Published in Exp Neurol on October 01, 1974
Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci (1995) 2.35
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur J Pharmacol (1984) 1.74
Breast milk jaundice: effect of 3-alpha 20-beta-pregnanediol on bilirubin conjugation by human liver. Arch Dis Child (1970) 1.40
The effect of steroids and nucleotidesoon solubilized bilirubin uridine diphosphate-glucuronyltransferase. Biochem J (1970) 1.15
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. Neuropharmacology (2003) 1.14
Vulnerability of developing brain: relative effects of growth restriction during the fetal and suckling periods on behavior and brain composition of adult rats. J Nutr (1973) 1.09
Innovative solutions to novel drug development in mental health. Neurosci Biobehav Rev (2013) 1.08
Interactions between dopamine and 5-HT3 receptors suggest new treatments for psychosis and drug addiction. Trends Pharmacol Sci (1989) 1.02
Vulnerability of developing brain. 8. Regional acetylcholinesterase activity in the brains of adult rats undernourished in early life. Br J Nutr (1972) 0.96
Effects of albumin, amino acids, and clofibrate on the uptake of tryptophan by the rat brain. J Neurochem (1980) 0.95
The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat. Br J Pharmacol (1998) 0.95
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex. Br J Pharmacol (1990) 0.94
The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli. Psychopharmacology (Berl) (2011) 0.93
The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin. Biochem Pharmacol (1969) 0.91
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. Eur J Pharmacol (1987) 0.91
Elevated acetylcholinesterase activity in adult rat brain after undernutrition in early life. Brain Res (1971) 0.91
Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity. Psychopharmacology (Berl) (1995) 0.90
The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. Br J Pharmacol (1993) 0.89
MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. Eur J Pharmacol (1988) 0.89
A comparison of an improved o-phthalaldehyde fluorometric method and high pressure liquid chromatography in the determination of brain 5-hydroxyindoles of rats treated with L-tryptophan and p-chlorophenyl-alanine. Br J Pharmacol (1981) 0.89
Vulnerability of developing brain. 3. Development of four enzymes in the brains of normal and undernourished rats. Brain Res (1971) 0.89
Do steroids contribute to newborn jaundice? Proc R Soc Med (1971) 0.88
The effect of age, growth retardation and asphyxia on ascorbic acid concentrations in developing brain. J Neurochem (1973) 0.87
Influence of asphyxia and of dexamethasone on ATP concentrations in the immature rat brain. Biol Neonate (1974) 0.87
Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit. Behav Pharmacol (2003) 0.87
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat. Eur J Pharmacol (1985) 0.87
Alpha 2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat. Eur J Pharmacol (1988) 0.87
R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol (1991) 0.86
Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat. Neuropharmacology (1986) 0.86
Effects of growth retardation and asphyxia on brain electrolytes and on glycolysis in developing rats. Pediatr Res (1973) 0.85
Discrimination learning in ascorbic acid-deficient guinea pigs. Nature (1974) 0.84
4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity. J Med Chem (1997) 0.84
Effects of tryptophan and portocaval anastomosis on activity and brain tryptophan metabolism [proceedings]. Br J Pharmacol (1977) 0.83
One-trial tolerance to the effects of chlordiazepoxide on the elevated plus maze may be due to locomotor habituation, not repeated drug exposure. Psychopharmacology (Berl) (1994) 0.83
The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptor. Eur J Pharmacol (1990) 0.83
Centrally active 5-HT receptor agonists and antagonists. Neurosci Biobehav Rev (1992) 0.83
Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. Eur J Pharmacol (1988) 0.82
Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam. Br J Pharmacol (1990) 0.82
The effects of GR127935, a putative 5-HT1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig. Neuropharmacology (1995) 0.82
Vulnerability of developing brain. V. Effects of fetal and postnatal undernutrition on regional brain enzyme activities in three-week-old rats. Pediatr Res (1972) 0.81
In vivo labelling of the NMDA receptor channel complex by [3H]MK-801. Eur J Pharmacol (1988) 0.81
Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav Pharmacol (1998) 0.81
Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur J Pharmacol (1998) 0.81
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047). Br J Pharmacol (1990) 0.81
A quantitative neurohistological study of the long term effects in the rat brain of stimulation in infancy. J Anat (1983) 0.81
Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists. J Med Chem (1997) 0.81
The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat. Psychopharmacology (Berl) (1995) 0.80
L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests. J Pharmacol Exp Ther (1997) 0.80
Specificity of the effects of steroids on bilirubin glucuronide transport by liver slice. Biochim Biophys Acta (1971) 0.80
