The binding of tetrodotoxin and alpha-bungarotoxin to normal and denervated mammalian muscle.

PubWeight™: 1.73‹?› | Rank: Top 3%

🔗 View Article (PMC 1330989)

Published in J Physiol on July 01, 1974

Authors

D Colquhoun, H P Rang, J M Ritchie

Articles citing this

Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle. J Gen Physiol (1976) 3.73

The actions of tubocurarine at the frog neuromuscular junction. J Physiol (1979) 3.69

Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres. J Physiol (1980) 2.91

Tetrodotoxin binding to normal depolarized frog muscle and the conductance of a single sodium channel. J Physiol (1975) 2.57

Sodium currents in mammalian muscle. J Physiol (1977) 2.25

The distribution of alpha-bungarotoxin binding sites of mammalian skeletal muscle developing in vivo. J Physiol (1977) 2.00

Effects of apamin, quinine and neuromuscular blockers on calcium-activated potassium channels in guinea-pig hepatocytes. J Physiol (1985) 1.79

Density and distribution of tetrodotoxin receptors in normal and detubulated frog sartorius muscle. J Gen Physiol (1976) 1.59

Behaviour of short and long latency components of the stretch reflex in human muscle. J Physiol (1975) 1.26

Properties of potassium and sodium channels in frog internode. J Physiol (1986) 1.24

Characteristics of saxitoxin binding to the sodium channel of sarcolemma isolated from rat skeletal muscle. J Physiol (1979) 1.24

Discrimination between subtypes of apamin-sensitive Ca(2+)-activated K+ channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530. Br J Pharmacol (1996) 1.01

SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol (2001) 1.01

The binding of labelled saxitoxin to the sodium channels in normal and denervated mammalian muscle, and in amphibian muscle. J Physiol (1977) 1.00

Mechanical and electrophysiological effects of sea anemone (Anemonia sulcata) toxins on rat innervated and denervated skeletal muscle. Br J Pharmacol (1981) 0.98

Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle. Br J Pharmacol (1985) 0.92

Sodium entry in rat diaphragm induced by depolarizing drugs. J Physiol (1977) 0.88

Compounds that block both intermediate-conductance (IK(Ca)) and small-conductance (SK(Ca)) calcium-activated potassium channels. Br J Pharmacol (2000) 0.87

Analysis of current noise evoked by nicotinic agonists in rat submandibular ganglion neurones. Br J Pharmacol (1983) 0.83

Differences in the actions of some blockers of the calcium-activated potassium permeability in mammalian red cells. Br J Pharmacol (1999) 0.81

Acetylcholine receptors and sodium channels in denervated and botulinum-toxin-treated adult rat muscle. J Physiol (1987) 0.80

Action potentials in fast- and slow-twitch mammalian muscles during reinnervation and development. J Gen Physiol (1980) 0.80

Neuromuscular transmission in the isolated diaphragm of the dystrophic mouse (129 ReJ/dy.dy) [proceedings]. J Physiol (1976) 0.79

The role of extracellular calcium in the contractions produced by acetylcholine in chronically denervated muscle. Br J Pharmacol (1977) 0.75

Articles cited by this

Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction. J Physiol (1973) 16.20

Voltage clamp experiments on internally perfused giant axons. J Physiol (1965) 14.69

The statistical nature of the acetycholine potential and its molecular components. J Physiol (1972) 13.95

An investigation of spontaneous activity at the neuromuscular junction of the rat. J Physiol (1956) 13.78

Voltage clamp experiments in striated muscle fibres. J Physiol (1970) 12.92

The permeability of the sodium channel to organic cations in myelinated nerve. J Gen Physiol (1971) 10.25

Pharmacological modifications of the sodium channels of frog nerve. J Gen Physiol (1968) 9.97

Currents related to movement of the gating particles of the sodium channels. Nature (1973) 9.80

The acetylcholine sensitivity of frog muscle fibres after complete or partial devervation. J Physiol (1960) 9.24

Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena. Pharmacol Rev (1966) 7.45

Ionic conductances of the surface and transverse tubular membranes of frog sartorius fibers. J Gen Physiol (1969) 5.45

