Published in Physiol Rev on April 01, 1970
An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses. J Exp Med (1973) 4.99
Partial Purification and Characterization of a Phytochrome-degrading Neutral Protease from Etiolated Oat Shoots. Plant Physiol (1972) 3.50
"Disaggregation" of phytochrome in vitro-a consequence of proteolysis. Plant Physiol (1971) 2.77
Pregrowth hormone: product of the translation in vitro of messenger RNA coding for growth hormone. Proc Natl Acad Sci U S A (1976) 2.50
Proteases of senescing oat leaves: I. Purification and general properties. Plant Physiol (1977) 2.06
Inhibition of cleavage of large poliovirus-specific precursor proteins in infected HeLa cells by inhibitors of proteolytic enzymes. J Virol (1972) 2.06
Purification of oat and rye phytochrome. Plant Physiol (1973) 1.72
Proteases of Senescing Oat Leaves: II. Reaction to Substrates and Inhibitors. Plant Physiol (1978) 1.59
The mechanism of photoaffinity labeling. Proc Natl Acad Sci U S A (1973) 1.57
Modulation of human neutrophil polymorphonuclear leucocyte migration by human plasma alpha-globulin inhibitors and synthetic esterase inhibitors. Immunology (1975) 1.52
Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. Proc Natl Acad Sci U S A (1980) 1.43
Active-site labelling of triose phosphate isomerase. The reaction of bromohydroxyacetone phosphate with a unique glutamic acid residue and the migration of the label to tyrosine. Biochem J (1972) 1.35
The extracellular matrix of normal chick embryo fibroblasts: its effect on transformed chick fibroblasts and its proteolytic degradation by the transformants. J Cell Biol (1985) 1.23
Affinity labeling of the catalytic subunit of cyclic AMP-dependent protein kinase by N alpha-tosyl-L-lysine chloromethyl ketone. Proc Natl Acad Sci U S A (1979) 1.17
Photo-affinity labels for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1971) 1.17
The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes. J Clin Invest (1976) 1.11
Specificity of the tyrosine-phenylalanine transport system in Bacillus subtilis. J Bacteriol (1973) 1.07
Covalent attachment of a peptidyl-transfer RNA analog to the 50S subunit of Escherichia coli ribosomes. Proc Natl Acad Sci U S A (1972) 1.06
Serine enzymes released by cultured neoplastic cells. J Exp Med (1978) 1.06
Regulation of hippocampal glutamate receptors: evidence for the involvement of a calcium-activated protease. Proc Natl Acad Sci U S A (1980) 0.99
Non-selective inhibition of transformed cell growth by a protease inhibitor. Proc Natl Acad Sci U S A (1974) 0.96
Bifunctional inhibitors of pepsin. Proc Natl Acad Sci U S A (1971) 0.96
Elastase-like enzymes in human neutrophils localized by ultrastructural cytochemistry. J Cell Biol (1980) 0.94
Lymphoproliferative activity of Pseudomonas exotoxin A is dependent on intracellular processing and is associated with the carboxyl-terminal portion. Infect Immun (1992) 0.83
Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Biochem J (1999) 0.83
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorg Med Chem (2006) 0.79
Effects of inhibitors of tumoricidal activity upon schistosomulum killing by activated macrophages. Infect Immun (1987) 0.79
A novel alpha-glucosidase from the acidophilic archaeon Ferroplasma acidiphilum strain Y with high transglycosylation activity and an unusual catalytic nucleophile. Biochem J (2005) 0.78
Inhibition or killing of an intracellular pathogen by activated macrophages is abrogated by TLCK or aminophylline. Immunology (1980) 0.77
Selective effects of inhibitors of protein synthesis on metabolism of nuclear anc cytoplasmic proteins: evidence for coordinate synthesis of non-histone chromosomal proteins. Proc Natl Acad Sci U S A (1975) 0.75
Effects of proteinase inhibitors on adenylate cyclase. Biochem J (1980) 0.75
Inhibiting the onset of hormone-induced desentiziation of viable thymocytes by N alpha-tosyl-L-lysine chloromethyl ketone. Proc Natl Acad Sci U S A (1980) 0.75
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. EMBO J (1992) 5.05
p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin. Biochem Biophys Res Commun (1967) 4.79
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature (1992) 4.16
Comparison of the esterase activities of trypsin, plasmin, and thrombin on guanidinobenzoate esters. Titration of the enzymes. Biochemistry (1969) 2.61
Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases. J Biol Chem (1981) 2.29
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin. Thromb Res (1979) 2.09
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones. Biochimie (1994) 2.07
Inactivation of trypsin-like enzymes with peptides of arginine chloromethyl ketone. Methods Enzymol (1981) 2.00
Factors associated with complications and mortality in adult patients hospitalized for infectious cellulitis. Eur J Clin Microbiol Infect Dis (2003) 1.92
A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS. Proc Natl Acad Sci U S A (1954) 1.85
