Published in Br J Pharmacol on November 01, 1972
Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed rat. Br J Pharmacol (1973) 2.50
Interaction between clonidine and desipramine in man. Br Med J (1973) 1.11
Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog. Br J Pharmacol (1974) 0.95
Pharmacology of centrally acting hypotensive drugs. Br J Clin Pharmacol (1980) 0.78
Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves. Arch Int Pharmacodyn Ther (1972) 2.24
Pharmacological studies on the hypotensive effects of clonidine. Eur J Pharmacol (1971) 1.49
Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature (1998) 8.75
White-coat hypertension as a cause of cardiovascular dysfunction. Lancet (1996) 4.68
Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am J Epidemiol (1973) 3.77
Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet (1998) 3.41
Clinical pharmacology and pharmacokinetics of clonidine. Clin Pharmacol Ther (1976) 3.13
Analysis of the pressor dose response. Clin Pharmacol Ther (1982) 2.44
Immediate cardiovascular responses to oral prazosin--effects of concurrent beta-blockers. Clin Pharmacol Ther (1981) 2.36
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J (1999) 2.23
A pharmacodynamic and pharmacokinetic assessment of a new alpha-adrenoceptor antagonist, doxazosin (UK33274) in normotensive subjects. Br J Clin Pharmacol (1982) 2.06
Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. Lancet (1983) 2.03
Sexual activity between doctors and patients. N Z Med J (1996) 2.01
Clonidine withdrawal in hypertension. Changes in blood-pressure and plasma and urinary noradrenaline. Lancet (1977) 2.01
Topographic detection of photorefractive keratectomy. Ophthalmology (1998) 1.97
Coordinating and standardizing long-term care: evaluation of the west of Scotland shared-care scheme for hypertension. Br J Gen Pract (1994) 1.92
Pharmacokinetics and concentration-effect relationships of intervenous and oral clonidine. Clin Pharmacol Ther (1977) 1.91
Doxazosin, an alpha 1-adrenoceptor antagonist: pharmacokinetics and concentration-effect relationships in man. Br J Clin Pharmacol (1983) 1.89
Assessment of selective beta-adrenoceptor blockade in man. Br J Pharmacol (1973) 1.85
Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521. Br J Clin Pharmacol (1982) 1.81
Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium. Br Heart J (1983) 1.79
"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic. Br Med J (Clin Res Ed) (1984) 1.69
Cardiovascular reflexes in Parkinsonism. Clin Sci (1971) 1.62
Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa. Br Med J (1971) 1.60
Brain concentration of propranolol in relation to hypotensive effect in the rabbit with observations on brain propranolol levels in man. J Pharmacol Exp Ther (1975) 1.56
The effects of cardioselective and non-selective beta-adrenoceptor blockade on the hypokalaemic and cardiovascular responses to adrenomedullary hormones in man. Clin Sci (Lond) (1983) 1.56
Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man. Clin Sci (Lond) (1985) 1.49
Verapamil pharmacokinetics and apparent hepatic and renal blood flow. Br J Clin Pharmacol (1985) 1.46
Central hypotensive effect of propranolol in the rabbit. Br J Pharmacol (1973) 1.44
Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension (1999) 1.44
The importance of central adrenergic neurones in renal hypertension in rabbits. J Physiol (1974) 1.43
Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man. Gut (1984) 1.36
Metabolism of isoprenaline after aerosol and direct intrabronchial administration in man and dog. Br J Pharmacol (1974) 1.32
Technical report: quantitative assessment of diaphragmatic movement--a reproducible method using ultrasound. Clin Radiol (1992) 1.30
Acute and chronic effects of the converting enzyme inhibitors enalapril and lisinopril on reflex control of heart rate in normotensive man. J Hypertens (1985) 1.29
