Published in Science on October 12, 1979
Calmodulin activates prokaryotic adenylate cyclase. Proc Natl Acad Sci U S A (1980) 3.83
Calmodulin activation of plant microsomal Ca uptake. Proc Natl Acad Sci U S A (1980) 2.94
Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells. J Physiol (1993) 2.47
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Association between endocrine pancreatic secretory granules and in-vitro-assembled microtubules is dependent upon microtubule-associated proteins. J Cell Biol (1982) 1.51
Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells. EMBO J (1992) 1.24
Isolation and characterization of calmodulin from an insulin-secreting tumour. Biochem J (1981) 1.12
Evidence for the participation of calmodulin in stimulus-secretion coupling in the pancreatic beta-cell. Biochem J (1980) 1.08
Correlation of Ca2+-and calmodulin-dependent protein kinase activity with secretion of insulin from islets of Langerhans. Biochem J (1983) 1.04
Possible role for calmodulin in insulin release. Studies with trifluoperazine in rat pancreatic islets. J Clin Invest (1980) 1.04
Cyclic AMP-dependent protein phosphorylation and insulin secretion in intact islets of Langerhans. Biochem J (1984) 1.03
Secretory protein decondensation as a distinct, Ca2+-mediated event during the final steps of exocytosis in Paramecium cells. J Cell Biol (1981) 0.99
Effects of trifluoperazine and pimozide on stimulus-secretion coupling in pancreatic B-cells. Suggestion for a role of calmodulin? Biochem J (1981) 0.98
Cyclic nucleotide phosphodiesterase of rat pancreatic islets. Effects of Ca2+, calmodulin and trifluoperazine. Biochem J (1981) 0.91
Calmodulin activation of rat lung adenylate cyclase is independent of the cytoplasmic factors modulating the enzyme. Biochem J (1981) 0.88
Cyclic AMP dynamics in the pancreatic β-cell. Ups J Med Sci (2012) 0.84
Calcium dependency and free calcium concentrations during insulin secretion in a hamster beta cell line. J Clin Invest (1986) 0.84
Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans. Biochem J (1982) 0.83
GTP is not required for calmodulin stimulation of bovine brain adenylate cyclase. Proc Natl Acad Sci U S A (1982) 0.83
Differential effects of Ca2+-calmodulin on adenylate cyclase activity cyclase activity in mouse and rat pancreatic islets. Biochem J (1982) 0.82
Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C. Biochem J (1988) 0.80
Effect of trifluoperazine on rabbit cortical collecting tubular response to vasopressin. J Physiol (1986) 0.80
Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer. Metabolomics (2014) 0.78
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity. Nutr Diabetes (2016) 0.78
Crayfish abdominal muscle adenylate cyclase. Studies on the stimulation by a Ca2+-binding protein. Biochem J (1983) 0.76
Pancreatic beta-cell web: its possible role in insulin secretion. Science (1972) 2.63
A possible role for the adenylcyclase system in insulin secretion. J Clin Invest (1967) 2.54
Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose. J Clin Invest (1968) 2.46
The stimulus-secretion coupling of glucose-induced insulin release. 3. Uptake of 45 calcium by isolated islets of Langerhans. Endocrinology (1971) 2.01
Insulin release: the fuel hypothesis. Metabolism (1979) 1.84
L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. Nature (1980) 1.81
Glucagon: role in the hyperglycemia of diabetes mellitus. Science (1975) 1.72
Large glucagon immunoreactivity in extracts of pancreas. J Biol Chem (1970) 1.70
The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system. Diabetes (1971) 1.66
The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate. J Clin Invest (1972) 1.62
Insulin secretion: multifactorial regulation for a single process of release. The Minkowski award lecture delivered on September 7, 1972 before the European Association for the study of Diabetes at Madrid, Spain. Diabetologia (1973) 1.62
Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets. Am J Physiol (1973) 1.57
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem J (1978) 1.52
The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia (1979) 1.52
The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations. J Lab Clin Med (1970) 1.49
Stimulation of insulin secretion by noncarbohydrate metabolites. J Lab Clin Med (1968) 1.38
The stimulus-secretion coupling of glucose-induced insulin release. Metabolic effects of menadione in isolated islets. Eur J Biochem (1978) 1.36