Acetylcholine receptors in muscle fibres. Nature (1971) 5.14

The antagonism between tubocurarine and substances which depolarize the motor end-plate. J Physiol (1960) 4.81

Radial spread of contraction in frog muscle fibres. J Physiol (1969) 4.54

Reconstruction of the action potential of frog sartorius muscle. J Physiol (1973) 4.49

An upper limit to the number of sodium channels in nerve membrane? J Physiol (1967) 3.98

Acetylcholine receptors of muscle grown in vitro. Proc Natl Acad Sci U S A (1972) 3.96

Selective disruption of the sarcotubular system in frog sartorius muscle. A quantitative study with exogenous peroxidase as a marker. J Cell Biol (1968) 3.61

The binding of labelled tetrodotoxin to non-myelinated nerve fibres. J Physiol (1972) 3.60

Inward spread of activation in vertebrate muscle fibres. J Physiol (1971) 3.49

Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). Proc Natl Acad Sci U S A (1972) 3.34

Action potential generation in denervated rat skeletal muscle. II. The action of tetrodotoxin. Acta Physiol Scand (1971) 3.02

Fast and slow mammalian muscles after denervation. Exp Neurol (1970) 2.83

The binding of tetrodotoxin to nerve membranes. J Physiol (1971) 2.74

The role of sodium current in the radial spread of contraction in frog muscle fibers. J Gen Physiol (1970) 2.68

Acetylcholine receptors. Distribution and extrajunctional density in rat diaphragm after denervation correlated with acetylcholine sensitivity. J Gen Physiol (1972) 2.66

A lesion of the transverse tubules of skeletal muscle. J Physiol (1969) 2.53

Equilibrium and kinetic properties of the interaction between tetrodotoxin and the excitable membrane of the squid giant axon. J Gen Physiol (1970) 2.48

Studies on tetrodotoxin resistant action potentials in denervated skeletal muscle. Acta Physiol Scand (1971) 2.24

A new kind of drug antagonism: evidence that agonists cause a molecular change in acetylcholine receptors. Mol Pharmacol (1969) 2.18

The binding of labelled saxitoxin to the sodium channels in nerve membranes. J Physiol (1973) 2.10

Partial characterization of a tetrodotoxin-binding component from nerve membrane. Proc Natl Acad Sci U S A (1972) 2.06

The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta. J Physiol (1973) 2.04

Actions of saxitoxin on peripheral neuromuscular systems. J Physiol (1965) 2.00

Garfish olfactory nerve: easily accessible source of numerous long, homogeneous, nonmyelinated axons. Science (1971) 2.00

Action potential generation in denervated rat skeletal muscle. I. Quantitative aspects. Acta Physiol Scand (1971) 1.99

Sodium dependence of the inward spread of activation in isolated twitch muscle fibres of the frog. J Physiol (1972) 1.86

Types and locations of cholinergic receptor-like molecules in muscle fibres. Nat New Biol (1973) 1.67

Kinetic properties of the sodium current in striated muscle fibres on the basis of the Hodgkin-Huxley theory. J Physiol (1972) 1.66

Tetrodotoxin, saxitoxin, and related substances: their applications in neurobiology. Int Rev Neurobiol (1972) 1.65

The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres. J Physiol (1972) 1.58

Solubilization of a specific tetrodotoxin-binding component from garfish olfactory nerve membrane. Biochemistry (1972) 1.56

The kinetics of the interaction between tetrodotoxin and mammalian nonmyelinated nerve fibers. Mol Pharmacol (1972) 1.39

Binding of radioactive tetrodotoxin to nerve membrane preparations. Biochim Biophys Acta (1972) 1.38

The rate of action of competitive neuromuscular blocking agents. J Pharmacol Exp Ther (1967) 1.26

Tetrodotoxin receptors in plasma membranes isolated from lobster nerve fibers. Biochim Biophys Acta (1973) 1.08

N,O-di and N,N,O-tri ( 3 H) acetyl -bungarotoxins as specific labelling agents of cholinergic receptors. Br J Pharmacol (1973) 1.07

A physiological study of chick myotubes grown in tissue culture. J Physiol (1973) 1.03

The binding of labelled tetrodotoxin and cobra toxin by the rat diaphragm. Br J Pharmacol (1973) 1.03

