Published in Cell Tissue Kinet on November 01, 1972
Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J Natl Cancer Inst (1972) 4.06
A new mouse tumor model system (RIF-1) for comparison of end-point studies. J Natl Cancer Inst (1980) 3.75
Factors influencing the quantitative estimation of the in vivo survival of cells from solid tumors. J Natl Cancer Inst (1967) 2.50
Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys (1984) 2.47
The sexual history in general medicine practice. Arch Intern Med (1984) 2.42
Genetic instability induced by the tumor microenvironment. Cancer Res (1996) 2.33
The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Cell (1996) 1.99
WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. J Thromb Haemost (2010) 1.69
Response of solid tumor cells exposed to chemotherapeutic agents in vivo: cell survival after 2- and 24-hour exposure. J Natl Cancer Inst (1973) 1.64
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials. Int J Radiat Oncol Biol Phys (1993) 1.52
The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors--I. Adriamycin. Int J Radiat Oncol Biol Phys (1979) 1.49
In vivo-in vitro tumor systems: new models for studing the response of tumours to therapy. Lab Anim Sci (1977) 1.49
Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev (1987) 1.48
Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res (2000) 1.37
In vitro and in vivo labelling of animal tumours with tritiated thymidine. Cell Tissue Kinet (1973) 1.36
The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology (1972) 1.35
The use of rodent tumors in experimental cancer therapy. Conclusions and recommendations from an international workshop. Cancer Res (1985) 1.33
Oxygenation status of a transplantable tumor during fractionated radiation therapy. J Natl Cancer Inst (1968) 1.27
Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation. Cancer Res (1974) 1.27
Cellular radiosensitivity and tumor radiation response in the EMT6 tumor cell system. Radiat Res (1973) 1.25
The hypoxic tumor cell: a target for selective cancer chemotherapy. Biochem Pharmacol (1980) 1.24
Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue. Radiother Oncol (1999) 1.22
Independent regulation of invasion and anchorage-independent growth by different autophosphorylation sites of the macrophage colony-stimulating factor 1 receptor. Cancer Res (1996) 1.21
The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Invest (1999) 1.16
Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer (1994) 1.13
Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene (1998) 1.10
Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1. Cancer Res (1984) 1.07
Tumor oxygenation and reoxygenation during radiation therapy: their importance in predicting tumor response. Int J Radiat Oncol Biol Phys (1986) 1.07
Mitomycin C: a prototype bioreductive agent. Oncol Res (1994) 1.06
Hypoxia-selective nitrobenzyloxycarbonyl derivatives of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines. J Med Chem (1999) 1.04
Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res (1980) 1.03
Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells. Cancer Res (1989) 1.01
In vivo-in vitro tumour cell lines: characteristics and limitations as models for human cancer. Br J Cancer Suppl (1980) 1.01
The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells. J Biol Chem (1998) 1.00
A technique for determining the proportion of the clonogenic cells in S phase in ENT6 cell cultures and tumors. Cell Tissue Kinet (1976) 0.99
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. J Immunol (1996) 0.97
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase. Proc Natl Acad Sci U S A (1996) 0.96
Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck: results of the Yale Mitomycin Randomized Trials. J Clin Oncol (1997) 0.94
Blood flow in irradiated mouse sarcoma as determined by the clearance of xenon-133. Cancer Res (1972) 0.94
Physical examination as a screening test for pelvic fractures in blunt trauma patients. W V Med J (1997) 0.93
Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cells in vitro. Int J Cancer (1986) 0.93
Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns. Cancer Res (1993) 0.91
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts. J Biol Chem (1988) 0.91
Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. Magn Reson Med (1991) 0.90
The effect of treatment in fractionated schedules with the combination of X-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin. Int J Radiat Oncol Biol Phys (1985) 0.90
Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro. Cancer Res (1985) 0.90
Vitamin A inhibits radiation-induced pneumonitis in rats. J Nutr (1998) 0.90
Biological basis of radiation sensitivity. Part 2: Cellular and molecular determinants of radiosensitivity. Oncology (Williston Park) (2000) 0.89
Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor. Int J Radiat Oncol Biol Phys (1985) 0.89
Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells. Chem Res Toxicol (2000) 0.89
Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys (1989) 0.88
Effect of host age on the transplantation, growth, and radiation response of EMT6 tumors. Cancer Res (1981) 0.88
