Published in Biochem J on November 15, 1979
The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. Biochem J (1979) 1.02
Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion. J Biol Chem (2010) 1.01
Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue. Biochem J (1984) 0.87
Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes (1967) 11.63
Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme. Anal Biochem (1969) 7.65
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios. Biochem Biophys Res Commun (1975) 2.77
Standard Gibbs free energy, enthalpy, and entropy changes as a function of pH and pMg for several reactions involving adenosine phosphates. J Biol Chem (1969) 2.37
The stimulus-secretion coupling of glucose-induced insulin release. 3. Uptake of 45 calcium by isolated islets of Langerhans. Endocrinology (1971) 2.01
Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction. Nature (1975) 1.91
The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia (1979) 1.52
The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations. J Lab Clin Med (1970) 1.49
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Eur J Biochem (1978) 1.36
Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase. J Biol Chem (1974) 1.33
Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets. Diabetologia (1973) 1.16
Calcium antagonists and islet function: VII. Effect of calcium deprivation. J Membr Biol (1978) 1.07
The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. Biochem J (1979) 1.02
Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide. Biochem J (1974) 1.01
Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets. Diabetologia (1974) 0.97
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic and functional effects of NH4+ in rat islets. J Clin Invest (1978) 0.96
Effect of phenylpyruvate on enzymes involved in fatty acid synthesis in rat brain. Biochem J (1973) 0.95
Effects of alpha-ketomonocarboxylic acids upon insulin secretion and metabolism of isolated pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol (1975) 0.89
Effects of bicyclic leucine analogues on insulin release from the perfused rat pancreas and fluorescence of reduced pyridine nucleotides from perifused pancreatic islets. Life Sci (1975) 0.83
Effects of glucose and acetylcholine on islet tissue NADH and insulin release. Life Sci (1978) 0.81
Inhibition of p-chloromercuribenzoate- and glucose-induced insulin release in vitro by methylene blue, diamide, and tert-butyl hydroperoxide. Mol Pharmacol (1977) 0.79
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet (1997) 4.77
Pancreatic beta-cell web: its possible role in insulin secretion. Science (1972) 2.63
A possible role for the adenylcyclase system in insulin secretion. J Clin Invest (1967) 2.54
Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Nature (1988) 2.07
The stimulus-secretion coupling of glucose-induced insulin release. 3. Uptake of 45 calcium by isolated islets of Langerhans. Endocrinology (1971) 2.01
Insulin release: the fuel hypothesis. Metabolism (1979) 1.84
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature (1980) 1.81
The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system. Diabetes (1971) 1.66
Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate. Biochem J (1983) 1.65
Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem (1996) 1.64
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature (1990) 1.64
The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate. J Clin Invest (1972) 1.62
Insulin secretion: multifactorial regulation for a single process of release. The Minkowski award lecture delivered on September 7, 1972 before the European Association for the study of Diabetes at Madrid, Spain. Diabetologia (1973) 1.62
The internal pH and membrane potential of the insulin-secretory granule. Biochem J (1982) 1.59
Calmodulin activation of adenylate cyclase in pancreatic islets. Science (1979) 1.58
Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets. Am J Physiol (1973) 1.57
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem J (1978) 1.52
Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes (1999) 1.52
The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia (1979) 1.52
The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations. J Lab Clin Med (1970) 1.49
Cathepsin B-related proteases in the insulin secretory granule. J Biol Chem (1984) 1.47
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes (1999) 1.39
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell. Semin Cell Dev Biol (2000) 1.38
Stimulation of insulin secretion by noncarbohydrate metabolites. J Lab Clin Med (1968) 1.38
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Eur J Biochem (1978) 1.36
Isolation and characterisation of insulin secretory granules from a rat islet cell tumour. Diabetologia (1982) 1.36
Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. J Biol Chem (1992) 1.34
The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity. Endocrinology (1973) 1.33
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J (1987) 1.33
Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc Natl Acad Sci U S A (1982) 1.32
Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents. Biochem J (1989) 1.32
Patterns of calcium localization in pancreatic endocrine cells. J Cell Sci (1976) 1.30
Effect of adrenaline and glucose on release of glucagon and insulin in vitro. Nat New Biol (1971) 1.29
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. J Biol Chem (2001) 1.28
Effect of fasting upon insulin secretion in the rat. Am J Physiol (1967) 1.27
Effect of glucose on K+ handling by pancreatic islets. FEBS Lett (1977) 1.27
T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet (1991) 1.26
Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets. Endocrinology (1984) 1.24
Dynamics of O2 consumption in rat pancreatic islets. Diabetologia (1980) 1.24
Glucose-induced changes in cytosolic ATP content in pancreatic islets. Biochim Biophys Acta (1987) 1.24
Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype. Diabetologia (2007) 1.23
Regulation of calcium fluxes and their regulatory roles in pancreatic islets. Ann N Y Acad Sci (1978) 1.23
Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. Biochem J (1998) 1.22
Insulin secretion by isolated islets in presence of glucose, insulin and anti-insulin serum. Proc Soc Exp Biol Med (1967) 1.21
Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia (2007) 1.21
A computational strategy for the deconvolution of NMR spectra with multiplet structures and constraints: analysis of overlapping 13C-2H multiplets of 13C enriched metabolites from cell suspensions incubated in deuterated media. Magn Reson Med (1996) 1.21
Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin Endocrinol Metab (2010) 1.19
Enteropathy precedes type 1 diabetes in the BB rat. Gut (2004) 1.19
Hexose metabolism in pancreatic islets. Absence of glucose-6-phosphatase in rat islet cells. Mol Cell Endocrinol (1987) 1.19
Role of microtubules in the phasic pattern of insulin release. Ann N Y Acad Sci (1975) 1.19
The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets. Mol Cell Endocrinol (1980) 1.19
A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. Biochem J (1992) 1.19
Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes (1996) 1.17
Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects. Arch Biochem Biophys (1996) 1.17
Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. J Clin Invest (1993) 1.17
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci U S A (1981) 1.16
Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules. Biochem J (1987) 1.16
The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state. Biochem J (1984) 1.15
Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules. Biochem J (1982) 1.15
Identification and characterization of a human cDNA and gene encoding a ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein. J Mol Endocrinol (2002) 1.14
Alloxan toxicity to the pancreatic B-cell. A new hypothesis. Biochem Pharmacol (1982) 1.13
Production and characterization of monoclonal antibodies to insulin secretory granule membranes. Biochem J (1987) 1.13
Differences in glucose handling by pancreatic A- and B-cells. J Biol Chem (1984) 1.13
Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. Endocrinology (1985) 1.12
Isolation and characterization of calmodulin from an insulin-secreting tumour. Biochem J (1981) 1.12
Regulation of calcium fluxes in rat pancreatic islets: calcium extrusion by sodium-calcium countertransport. J Membr Biol (1980) 1.11
The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient. Arch Biochem Biophys (1983) 1.11
The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by islets of Langerhans. Metabolism (1968) 1.11
Calcium antagonists and islet function. XI. Effect of nifedipine. Horm Res (1977) 1.10
Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis. Experientia (1977) 1.10
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine. Diabetes (1980) 1.10
Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia (2009) 1.10
Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism (1999) 1.10
The stimulus-secretion coupling of glucose-induced insulin release. Insulin release due to glycogenolysis in glucose-deprived islets. Biochem J (1977) 1.08