Molecular events resulting in radiation injury, repair and sensitization of DNA.

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Published in Radiat Res Suppl on January 01, 1967

Authors

W Szybalski

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Mapping of deletions and substitutions in heteroduplex DNA molecules of bacteriophage lambda by electron microscopy. Science (1969) 5.54

Nomenclature of transposable elements in prokaryotes. Gene (1979) 4.13

Microbial Selection. Science (1952) 4.08

Physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis (actinomycin, daunomycin, cinerubin, nogalamycin, chormomycin, mithramycin, and olivomycin). Biochemistry (1966) 4.06

Electron microscopy of polar insertions in the lac operon of Escherichia coli. Mol Gen Genet (1972) 3.85

Escherichia coli genome targeting, I. Cre-lox-mediated in vitro generation of ori- plasmids and their in vivo chromosomal integration and retrieval. Gene (1994) 3.84

In vivo excision and amplification of large segments of the Escherichia coli genome. Nucleic Acids Res (1994) 3.61

Polar mutations in lac, gal and phage lambda consist of a few IS-DNA sequences inserted with either orientation. Mol Gen Genet (1972) 3.59

A comprehensive molecular map of bacteriophage lambda. Gene (1979) 3.46

Deletions and insertions in the immunity region of coliphage lambda: revised measurement of the promoter-startpoint distance. Virology (1974) 3.44

Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA. Proc Natl Acad Sci U S A (1967) 2.70

Nomenclature of transposable elements in prokaryotes. Plasmid (1979) 2.17

Patterns of interaction between polyribonucleotides and individual DNA strands derived from several vertebrates, bacteria and bacteriophages. J Mol Biol (1966) 2.13

Electron micrographic maps of deletions and substitutions in the genomes of transducing coliphages lambda dg and lambda bio. Virology (1969) 2.04

Coliphage lambdanutL-: a unique class of mutants defective in the site of gene N product utilization for antitermination of leftward transcription. J Mol Biol (1978) 2.00

Pyrimidine clusters on the transcribing strand of DNA and their possible role in the initiation of RNA synthesis. Cold Spring Harb Symp Quant Biol (1966) 1.96

A simple method for identifying the palindromic sequences recognized by restriction endonucleases: the nucleotide sequence of the AvaII site. Gene (1978) 1.91

Universal restriction endonucleases: designing novel cleavage specificities by combining adapter oligodeoxynucleotide and enzyme moieties. Gene (1985) 1.85

Identification of palindromic sequences recognized by restriction endonucleases, as based on the tabularized sequencing data for seven viral and plasmid DNAs. Gene (1980) 1.82

Controls and polarity of transcription during bacteriophage T4 development. J Mol Biol (1971) 1.77

Fractionation of the complementary strands of coliphage T4 DNA based on the asymmetric distribution of the poly U and poly U,G binding sites. Virology (1968) 1.75

Control of short leftward transcripts from the immunity and ori regions in induced coliphage lambda. Mol Gen Genet (1973) 1.74

Cleaving yeast and Escherichia coli genomes at a single site. Science (1990) 1.70

Patterns of convergent and overlapping transcription within the b2 region of coliphage lambda. Virology (1969) 1.58

Suppression of RNA precipitation during Cs2SO4 density gradient centrifugation. Biochem Biophys Res Commun (1966) 1.54

Orientation of transcription of the lac operon and its repressor gene in Escherichia coli. J Mol Biol (1969) 1.52

Packaging of plasmid DNA containing the cohesive ends of coliphage lambda. Gene (1980) 1.45

GENETIC INTERACTION AMONG STREPTOMYCETES: HETEROKARYOSIS AND SYNKARYOSIS. Proc Natl Acad Sci U S A (1957) 1.43

Insertion sequence IS2 associated with int-constitutive mutants of bacteriophage lambda. Gene (1977) 1.43

Orientation and control of transcription in E. coli phage lambda. Nature (1969) 1.43

Physical and biological consequences of interactions between integration host factor (IHF) and coliphage lambda late p'R promoter and its mutants. Gene (1989) 1.42

Control of cloned gene expression by promoter inversion in vivo: construction of improved vectors with a multiple cloning site and the Ptac promoter. Gene (1987) 1.39

DNA base composition of Neisseria, Moraxella, and Acinetobacter, as determined by measurement of buoyant density in CsCl gradients. Can J Microbiol (1969) 1.37

