Published in J Biol Chem on November 25, 1974
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci U S A (1976) 6.38
Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol (1998) 4.35
LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell (2008) 4.02
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab (2008) 3.33
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res (2008) 3.31
Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts. J Clin Invest (1975) 3.18
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. Proc Natl Acad Sci U S A (1975) 3.16
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A (2007) 3.01
Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins. J Cell Biol (1979) 2.98
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci U S A (2007) 2.46
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A (1999) 2.20
A mouse macrophage lipidome. J Biol Chem (2010) 2.14
Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J Clin Invest (1976) 2.14
Cholesterol, inflammation and innate immunity. Nat Rev Immunol (2015) 1.72
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol (2010) 1.61
Mir-33 regulates cell proliferation and cell cycle progression. Cell Cycle (2012) 1.60
Essential role for mevalonate synthesis in DNA replication. Proc Natl Acad Sci U S A (1979) 1.53
Dual targeting of Osh1p, a yeast homologue of oxysterol-binding protein, to both the Golgi and the nucleus-vacuole junction. Mol Biol Cell (2001) 1.52
Transport of cholesterol from the endoplasmic reticulum to the plasma membrane. J Cell Biol (1985) 1.49
The diverse functions of oxysterol-binding proteins. Annu Rev Cell Dev Biol (2010) 1.43
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med (2013) 1.36
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation. Proc Natl Acad Sci U S A (1978) 1.34
Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. Proc Natl Acad Sci U S A (1979) 1.32
Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA. Mol Cell Biol (1985) 1.25
Disruption of cholesterol homeostasis by plant sterols. J Clin Invest (2004) 1.22
Intracellular transport of phosphatidylcholine to the plasma membrane. J Cell Biol (1985) 1.22
Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol. Prog Lipid Res (2008) 1.21
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proc Natl Acad Sci U S A (1996) 1.15
A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis. J Clin Invest (1990) 1.15
Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia. J Exp Med (1976) 1.15
Induction of apoptosis in endothelial cells treated with cholesterol oxides. Am J Pathol (1996) 1.13
Metabolism of cationized lipoproteins by human fibroblasts. Biochemical and morphologic correlations. J Cell Biol (1977) 1.11
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. J Biol Chem (2011) 1.07
Biologically active low density lipoprotein in human peripheral lymph. J Clin Invest (1978) 1.05
Lipogenesis and the synthesis and secretion of very low density lipoprotein by avian liver cells in nonproliferating monolayer culture. Hormonal effects. J Cell Biol (1977) 1.05
Sterol carrier protein-2: new roles in regulating lipid rafts and signaling. Biochim Biophys Acta (2007) 1.04
Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice. Mol Cell Biol (1994) 1.02
Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts. Proc Natl Acad Sci U S A (1980) 1.01
Immunotitration of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in various physiological states. Proc Natl Acad Sci U S A (1979) 1.00
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. J Lipid Res (2011) 0.99
Hyperphosphorylation regulates the activity of SREBP1 during mitosis. Proc Natl Acad Sci U S A (2005) 0.98
Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. Biol Reprod (2009) 0.98
Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages. Infect Immun (2011) 0.97
Green and black tea extracts inhibit HMG-CoA reductase and activate AMP kinase to decrease cholesterol synthesis in hepatoma cells. J Nutr Biochem (2008) 0.96
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. Biochem J (1987) 0.95
Cholesterol-dependent anaplasma phagocytophilum exploits the low-density lipoprotein uptake pathway. PLoS Pathog (2009) 0.94
Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. J Clin Endocrinol Metab (2010) 0.93
Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts. Proc Natl Acad Sci U S A (1978) 0.91
Cholesterol biosynthesis and homeostasis in regulation of the cell cycle. PLoS One (2013) 0.90
Isopentenyladenine as a mediator of mevalonate-regulated DNA replication. Proc Natl Acad Sci U S A (1980) 0.89
In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals. J Clin Invest (1995) 0.88
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res (2013) 0.87
Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death. BMC Pharmacol (2001) 0.85
Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone. Proc Natl Acad Sci U S A (1978) 0.85
24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival. Neuroscientist (2015) 0.85
Changes in sterol biosynthesis accompanying cessation of glial cell growth in serum-free medium. Biochem J (1980) 0.84
Stimulation with a monoclonal antibody (mAb4E4) of scavenger receptor-mediated uptake of chemically modified low density lipoproteins by THP-1-derived macrophages enhances foam cell generation. J Clin Invest (1994) 0.83
