals. Proc Natl Acad Sci U S A (1989) 0.84
Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources. J Exp Med (1987) 0.84
Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal. J Clin Invest (1986) 0.84
Metalloporphyrins - an update. Front Pharmacol (2012) 0.83
Prevention of neonatal hyperbilirubinaemia in non-human primates by Zn-protoporphyrin. Biochem J (1985) 0.80
Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications. J Clin Invest (1985) 0.77
Studies with the haeme oxygenase inhibitor Sn-protoporphyrin in patients with primary biliary cirrhosis and idiopathic haemochromatosis. Gut (1990) 0.76
Differential effects of metalloporphyrins on messenger RNA levels of delta-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J Clin Invest (1994) 0.76
Sn-protoporphyrin blocks the increase in serum bilirubin levels that develops postnatally in homozygous Gunn rats. J Exp Med (1988) 0.75
Theoretical investigations on the hydrolysis pathway of tin verdoheme complexes: elucidation of tin's ring opening inhibition role. J Mol Model (2009) 0.75
Diagnosis of pseudomembranous colitis. Br Med J (1978) 5.96
Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci U S A (1974) 2.41
Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin. Pediatrics (1992) 2.14
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450. J Biol Chem (1975) 2.05
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc Natl Acad Sci U S A (1981) 2.04
Plasma membranes of the rat liver. Isolation and enzymatic characterization of a fraction rich in bile canaliculi. J Cell Biol (1969) 1.95
Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation. J Biol Chem (1967) 1.93
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther (1976) 1.87
Metals as regulators of heme metabolism. Science (1977) 1.86
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A (1994) 1.85
Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J (1976) 1.84
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation. J Biol Chem (1982) 1.83
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process. J Biol Chem (1977) 1.83
Assays for porphyrins, delta-aminolevulinic-acid dehydratase, and porphyrinogen synthetase in microliter samples of whole blood: applications to metabolic defects involving the heme pathway. Proc Natl Acad Sci U S A (1972) 1.77
Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process. J Biol Chem (1968) 1.76
Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia (2005) 1.69
Prevention of cyclical attacks of acute intermittent porphyria with a long-acting agonist of luteinizing hormone-releasing hormone. N Engl J Med (1984) 1.68
The influence of pregnancy and oral contraceptive steroids on the concentration of plasma proteins. Studies with a quantitative immunodiffusion method. Am J Obstet Gynecol (1970) 1.65
Porphyria cutanea tarda associated with the acquired immune deficiency syndrome. Am J Hematol (1987) 1.57
Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range. Biochem Med (1973) 1.53
Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III. J Biol Chem (1983) 1.50
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. Proc Natl Acad Sci U S A (1973) 1.48
A microassay for uroporphyrinogen I synthase, one of three abnormal enzyme activities in acute intermittent porphyria, and its application to the study of the genetics of this disease. Proc Natl Acad Sci U S A (1974) 1.48
Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension (2001) 1.48
Interactions between nutritional factors and drug biotransformations in man. Proc Natl Acad Sci U S A (1976) 1.47
Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Pediatrics (1998) 1.44
Operative choledochoscopy. Br J Surg (1979) 1.43
Steroid control of porphyrin and heme biosynthesis: a new biological function of steroid hormone metabolites. Proc Natl Acad Sci U S A (1967) 1.41
Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc Natl Acad Sci U S A (1995) 1.41
Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids. Proc Natl Acad Sci U S A (1967) 1.41
Induction of aryl hydrocarbon hydroxylase in human skin. Drug Metab Dispos (1974) 1.39
Heme biosynthesis and drug metabolism in mice with hereditary hemolytic anemia. Heme oxygenase induction as an adaptive response for maintaining cytochrome P-450 in chronic hemolysis. J Biol Chem (1979) 1.39
Stimulatory effect of brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol Ther (1979) 1.38
Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin Pharmacol Ther (1977) 1.38
Lead and methyl mercury: effects of acute exposure on cytochrome P-450 and the mixed function oxidase system in the liver. J Exp Med (1972) 1.35
Studies of the influence of chloro-substituent sites and conformational energy in polychlorinated biphenyls on uroporphyrin formation in chick-embryo liver cell cultures. Biochem J (1986) 1.35
Biologic actions of some natural steroids on the liver. N Engl J Med (1968) 1.34