The stimulus-secretion coupling of glucose-induced insulin release. XIV. Glucose regulation of insular biosynthetic activity. Endocrinology (1973) 1.33
Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc Natl Acad Sci U S A (1982) 1.32
Patterns of calcium localization in pancreatic endocrine cells. J Cell Sci (1976) 1.30
Effect of adrenaline and glucose on release of glucagon and insulin in vitro. Nat New Biol (1971) 1.29
Characterization of glucagon-like immunoreactivity (GLI). Diabetes (1970) 1.29
Effect of fasting upon insulin secretion in the rat. Am J Physiol (1967) 1.27
Effect of glucose on K+ handling by pancreatic islets. FEBS Lett (1977) 1.27
Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets. Endocrinology (1984) 1.24
Dynamics of O2 consumption in rat pancreatic islets. Diabetologia (1980) 1.24
Glucose-induced changes in cytosolic ATP content in pancreatic islets. Biochim Biophys Acta (1987) 1.24
Regulation of calcium fluxes and their regulatory roles in pancreatic islets. Ann N Y Acad Sci (1978) 1.23
Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan-diabetic dogs. Metabolism (1975) 1.22
Elevated plasma glucagon levels in cirrhosis of the liver. N Engl J Med (1973) 1.22
Insulin secretion by isolated islets in presence of glucose, insulin and anti-insulin serum. Proc Soc Exp Biol Med (1967) 1.21
A computational strategy for the deconvolution of NMR spectra with multiplet structures and constraints: analysis of overlapping 13C-2H multiplets of 13C enriched metabolites from cell suspensions incubated in deuterated media. Magn Reson Med (1996) 1.21
Enteropathy precedes type 1 diabetes in the BB rat. Gut (2004) 1.19
Hexose metabolism in pancreatic islets. Absence of glucose-6-phosphatase in rat islet cells. Mol Cell Endocrinol (1987) 1.19
Role of microtubules in the phasic pattern of insulin release. Ann N Y Acad Sci (1975) 1.19
The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets. Mol Cell Endocrinol (1980) 1.19
Insulinotropic action of methyl pyruvate: enzymatic and metabolic aspects. Arch Biochem Biophys (1996) 1.17
Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid. Proc Natl Acad Sci U S A (1981) 1.16
The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state. Biochem J (1984) 1.15
Alloxan toxicity to the pancreatic B-cell. A new hypothesis. Biochem Pharmacol (1982) 1.13
The isolation and sequencing of human gastric inhibitory peptide (GIP). FEBS Lett (1984) 1.13
Differences in glucose handling by pancreatic A- and B-cells. J Biol Chem (1984) 1.13
Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. Endocrinology (1985) 1.12
The stimulus-secretion coupling of glucose-induced insulin release: fuel metabolism in islets deprived of exogenous nutrient. Arch Biochem Biophys (1983) 1.11
Regulation of calcium fluxes in rat pancreatic islets: calcium extrusion by sodium-calcium countertransport. J Membr Biol (1980) 1.11
The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by islets of Langerhans. Metabolism (1968) 1.11
Calcium antagonists and islet function. XI. Effect of nifedipine. Horm Res (1977) 1.10
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine. Diabetes (1980) 1.10
Molecular size of extractable glucagon and glucagon-like immunoreactivity (GLI) in plasma. Diabetes (1970) 1.10
Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse. Hypothesis. Experientia (1977) 1.10
Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism (1999) 1.10
The stimulus-secretion coupling of glucose-induced insulin release. Insulin release due to glycogenolysis in glucose-deprived islets. Biochem J (1977) 1.08
Deficient activity of FAD-linked glycerophosphate dehydrogenase in islets of GK rats. Diabetologia (1993) 1.08
Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets. Cancer Res (1980) 1.08
Cell signalling of the GLP-1 action in rat liver. Mol Cell Endocrinol (2003) 1.08
Demonstration and characterization of a second fraction of glucagon-like immunoreactivity in jejunal extracts. Am J Med Sci (1968) 1.08
Perturbation of pancreatic islet function in glucose-infused rats. Metabolism (1990) 1.07
Cytochalasin B-induced impariment of glucose metabolism in islets of Langerhans. Endocrinology (1976) 1.07
Dynamics of insulin release and microtubular-microfilamentous system. VII. Do microfilaments provide the motive force for the translocation and extrusion of beta granules? Diabetes (1975) 1.07
