Published in Nature on March 02, 1968
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res (1981) 24.41
Mutants that make more lac repressor. Proc Natl Acad Sci U S A (1968) 6.26
Catabolite-insensitive revertants of lac promoter mutants. Proc Natl Acad Sci U S A (1970) 5.83
Fusions of the lac and trp Regions of the Escherichia coli Chromosome. J Bacteriol (1970) 4.22
Arabinose-leucine deletion mutants of Escherichia coli B-r. J Bacteriol (1969) 4.01
Mechanism of initiation and repression of in vitro transcription of the lac operon of Escherichia coli. Proc Natl Acad Sci U S A (1971) 3.71
Genetic analysis of the maltose A region in Escherichia coli. J Bacteriol (1969) 3.52
Organization of the rosy locus in Drosophila melanogaster: further evidence in support of a cis-acting control element adjacent to the xanthine dehydrogenase structural element. Genetics (1979) 3.00
The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3',5'-adenosine monophosphate. Proc Natl Acad Sci U S A (1968) 2.92
The location of the repressor binding sites in the lac operon. Proc Natl Acad Sci U S A (1974) 2.64
CAP and RNA polymerase interactions with the lac promoter: binding stoichiometry and long range effects. Nucleic Acids Res (1983) 2.60
Binding of adenosine 3':5'-cyclic phosphate to G factor of Escherichia coli, and its effects on GTPase, RNase V, and protein synthesis. Proc Natl Acad Sci U S A (1970) 2.49
A lipid requirement for induction of lactose transport in Escherichia coli. Proc Natl Acad Sci U S A (1969) 2.25
An adenosine 3':5'-cyclic monophosphate-binding protein that acts on the transcription process. Proc Natl Acad Sci U S A (1971) 2.17
Location and orientation of the phoA locus on the Escherichia coli K-12 linkage map. J Bacteriol (1971) 1.65
Deletion and complementation analysis of biotin gene cluster of Escherichia coli. J Bacteriol (1972) 1.57
Location of promoter and operator sites in the biotin gene cluster of Escherichia coli. Proc Natl Acad Sci U S A (1972) 1.55
Promoter-like mutant with increased expression of the glycerol kinase operon of Escherichia coli. J Bacteriol (1971) 1.47
Point mutations change the thermal denaturation profile of a short DNA fragment containing the lactose control elements. Comparison between experiment and theory. EMBO J (1982) 1.37
Nitrofurans, a group of synthetic antibiotics, with a new mode of action: discrimination of specific messenger RNA classes. Proc Natl Acad Sci U S A (1976) 1.30
Catabolite repression in Escherichia coli. A study of two hypotheses. Biochem J (1968) 1.23
A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate. Proc Natl Acad Sci U S A (1973) 1.21
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A (1981) 1.16
Genetic map of the lactose repressor gene (i) of Escherichia coli. Genetics (1972) 1.13
Regulatory mutants of the tryptophan operon of Salmonella typhimurium. Genetics (1970) 1.13
In vivo role of the relA+ gene in regulation of the lac operon. J Bacteriol (1981) 1.04
Characterization of strong polar mutations in a region immediately adjacent to the L-arabinose operator in Escherichia coli B-r. J Bacteriol (1972) 1.02
Polarity in gene araB of the l-Arabinose operon in Escherichia coli B/r. J Bacteriol (1969) 1.00
Mutations partially inactivating the lactose repressor of Escherichia coli. J Bacteriol (1974) 0.90
Isolation of specialized transducing bacteriophages carrying deletions of the regulatory region of the Escherichia coli K-12 tryptophan operon. J Bacteriol (1976) 0.82
Sequence analysis of chromatin immunoprecipitation data for transcription factors. Methods Mol Biol (2010) 0.81
Operon coordination in different bacterial hosts. J Bacteriol (1970) 0.79
Gene expression in bacteria and some concerns about the misuse of science. Bacteriol Rev (1970) 0.75
Regulation of the synthesis of the lactose repressor. J Bacteriol (1974) 0.75
Induction of bacterial enzymes. Biochem J (1972) 0.75
Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol (1995) 46.37
TnphoA: a transposon probe for protein export signals. Proc Natl Acad Sci U S A (1985) 21.06
Molecular basis of base substitution hotspots in Escherichia coli. Nature (1978) 13.79
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cell Biol (1987) 11.36
Transposable elements. Cell (1980) 10.84
Discrimination as a consequence of genetic testing. Am J Hum Genet (1992) 10.40