Population screening reduces mortality rate from aortic aneurysm in men. Br J Surg (2000) 1.79
Methods for measuring the three-dimensional structure of fish schools. Anim Behav (1965) 1.68
Chromatography of trypsin and its derivatives. Characterization of a new active form of bovine trypsin. J Biol Chem (1968) 1.66
The design of peptidyldiazomethane inhibitors to distinguish between the cysteine proteinases calpain II, cathepsin L and cathepsin B. Biochem J (1988) 1.60
Rapid interaction of cathepsin L by Z-Phe-PheCHN12 and Z-Phe-AlaCHN2. Biochem Biophys Res Commun (1981) 1.58
Thiobenzyl benzyloxycarbonyl-L-lysinate, substrate for a sensitive colorimetric assay for trypsin-like enzymes. Anal Biochem (1979) 1.57
Insomnia and the eye of the beholder: are there clinical markers of objective sleep disturbances among adults with and without insomnia complaints? J Consult Clin Psychol (2000) 1.57
A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones. Biochem Biophys Res Commun (1979) 1.56
Regulatory circuits involved with pH-regulated gene expression in Salmonella typhimurium. Microbiology (1994) 1.55
Sleep in the laboratory and sleep at home: comparisons of older insomniacs and normal sleepers. Sleep (1997) 1.51
The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinases. Biochem J (1980) 1.50
Photochemical Activities of Spinach Chloroplasts Following Treatment with the Detergent Triton X-100. Plant Physiol (1965) 1.44
Looking through the retrospectoscope in the era of evidence-based medicine. J Clin Oncol (1997) 1.43
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. J Virol (1994) 1.41
Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone. Biochem J (1974) 1.37
Diazomethyl ketone substrate derivatives as active-site-directed inhibitors of thiol proteases. Papain. Biochemistry (1977) 1.30
Screening for abdominal aortic aneurysms in men. BMJ (2004) 1.21
Sleep in the laboratory and sleep at home II: comparisons of middle-aged insomnia sufferers and normal sleepers. Sleep (2001) 1.21
Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones. Virology (1989) 1.18
The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases. Biochem J (1986) 1.17
Degradation of substituted phenylurea herbicides by Arthrobacter globiformis strain D47 and characterization of a plasmid-associated hydrolase gene, puhA. Appl Environ Microbiol (2001) 1.17
Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein. Biochemistry (1978) 1.17
Inactivation of cathepsin B by active site-directed disulfide exchange. Application in covalent affinity chromatography. J Biol Chem (1983) 1.16
An exploration of the primary specificity site of cathepsin B. Arch Biochem Biophys (1983) 1.15
Occupational sunlight exposure and melanoma in the U.S. Navy. Arch Environ Health (1991) 1.14
Novel, starch-like polysaccharides are synthesized by an unbound form of granule-bound starch synthase in glycogen-accumulating mutants of Chlamydomonas reinhardtii. Plant Physiol (1999) 1.13
The reactivity of His-57 in chymotrypsin to alkylation. Arch Biochem Biophys (1971) 1.13
Cofactor dependence of factor Xa incorporation into the prothrombinase complex. J Biol Chem (1981) 1.12
Active center differences between cathepsins L and B: the S1 binding region. FEBS Lett (1988) 1.12
A single normal ultrasonographic scan at age 65 years rules out significant aneurysm disease for life in men. Br J Surg (2001) 1.10
A comparison of the mortality rate after elective repair of aortic aneurysms detected either by screening or incidentally. Eur J Vasc Endovasc Surg (2000) 1.09
Healthcare-associated, community-acquired and hospital-acquired bacteraemic urinary tract infections in hospitalized patients: a prospective multicentre cohort study in the era of antimicrobial resistance. Clin Microbiol Infect (2012) 1.09
Phototherapy of jaundice in the newborn infant. II. Effect of various light intensities. J Pediatr (1972) 1.08
The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. Biochem J (1993) 1.08
Inactivation of thiol proteases with peptidyl diazomethyl ketones. Methods Enzymol (1981) 1.08
Inactivation of cathepsin B1 by diazomethyl ketones. Biochem Biophys Res Commun (1977) 1.07
Pseudotrypsin. A modified bovine trypsin produced by limited autodigestion. J Biol Chem (1969) 1.07
Identification of the histidine residue at the active center of trypsin labelled by TLCK. Biochem Biophys Res Commun (1967) 1.07
Further observations on substrate-derived chloromethyl ketones that inactivate trypsin. Arch Biochem Biophys (1970) 1.05
Cross-reactivity between B. burgdorferi and other spirochetes affects specificity of serotests for detection of antibodies to the Lyme disease agent in dogs. Vet Microbiol (1993) 1.04
Combination antifungal therapy for cryptococcal meningitis. Postgrad Med J (1976) 1.04
Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification. Biochem J (1991) 1.03
The optomotor reaction of schooling carangid fishes. Anim Behav (1965) 1.02
Special needs of ritually circumcised women patients. J Obstet Gynecol Neonatal Nurs (1991) 1.01
