Published in N Engl J Med on June 14, 1973
Factors affecting the sensitivity of Limulus lysate. Appl Microbiol (1974) 3.16
Opsonizing antibodies, host factors, and the limulus assay for endotoxin. Infect Immun (1975) 1.03
Survey for positive Limulus amoebocyte lysate test in plasma from humans and common research animals. J Clin Microbiol (1978) 0.84
Assessment of the intrinsic contractile status of the heart during sepsis by myocardial pressure-dimension analysis. Ann Surg (1988) 0.76
Effects of meningococcal and Escherichia coli capsular polysaccharides on human and dog platelet aggregation in vitro. J Clin Pathol (1976) 0.75
An antibiotic policy for bacterial infections after thoracic and other injuries. Thorax (1977) 0.75
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Impact of stepping stones on incidence of HIV and HSV-2 and sexual behaviour in rural South Africa: cluster randomised controlled trial. BMJ (2008) 7.63
Detection of endotoxin in human blood and demonstration of an inhibitor. J Lab Clin Med (1970) 6.04
Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin. Thromb Diath Haemorrh (1968) 3.90
A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. Int J Tuberc Lung Dis (2008) 3.77
Detection of endotoxin in the blood of patients with sepsis due to gran-negative bacteria. N Engl J Med (1970) 3.55
Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore) (1977) 3.20
Factors associated with HIV sero-status in young rural South African women: connections between intimate partner violence and HIV. Int J Epidemiol (2006) 3.07
Hemolytic-uremic syndrome after shigellosis. Relation to endotoxemia and circulating immune complexes. N Engl J Med (1978) 2.95
Failure of the International Normalized Ratio to generate consistent results within a local medical community. Am J Clin Pathol (1993) 2.81
Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement. Ann Intern Med (1972) 2.79
A cluster randomized-controlled trial to determine the effectiveness of Stepping Stones in preventing HIV infections and promoting safer sexual behaviour amongst youth in the rural Eastern Cape, South Africa: trial design, methods and baseline findings. Trop Med Int Health (2006) 2.64
An invertebrate coagulation system activated by endotoxin: evidence for enzymatic mediation. J Clin Invest (1972) 2.61
Hematocrit value on intensive care unit entry influences the frequency of Q-wave myocardial infarction after coronary artery bypass grafting. The Institutions of the Multicenter Study of Perioperative Ischemia (McSPI) Research Group. J Thorac Cardiovasc Surg (1998) 2.49
A reevaluation of the role of crystalloid preload in the prevention of hypotension associated with spinal anesthesia for elective cesarean section. Anesthesiology (1993) 2.44
Prevalence of emotional, physical and sexual abuse of women in three South African provinces. S Afr Med J (2001) 2.09
Quantitative comparison of in vitro and in vivo methods for the detection of endotoxin. J Lab Clin Med (1971) 2.08
A critical reappraisal of the bleeding time. Semin Thromb Hemost (1990) 2.03
The RNA code and protein synthesis. Cold Spring Harb Symp Quant Biol (1966) 1.96
Factors associated with HIV sero-positivity in young, rural South African men. Int J Epidemiol (2006) 1.90
Hemoglobin infusion augments the tumor necrosis factor response to bacterial endotoxin (lipopolysaccharide) in mice. Crit Care Med (1999) 1.87
Thrombocytopenia with absent radius (TAR). Medicine (Baltimore) (1969) 1.82
A further consideration in the application of an analysis-of-variance model for the intrasubject replication design. J Appl Behav Anal (1974) 1.73
Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits. Nat Med (1999) 1.64
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J (1997) 1.60
First symptom in sporadic Creutzfeldt-Jakob disease. Neurology (2006) 1.58
The inverse relation between platelet volume and platelet number. Abnormalities in hematologic disease and evidence that platelet size does not correlate with platelet age. J Lab Clin Med (1983) 1.57
The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet. N Engl J Med (1990) 1.54