The effect of captopril on the reflex control heart rate: possible mechanisms. Br J Clin Pharmacol (1985) 1.29
Infections in 18,000 infants and children in a controlled study of respiratory tract disease. II. Variation in adenovirus infections by year and season. Am J Epidemiol (1972) 1.27
Central noradrenergic neurones and the cardiovascular actions of clonidine in the rabbit. Br J Pharmacol (1973) 1.27
Prazosin disposition in young and elderly subjects. Br J Clin Pharmacol (1981) 1.24
A pragmatic approach to the pressor dose-response as an index of vascular reactivity and adrenoceptor function in man. Br J Clin Pharmacol (1987) 1.22
Evidence for postjunctional vascular alpha 2-adrenoceptors in peripheral vascular regulation in man. Clin Sci (Lond) (1983) 1.22
Osteomyelitis caused by a bacterium known as M6. J Infect (1986) 1.21
The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow. Br J Clin Pharmacol (1985) 1.20
Idiopathic parkinsonism treated with bromocriptine. Lancet (1975) 1.20
Effects of the angiotensin converting enzyme inhibitor, captopril, in essential hypertension. Br J Clin Pharmacol (1982) 1.19
Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences. J Cereb Blood Flow Metab (1993) 1.18
Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nat Genet (1997) 1.18
Effects of clonidine on biochemical indices of sympathetic function and plasma renin activity in normotensive man. Clin Sci Mol Med (1977) 1.17
Pharmacokinetic and concentration-effect relationships of clonidine in essential hypertension. Eur J Clin Pharmacol (1977) 1.16
Preliminary experience with a hospital blood pressure follow up clinic with nurse practitioner assessment and microprocessor based data retrieval. Br Med J (Clin Res Ed) (1984) 1.16
Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol (1984) 1.16
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects. Br J Clin Pharmacol (1988) 1.16
Kinetic-dynamic relations and individual responses to enalapril. Hypertension (1990) 1.16
Policies for managing hypertensive patients: a survey of the opinions of British specialists. J Hum Hypertens (1990) 1.14
Prior thiazide diuretic treatment increases adrenaline-induced hypokalaemia. Lancet (1983) 1.14
Age and the pharmacokinetics of angiotensin converting enzyme inhibitors enalapril and enalaprilat. Br J Clin Pharmacol (1986) 1.13
The role of adrenal medullary catecholamines in potassium homoeostasis. Clin Sci (Lond) (1984) 1.13
[3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur J Pharmacol (1988) 1.13
Atenolol disposition in young and elderly subjects. Br J Clin Pharmacol (1982) 1.13
Platelet alpha-adrenoceptors--a valid model for brain or vascular adrenoceptors? Br J Clin Pharmacol (1986) 1.12
Interaction between clonidine and desipramine in man. Br Med J (1973) 1.11
Effect of age on the responsiveness of vascular alpha-adrenoceptors in man. J Cardiovasc Pharmacol (1982) 1.10
Plasma noradrenaline concentration in essential hypertension during long-term beta-adrenoceptor blockade with oxprenolol. Br J Clin Pharmacol (1980) 1.09
Pharmacology of M & B 17803A in man and dog. Br J Pharmacol (1971) 1.09
Acute thermoregulatory and cardiovascular effects of 6-hydroxydopamine administered centrally in rabbits and cats. Br J Pharmacol (1972) 1.09
Nifedipine does not influence adrenaline induced hypokalaemia in man. Br J Clin Pharmacol (1983) 1.09
Central and peripheral adrenergic mechanisms in the development of deoxycorticosterone-saline hypertension in rats. Circ Res (1975) 1.07
The experiences of an acute stroke unit--implications for multicentre acute stroke trials. J Neurol Neurosurg Psychiatry (1993) 1.06
The influence of naloxone on the circulatory effects of captopril. Br J Clin Pharmacol (1984) 1.06
Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. Eur J Clin Pharmacol (1986) 1.05
Blood pressure in genetically hypertensive rats. Influence of the Y chromosome. Hypertension (1995) 1.05
