Published in Exp Mol Pathol on April 01, 1973
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Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells. Proc Natl Acad Sci U S A (1974) 1.45
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Clonal characteristics of cutaneous scars and implications for atherogenesis. Am J Pathol (1981) 0.96
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Clonal characteristics in layers of human atherosclerotic plaques. A study of the selection hypothesis of monoclonality. Am J Pathol (1978) 0.85
Structural changes within the media of coronary arteries related to intimal thickening. Am J Pathol (1977) 0.85
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Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
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Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res (1992) 1.98
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet (1997) 1.88
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet (1981) 1.85
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J Neurosci (1997) 1.80
Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am J Pathol (1974) 1.78
Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion. Somatic Cell Genet (1976) 1.78
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem (1996) 1.66
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52
Increased susceptibility of Down's syndrome fibroblasts to transformation by SV40. Proc Soc Exp Biol Med (1967) 1.49
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport (1996) 1.48
Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells. Proc Natl Acad Sci U S A (1974) 1.45
Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet (1975) 1.45
A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease. J Infect Dis (1997) 1.44
Triple marker (alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin) versus alpha-fetoprotein plus free-beta subunit in second-trimester maternal serum screening for fetal Down syndrome: a prospective comparison study. Am J Obstet Gynecol (1995) 1.44
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet (1996) 1.43
Growth characteristics of Werner syndrome cells in vitro. Adv Exp Med Biol (1985) 1.39
Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Exp Cell Res (1998) 1.37
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. Am J Hum Genet (1996) 1.31
The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell (1999) 1.29
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. I. Clonal morphology and growth potential. Pediatr Res (1974) 1.29
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. Hum Genet (1981) 1.24
Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem (1999) 1.22
Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation. Nature (1979) 1.21
Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet (1996) 1.19
Cytogenetic aspects of Werner syndrome. Adv Exp Med Biol (1985) 1.19
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet (1997) 1.17
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Hum Mol Genet (1996) 1.17
Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet (1990) 1.16
Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha. Proc Natl Acad Sci U S A (1983) 1.16
Parasexual cycle in cultivated human somatic cells. Science (1969) 1.13
Preparation of cell-size unilamellar liposomes with high captured volume and defined size distribution. Biochim Biophys Acta (1981) 1.11
Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice. Isr J Med Sci (1985) 1.10
Evidence of clonal attenuation, clonal succession, and clonal expansion in mass cultures of aging Werner's syndrome skin fibroblasts. Cytogenet Cell Genet (1981) 1.08
A definitive cloning technique for human fibroblast cultures. Proc Soc Exp Biol Med (1966) 1.08
Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression. J Gerontol A Biol Sci Med Sci (2001) 1.07
APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease. Am J Hum Genet (1991) 1.06
Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol (1994) 1.05
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Am J Med Genet (2000) 1.04
Reflex sympathetic dystrophy. Review of 140 cases. Minn Med (1970) 1.04
Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the beta-amyloid precursor protein. Brain Res Mol Brain Res (1994) 1.03
Cultured renal epithelial cells from birds and mice: enhanced resistance of avian cells to oxidative stress and DNA damage. J Gerontol A Biol Sci Med Sci (1998) 1.03
Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis. Am J Pathol (1998) 1.03
Homozygosity mapping and Werner's syndrome. Lancet (1992) 1.02
Cellular aging--clonal senescence. A review (Part I). Am J Pathol (1977) 1.01
Alkaline phosphatase "constitutive" clones: evidence for de-novo heterogeneity of established human skin fibroblast strains. Exp Cell Res (1967) 1.00
Preparation of multivesicular liposomes. Biochim Biophys Acta (1983) 0.99
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. Am J Med Genet (1999) 0.99
Delayed and reduced cell replication and diminishing levels of DNA polymerase-alpha in regenerating liver of aging mice. J Cell Physiol (1984) 0.98
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc Natl Acad Sci U S A (1999) 0.98
Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death. Mol Chem Neuropathol (1997) 0.98
Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines. Hum Genet (1999) 0.98
Proliferative homeostasis and its age-related aberrations. Mech Ageing Dev (1979) 0.98
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. III. The fetal urine as a potential source of clonable cells. Humangenetik (1975) 0.97
Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases. Trans Assoc Am Physicians (1965) 0.97
Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol (1995) 0.97
Effects of cytochalasin B on cultivated human diploid fibroblasts and its use for the isolation of tetraploid clones. Exp Cell Res (1973) 0.96
Do cultural differences affect Alzheimer disease? JAMA (1996) 0.95
Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential. J Cell Biol (1975) 0.95
High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice. Am J Pathol (1996) 0.95
Cellular aging in Werner's syndrome: a unique phenotype? J Invest Dermatol (1979) 0.95
DNA double-strand breaks in mouse kidney cells with age. Biogerontology (2001) 0.94
A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines. J Biol Chem (1989) 0.94
Evidence for clonal attenuation of growth potential in HeLa cells. In Vitro (1978) 0.93
Genetics and aging; the Werner syndrome as a segmental progeroid syndrome. Adv Exp Med Biol (1985) 0.93
Syndromes of accelerated aging. Natl Cancer Inst Monogr (1982) 0.91
Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease. Ann Neurol (1992) 0.91
The advantages of using triple-marker screening for chromosomal abnormalities. Am J Obstet Gynecol (1995) 0.91
Evidence for a clonal origin of head and neck tumors. Int J Cancer (1972) 0.91
Overexpression of amyloid precursor protein alters its normal processing and is associated with neurotoxicity. Biochem Biophys Res Commun (1992) 0.91
Localization of CNS glucoregulatory insulin receptors within the ventromedial hypothalamus. Brain Res (1975) 0.91
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics (2000) 0.90
Tolerance and suppression in a primed immune system. Transplantation (1996) 0.89
Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells. J Neurochem (1992) 0.89
Mechanisms of conditioned meal initiation. Physiol Behav (1989) 0.88
A Novel LMNA Mutation Causes Altered Nuclear Morphology and Symptoms of Familial Partial Lipodystrophy (Dunnigan Variety) with Progeroid Features. Mol Syndromol (2010) 0.88
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type. Hum Genet (1998) 0.87
Clonal attenuation: causes and consequences. J Gerontol (1993) 0.87
Alzheimer's disease. Dominant susceptibility genes. Nature (1990) 0.85
No detectable mutations at Werner helicase locus in progeria. Lancet (1996) 0.85
Frontiers of aging. Science (2001) 0.85
Structure and function of the human Werner syndrome gene promoter: evidence for transcriptional modulation. Nucleic Acids Res (1998) 0.85
Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers. J Neurosci Res (1999) 0.85
Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions. J Neurosci Res (2000) 0.85
Interactions of aging and environmental agents: the gerontological perspective. Prog Clin Biol Res (1987) 0.84
Evidence contrary to the protein error hypothesis for in vitro senescence. J Cell Physiol (1976) 0.84
Atherosclerosis is the leading cause of death in the developed societies. Am J Pathol (1998) 0.84