Effects of chronic experimental liver dysfunction and L-tryptophan on behaviour in the rat. Pharmacol Biochem Behav (1978) 0.80
The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents. J Pharmacol Exp Ther (1996) 0.79
Determination of brain 5-hydroxytryptamine turnover in freely moving rats using repeated sampling of cerebrovascular fluid. J Neurochem (1983) 0.79
Growth of suckling rats after treatment with dexamethasone or cortisol. Implications for steroid therapy in human infants. Arch Dis Child (1973) 0.79
Characteristics of analgesias induced by brief or prolonged stress. Ann N Y Acad Sci (1986) 0.79
Adrenocortical function in rats subjected to nutritional deprivation in early life. J Endocrinol (1972) 0.79
An alternative animal model for the full-term small-for-dates human baby. Biol Neonate (1973) 0.78
Effect of maternal undernutrition and other factors on birth weight in the rat. Biol Neonate (1972) 0.77
Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor. Eur J Pharmacol (1991) 0.77
Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site-directed inhibitor of monoamine oxidase. Eur J Pharmacol (1986) 0.77
Competitive NMDA receptor antagonists attenuate the behavioural and neurochemical effects of amphetamine in mice. Eur J Pharmacol (1994) 0.77
A water-maze test of learning ability for guinea-pigs. Lab Anim (1974) 0.77
Free and bound tryptophan in human plasma during the perinatal period. Acta Paediatr Scand (1979) 0.76
Further studies of body growth and brain development in "small-for-dates" rats. Biol Neonate (1974) 0.76
Involvement of dopamine in the antinociceptive response to footshock. Psychopharmacology (Berl) (1984) 0.76
Analgesia induced by brief or more prolonged stress differs in its dependency on naloxone, 5-hydroxytryptamine and previous testing of analgesia. Neuropharmacology (1984) 0.76
Phosphofructokinase and fumarate hydratase in developing rat brain. J Neurochem (1971) 0.76
Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.76
Lack of effect of CCKB receptor antagonists in ethological and conditioned animal screens for anxiolytic drugs. Psychopharmacology (Berl) (1995) 0.75
Plasma 11-hydroxy corticosteroid concentrations in stressed adult rats after undernutrition in early life. Biochem J (1971) 0.75
A comparison of the effects of cytosine arabinoside and adenine arabinoside on some aspects of brain growth and development in the rat. Br J Pharmacol (1975) 0.75
Nutritionally small-for-dates rats: their subsequent growth, regional brain 5-hydroxytryptamine turnover, and behavior. Pediatr Res (1976) 0.75
Effect of undernutrition in early life on glutamate decarboxylase activity in the adult brain. Biochem J (1972) 0.75
The effect of anoxia on cerebral acid hydrolases in the five-day-old rat. Biochem J (1972) 0.75
Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J Pharmacol Exp Ther (1996) 0.75
Undernutrition and the development of certain enzymes in rat brain. Biochem J (1970) 0.75
Ascorbic acid in fetal human brain. Arch Dis Child (1974) 0.75
Maze learning by adult rats after inhibition of neuronal multiplication in utero. Pediatr Res (1975) 0.75
The effect of L-tryptophan on motor activity and its prevention by an extracerebral decarboxylase inhibitor and by 5-HT receptor blockers. Psychopharmacology (Berl) (1980) 0.75
Lack of effect of flumazenil and CGS 8216 on the anxiolytic-like properties of loreclezole. Eur J Pharmacol (1994) 0.75
Effects of portocaval anastomosis on behaviour and brain tryptophan metabolism. J Neural Transm Suppl (1978) 0.75
Uptake of (3H) corticosterone and the immune response in growth-retarded rats. Pediatr Res (1973) 0.75
On the stimulation of the rate of hydroxylation of tryptophan in the brain of hamsters during hibernation. J Neurochem (1978) 0.75
Analgesia induced by brief footshock: blockade by fenfluramine and 5-methoxy-N,N-dimethyltryptamine and prevention of blockade by 5-HT antagonists. Brain Res (1983) 0.75
Brain 5-hydroxytryptamine metabolism after portocaval anastomosis: relationship with ambulation. Pharmacol Biochem Behav (1981) 0.75
Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions. Brain Res (1982) 0.75
Permanent changes in the activity and subcellular distribution of acetylcholinesterase and lactate dehydrogenase in adult rat cerebellum after X-irradiation in infancy. Exp Neurol (1972) 0.75
Neurotoxin-related research: from the laboratory to the clinic. Ann N Y Acad Sci (1992) 0.75
Glycerol in treatment of cerebral oedema. Lancet (1973) 0.75
Some aspects of the behavior of young and adult rats treated with p-chlorophenylalanine in infancy. Dev Psychobiol (1974) 0.75
The effects of cholinergic drugs support an avoidance learning hypothesis of brief footshock-induced analgesia. Neuropharmacology (1986) 0.75
Letter: 5-hydroxyindoleacetic acid in Down's syndrome. Lancet (1974) 0.75
Tryptophan and 5-hydroxytryptamine metabolism in the immature rat brain during recovery from asphyxia. J Neurochem (1977) 0.75
Analgesia induced by brief footshock is inhibited by 5-hydroxytryptamine but unaffected by antagonists of 5-hydroxytryptamine or by naloxone. Neuropharmacology (1982) 0.75
Effect of age on variables influencing the supply of tryptophan to the brain. J Neurochem (1982) 0.75