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci U S A (1987) 1.31
Tin: a potent inducer of heme oxygenase in kidney. Science (1976) 1.27
Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin-protoporphyrin. Hepatology (1984) 1.26
On the genetic activity of benzimidazole and thiophanate fungicides on diploid Aspergillus nidulans. Mutat Res (1974) 1.25
Effect of lead and genetic factors on heme biosynthesis in the human red cell. Ann N Y Acad Sci (1975) 1.24
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. J Pharmacol Exp Ther (1984) 1.24
Contingency detection and the contingent organization of behavior in interactions: implications for socioemotional development in infancy. Psychol Bull (1996) 1.24
Control of heme metabolism with synthetic metalloporphyrins. J Clin Invest (1986) 1.23
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone. J Clin Invest (1983) 1.22
Solubilization and partial purification of heme oxygenase from rat liver. J Biol Chem (1977) 1.19
Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J Biol Chem (1978) 1.19
Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated delta-aminolevulinic acid dehydratase of whole blood and the blood lead level. Biochem Med (1973) 1.19
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver. Proc Natl Acad Sci U S A (1976) 1.18
Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols. Proc Natl Acad Sci U S A (1977) 1.18
Stimulation of mammalian erythropoiesis by 5beta-H steroid metabolites. Proc Natl Acad Sci U S A (1970) 1.17
Hormones and the liver. The effect of estrogens, progestins, and pregnancy on hepatic function. Am J Obstet Gynecol (1969) 1.16
Tin-protoporphyrin suppression of hyperbilirubinemia in mutant mice with severe hemolytic anemia. Blood (1983) 1.15
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria. Biochem J (1983) 1.15
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait. J Exp Med (1975) 1.14
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism. Arch Biochem Biophys (1987) 1.14
Molecular aspects of the inherited porphyrias. J Intern Med (2000) 1.13
Additive effect of erythropoietin and heme on murine hematopoietic recovery after azidothymidine treatment. Blood (1993) 1.13
Hyperbeta-lipoproteinemia in acute intermittent porphyria; preliminary report. N Engl J Med (1970) 1.12
Drug metabolism in normal children, lead-poisoned children, and normal adults. Clin Pharmacol Ther (1975) 1.12
Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period. J Exp Med (1975) 1.12
Drug metabolism by the human hepatoma cell, Hep G2. Biochem Biophys Res Commun (1987) 1.11
The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase. Ann Clin Res (1976) 1.11
The occurrence of substances in human plasma capable of inducing the enzyme delta-aminolevulinate synthetase in liver cells. Proc Natl Acad Sci U S A (1969) 1.11
Diet-hormone interactions: protein/carbohydrate ratio alters reciprocally the plasma levels of testosterone and cortisol and their respective binding globulins in man. Life Sci (1987) 1.10
Genetic, metabolic, and biochemical aspects of the porphyrias. Adv Hum Genet (1981) 1.10
The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system. J Biol Chem (1975) 1.10
Manganese and zinc blockade of enzyme induction: studies with microsomal heme oxygenase. Proc Natl Acad Sci U S A (1979) 1.09
Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics (1999) 1.09
Studies in porphyria. II. Evidence for a deficiency of steroid delta-4-5-alpha-reductase activity in acute intermittent porphyria. J Exp Med (1973) 1.08
Induction of hepatic delta-amino-levulinic acid synthetase by oral contraceptive steroids. J Clin Endocrinol Metab (1970) 1.08
Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility. Pediatrics (1988) 1.07
Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expression. J Pharmacol Exp Ther (1999) 1.07
Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics (1995) 1.07
Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin Pharmacol Ther (1976) 1.06
An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin. J Clin Invest (1984) 1.06
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production. J Clin Invest (1985) 1.05
Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes. J Clin Invest (1978) 1.05
Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen. J Exp Med (1982) 1.05
Studies in porphyria. I. A defect in the reductive transformation of natural steroid hormones in the hereditary liver disease, acute intermittent porphyria. J Exp Med (1972) 1.04
The cytochrome P-450-depleted animal: an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci U S A (1982) 1.03
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin. Proc Natl Acad Sci U S A (1985) 1.03
Heme oxygenase induction with attenuation of experimentally induced corneal inflammation. Biochem Pharmacol (1997) 1.02
Effect of brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther (1984) 1.02