Effect of reduced low-density lipoprotein receptor level on HepG2 cell cholesterol metabolism. Biochem J (1998) 0.82
Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PLoS One (2011) 0.81
LXR, prostate cancer and cholesterol: the Good, the Bad and the Ugly. Am J Cancer Res (2013) 0.80
CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface. Mol Biol Cell (2015) 0.79
Plant sterols as anticancer nutrients: evidence for their role in breast cancer. Nutrients (2013) 0.78
HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains. J Lipid Res (2012) 0.78
Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats. Lipids Health Dis (2013) 0.78
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. BMC Neurosci (2014) 0.77
Regulation of cholesterol biosynthesis in HeLa S3G cells by serum lipoproteins: dexamethasone-mediated interference with suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Proc Natl Acad Sci U S A (1978) 0.77
The effect of mevalonic acid deprivation on enzymes of DNA replication in cells emerging from quiescence. Biochem J (1992) 0.76
Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension. PLoS One (2011) 0.76
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells. Biochem J (1987) 0.75
Macrophages of genetically characterized familial hypercholesterolaemia patients show up-regulation of LDL-receptor-related proteins. J Cell Mol Med (2016) 0.75
Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice. Proc Natl Acad Sci U S A (1979) 0.75
Effect of 25-hydroxycholesterol and bile acids on the regulation of cholesterol metabolism in Hep G2 cells. Biochem J (1989) 0.75
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds. Front Oncol (2016) 0.75
How are STAT1 and cholesterol metabolism associated in antiviral responses? JAKSTAT (2013) 0.75
A receptor-mediated pathway for cholesterol homeostasis. Science (1986) 19.28
Regulation of the mevalonate pathway. Nature (1990) 18.25
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell (1997) 17.78
Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature (1979) 17.18
The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem (1977) 13.34
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54
Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol (1985) 11.53
Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci U S A (1979) 11.19
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol (1983) 10.95
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest (1993) 9.56
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell (2000) 9.13
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev (2000) 9.09
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem (1974) 9.02
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell (2000) 8.29
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest (1996) 7.93
Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell (1977) 7.74
Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem (1983) 7.70
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions. Cell (1984) 7.66
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci U S A (1999) 7.48
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell (1994) 7.10
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res (1980) 6.50
Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci U S A (1976) 6.38
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest (1997) 6.18
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest (1997) 6.16
Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell (1983) 5.99
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell (2000) 5.92
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J Biol Chem (1990) 5.91
Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest (1973) 5.87
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 5.81
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell (1981) 5.59
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature (1999) 5.51
The LDL receptor gene: a mosaic of exons shared with different proteins. Science (1985) 5.49
Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans. Cell (1976) 5.33
Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proc Natl Acad Sci U S A (1974) 5.05
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem (1974) 4.98
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev (1998) 4.86
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest (1998) 4.78
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest (1997) 4.75
Receptor-mediated control of cholesterol metabolism. Science (1976) 4.67
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A (1993) 4.61
Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (1985) 4.51
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum Mutat (1992) 4.48
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci U S A (1995) 4.40
Receptor-mediated endocytosis: insights from the lipoprotein receptor system. Proc Natl Acad Sci U S A (1979) 4.22
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21
Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proc Natl Acad Sci U S A (1976) 4.17
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell (1996) 4.12
The clinical investigator: bewitched, bothered, and bewildered--but still beloved. J Clin Invest (1997) 4.09
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell (1990) 3.99
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J Biol Chem (1978) 3.97
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J Clin Invest (1994) 3.97