Published in J Pharmacol Exp Ther on November 01, 1996
Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) (2005) 2.25
Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov (2013) 1.27
Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801. Psychopharmacology (Berl) (2008) 0.83
The role of dopamine D1 and D3 receptors in N-methyl-D-aspartate (NMDA)/glycineB site-regulated complex cognitive behaviors following repeated morphine administration. Int J Neuropsychopharmacol (2017) 0.75
The awakening cortisol response: methodological issues and significance. Stress (2004) 2.88
Is there a difference between leads and drugs? A historical perspective. J Chem Inf Comput Sci (2001) 2.38
Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci (1995) 2.35
Serum adiponectin concentration is a positive predictor of all-cause and cardiovascular mortality in type 1 diabetes. J Intern Med (2011) 2.30
Sex-related differences in the long-term risk of microvascular complications by age at onset of type 1 diabetes. Diabetologia (2011) 2.07
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. Proc Natl Acad Sci U S A (1988) 1.99
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. Eur J Pharmacol (1984) 1.74
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem (1993) 1.56
The glycine site of the NMDA receptor--five years on. Trends Pharmacol Sci (1993) 1.54
Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results. Aliment Pharmacol Ther (2003) 1.52
The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate. Biochem J (1988) 1.49
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem (1996) 1.44
Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiol (Oxf) (2011) 1.43
G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains. Handb Exp Pharmacol (2008) 1.41
False-positive PCR results linked to administration of seasonal influenza vaccine. J Med Microbiol (2011) 1.41
Psychosocial interventions for people with both severe mental illness and substance misuse. Cochrane Database Syst Rev (2008) 1.36
Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem (1996) 1.29
A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence. Leukemia (2009) 1.27
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression. Neuropharmacology (2005) 1.18
The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology (1996) 1.17
Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. Neuropharmacology (2003) 1.14
[Functional morphology of stria vascularis after treatment with ethacrynic acid or atoxyl (author's transl)]. Arch Otorhinolaryngol (1978) 1.11
Thyroid function in the preterm infant: a longitudinal assessment. J Pediatr (1978) 1.10
Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases. Leukemia (2011) 1.10
Innovative solutions to novel drug development in mental health. Neurosci Biobehav Rev (2013) 1.08
Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. Gut (2010) 1.08
Association between mannose-binding lectin, high-sensitivity C-reactive protein and the progression of diabetic nephropathy in type 1 diabetes. Diabetologia (2010) 1.08
Relationship between lipid profiles and kidney function in patients with type 1 diabetes. Diabetologia (2007) 1.07
Monitoring the effect of a tryptophan load on brain indole metabolism in freely moving rats by simultaneous cerebrospinal fluid sampling and brain dialysis. J Neurochem (1985) 1.05
Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology (Berl) (1985) 1.03
Interactions between dopamine and 5-HT3 receptors suggest new treatments for psychosis and drug addiction. Trends Pharmacol Sci (1989) 1.02
A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity. Nature (1987) 1.02
Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Mol Cell Neurosci (2006) 1.01
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther (1997) 0.99
Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. Leukemia (2011) 0.98
Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes. Diabetologia (2009) 0.98
Novel selective compounds for the investigation of imidazoline receptors. Ann N Y Acad Sci (1999) 0.96
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A (1990) 0.96
Control of brain tryptophan concentration in rats on a high fat diet. Nature (1976) 0.96
Effects of ischaemia on neurotransmitter release from the isolated retina. J Neurochem (1994) 0.96
In vitro and in vivo inhibition of prolyl endopeptidase. Eur J Pharmacol (1991) 0.96
Diurnal patterns of salivary cortisol across the adolescent period in healthy females. Psychoneuroendocrinology (2008) 0.95
Sexual assault: review of a national model protocol for forensic and medical evaluation. New Hampshire Sexual Assault Medical Examination Protocol Project Committee. Obstet Gynecol (1992) 0.95
Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS. Neuroreport (1999) 0.95
Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor. Neuropharmacology (2005) 0.95
Effects of albumin, amino acids, and clofibrate on the uptake of tryptophan by the rat brain. J Neurochem (1980) 0.95
The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat. Br J Pharmacol (1998) 0.95
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex. Br J Pharmacol (1990) 0.94
The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli. Psychopharmacology (Berl) (2011) 0.93
Anthropogenic platinum group element (Pt, Pd and Rh) concentrations in road dusts and roadside soils from Perth, Western Australia. Sci Total Environ (2003) 0.92
Evidence for accelerated desensitisation of 5-HT(2C) receptors following combined treatment with fluoxetine and the 5-HT(1A) receptor antagonist, WAY 100,635, in the rat. Neuropharmacology (2000) 0.92
Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy? Diabetologia (2012) 0.92
Evaluation of formal feedback on endoscopic competence among trainees: the EFFECT trial. Ir J Med Sci (2008) 0.91
Trypsin-like activity levels of Treponema denticola and Porphyromonas gingivalis in adults with periodontitis. J Clin Periodontol (1994) 0.91
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology (2003) 0.91
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J Med Chem (1995) 0.91
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. Eur J Pharmacol (1987) 0.91
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Mol Psychiatry (2007) 0.91
Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus maze are confounded by increases in locomotor activity. Psychopharmacology (Berl) (1995) 0.90
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem (2001) 0.90
Effects of two truncated forms of human calcitonin-gene related peptide: implications for receptor classification. Eur J Pharmacol (1994) 0.90
3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex. J Med Chem (1993) 0.90
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors. Neuropharmacology (1998) 0.90
3,4-Dihydroxyphenylethylamine and 5-hydroxytryptamine metabolism in the rat: acidic metabolites in cisternal cerebrospinal fluid before and after giving probenecid. J Neurochem (1985) 0.90
The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents. Br J Pharmacol (1993) 0.89
A comparison of an improved o-phthalaldehyde fluorometric method and high pressure liquid chromatography in the determination of brain 5-hydroxyindoles of rats treated with L-tryptophan and p-chlorophenyl-alanine. Br J Pharmacol (1981) 0.89
Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain. Osteoarthritis Cartilage (2008) 0.89
A simple apparatus for ultrafiltration of small volumes: application to the measurement of free and albumin-bound tryptophan in plasma. Anal Biochem (1977) 0.89
MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. Eur J Pharmacol (1988) 0.89
Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology (Berl) (1986) 0.88
High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group. J Med Chem (1994) 0.88
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain. Mol Pharmacol (1992) 0.88
Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. Osteoarthritis Cartilage (2012) 0.88
An increased throughput method for the determination of partition coefficients. Pharm Res (2000) 0.88
8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance. Appetite (1986) 0.88
An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats. Br J Pharmacol (1989) 0.88
Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. J Med Chem (1999) 0.87
Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit. Behav Pharmacol (2003) 0.87
Alpha 2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat. Eur J Pharmacol (1988) 0.87
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat. Eur J Pharmacol (1985) 0.87
[The development of the organ of Corti in the guinea pig]. Adv Anat Embryol Cell Biol (1975) 0.86
Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers. J Psychopharmacol (2009) 0.86
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J Med Chem (1996) 0.86
R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol (1991) 0.86
Assessment of adherence to published surveillance guidelines--opportunity to enhance efficiency of endoscopic practice. Ir Med J (2008) 0.86