On the formation of spontaneous deletions: the importance of short sequence homologies in the generation of large deletions. Cell (1982) 9.72
Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc Natl Acad Sci U S A (1970) 9.37
A genetic approach to analyzing membrane protein topology. Science (1986) 9.01
Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and phi80 transducing phages. J Mol Biol (1975) 8.79
Identification of a protein required for disulfide bond formation in vivo. Cell (1991) 8.56
Protein localization in E. coli: is there a common step in the secretion of periplasmic and outer-membrane proteins? Cell (1981) 8.24
Mechanism of incorporation of cell envelope proteins in Escherichia coli. Annu Rev Microbiol (1982) 8.18
Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacI gene of Escherichia coli. J Mol Biol (1978) 8.13
E. coli mutant pleiotropically defective in the export of secreted proteins. Cell (1981) 7.72
Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli. J Mol Biol (1977) 7.41
An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc Natl Acad Sci U S A (1988) 6.31
Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli. J Bacteriol (1983) 6.27
Mutagenic deamination of cytosine residues in DNA. Nature (1980) 6.26
Mutations in a new chromosomal gene of Escherichia coli K-12, pcnB, reduce plasmid copy number of pBR322 and its derivatives. Mol Gen Genet (1986) 5.87
A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc Natl Acad Sci U S A (1989) 5.78
Determinants of membrane protein topology. Proc Natl Acad Sci U S A (1987) 5.76
Regulation of a membrane component required for protein secretion in Escherichia coli. Cell (1982) 5.70
Lac repressor genetic map in real space. Trends Biochem Sci (1997) 5.56
Synthesis and processing of an Escherichia coli alkaline phosphatase precursor in vitro. Proc Natl Acad Sci U S A (1977) 5.29
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J Bacteriol (1992) 5.16
Genetic studies of the lac repressor. III. Additional correlation of mutational sites with specific amino acid residues. J Mol Biol (1977) 5.15
Genetic studies of the lac repressor. I. Correlation of mutational sites with specific amino acid residues: construction of a colinear gene-protein map. J Mol Biol (1977) 5.14
The use of transposon TnphoA to detect genes for cell envelope proteins subject to a common regulatory stimulus. Analysis of osmotically regulated genes in Escherichia coli. J Mol Biol (1987) 4.98
Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol (1999) 4.87
Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli. Nature (1980) 4.77
Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins. J Bacteriol (1979) 4.69
Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J Bacteriol (1989) 4.56
The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions. Proc Natl Acad Sci U S A (1988) 4.36
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli. J Bacteriol (1983) 4.35
Catabolite sensitive site of the lac operon. Nature (1969) 4.29
Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc Natl Acad Sci U S A (1992) 4.29
DNA sequence at the integration sites of the insertion element IS1. Cell (1978) 4.27
Fusions of the lac and trp Regions of the Escherichia coli Chromosome. J Bacteriol (1970) 4.22
Genetic characterization of mutations which affect catabolite-sensitive operons in Escherichia coli, including deletions of the gene for adenyl cyclase. J Bacteriol (1973) 4.03
Effects of surrounding sequence on the suppression of nonsense codons. J Mol Biol (1983) 3.95
Evidence for specificity at an early step in protein export in Escherichia coli. J Bacteriol (1985) 3.93
A pathway for disulfide bond formation in vivo. Proc Natl Acad Sci U S A (1993) 3.86
The promoter-operator region of the lac operon of Escherichia coli. J Mol Biol (1968) 3.84
Isolation of pure lac operon DNA. Nature (1969) 3.79
Use of gene fusions to study outer membrane protein localization in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.78
Genetic analysis of protein export in Escherichia coli. Annu Rev Genet (1990) 3.73
Mutational alteration of the maximal level of Lac operon expression. Cold Spring Harb Symp Quant Biol (1966) 3.71
The prevention of hepatitis B with vaccine. Report of the centers for disease control multi-center efficacy trial among homosexual men. Ann Intern Med (1982) 3.69
Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm. Proc Natl Acad Sci U S A (1999) 3.60