Synergistic effect of a tumor-promoting phorbol ester and a hypoglycemic sulfonylurea upon insulin release. Endocrinology (1983) 1.07
The stimulus-secretion coupling of glucose-induced insulin release. Sorbitol metabolism in isolated islets. Eur J Biochem (1974) 1.07
The stimulus secretion coupling of glucose-induced insulin release. XXVII. Effect of glucose on K+ fluxes in isolated islets. Pflugers Arch (1978) 1.07
Effects of glucose and glucagon on the fructose 2,6-bisphosphate content of pancreatic islets and purified pancreatic B-cells. A comparison with isolated hepatocytes. Biochem J (1984) 1.07
Hyperglucagonism induced by glucocorticoid treatment in man. N Engl J Med (1973) 1.07
Calcium antagonists and islet function: VII. Effect of calcium deprivation. J Membr Biol (1978) 1.07
The role of cyclic AMP in insulin release. Experientia (1984) 1.06
The stimulus-secretion coupling of glucose-induced insulin release. Fasting-induced adaptation of key glycolytic enzymes in isolated islets. J Biol Chem (1976) 1.06
Factitious hypoglycaemia documented by a modified assay for the measurement of plasma sulphonylurea. Diabet Med (1995) 1.05
Calcium antagonists and islet function--III. The possible site of action of verapamil. Biochem Pharmacol (1977) 1.05
The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic response of pancreatic islets of L-glutamine and L-leucine. J Biol Chem (1982) 1.05
Pancreatic secretion of total protein and of three hydrolases collected in healthy subjects via duodenoscopic cannulation. Effects of secretin, pancreozymin, and caerulein. Gastroenterology (1975) 1.05
Gating and blocking of calcium channels by dihydropyridines in the pancreatic B-cell. Biochem Biophys Res Commun (1984) 1.05
The C-terminus ends of secretin and VIP interact with the N-terminal domains of their receptors. Peptides (1996) 1.04
Development of high affinity selective VIP1 receptor agonists. Peptides (1997) 1.04
Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets. Am J Physiol (1979) 1.03
Exocrine pancreas: evidence for topographic partition of secretory function. Science (1975) 1.03
The stimulus-secretion coupling of glucose-induced insulin release. XXVIII. Effect of glucose on Na+ fluxes in isolated islets. Pflugers Arch (1978) 1.03
Cooling dissociates glucose-induced insulin release from electrical activity and cation fluxes in rodent pancreatic islets. J Physiol (1984) 1.03
Similarities in the stimulus-secretion coupling mechanisms of glucose- and 2-keto acid-induced insulin release. Endocrinology (1980) 1.03
The stimulus secretion coupling of glucose-induced insulin release. Arch Biochem Biophys (1979) 1.03
The stimulus-secretion coupling of glucose-induced insulin release. XXII. Qualitative and quantitative aspects of glycolysis in isolated islets. Acta Diabetol Lat (1977) 1.02
The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets. Biochem J (1979) 1.02
Selective uptake of alloxan by pancreatic B-cells. Biochem J (1982) 1.02
Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia (1994) 1.01
Stimulus-secretion coupling of glucose-induced insulin release. Effect of intracellular acidification upon calcium efflux from islet cells. Metabolism (1980) 1.01
Hexose metabolism in pancreatic islets. Inhibition of hexokinase. Biochem J (1984) 1.01
Control of gluconeogenesis by acetyl CoA in rats treated with glucagon and anti-insulin serum. Biochem Biophys Res Commun (1966) 1.01
The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets. Biochim Biophys Acta (1981) 1.00
Insulin release : the fuel concept. Diabete Metab (1983) 1.00
Regulation of calcium fluxes in pancreatic islets: two calcium movements' dissociated response to glucose. Am J Physiol (1980) 1.00
Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release. J Physiol (1978) 1.00
Presence of glucagon immunoreactivity in the globulin fraction of human plasma ("big plasma glucagon"). J Clin Endocrinol Metab (1974) 1.00
The stimulus-secretion coupling of glucose-induced insulin release. XX. fasting: a model for altered glucose recognition by the B-cell. Metabolism (1976) 0.99
Carica papaya latex is a rich source of a class II chitinase. Phytochemistry (1997) 0.99
Anomeric specificity of D-glucose phosphorylation by rat liver glucose-6-phosphatase. Biochem J (1989) 0.99
The stimulus-secretion coupling of glucose-induced insulin release. IX. The participation of the beta cell web. Diabetes (1972) 0.99
Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells. Diabetes (1996) 0.98