Published in Brain Res Mol Brain Res on October 01, 1994
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol (2004) 1.43
Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. Am J Pathol (2004) 1.20
L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. Neurobiol Dis (2010) 1.10
Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res (2006) 1.07
Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis. Am J Pathol (1998) 1.03
Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease. J Neurosci (2013) 1.00
Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine. Biochim Biophys Acta (2011) 0.94
Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis (2011) 0.89
Caffeoylquinic acids in Centella asiatica protect against amyloid-β toxicity. J Alzheimers Dis (2014) 0.88
Back to the future with phenotypic screening. ACS Chem Neurosci (2014) 0.86
Induction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficits. PLoS One (2013) 0.86
Carboxyl-terminal fragment of amyloid precursor protein and hydrogen peroxide induce neuronal cell death through different pathways. J Neural Transm (Vienna) (2006) 0.85
Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro. J Neuroimmune Pharmacol (2012) 0.85
The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide. PLoS One (2012) 0.83
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug. Dis Model Mech (2011) 0.82
Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease. Exp Neurol (2014) 0.82
The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases. Curr Neuropharmacol (2013) 0.80
Inclusion body myositis. J Neurol Neurosurg Psychiatry (1996) 0.79
Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons. BMC Neurosci (2009) 0.78
Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry (2016) 0.75
Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects. ACS Med Chem Lett (2015) 0.75
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med (1996) 6.79
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab Invest (1970) 6.44
Population genetic structure of variable drug response. Nat Genet (2001) 6.35
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine (Baltimore) (1966) 6.15
DNA deletion associated with hereditary neuropathy with liability to pressure palsies. Cell (1993) 4.57
The Werner syndrome protein is a DNA helicase. Nat Genet (1997) 4.03
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature (1998) 3.84
Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci U S A (1989) 3.55
Involvement of the sympathetic nervous system in tetanus. Studies on 82 cases. Lancet (1968) 3.18
Interstitial deletion of (17)(p11.2p11.2) in nine patients. Am J Med Genet (1986) 3.12
Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion. Pediatrics (1978) 3.04
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron (2001) 2.92
The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet (1993) 2.88
Radiologic determination of intravascular volume status using portable, digital chest radiography: a prospective investigation in 100 patients. Crit Care Med (2001) 2.78
Genetic syndromes in man with potential relevance to the pathobiology of aging. Birth Defects Orig Artic Ser (1978) 2.66
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet (1996) 2.57
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron (2001) 2.29
Molecular analysis of the Smith-Magenis syndrome: a possible contiguous-gene syndrome associated with del(17)(p11.2). Am J Hum Genet (1991) 2.26
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med (1999) 2.25
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol (2001) 2.16
Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet (1975) 2.15
Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type. J Neurogenet (1987) 2.12
Purification of a leucine-specific binding protein from Escherichia coli. Biochem Biophys Res Commun (1970) 2.09
Temperature regulation in survivors of accidental hypothermia of the elderly. Lancet (1967) 2.03
Structure of Marek's disease virus DNA: detailed restriction enzyme map. J Virol (1984) 2.03
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res (1992) 1.98
Treatment of sympathetic overactivity in tetanus. Lancet (1969) 1.98
Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arterioscler Thromb Vasc Biol (2000) 1.94
Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics (1999) 1.88
An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants. Hum Genet (1997) 1.88
Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am J Hum Genet (2001) 1.85
Predictive value of minor anomalies. I. Association with major malformations. J Pediatr (1987) 1.85
Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet (1981) 1.85
A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3. Hum Mol Genet (1997) 1.84
Xylose isomerase from Escherichia coli. Characterization of the protein and the structural gene. J Biol Chem (1984) 1.82
Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J Neurosci (1997) 1.80
Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics (2000) 1.79
Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am J Pathol (1974) 1.78
Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion. Somatic Cell Genet (1976) 1.78
Binding assays for amino acids. The utilization of a cystine binding protein from Escherichia coli for the determination of acid-soluble cystine in small physiological samples. J Biol Chem (1974) 1.74
Biosynthesis of bacterial glycogen. Primary structure of Escherichia coli ADP-glucose synthetase as deduced from the nucleotide sequence of the glg C gene. J Biol Chem (1983) 1.73
Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta (2005) 1.73
