Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 4344813)

Published in Biochem Biophys Res Commun on December 18, 1972

Authors

R Heintz, P Benveniste, W H Robinson, R M Coates

Articles by these authors

Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme. Biochemistry (2000) 2.31

Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites. J Am Chem Soc (2001) 2.07

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J Exp Med (1993) 1.57

Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase. Eur J Biochem (2000) 1.57

Manipulation by tridemorph, a systemic fungicide, of the sterol composition of maize leaves and roots. Plant Physiol (1983) 1.48

Differential effects of plant sterols on water permeability and on acyl chain ordering of soybean phosphatidylcholine bilayers. Proc Natl Acad Sci U S A (1991) 1.39

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci U S A (2009) 1.39

The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. Plant J (2001) 1.34

Isolation and identification of sterols from subcellular fractions of bean leaves (Phaseolus vulgaris). Biochim Biophys Acta (1972) 1.34

Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis. Org Lett (2000) 1.28

Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum). Arch Biochem Biophys (2001) 1.28

SC-52151, a novel inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother (1995) 1.25

Delta8(14)-steroids in the bacterium Methylococcus capsulatus. Biochem J (1976) 1.22

Isolation and characterization of an Arabidopsis thaliana cDNA encoding a delta 7-sterol-C-5-desaturase by functional complementation of a defective yeast mutant. Plant J (1996) 1.17

Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase in a tobacco mutant that overproduces sterols. Biochem Biophys Res Commun (1992) 1.17

Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation (1992) 1.16

Role of highly conserved residues in the reaction catalyzed by recombinant Delta7-sterol-C5(6)-desaturase studied by site-directed mutagenesis. Biochemistry (2000) 1.16

Demyelination and inhibition of tumor necrosis factor (TNF). Clin Exp Rheumatol (2004) 1.14

Cloning of cDNAs or genes encoding enzymes of sterol biosynthesis from plants and other eukaryotes: heterologous expression and complementation analysis of mutations for functional characterization. Prog Lipid Res (1997) 1.11

Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chem Biol (2000) 1.11

Formation and function of the active ribosome complex. Cold Spring Harb Symp Quant Biol (1966) 1.09

Plant sterol metabolism. Enzymatic cleavage of the 9beta, 19beta-cyclopropane ring of cyclopropyl sterols in bramble tissue cultures. J Biol Chem (1974) 1.09

Long-term reversal of diabetes by the injection of immunoprotected islets. Proc Natl Acad Sci U S A (1993) 1.07

Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis. Eur J Biochem (1998) 1.07

Overexpression of an Arabidopsis cDNA encoding a sterol-C24(1)-methyltransferase in tobacco modifies the ratio of 24-methyl cholesterol to sitosterol and is associated with growth reduction. Plant Physiol (1998) 1.04

Identification of cDNAs encoding sterol methyl-transferases involved in the second methylation step of plant sterol biosynthesis. Eur J Biochem (1997) 1.04

Biosynthesis of cyclic diterpene hydrocarbons in rice cell suspensions: conversion of 9,10-syn-labda-8(17),13-dienyl diphosphate to 9beta-pimara-7,15-diene and stemar-13-ene. Arch Biochem Biophys (1996) 1.04

An Arabidopsis mutant deficient in sterol biosynthesis: heterologous complementation by ERG 3 encoding a delta 7-sterol-C-5-desaturase from yeast. Plant J (1995) 1.02

Regulation by Phospholipids and Kinetic Studies of Plant Membrane-Bound UDP-Glucose Sterol beta-d-Glucosyl Transferase. Plant Physiol (1987) 1.00

Transformation of Saccharomyces cerevisiae with a cDNA encoding a sterol C-methyltransferase from Arabidopsis thaliana results in the synthesis of 24-ethyl sterols. FEBS Lett (1996) 0.99

Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch Biochem Biophys (2000) 0.98

Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis). Arch Biochem Biophys (1994) 0.98

In Vitro Selection of Calli Resistant to a Triazole Cytochrome-P-450-Obtusifoliol-14-Demethylase Inhibitor from Protoplasts of Nicotiana tabacum L. cv Xanthi. Plant Physiol (1990) 0.97