The pharmacology of batrachotoxin. IV. Interaction with tetrodotoxin on innervated and chronically denervated rat skeletal muscle. J Pharmacol Exp Ther (1972) 0.99

Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies. Mol Pharmacol (1972) 0.98

Purification, properties and amino acid sequence of -bungarotoxin from the venom of Bungarus multicinctus. Hoppe Seylers Z Physiol Chem (1972) 0.96

Action potential generation in singly and multiply innervated avian muscle fibres. J Physiol (1973) 0.77

Articles by these authors

On the stochastic properties of single ion channels. Proc R Soc Lond B Biol Sci (1981) 11.30

Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proc R Soc Lond B Biol Sci (1977) 10.37

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (1985) 9.25

On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Philos Trans R Soc Lond B Biol Sci (1982) 7.45

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels. Nature (1981) 7.16

Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature (1981) 6.62

On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations. J Physiol (1968) 5.91

A P2X purinoceptor expressed by a subset of sensory neurons. Nature (1995) 4.86

ATP receptor-mediated synaptic currents in the central nervous system. Nature (1992) 4.57

The movements of labelled ions in mammalian non-myelinated nerve fibres. J Physiol (1965) 4.53

The actions of tubocurarine at the frog neuromuscular junction. J Physiol (1979) 3.69

Conductance of channels opened by acetylcholine-like drugs in muscle end-plate. Nature (1975) 3.64

The binding of labelled tetrodotoxin to non-myelinated nerve fibres. J Physiol (1972) 3.60

A quantitative description of membrane currents in rabbit myelinated nerve. J Physiol (1979) 3.56

Acetylcholine receptors: too many channels, too few functions. Science (1995) 3.55

On the mechanism of desensitization at cholinergic receptors. Mol Pharmacol (1970) 3.00

Drug receptors and their function. Nature (1971) 2.98

An alkylating derivative of benzilylcholine with specific and long-lasting parasympatholytic activity. Mol Pharmacol (1966) 2.95

The origin of the initial heat associated with a single impulse in mammalian non-myelinated nerve fibres. J Physiol (1968) 2.85

The binding of tetrodotoxin to nerve membranes. J Physiol (1971) 2.74

The binding of saxitoxin and tetrodotoxin to excitable tissue. Rev Physiol Biochem Pharmacol (1977) 2.70

Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells. J Physiol (1979) 2.67

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction. Proc R Soc Lond B Biol Sci (1985) 2.64

The kinetics of action of acetylcholine antagonists in smooth muscle. Proc R Soc Lond B Biol Sci (1966) 2.56

Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath. Proc Natl Acad Sci U S A (1977) 2.55

Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol (1992) 2.50

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc Biol Sci (1992) 2.49

The characteristics of synaptic currents and responses to acetylcholine of rat submandibular ganglion cells. J Physiol (1981) 2.44

Acetylcholine receptors. Q Rev Biophys (1974) 2.36

Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events. Philos Trans R Soc Lond B Biol Sci (1992) 2.32

Early tension relaxation during a muscle twitch. J Physiol (1951) 2.31

An analysis of the action of a false transmitter at the neuromuscular junction. J Physiol (1977) 2.29

A note on correlations in single ion channel records. Proc R Soc Lond B Biol Sci (1987) 2.26

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J Physiol (1998) 2.26

Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus. J Physiol (1992) 2.24

On the permeability of mammalian non-myelinated fibres to sodium and to lithium ions. J Physiol (1963) 2.24

A seven-year field trial of two typhoid vaccines in Guyana. Lancet (1967) 2.20

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci (1988) 2.18

A new kind of drug antagonism: evidence that agonists cause a molecular change in acetylcholine receptors. Mol Pharmacol (1969) 2.18

The binding of labelled saxitoxin to the sodium channels in nerve membranes. J Physiol (1973) 2.10

Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane. Proc Natl Acad Sci U S A (1974) 2.06

Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres. J Physiol (1981) 2.01

On the mode of action of local anesthetics. Annu Rev Pharmacol (1966) 1.99

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits. J Physiol (2003) 1.99

The oxygen consumption of mammalian non-myelinated nerve fibres at rest and during activity. J Physiol (1967) 1.93