Typhoid fever. Studies of blood coagulation, bacteremia, and endotoxemia. Arch Intern Med (1978) 1.52
Rabbit macrophages secrete two biochemically and immunologically distinct endogenous pyrogens. Infect Immun (1981) 1.42
Tissue factor generation by human mononuclear cells: effects of endotoxin and dissociation of tissue factor generation from mitogenic response. J Lab Clin Med (1977) 1.41
Equilibrium and kinetic inhibition assays based upon fluorescence polarization. Methods Enzymol (1981) 1.36
Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection. Am J Med (1977) 1.34
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol (2005) 1.32
Determinants of multidrug-resistant tuberculosis in South Africa: results from a national survey. S Afr Med J (2007) 1.31
Lack of endotoxin in Borrelia hispanica and Treponema pallidum. Proc Soc Exp Biol Med (1983) 1.26
Yersinia pestis infection in Vietnam. II. Quantiative blood cultures and detection of endotoxin in the cerebrospinal fluid of patients with meningitis. J Infect Dis (1976) 1.26
Mass mailing and staff experience in a total recruitment program for a clinical trial: the SHEP experience. Systolic Hypertension in the Elderly Program. Cooperative Research Group. Control Clin Trials (1999) 1.26
Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: a 24-institution study. Institutions of the Multicenter Study of Perioperative Ischemia Research Group. Anesthesiology (1998) 1.25
Mapping of the prostate in endorectal coil-based MRI/MRSI and CT: a deformable registration and validation study. Med Phys (2004) 1.21
Portal and systemic bacteraemia and endotoxaemia in liver disease. Gut (1978) 1.17
Investigation of hormone-receptor interactions by means of fluorescence labeling. Cancer Res (1978) 1.15
Fluorescence polarization immunoassay. Theory and experimental method. Immunochemistry (1973) 1.14
Mechanisms of thrombocytopenia in malignant tertian malaria. Br Med J (1973) 1.13
Recurrent hyperinfestation with Strongyloides stercoralis in a renal allograft recipient. Br Med J (Clin Res Ed) (1982) 1.13
Mild Hypogonadotropic hypogonadism in obese men. Metabolism (1982) 1.11
Bleeding time: a guide to its diagnostic and clinical utility. Arch Pathol Lab Med (1990) 1.09
Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis. Arthritis Rheum (2001) 1.08
Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity. J Immunol (1996) 1.08
A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74. Nucleic Acids Res (1993) 1.07
Diphtheroid bacterial endocarditis after insertion of a Starr valve. Ann Intern Med (1966) 1.07
Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. J Biol Chem (1994) 1.07
Measurement of thrombopoiesis in rabbits using 75selenomethionine. J Clin Invest (1969) 1.06
Scoliosis in pediatric spinal cord-injured patients. J Pediatr Orthop (1990) 1.05
Progress in the development of RBC substitutes. Transfusion (2001) 1.03
Platelet, erythrocyte, and fibrinogen kinetics in the hemolytic-uremic syndrome of infancy. J Pediatr (1973) 1.03
Stimulation of thrombopoiesis in mice by human recombinant interleukin 6. J Clin Invest (1990) 1.02
Hemoglobin increases mortality from bacterial endotoxin. Infect Immun (1997) 1.02
Abnormal levels of plasma hormones in men with prostate cancer: evidence toward a "two-disease" theory. Prostate (1982) 1.02
The effects of acute thrombocytopenia on megakaryocyte-CFC and granulocyte-macrophage-CFC in mice: studies of bone marrow and spleen. Blood (1980) 1.02
Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol. Metabolism (1982) 1.01
A simple, fluorescent method to internally label platelets suitable for physiological measurements. Am J Hematol (1997) 1.01
Biological and biochemical characteristics of murine megakaryoblastic cell line L8057. Exp Hematol (1993) 1.01
Mechanisms of platelet production. Blood Cells (1989) 1.00
Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men. J Clin Endocrinol Metab (1982) 1.00
Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease. Arch Neurol (1979) 1.00