The essentiality of histidine in the catalytic action of subtilisin. Covalent modification by a specific reagent. J Biol Chem (1968) 1.01
Synthesis and properties of peptidyl derivatives of arginylfluoromethanes. Biochem J (1988) 0.99
Incidence of leukemia in occupations with potential electromagnetic field exposure in United States Navy personnel. Am J Epidemiol (1990) 0.97
Synthesis and properties of Cbz-Phe-Arg-CHN2 (benzyloxycarbonylphenylalanylarginyldiazomethane) as a proteinase inhibitor. Biochem J (1988) 0.97
The properties of peptidyl diazoethanes and chloroethanes as protease inactivators. Arch Biochem Biophys (1989) 0.95
The Gloucestershire Aneurysm Screening Programme: the first 2 years' experience. Eur J Vasc Surg (1993) 0.95
Active site mapping of human and rat urinary kallikreins by peptidyl chloromethyl ketones. Arch Biochem Biophys (1980) 0.94
Specific labeling of cysteine proteinases in pathogenic and nonpathogenic Entamoeba histolytica. Infect Immun (1990) 0.94
Recommendations for screening intervals for small aortic aneurysms. Br J Surg (2003) 0.93
Lysis of trypanosomes by peptidyl fluoromethyl ketones. Biochem Biophys Res Commun (1990) 0.92
Inactivation of calpain by peptidyl fluoromethyl ketones. J Med Chem (1992) 0.92
Iodination of peptidyl chloromethyl ketones for protease affinity labels. Anal Biochem (1988) 0.91
Borreliosis in equids in northeastern United States. Am J Vet Res (1988) 0.91
Screening for abdominal aortic aneurysm: a single scan is enough. Br J Surg (1994) 0.91
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis. Arch Biochem Biophys (1991) 0.90
The synthesis of lysylfluoromethanes and their properties as inhibitors of trypsin, plasmin and cathepsin B. Biochem J (1987) 0.89
The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents. Biochem J (1989) 0.89
Do our methods lead to insomniacs' madness?: Daytime testing after laboratory and home-based polysomnographic studies. Sleep (1997) 0.89
The use of isoxazolium salts for carboxyl group modification in proteins. Trypsin. Biochemistry (1969) 0.89
Adolescents' insight in heavy drinking. J Adolesc Health (1998) 0.88
Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone. Biochim Biophys Acta (1979) 0.88
Psychological morbidity associated with abdominal aortic aneurysm screening. Eur J Vasc Endovasc Surg (1997) 0.88
Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors. Biochem J (1991) 0.88
Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase. Biochem J (1992) 0.87
The specificity of cathepsin B. Acta Biol Med Ger (1981) 0.87
Synthesis of procoagulant factor VIII, factor VIII related antigen and other coagulation factors by the isolated perfused rat liver. Br J Haematol (1979) 0.86
The biosynthesis of 2-amino-4-hydroxy-6-substituted pteridines. The origin of carbon atoms 6, 7, and 9 of folic acid. J Biol Chem (1966) 0.86
Identification of histidine 64 in the active site of subtilisin. Proc Natl Acad Sci U S A (1968) 0.86
Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes. Biochem J (1993) 0.86
Isolation and characterization of a trypsin-like serine proteinase from the membranes of Walker 256 carcino-sarcoma cells. Biochem J (1983) 0.86
Synthesis of lysine-containing sulphonium salts and their properties as proteinase inhibitors. Biochem J (1988) 0.86
Inhibition of intraerythrocytic development of Plasmodium falciparum by proteinase inhibitors. FEBS Lett (1990) 0.86
Effects of acoustico-lateralis denervation in a facultative schooling fish: a nearest-neighbor matrix analysis. Behav Neural Biol (1981) 0.86
Inactivation of trypsin-like proteases by active-site-directed sulfonylation. Ability of the departing group to confer selectivity. Arch Biochem Biophys (1976) 0.85
Human plasma kallikrein. Purification and preliminary characterization. Arch Biochem Biophys (1974) 0.85
Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length. J Med Chem (1978) 0.85
The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides. Biochem J (1989) 0.85
A phase I-B trial of the radiosensitizer: etanidazole (SR-2508) with radiosurgery for the treatment of recurrent previously irradiated primary brain tumors or brain metastases (RTOG Study 95-02). Radiother Oncol (2008) 0.85
Inhibition of cysteine proteinase activity by Z-Phe-Phe-diazomethane and of aspartic proteinase activity by pepstatin in different organs from some animals and isolated cells from rat liver. Acta Biol Med Ger (1982) 0.85
Pyogenic granulomas of the cornea. Surv Ophthalmol (1985) 0.84
The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketone. Thromb Res (1982) 0.84
Active-site-directed phenacyl halides inhibitory to trypsin. Arch Biochem Biophys (1971) 0.84
In vivo studies of a synthetic inhibitor of thrombin. J Lab Clin Med (1982) 0.84
Intravenous ciprofloxacin as empirical treatment of febrile neutropenic patients. Am J Med (1989) 0.84
A simple, rapid fluorimetric assay of amoxycillin in plasma. Clin Chim Acta (1977) 0.84