The dependence on external cations of the oxygen consumption of mammalian non-myelinated fibres at rest and during activity. J Physiol (1968) 1.88

A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. J Physiol (1976) 1.86

The ionic content of mammalian non-myelinated nerve fibres and its alteration as a result of electrical activity. J Physiol (1968) 1.85

Re-analysis of clinical trial of homoeopathic treatment in fibrositis. Lancet (1990) 1.81

Complementary medicine in the medical curriculum. J R Soc Med (1997) 1.75

Molecular dissection of the myelinated axon. Ann Neurol (1993) 1.73

Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones. J Physiol (1990) 1.71

Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres. Nature (1980) 1.71

Neuronal-type Na+ and K+ channels in rabbit cultured Schwann cells. Nature (1984) 1.68

Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proc Biol Sci (1996) 1.65

The relationship between desensitization and the metaphilic effect at cholinergic receptors. Mol Pharmacol (1970) 1.62

The channel-blocking action of methonium compounds on rat submandibular ganglion cells. Br J Pharmacol (1984) 1.60

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J Physiol (1997) 1.60

Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells. Proc Natl Acad Sci U S A (1985) 1.60

The ionic requirements for the action of acetylcholine on mammalian non-myelinated fibres. J Physiol (1963) 1.58

The interaction at equilibrium between tetrodotoxin and mammalian non-myelinated nerve fibres. J Physiol (1972) 1.58

Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J Neurosci (1989) 1.57

The binding of tritiated ouabain to mammalian non-myelinated nerve fibres. J Physiol (1970) 1.57

Effects of pravastatin in 3260 patients with unstable angina: results from the LIPID study. Lancet (2000) 1.56

Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents. Annu Rev Physiol (1995) 1.55

On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons. Proc R Soc Lond B Biol Sci (1988) 1.52

High conductance anion-selective channels in rat cultured Schwann cells. Proc R Soc Lond B Biol Sci (1984) 1.52

Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu Rev Physiol (1995) 1.51

Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells. J Physiol (1991) 1.51

Energetic aspects of nerve conduction: the relationships between heat production, electrical activity and metabolism. Prog Biophys Mol Biol (1973) 1.50

Conductances of single ion channels opened by nicotinic agonists are indistinguishable. Nature (1984) 1.50

A comparison of the effect of temperature, metabolic inhibitors and of ouabain on the electrogenic componen of the sodium pump in mammalian non-myelinated nerve fibres. J Physiol (1969) 1.49

Mechanisms of drug action at the voluntary muscle endplate. Annu Rev Pharmacol (1975) 1.49

The effect of disulfide bond reduction on the properties of cholinergic receptors in chick muscle. Mol Pharmacol (1971) 1.48

Desensitization of the acetylcholine receptor of frog end-plates measured in a Vaseline-gap voltage clamp. J Physiol (1989) 1.48

Anomalous temperature dependence of the sodium conductance in rabbit nerve compared with frog nerve. Nature (1979) 1.48

Block of acetylcholine-activated ion channels by an uncharged local anaesthetic. Nature (1981) 1.47

The action of ganglionic blocking drugs on the synaptic responses of rat submandibular ganglion cells. Br J Pharmacol (1982) 1.46

The modes of action of gallamine. Proc R Soc Lond B Biol Sci (1981) 1.45

Organization of ion channels in the myelinated nerve fiber. Science (1985) 1.44

Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons of the rat. Proc R Soc Lond B Biol Sci (1987) 1.40

The kinetics of the interaction between tetrodotoxin and mammalian nonmyelinated nerve fibers. Mol Pharmacol (1972) 1.39

The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. J Physiol (1997) 1.36

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle. Mol Pharmacol (1976) 1.36

Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol (2001) 1.35

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proc Biol Sci (1995) 1.35

A voltage-gated chloride conductance in rat cultured astrocytes. Proc R Soc Lond B Biol Sci (1986) 1.35

Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings. Proc Biol Sci (1991) 1.34

Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones. J Physiol (1991) 1.33

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. J Neurosci (1998) 1.32

The presence of voltage-gated sodium, potassium and chloride channels in rat cultured astrocytes. Proc R Soc Lond B Biol Sci (1985) 1.27