Published in Bull Cancer on January 01, 1979
Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue. Br J Cancer (1984) 0.80
Evolutionary dynamics and significance of multiple subclonal mutations in cancer. DNA Repair (Amst) (2017) 0.75
Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res (1973) 7.59
Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. Cancer Res (1973) 4.54
Selective heat sensitivity of cancer cells. Biochemical and clinical studies. Cancer (1967) 3.04
Chemical carcinogenesis. Annu Rev Biochem (1975) 2.70
Fluorinated pyrimidines. Prog Nucleic Acid Res Mol Biol (1965) 2.63
In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons. Proc Natl Acad Sci U S A (1971) 2.21
Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro. Int J Cancer (1969) 1.96
Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells. Cancer Res (1976) 1.64
Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons. Proc Natl Acad Sci U S A (1971) 1.61
Cancer chemotherapy with purine and pyrimidine analogues. Annu Rev Pharmacol (1967) 1.59
Endogenous oncornaviruses in chemically induced transformation. I. Transformation independent of virus production. Virology (1975) 1.55
Fluorinated pyrimidines and their nucleosides. Adv Enzymol Relat Areas Mol Biol (1983) 1.54
In vitro malignant transformation by methylcholanthrene of the progeny of single cells derived from C3H mouse prostate. Proc Natl Acad Sci U S A (1970) 1.53
Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides. Mol Pharmacol (1965) 1.50
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate. Biochem Biophys Res Commun (1972) 1.50
Malignant transformation in vitro by carcinogenic hydrocarbons. Science (1967) 1.41
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. J Biol Chem (1989) 1.39
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem (1992) 1.38
Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons. Cancer Res (1972) 1.33
Transformation of C3H/10T1/2CL8 mouse embryo fibroblasts by ultraviolet irradiation and a phorbol ester. Nature (1976) 1.32
Chemical oncogenesis in culture. Adv Cancer Res (1973) 1.31
Transformation of hamster embryo cells by epoxides and other derivatives of polycyclic hydrocarbons. Cancer Res (1972) 1.25
An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene. Biochem Biophys Res Commun (1971) 1.24
Antigenicity of clones of mouse prostate cells transformed in vitro. Int J Cancer (1972) 1.21
Cell cycle dependency of oncogenic transformation induced by N-methyl-N'-nitro-N-nitrosoquanidine in culture. Cancer Res (1974) 1.20
The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine. Cancer Res (1972) 1.19
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. Cancer Res (1982) 1.18
Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 1.17
Studies on the quantitative biology of hyperthermic killing of HeLa cells. Cancer Res (1973) 1.16
Phase I study of (6R)-5,10-dideazatetrahydrofolate: a folate antimetabolite inhibitory to de novo purine synthesis. J Natl Cancer Inst (1993) 1.15
Liver homogenate-mediated mutagenesis in chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins. Mutat Res (1977) 1.13
Fluorinated pyrimidines. 38. The incorporation of 5-trifluoromethyl-2'-deoxyuridine into the deoxyribonucleic acid of vaccinia virus. Mol Pharmacol (1970) 1.13
Cultivation in vitro of cells derived from adult C3H mouse ventral prostate. J Natl Cancer Inst (1969) 1.13
Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem (2000) 1.13
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells. Cancer Res (1978) 1.12
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res (1983) 1.11
Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. Biochemistry (1974) 1.11
Complementation mapping in microcell hybrids: localization of Fpgs and Ak-1 on Mus musculus chromosome 2. Somatic Cell Genet (1983) 1.10
Fluorinated pyrimidines. XXXVII. Effects of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture. Mol Pharmacol (1970) 1.10
Problems in the chemotherapy of cancer in the neonate. Am J Pediatr Hematol Oncol (1981) 1.08
The mutagenicity to mammalian cells of pyrimidine nucleoside analogs. Mutat Res (1972) 1.07
Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells. J Biol Chem (1976) 1.07
The binding of polycyclic aromatic hydrocarbons to the DNA, RNA, and proteins of transformable cells in culture. Cancer Res (1971) 1.05
Comparative studies of fluorinated pyrimidines with various cell lines. Cancer Res (1968) 1.04
Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc Natl Acad Sci U S A (1979) 1.04
In vitro malignant transformation of cells derid from mouse prostate in the presence of 3-methylcholanthrene. J Natl Cancer Inst (1969) 1.03
Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells. Cancer Res (1970) 1.03
Binding of tritium-labeled polycyclic hydrocarbons to DNA of mouse skin. Cancer Res (1967) 1.02
Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and noncarcinogenic compounds. Mol Pharmacol (1970) 1.02
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem (1985) 1.01
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. Biochemistry (1991) 1.00
A simple procedure for the synthesis of high specific activity tritiated (6S)-5-formyltetrahydrofolate. Anal Biochem (1982) 1.00
The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines. Cancer Res (1976) 0.99
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase. Proc Natl Acad Sci U S A (1979) 0.97
Antigenicity of cells derived from mouse prostate cells after malignant transformation in vitro by carcinogenic hydrocarbons. Cancer Res (1970) 0.97
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem (1988) 0.97
Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine. Chemotherapy (1976) 0.97
Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. J Biol Chem (1995) 0.95
Inhibition of induced differentiation of C3H/10T 1/2 clone 8 mouse embryo cells by tumor promoters. Cancer Res (1980) 0.95
Augmentation of the therapeutic activity of lometrexol -(6-R)5,10-dideazatetrahydrofolate- by oral folic acid. Cancer Res (1996) 0.95
Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase. Biochemistry (1997) 0.94
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides. Cancer Res (1976) 0.94
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. Proc Natl Acad Sci U S A (1979) 0.93
Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage. J Biol Chem (1995) 0.93
Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA. Cancer Res (1969) 0.93
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells. Cancer Res (1993) 0.92
Probabilistic view of the transformation of cultured C3H/10T1/2 mouse embryo fibroblasts by 3-methylcholanthrene. Proc Natl Acad Sci U S A (1980) 0.92
Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine. Nature (1978) 0.92
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine. Cancer Res (1980) 0.92
Influence of drugs and synchrony on the hyperthermic killing of HeLa cells. Cancer Res (1973) 0.92
Fluorinated pyrimidines. XLIV. Interaction of 5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate with deoxyribonucleic acid polymerases. Mol Pharmacol (1973) 0.92
Metabolism of polycyclic aromatic hydrocarbons in cell cultuires. Cancer Res (1971) 0.91
Fluorinated pyrimidines. XXVII. Attempts to determine transcription errors during the formation of fluorouracil-containing messenger ribonucleic acid. Biochemistry (1966) 0.90
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res (1986) 0.90
Attempts to produce carcinogenesis in organ cultures of mouse prostate with polycyclic hydrocarbons. Int J Cancer (1967) 0.90
Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol (1995) 0.89
Fluorinated pyrimidines. XL. The reduction of 5-fluorouridine 5'-diphosphate by ribonucleotide reductase. Mol Pharmacol (1972) 0.89
Breakdown of HeLa cell DNA mediated by vaccinia virus. Proc Natl Acad Sci U S A (1973) 0.89
Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem (2000) 0.88
Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Mol Pharmacol (1992) 0.87
Fluorinated pyrimidines. XXXI. Mechanisms of inhibition of vaccinia virus replication in HeLa cells by pyrimidine nucleosides. Proc Soc Exp Biol Med (1969) 0.87
Neoantigens on chemically transformed cloned C3H mouse embryo cells. Cancer Res (1975) 0.87
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues. J Med Chem (1989) 0.87
On the molecular mechanism of the antiviral activity of trifluorothymidine. Ann N Y Acad Sci (1975) 0.87
Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin. Science (1978) 0.86
Characteristics of murine prostatic acid phosphatase: comparison with other tissues and species. Arch Biochem Biophys (1968) 0.86
Utilization of host-cell DNA by vaccinia virus replicating in HeLa cells irradiated intranuclearly with tritium. J Gen Virol (1971) 0.86
Studies on the cellular and molecular mechanisms of hydrocarbon carcinogenesis. Eur J Cancer (1970) 0.86
Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to DNA, RNA, and proteins of transformable cells. Chem Biol Interact (1972) 0.86
Studies on the organ culture of human tumors. Cancer Res (1966) 0.86
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. Cancer Res (1982) 0.86
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate. J Biol Chem (1998) 0.85
Influence of "feeder cells" and inducers and inhibition of microsomal mixed-function oxidases on hydrocarbon-induced malignant transformation of cells derived from C3H mouse prostate. Cancer Res (1972) 0.85
The influence of serum components on the growth and mutation of Chinese hamster cells in medium containing aminopterin. Mutat Res (1974) 0.85
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture. Cancer Res (1970) 0.85
Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents. Cancer Res (1979) 0.85