The mechanical properties and molecular dynamics of plant cell wall polysaccharides studied by Fourier-transform infrared spectroscopy. Plant Physiol (2000) 1.71
Renaturation and identification of periplasmic proteins in two-dimensional gels of Escherichia coli. J Biol Chem (1982) 1.69
Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J Neurochem (1996) 1.66
Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome. Hum Genet (2001) 1.66
Resolution of the multiplicity of the glutamate and aspartate transport systems of Escherichia coli. J Biol Chem (1977) 1.65
Purification and properties of a ribose-binding protein from Escherichia coli. J Biol Chem (1974) 1.62
A multichamber equilibrium dialysis apparatus. Anal Biochem (1972) 1.61
Acute polyneuritis requiring artificial respiration. Q J Med (1968) 1.58
Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. Proc Natl Acad Sci U S A (1993) 1.58
Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. Hum Mol Genet (1997) 1.57
Laryngectomy in the management of severe dysphagia in non-malignant conditions. Lancet (1965) 1.53
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52
Regulation of Glutamine Transport in Escherichia coli. J Bacteriol (1975) 1.51
The structure of Marek disease virus DNA: the presence of unique expansion in nonpathogenic viral DNA. Proc Natl Acad Sci U S A (1985) 1.50
Mandrax poisoning: conservative management of 116 patients. Br Med J (1968) 1.50
First observation of the decays B(0) → D(+)K(-)π(+)π(-) and B(-) → D(0)K(-)π(+)π(-). Phys Rev Lett (2012) 1.50
Increased susceptibility of Down's syndrome fibroblasts to transformation by SV40. Proc Soc Exp Biol Med (1967) 1.49
Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport (1996) 1.48
Symposium on in vitro studies related to atherogenesis. Life histories of hyperplastoid cell lines from aorta and skin. Exp Mol Pathol (1973) 1.47
Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. Ophthalmology (1992) 1.46
Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics (2001) 1.46
Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence. Biochemistry (1991) 1.46
Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet (1975) 1.45
Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells. Proc Natl Acad Sci U S A (1974) 1.45
Stool antigen testing for the diagnosis and confirmation of eradication of Helicobacter pylori infection: a prospective blinded trial. Intern Med J (2005) 1.44
A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective protection against primary and recurrent HSV-2 disease. J Infect Dis (1997) 1.44
Triple marker (alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin) versus alpha-fetoprotein plus free-beta subunit in second-trimester maternal serum screening for fetal Down syndrome: a prospective comparison study. Am J Obstet Gynecol (1995) 1.44
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum Genet (1996) 1.43
Growth characteristics of Werner syndrome cells in vitro. Adv Exp Med Biol (1985) 1.39
Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Exp Cell Res (1998) 1.37
A binding protein for L-glutamine and its relation to active transport in E. coli. Arch Biochem Biophys (1971) 1.35
Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs. J Biochem (1984) 1.35
Expression of the Escherichia coli xylose isomerase gene in Saccharomyces cerevisiae. Appl Environ Microbiol (1987) 1.35
Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats. Toxicol Appl Pharmacol (1990) 1.32
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. Am J Hum Genet (1996) 1.31
Cardiovascular disturbances in severe tetanus due to overactivity of the sympathetic nervous system. Anaesthesia (1969) 1.30
SP-40,40 is a constituent of Alzheimer's amyloid. Acta Neuropathol (1992) 1.30
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br J Cancer (2004) 1.29
The Werner syndrome protein is involved in RNA polymerase II transcription. Mol Biol Cell (1999) 1.29
Cultivated cells from diagnostic amniocentesis in second trimester pregnancies. I. Clonal morphology and growth potential. Pediatr Res (1974) 1.29
The discussion of end-of-life medical care by primary care patients and physicians: a multicenter study using structured qualitative interviews. The EOL Study Group. J Gen Intern Med (1994) 1.28
Plasma paraoxonase polymorphism: a new enzyme assay, population, family, biochemical, and linkage studies. Am J Hum Genet (1983) 1.27
The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chem Biol Interact (1999) 1.26
Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines. Proc Natl Acad Sci U S A (1993) 1.25
Apolipoprotein J is associated with paraoxonase in human plasma. Biochemistry (1994) 1.24
The amino acid sequence of D-ribose-binding protein from Escherichia coli K12. J Biol Chem (1983) 1.24
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts. Hum Genet (1981) 1.24
A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. Exp Neurol (2006) 1.23
Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem (1999) 1.22
Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicol Lett (1995) 1.22
Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation. Nature (1979) 1.21
The spectrum and evolution of phenotypic findings in PTEN mutation positive cases of Bannayan-Riley-Ruvalcaba syndrome. J Med Genet (2001) 1.21
Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum Mol Genet (1996) 1.19
Cytogenetic aspects of Werner syndrome. Adv Exp Med Biol (1985) 1.19
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am J Med Genet (1997) 1.17
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein. Hum Mol Genet (1996) 1.17
Observations during endobronchial anaesthesia. II. Oxygenation. Br J Anaesth (1974) 1.17