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status. Proc Natl Acad Sci U S A (1999) 3.60
Alkaline phosphatase fusions: sensors of subcellular location. J Bacteriol (1990) 3.59
Proliferation of mutators in A cell population. J Bacteriol (1997) 3.55
FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. J Bacteriol (1992) 3.50
Evidence for two sites in the lac promoter region. J Mol Biol (1972) 3.44
Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli. Nature (1984) 3.42
The role of the thioredoxin and glutaredoxin pathways in reducing protein disulfide bonds in the Escherichia coli cytoplasm. J Biol Chem (1997) 3.42
Transposition of the lac region to the gal region of the Escherichia coli chromosome: isolation of lambda-lac transducing bacteriophages. J Bacteriol (1971) 3.28
Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites. Proc Natl Acad Sci U S A (1997) 3.25
The bonds that tie: catalyzed disulfide bond formation. Cell (1993) 3.20
Do not use epinephrine in digital blocks: myth or truth? Plast Reconstr Surg (2001) 3.17
The FtsQ protein of Escherichia coli: membrane topology, abundance, and cell division phenotypes due to overproduction and insertion mutations. J Bacteriol (1991) 3.15
Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol (2000) 3.14
Escherichia coli mutants accumulating the precursor of a secreted protein in the cytoplasm. Nature (1979) 3.10
A mechanism for repressor action. J Mol Biol (1969) 3.09
Deletion of the Escherichia coli crp gene. J Bacteriol (1975) 3.08
SecD and SecF facilitate protein export in Escherichia coli. EMBO J (1994) 3.04
A bacterial virulence determinant encoded by lysogenic coliphage lambda. Nature (1990) 3.02
Construction of two Escherichia coli amber suppressor genes: tRNAPheCUA and tRNACysCUA. Proc Natl Acad Sci U S A (1986) 3.00
An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc Natl Acad Sci U S A (1996) 2.98
Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev (1997) 2.96
Mutagenic specificity of ultraviolet light. J Mol Biol (1985) 2.89
Detection and isolation of the repressor protein for the tryptophan operon of Escherichia coli. Proc Natl Acad Sci U S A (1972) 2.89
Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro. J Bacteriol (1981) 2.88
Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs. Proc Natl Acad Sci U S A (1989) 2.87
Sequence analysis of Tn9 insertions in the lacZ gene. J Mol Biol (1980) 2.85
secD, a new gene involved in protein export in Escherichia coli. J Bacteriol (1987) 2.84
F-prime factor formation in E. coli K12. Genet Res (1966) 2.80
The nucleotide sequence of the gene for malF protein, an inner membrane component of the maltose transport system of Escherichia coli. Repeated DNA sequences are found in the malE-malF intercistronic region. J Biol Chem (1984) 2.79
Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology (2001) 2.78
Major surface antigen gene of a human malaria parasite cloned and expressed in bacteria. Nature (1984) 2.74
Mutations that allow disulfide bond formation in the cytoplasm of Escherichia coli. Science (1993) 2.73
A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J (1993) 2.70
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol (1998) 2.70
Characterization of amber and ochre suppressors in Salmonella typhimurium. J Bacteriol (1979) 2.68
A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations. Genetics (1990) 2.66
A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry (1992) 2.65
Roles of thiol-redox pathways in bacteria. Annu Rev Microbiol (2001) 2.60
SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell (1995) 2.58
mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions. J Bacteriol (1988) 2.57
Disulfide bond formation in the Escherichia coli cytoplasm: an in vivo role reversal for the thioredoxins. EMBO J (1998) 2.56
Base substitution mutations induced by metabolically activated aflatoxin B1. Proc Natl Acad Sci U S A (1983) 2.48
Mutational specificity in bacteria. Annu Rev Genet (1983) 2.47
The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitness. Genetics (2000) 2.47
Gene amplification in the lac region of E. coli. Cell (1984) 2.46
Translational restarts: AUG reinitiation of a lac repressor fragment. Proc Natl Acad Sci U S A (1972) 2.45
Escherichia coli alkaline phosphatase fails to acquire disulfide bonds when retained in the cytoplasm. J Bacteriol (1991) 2.42