Platelet production after administration of antiplatelet serum and 5-fluorouracil. Blood (1980) 0.99
Geohelminth infection and re-infection after chemotherapy among slum-dwelling children in Durban, South Africa. Ann Trop Med Parasitol (2009) 0.99
The effect of medroxyprogesterone acetate on the pituitary-adrenal axis. J Clin Endocrinol Metab (1976) 0.99
Involvement of the central loop of the lactose permease of Escherichia coli in its allosteric regulation by the glucose-specific enzyme IIA of the phosphoenolpyruvate-dependent phosphotransferase system. J Bacteriol (1996) 0.99
Measurement of megakaryocyte frequency and ploidy distribution in unfractionated murine bone marrow. Exp Hematol (1989) 0.99
Relationship of adverse events to serum drug levels in patients receiving high-dose azithromycin for mycobacterial lung disease. Clin Infect Dis (1997) 0.98
The effects of 5-fluorouracil on hematopoiesis: studies of murine megakaryocyte-CFC, granulocyte-macrophage-CFC, and peripheral blood cell levels. Exp Hematol (1983) 0.98
Neuropsychological dysfunction, mood disturbance, and emotional status of munitions workers. Appl Neuropsychol (2001) 0.97
Effects of bacterial infection and irradiation on serum colony-stimulating factor levels in tolerant and nontolerant CF1 mice. Blood (1978) 0.96
Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood (1987) 0.96
Abnormal 24-hr mean plasma concentrations of dehydroisoandrosterone and dehydroisoandrosterone sulfate in women with primary operable breast cancer. Cancer Res (1981) 0.96
Biological activities of tritiated endotoxins: correlation of the Limulus lysate assay with rabbit pyrogen and complement-activation assays for endotoxin. J Lab Clin Med (1977) 0.96
Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults. J Clin Endocrinol Metab (1980) 0.95
Antidepressant binding to the porcine and human platelet serotonin transporters. Mol Pharmacol (1988) 0.95
Interactions of lipid a and liposome-associated lipid A with Limulus polyphemus amoebocytes. Infect Immun (1983) 0.94
Localization of megakaryocytes in normal mice and following administration of platelet antiserum, 5-fluorouracil, or radiostrontium: evidence for the site of platelet production. Exp Hematol (1997) 0.94
Bubonic plague: detection of endotoxemia with the limulus test. Ann Intern Med (1973) 0.93
Effects of obesity on estradiol metabolism: decreased formation of nonuterotropic metabolites. J Clin Endocrinol Metab (1983) 0.92
Multidimensional flow cytometric blood cell differentiation without erythrocyte lysis. Blood Cells (1991) 0.92
Comparison of indoor air quality in electrified and un-electrified dwellings in rural South African villages. Indoor Air (2004) 0.92
Neuraminidase-induced thrombocytopenia in mice: effects on thrombopoiesis. J Cell Physiol (1991) 0.92
Simultaneous factor analysis of several Gramian matrices. Psychometrika (1966) 0.92
The impact of first year adherence to antiretroviral therapy on long-term clinical and immunological outcomes in the DART trial in Uganda and Zimbabwe. Trop Med Int Health (2012) 0.91
Regulators of thrombopoiesis: their biochemistry and physiology. Blood Cells (1989) 0.91
A method for the removal of endotoxin from purified colony-stimulating factor. Proc Soc Exp Biol Med (1980) 0.91
Stem cell migration induced by erythropoietin or haemolytic anaemia: the effects of actinomycin and endotoxin contamination of erythropoietin preparations. Br J Haematol (1979) 0.90
Distribution of bacterial endotoxin in human and rabbit blood and effects of stroma-free hemoglobin. Infect Immun (1993) 0.90
Cortisol production in obesity. Metabolism (1980) 0.90
Isolation and studies of the granules of the amebocytes of Limulus polyphemus, the horseshoe crab. J Cell Physiol (1975) 0.90
The safety and efficacy of ten percent pentastarch as a cardiopulmonary bypass priming solution. A randomized clinical trial. J Thorac Cardiovasc Surg (1992) 0.90
A survey of blood lead levels among young Johannesburg school children. Environ Res (2002) 0.90
Selective cutaneous hyperpigmentation in mice following zidovudine administration. Arch Dermatol (1992) 0.90