Genetic study and further biochemical characterization of a tobacco mutant that overproduces sterols. Mol Gen Genet (1991) 0.97

Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical phase 1 study. Acta Neurol Scand (1986) 0.96

Protein synthesis. Annu Rev Biochem (1966) 0.96

Soybean phosphatidylcholine vesicles containing plant sterols: a fluorescence anisotropy study. Biochim Biophys Acta (1990) 0.95

Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana. Plant Mol Biol (2001) 0.95

Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles. Plant Mol Biol (1999) 0.95

Plant sterol-C24-methyl transferases: different profiles of tobacco transformed with SMT1 or SMT2. Lipids (2000) 0.93

Biochemical characterization of a sterol mutant plant regenerated from a tobacco callus resistant to a triazole cytochrome-P-450-obtusifoliol-14-demethylase inhibitor. Biochem Biophys Res Commun (1989) 0.93

Synthesis of brominated heptanones and bromoform by a bromoperoxidase of marine origin. Biochemistry (1981) 0.92

An immunologic basis for the fibrotic reaction to implanted microcapsules. Transplant Proc (1991) 0.92

Phospholipid-Dependence of Plant UDP-Glucose Sterol beta-d-Glucosyl Transferase : IV. Reconstitution into Small Unilamellar Vesicles. Plant Physiol (1989) 0.92

Autoantibodies in early arthritis: advances in diagnosis and prognostication. Clin Exp Rheumatol (2004) 0.92

[Acute interstitial nephritis - a possible cause of acute renal failure (author's transl)]. Dtsch Med Wochenschr (1974) 0.91

Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. J Exp Med (2000) 0.90

Cyclopropyl sterol and phospholipid composition of membrane fractions from maize roots treated with fenpropimorph. Plant Physiol (1989) 0.89

Biosynthesis of monoterpenes: inhibition of (+)-pinene and (-)-pinene cyclases by thia and aza analogs of the 4R- and 4S-alpha-terpinyl carbocation. Arch Biochem Biophys (1992) 0.89

Studies on the immunoregulation of thyroid autoantibody production in vitro. Clin Exp Immunol (1985) 0.88

Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives. J Biol Chem (1984) 0.88

Citrullination and autoimmune disease: 8th Bertine Koperberg meeting. Ann Rheum Dis (2005) 0.88

Microsomal delta 8,14-sterol delta 14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction. Eur J Biochem (1989) 0.88

In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules. Biochem Pharmacol (1985) 0.87

Spontaneous secretion of thyroid autoantibodies by cultured peripheral blood lymphocytes from patients with Hashimoto's thyroiditis detected by micro-ELISA techniques. Clin Exp Immunol (1984) 0.87

Inhibition of sterol biosynthesis enzymes in vitro by analogues of high-energy carbocationic intermediates. Biochem Soc Trans (1990) 0.86

Some properties of reticulocyte ribosomal subunits. Arch Biochem Biophys (1968) 0.85

Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. J Biol Chem (2000) 0.84

Isolation and structure of a hoplonemertine toxin. Toxicon (1971) 0.84

Unlocking the "PAD" lock on rheumatoid arthritis. Ann Rheum Dis (2004) 0.83

Identification and bioassay of kairomones forHelicoverpa zea. J Chem Ecol (1996) 0.83

Biogenetic-type rearrangements of terpenes. Fortschr Chem Org Naturst (1976) 0.83

[Shunt sepsis. On the clinical aspects of septic complications of intermittent hemodialysis]. Dtsch Med Wochenschr (1967) 0.83

Interaction of the polyene antibiotic filipin with model and natural membranes containing plant sterols. Biochim Biophys Acta (1988) 0.83

[Clinical observations of a case of phostoxin poisoning]. Arch Toxikol (1967) 0.83

Human C-peptide response in xenotransplanted diabetic Lewis rats. Transplant Proc (1992) 0.82

Inactivation by phenylglyoxal of the specific binding of 1-naphthyl acetic Acid with membrane-bound auxin binding sites from maize coleoptiles. Plant Physiol (1984) 0.82

Uremic cardiomyopathy: studies on cardiac function in the guinea pig. Clin Nephrol (1978) 0.82