Cleaving DNA at any predetermined site with adapter-primers and class-IIS restriction enzymes. Science (1988) 1.37

Preparing and using agarose microbeads. Methods Enzymol (1992) 1.34

Regulation of integration by coliphage lambda: activation of int transcription by the cII and cIII proteins. Virology (1979) 1.29

Distance from a promoter mutation to an RNA synthesis startpoint on bacteriophage lambda DNA. Nat New Biol (1972) 1.26

Transcriptional controls in developing bacteriophages. J Cell Physiol (1969) 1.25

A relationship between DNA helix stability and recognition sites for RNA polymerase. Science (1979) 1.23

Initiation and patterns of transcription during phage development. Proc Can Cancer Conf (1969) 1.22

Orientation of transcription for the galactose operon as determined by hybridization of gal mRNA with the separated DNA strands of coliphages lambda-dg. J Mol Biol (1968) 1.21

Controls of rightward transcription in coliphage lambda. J Mol Biol (1970) 1.19

RecA-AC: single-site cleavage of plasmids and chromosomes at any predetermined restriction site. Nucleic Acids Res (1992) 1.18

Conferring operator specificity on restriction endonucleases. Science (1988) 1.17

Physical mapping of the att-N region of coliphage lambda: apparent oversaturation of coding capacity in the gam-ral segment. Biochimie (1974) 1.15

Organization of ribosomal protein genes in Escherichia coli. I. Physical structure of DNA from transducing lambda phages carrying genes from the aroE-str region. J Mol Biol (1976) 1.15

Conversion of the FokI endonuclease to a universal restriction enzyme: cleavage of phage M13mp7 DNA at predetermined sites. Gene (1985) 1.15

A family of removable cassettes designed to obtain antibiotic-resistance-free genomic modifications of Escherichia coli and other bacteria. Gene (2000) 1.14

Mutations and decreases in density of transforming DNA produced by derivatives of the carcinogens 2-acetyl-aminofluorene and N-methyl-4-aminoazobenzene. Mol Pharmacol (1968) 1.13

Processing of the major leftward mRNA of coliphage lambda. Virology (1976) 1.11

THE MECHANISM OF CHEMICAL MUTAGENESIS. I. KINETIC STUDIES ON THE ACTION OF TRIETHYLENE MELAMINE (TEM) AND AZASERINE. Proc Natl Acad Sci U S A (1958) 1.08

Antitermination and termination functions of the cloned nutL, N, and tL1 modules of coliphage lambda. Gene (1981) 1.05

4S oop RNA is a leader sequence for the immunity-establishment transcription in coliphage lambda. Nature (1976) 1.03

Regulation of leftward transcription in the J-b2-att region of coliphage lambda. Mol Gen Genet (1971) 1.02

Identification of the transcribing DNA strand for the rII and endolysin genes of coliphage T4. J Mol Biol (1968) 1.02

N-independent leftward transcription in coliphage lambda: deletions, insertions and new promoters bypassing termination functions. Mol Gen Genet (1979) 1.02

Congruent transcriptional controls and heterology of base sequences in coliphages lambda and phi-80. Virology (1969) 1.02

Structural requirements for FokI-DNA interaction and oligodeoxyribonucleotide-instructed cleavage. J Mol Biol (1996) 1.00

Size, number, and distribution of poly G binding sites on the separated DNA strands of coliphage T7. Biochim Biophys Acta (1968) 0.99

Discrete length classes of DNA depend on mode of dehydration. Proc Natl Acad Sci U S A (1978) 0.99

MECHANISM OF CHEMICAL MUTAGENESIS IV. : Reaction between Triethylene Melamine and Nucleic Acid Components. J Bacteriol (1961) 0.98

Studies on polynucleotides. XCVII. Opposing orientations and location of the su+3 gene in the transducing coliphages phi-80psu+3 and phi-80dsu+3su-3. J Mol Biol (1971) 0.96

X-ray sensitization by halopyrimidines. Cancer Chemother Rep (1974) 0.96

Nobel prizes and restriction enzymes. Gene (1978) 0.95

Transcription of the lambdadv plasmid and inhibition of lambda phages in lambdadv carrier cells of Escherichia coli. Virology (1970) 0.94

A novel method for converting common restriction enzymes into rare cutters: integration host factor-mediated Achilles' cleavage (IHF-AC). Gene (1992) 0.94