Cardiovascular effects of intracerebroventricular d-, l- and dl-propranolol in the conscious rabbit. J Pharmacol Exp Ther (1974) 1.05
Plasma concentration of levodopa in Parkinsonism before and after inhibition of peripheral decarboxylase. J Neurol Sci (1972) 1.05
Nifedipine: individual responses and concentration-effect relationships. Hypertension (1988) 1.03
Concentration effect modelling with converting enzyme inhibitors in man. Br J Clin Pharmacol (1983) 1.03
Hypercholesterolaemia in treated hypertensives: a controlled trial of intensive dietary advice. J Hypertens Suppl (1989) 1.03
The pharmacodynamics and dose-response relationships of the angiotensin converting enzyme inhibitor, cilazapril, in essential hypertension. Br J Clin Pharmacol (1986) 1.03
A comparison of the management of hypertensive patients by nurse practitioners compared with conventional hospital care. J Hum Hypertens (1990) 1.02
Effect of naloxone on the actions of captopril. Clin Pharmacol Ther (1985) 1.02
Sedative and cardiovascular effects of clonidine and nitrazepam. Clin Pharmacol Ther (1980) 1.02
Regional impairment of cerebral oxidative metabolism in Parkinson's disease. J Neurol Neurosurg Psychiatry (1979) 1.02
Haemodynamic and humoral effects of oral perindopril, an angiotensin converting enzyme inhibitor, in man. Br J Clin Pharmacol (1987) 1.02
Calcium antagonists decrease adrenal and vascular responsiveness to angiotensin II in normal man. Clin Sci (Lond) (1981) 1.01
Decreased vascular responsiveness to noradrenaline following regular ethanol consumption. Br J Clin Pharmacol (1985) 1.00
Vascular and aldosterone responses to angiotensin II in normal humans: effects of nicardipine. J Cardiovasc Pharmacol (1986) 1.00
Enalapril and autonomic reflexes and exercise performance. J Hypertens Suppl (1983) 1.00
Differences in first dose response to angiotensin converting enzyme inhibition in congestive heart failure: a placebo controlled study. Br Heart J (1991) 1.00
Measuring therapy adherence in Parkinson's disease: a comparison of methods. J Neurol Neurosurg Psychiatry (2006) 1.00
Letter: Clonidine overdose. Br Med J (1975) 0.99
Simultaneous assay of 3,4-dihydroxyphenylethylene glycol and norepinephrine in human plasma by high-performance liquid chromatography with electrochemical detection. J Chromatogr (1985) 0.99
The symptoms of patients treated for Parkinson's disease. Clin Neuropharmacol (1985) 0.99
Plasma concentration of alpha-methyldopa and sulphate conjugate after oral administration of methyldopa and intravenous administration of methyldopa and methyldopa hydrochloride ethyl ester. Eur J Clin Pharmacol (1975) 0.99
Effect of nifedipine on blood pressure and adrenocortical responses to trophic stimuli in humans. J Cardiovasc Pharmacol (1982) 0.98
Parkinsonism treated with 3-O-methyldopa. Clin Pharmacol Ther (1973) 0.98
Calcium antagonists and hormone release: effect of nifedipine on luteinizing hormone-releasing hormone and thyrotropin-releasing hormone-induced pituitary hormone release. J Clin Endocrinol Metab (1983) 0.98
The Fourth Lilly Prize Lecture, University of Aberdeen, September 1980. The clinical pharmacology of clonidine and related central antihypertensive agents. Br J Clin Pharmacol (1981) 0.98
The effect of age on the responses of human isolated arteries to noradrenaline. Br J Clin Pharmacol (1982) 0.97
The effect of enalapril on baroreceptor mediated reflex function in normotensive subjects. Br J Clin Pharmacol (1986) 0.97
Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study. Eur J Neurol (2005) 0.97
Effects of intravenous S-9780, an angiotensin-converting enzyme inhibitor, in normotensive subjects. J Cardiovasc Pharmacol (1987) 0.97
The haemodynamic and humoral effects of treatment for one month with the angiotensin converting enzyme inhibitor perindopril in salt replete hypertensive patients. Eur J Clin Pharmacol (1987) 0.97