Interleukin 1 increases thymidine labeling index of normal tissues of mice but not the tumor. Int J Radiat Oncol Biol Phys (1994) 0.88
Interim results of a randomized trial of mitomycin C as an adjunct to radical radiotherapy in the treatment of locally advanced squamous-cell carcinoma of the cervix. Int J Cancer (2000) 0.88
Radiosensitization of EMT6 cells by four platinum complexes. Int J Radiat Oncol Biol Phys (1985) 0.87
Migration and internalization of cells and polystyrene microsphere in tumor cell spheroids. Exp Cell Res (1982) 0.87
Regulation of scatter factor production via a soluble inducing factor. J Cell Biol (1994) 0.87
Antitumour effects of genetically engineered Salmonella in combination with radiation. Eur J Cancer (2000) 0.87
Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas. Int J Cancer (2000) 0.86
Iododeoxyuridine radiosensitization by low- and high-energy photons for brachytherapy dose rates. Radiat Res (1990) 0.85
Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C. Oncol Res (1998) 0.85
Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res (1985) 0.84
Quantitative estimation of histological changes in subcutaneous vasculature of the mouse after x-irradiation. Int J Radiat Oncol Biol Phys (1977) 0.84
Applicability of animal tumor data to cancer therapy in humans. Int J Radiat Oncol Biol Phys (1988) 0.83
Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. Int J Radiat Oncol Biol Phys (1986) 0.83
Radiation pneumonitis. Bronchoalveolar lavage assessment and modulation by a recombinant cytokine. Am Rev Respir Dis (1993) 0.83
Correlation between drug uptake and selective toxicity of porfiromycin to hypoxic EMT6 cells. Cancer Res (1987) 0.82
Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase. Adv Enzyme Regul (1998) 0.82
Effects of clumps and clusters on survival measurements with clonogenic assays. Cancer Res (1985) 0.82
Therapeutic enhancement in mice by clinically relevant dose and fractionation schedules of cis-diamminedichloroplatinum (II) and irradiation. Radiother Oncol (1986) 0.82
Enhancement of tumor radiation response by the combination of a perfluorochemical emulsion and hyperbaric oxygen. Int J Radiat Oncol Biol Phys (1987) 0.82
Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo. J Natl Cancer Inst (1983) 0.81
Failure of 5-thio-D-glucose to alter cell survival in irradiated or unirradiated EMT6 tumors. Radiat Res (1984) 0.81
Fluosol and hyperbaric oxygen as an adjunct to radiation therapy in the treatment of malignant gliomas: a pilot study. Biomater Artif Cells Immobilization Biotechnol (1992) 0.81
Mitomycin-C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity. Int J Radiat Oncol Biol Phys (1982) 0.81
The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors. VI. BCNU. Int J Radiat Oncol Biol Phys (1979) 0.81
Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells. Cancer Res (2001) 0.80
Cytotoxicities of mitomycin C and x rays to aerobic and hypoxic cells in vitro. Int J Radiat Oncol Biol Phys (1982) 0.80
Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo. Int J Radiat Oncol Biol Phys (1979) 0.80
Acute and chronic effects of x irradiation on blood flow in the mouse limb. Radiology (1974) 0.80
Studies on the mechanism of the cytotoxic action of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells. Adv Enzyme Regul (1993) 0.80
Perfluorochemicals and hyperbaric oxygen in radiation therapy. Int J Radiat Oncol Biol Phys (1986) 0.80
Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase. Biochem Pharmacol (1996) 0.80
Preferential radiosensitization of mouse sarcoma relative to normal skin by chronic intra-arterial infusion of halogenated pyrimidine analogs. J Natl Cancer Inst (1971) 0.80
Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo. Invest Radiol (1988) 0.79
Reoxygenation in the RIF-1 tumor. Int J Radiat Oncol Biol Phys (1984) 0.79
Interleukin-1 modulatory effect on the action of chemotherapeutic drugs and localized irradiation of the lip, duodenum, and tumor. Int J Radiat Oncol Biol Phys (1993) 0.78
Influence of a 1400-gauss magnetic field on the radiosensitivity and recovery of EMT6 cells in vitro. Int J Radiat Biol Relat Stud Phys Chem Med (1977) 0.78
Cytotoxic and radiosensitizing effects of hypoxic cell sensitizers on EMT6 mouse mammary tumour cells in vivo and in vitro. Br J Cancer Suppl (1978) 0.78
Enhanced IUdR radiosensitization by 241Am photons relative to 226Ra and 125I photons at 0.72 Gy/hr. Int J Radiat Oncol Biol Phys (1990) 0.78
Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C. Adv Enzyme Regul (1985) 0.78
The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors--II. Cyclophosphamide. Int J Radiat Oncol Biol Phys (1979) 0.78
Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proc Natl Acad Sci U S A (1999) 0.78
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma of the head and neck. Radiat Oncol Investig (1997) 0.78
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol. Biochem Pharmacol (2001) 0.78
Interleukin 1 protects against the lethal effects of irradiation of mice but has no effect on tumors in the same animals. Proc Soc Exp Biol Med (1989) 0.78
Enhancement of IUdR radiosensitization by low energy photons. Int J Radiat Oncol Biol Phys (1987) 0.78
Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions. Cancer Commun (1991) 0.78