Stereochemistry of the proton elimination in the formation of (+)- and (-)-alpha-pinene by monoterpene cyclases from sage (Salvia officinalis). Arch Biochem Biophys (1994) 0.82

Glucose-insulin kinetics of the extravascular bioartificial pancreas. A study using microencapsulated rat islets. ASAIO J (1993) 0.82

The veto phenomenon in T-cell regulation. Ann N Y Acad Sci (1988) 0.82

Homopolynucleotide inhibition of poly U-dependent polyphenylalanine synthesis. J Mol Biol (1967) 0.81

Indocyanine green: pharmacokinetics in the rabbit and relevant studies of its stability and purity. J Pharm Sci (1986) 0.81

Monoclonal antibody against A1 Lewis d antigen produced by the hybridoma immunized with a pulmonary carcinoma. Cancer Res (1982) 0.81

Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate. Arch Biochem Biophys (1992) 0.81

Identification of novel blood group-reactive monoclonal antibodies cytotoxic to human acinar cells but not islets. Transplant Proc (1989) 0.81

Plant sterol biosynthesis: novel potent and selective inhibitors of cytochrome P450-dependent obtusifoliol 14 alpha-methyl demethylase. Arch Biochem Biophys (1992) 0.80

Preferential development of gamma/delta-bearing T cells in athymic nude bone marrow. Curr Top Microbiol Immunol (1991) 0.80

[Renin secretion in vitro. Comparison of kidney slices and isolated glomeruli]. Res Exp Med (Berl) (1973) 0.80

UDP-glucose sterol beta-D-glucosyltransferase, a plasma membrane-bound enzyme of plants: enzymatic properties and lipid dependence. Biochimie (1993) 0.79

Cycloeucalenol-obtusifoliol isomerase. Structural requirements for transformation or binding of substrates and inhibitors. Eur J Biochem (1989) 0.79

Total synthesis of (+/-)-cameroonanol. Org Lett (2000) 0.79

Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new 2,3-oxidosqualene cyclase inhibitor. Biochem Pharmacol (1988) 0.79

[Nephrotic syndrome of the adult. 1]. Dtsch Med Wochenschr (1971) 0.79

Rapid purification of islets using magnetic microspheres coated with anti-acinar cell monoclonal antibodies. Transplantation (1990) 0.78

Inhibition by the fungicide fenpropimorph of cholesterol biosynthesis in 3T3 fibroblasts. Biochem J (1988) 0.78

Increased sterol biosynthesis in tobacco calli resistant to a triazole herbicide which inhibits demethylation of 14α-methyl sterols. Planta (1992) 0.78

Stereochemical aspects of the biosynthesis of the side chain of 9beta, 19-cyclopropyl sterols in maize seedlings treated with tridemorph. Plant Physiol (1985) 0.78

Islet purification by a novel immunomicrosphere cell depletion technique. Transplant Proc (1990) 0.78

Biochemical characterization of tobacco mutants resistant to azole fungicides and herbicides. Biochem Soc Trans (1993) 0.78

Characterization of alpha beta+ CD4- CD8- CTL lines isolated from mixed lymphocyte cultures of adult mouse spleen cells. Cell Immunol (1992) 0.78

25-Azacycloartanol, a potent inhibitor of S-adenosyl-L-methionine-sterol-C-24 and C-28 methyltransferases in higher plant cells. Biochem Biophys Res Commun (1980) 0.78

[Pathogenetic mechanisms of cardiac failure in hemodialysis patients]. Dtsch Med Wochenschr (1971) 0.78

Plasma renin activity (PRA) and aldosterone (PA) in patients with chronic glomerulonephritis (GN) and hypertension. Clin Nephrol (1976) 0.78

Ecdysteroid biosynthesis and embryonic development are disturbed in insects (Locusta migratoria) reared on plant diet (Triticum sativum) with a selectively modified sterol profile. Proc Natl Acad Sci U S A (1987) 0.78

Inhibition of 2,3-oxidosqualene cyclases. Biochemistry (1992) 0.78

Evidence for the presence of an enzyme capable of opening the cyclopropane ring of cycloeucalenol. Biochem Biophys Res Commun (1972) 0.78

Pulsatile tinnitus: the role of angiography. J Otolaryngol Suppl (1977) 0.77