Assembly of 18-nucleotide primers by ligation of three hexamers: sequencing of large genomes by primer walking. Anal Biochem (1994) 0.91

Amplification of cloned DNA as tandem multimers using BspMI-generated asymmetric cohesive ends. Gene (1988) 0.91

Analysis of the in vitro synthesis of 5'-gamma-32P-labeled transcripts from coliphage lambda by gel electrophoresis, RNA-DNA hybridization, and RNase T1 digestion. J Biol Chem (1980) 0.90

A broad-host-range in vivo pop-out and amplification system for generating large quantities of 50- to 100-kb genomic fragments for direct DNA sequencing. Gene (1996) 0.90

Insertion sequence IS2 near the gene for prophage lambda excision. Mol Gen Genet (1976) 0.90

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Asymmetric effects of deletions and substitutions on high negative interference in coliphage lambda. Genetics (1982) 0.89

Transcription termination sites in the major leftward operon of coliphage lambda. Virology (1978) 0.88

In vitro transcription from the b2 region of bacteriophage lambda. Virology (1980) 0.88

Expression of lambda int gene function in ColE1 hybrid plasmids carrying the C fragment of bacteriophage lambda. Virology (1979) 0.88

Electron microscopic mapping of RNA polymerase binding to coliphage lambda DNA. J Mol Biol (1978) 0.88

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Gamma-irradiation of deoxyribonucleic acid in dilute solutions. I. A sensitive method for detection of single-strand breaks in polydisperse DNA samples. J Mol Biol (1967) 0.87

Orientation of transcription for the amber suppressor gene su 3 as determined by hybridization between tyrosine tRNA and the separated DNA strands of transducing coliphage phi80d su3. J Mol Biol (1969) 0.87

A biochemical assay for the transcription-antitermination function of the coliphage lambda N gene product. Gene (1980) 0.86

Tandem transcription-termination sites in the late rightward operon of bacteriophage lambda. Mol Gen Genet (1983) 0.86

Genomic DNA sequencing by SPEL-6 primer walking using hexamer ligation. Gene (1998) 0.86

A novel gene-fusing vector: construction of a 5'-GGmCC-specific chimeric methyltransferase, M.BspRI/M.BsuRI. Gene (1991) 0.86

Transcription termination: sequence and function of the rho-independent tL3 terminator in the major leftward operon of bacteriophage lambda. Gene (1982) 0.86

Repression of transcription from the b2-att region of coliphage lambda by integration host factor. Virology (1989) 0.85

Physical mapping of the trp endpoint in the n-tL segment of phage lambda trpE-A. Virology (1974) 0.85

Repressor and rex product of coliphage lambda: lack of collaboration and joint controls. Mol Gen Genet (1973) 0.84

Incorporation of 5-fluorodeoxyuridine into the DNA of Bacillus subtilis phage PBS2 and its radiobiological consequences. J Mol Biol (1967) 0.84

Gamma-irradiation of deoxyribonucleic acid in dilute solutions. II. Molecular mechanisms responsible for inactivation of phage, its transfecting DNA, and of bacterial transforming activity. J Mol Biol (1967) 0.84

Gene expression by constitutive mutants of coliphage lambda. Mol Gen Genet (1972) 0.84

Achilles' heel cleavage: creation of rare restriction sites in lambda phage genomes and evaluation of additional operators, repressors and restriction/modification systems. Gene (1990) 0.84

Control of cloned gene expression by promoter inversion in vivo: construction of the heat-pulse-activated att-nutL-p-att-N module. Gene (1985) 0.84

Alterations in the p'R promoter of coliphage lambda modify both its activity and interaction with the integration host factor (IHF). Mol Gen Genet (1990) 0.83

Synthesis of the nutL DNA segments and analysis of antitermination and termination functions in coliphage lambda. Gene (1982) 0.83

A simple method for locating methylated bases in DNA, as applied to detect asymmetric methylation by M.FokIA. Gene (1988) 0.83

Increasing the Fokl cleavage specificity from 5 to 7 base pairs by two-step methylation. Nucleic Acids Res (1988) 0.82

Construction of lacIts and lacIqts expression plasmids and evaluation of the thermosensitive lac repressor. Gene (1995) 0.82

Characterization of the cloned terminators tR1, tL3 and tI and the nut R antitermination site of coliphage lambda. Gene (1982) 0.81