Published in Am J Physiol on May 01, 1979
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The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem (1994) 2.09
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Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem (1993) 1.88
Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men. J Clin Invest (1985) 1.85
Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J (1974) 1.78
Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J (1975) 1.71
Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J (1977) 1.69
Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle. Biochem J (1986) 1.66
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Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes (1974) 1.61
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Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution. J Biol Chem (1992) 1.43
Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol (1982) 1.40
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia (2004) 1.40
Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. Am J Physiol (1981) 1.39
Diabetes as an atherogenic factor. Prog Cardiovasc Dis (1984) 1.35
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An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med (1966) 1.33
Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem (2000) 1.31
Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol (1980) 1.29
Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis. Am J Physiol (1981) 1.25
Enhanced muscle glucose metabolism after exercise: modulation by local factors. Am J Physiol (1984) 1.24
Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate. Diabetes (1978) 1.21
Synthesis of essential amino acids from their alpha-keto analogues by perfused rat liver and muscle. J Clin Invest (1973) 1.21
Effect of glucagon: insulin ratios on hepatic metabolism. Diabetes (1974) 1.19
Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol (1999) 1.15
Stimulation of vascular Na(+)-K(+)-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol (1994) 1.14
Enhanced muscle glucose metabolism after exercise in the rat: the two phases. Am J Physiol (1984) 1.14
Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J (1985) 1.13
The purine nucleotide cycle. Studies of ammonia production by skeletal muscle in situ and in perfused preparations. J Biol Chem (1977) 1.13
Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia (1984) 1.13
Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab (2000) 1.12
Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab (2001) 1.10
Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis. Am J Physiol (1987) 1.08
Chronic hypoglycemia increases brain glucose transport. Am J Physiol (1986) 1.07
A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol (1995) 1.07
The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes (1979) 1.07
Regulation of production and release of lipoprotein by the perfused rat liver. J Lipid Res (1968) 1.06
The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver. J Biol Chem (1970) 1.06
Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes (1999) 1.06
Immortalization of immature and mature mouse astrocytes with SV40 T antigen. J Neurosci Res (1994) 1.05
Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol (1984) 1.04
Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin. Am J Physiol (1985) 1.04
Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. Am J Physiol (1989) 1.03
Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem (1988) 1.03
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol (1991) 1.02
Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol (1997) 1.00
The purine nucleotide cycle in skeletal muscle. Fed Proc (1978) 1.00
Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age. Am J Physiol (1983) 0.99
Regulation of ketone body metabolism in skeletal muscle. Am J Physiol (1973) 0.98
Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver. Biochem J (1975) 0.98
Nitrogen metabolism in the isolated perfused rat liver. Nitrogen balance, redox state and rates of proteolysis. Biochem J (1974) 0.97
Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol (1999) 0.97
Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care (1992) 0.96
A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia. J Clin Invest (1971) 0.95
Muscle nitrogen metabolism in chronic hepatic insufficiency. Metabolism (1976) 0.95
Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest (1992) 0.95
Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid. Am J Physiol (1970) 0.94
Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation. Metabolism (1986) 0.92
Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter. Isr J Med Sci (1972) 0.92
Influence of fluorocarbon emulsions on hepatic metabolism in perfused rat liver. Am J Physiol (1973) 0.92
Replenishment of citric acid cycle intermediates by the purine nucleotide cycle in rat skeletal muscle. Curr Top Cell Regul (1981) 0.90
Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology (1992) 0.90
Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. Diabetes (1991) 0.90
Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. Fed Proc (1977) 0.90
Intrinsic differences of insulin receptor kinase activity in red and white muscle. J Biol Chem (1986) 0.90
Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes (2000) 0.89