Published in N Engl J Med on December 20, 1979
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J Clin Invest (1986) 5.72
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Laboratory aspects of Lyme borreliosis. Clin Microbiol Rev (1988) 2.18
Lyme borreliosis in the severe combined immunodeficiency (scid) mouse manifests predominantly in the joints, heart, and liver. Am J Pathol (1990) 2.15
Lyme borreliosis: host responses to Borrelia burgdorferi. Microbiol Rev (1991) 1.87
Improved culture conditions for the growth and detection of Borrelia from human serum. Int J Med Sci (2013) 1.35
Immune complexes in early arthritis. L Detection of immune complexes before rheumatoid arthritis is definite. Clin Exp Immunol (1981) 1.21
Lyme disease: the sensible pursuit of answers. J Clin Microbiol (1993) 1.08
Immune complexes in human diseases: a review. Am J Pathol (1980) 1.05
Infection and inflammation in skeletal muscle from nonhuman primates infected with different genospecies of the Lyme disease spirochete Borrelia burgdorferi. Infect Immun (2003) 0.99
Lyme disease. West J Med (1991) 0.99
Use of serum immune complexes in a new test that accurately confirms early Lyme disease and active infection with Borrelia burgdorferi. J Clin Microbiol (2001) 0.97
The pathogenesis of arthritis in Lyme disease: humoral immune responses and the role of intra-articular immune complexes. Yale J Biol Med (1985) 0.89
Cryoprecipitogogue from normal serum: mechanism for cryoprecipitation of immune complexes. Proc Natl Acad Sci U S A (1981) 0.84
2nd European Symposium on Lyme Borreliosis. A NATO advanced research workshop. United Kingdom, 19-20 May 1993. Abstracts. Ann Rheum Dis (1993) 0.81
Lyme disease: a unique human model for an infectious etiology of rheumatic disease. Yale J Biol Med (1985) 0.78
Lyme disease in northern California. West J Med (1983) 0.78
Close to home: a history of Yale and Lyme disease. Yale J Biol Med (2011) 0.78
Dissociation of IgG aggregates at low pH. Immunology (1982) 0.77
Lyme disease and pregnancy. Infect Dis Obstet Gynecol (1995) 0.75
Two unusual cases of diffuse acrodermatitis chronica atrophicans seronegative for Lyme borreliosis. Eur J Clin Microbiol Infect Dis (2003) 0.75
The spirochetal etiology of Lyme disease. N Engl J Med (1983) 21.59
Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum (1977) 9.14
Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum. Ann Intern Med (1977) 7.42
Western blotting in the serodiagnosis of Lyme disease. J Infect Dis (1993) 6.45
Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science (1981) 6.34
The early clinical manifestations of Lyme disease. Ann Intern Med (1983) 5.73
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J Clin Invest (1986) 5.72
Cases of Lyme disease in the United States: locations correlated with distribution of Ixodes dammini. Ann Intern Med (1979) 4.73
A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med (2001) 4.35
The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J Clin Invest (1967) 4.22
Mechanism of interaction between Ku protein and DNA. J Biol Chem (1986) 4.22
Lyme carditis: cardiac abnormalities of Lyme disease. Ann Intern Med (1980) 4.12
Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete. J Clin Invest (1983) 4.08
Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparations for diagnosing early Lyme disease. J Infect Dis (1988) 4.08
Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N Engl J Med (1994) 4.07
Antibody response in Lyme disease: evaluation of diagnostic tests. J Infect Dis (1984) 4.07
Microtubular crystals in mammalian cells. J Cell Biol (1969) 3.98
Neurologic abnormalities of Lyme disease. Medicine (Baltimore) (1979) 3.98
Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68
A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. N Engl J Med (1998) 3.62
The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology (1985) 3.55
Chronic neurologic manifestations of Lyme disease. N Engl J Med (1990) 3.54
Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE. J Clin Microbiol (1999) 3.41
Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheum (1997) 3.29
Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J Exp Med (1996) 3.23
The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study. Ann Intern Med (1994) 3.20
Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun (1993) 3.04
Experimental Lyme arthritis in rats infected with Borrelia burgdorferi. J Infect Dis (1988) 3.02
Antibiotic therapy in Lyme disease. Ann Intern Med (1980) 2.93
Cytochalasin B reversibly inhibits phagocytosis: functional, metabolic, and ultrastructural effects in human blood leukocytes and rabbit alveolar macrophages. Yale J Biol Med (1971) 2.91
A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium. Science (1986) 2.91
Lyme disease: recommendations for diagnosis and treatment. Ann Intern Med (1991) 2.91
Treatment of the early manifestations of Lyme disease. Ann Intern Med (1983) 2.89
Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J Biol Chem (1986) 2.79
DNA characterization of the spirochete that causes Lyme disease. J Clin Microbiol (1984) 2.71
Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem (1993) 2.66
Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med (1991) 2.60
Detection of Borrelia burgdorferi DNA in museum specimens of Ixodes dammini ticks. Science (1990) 2.58
Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection. Infect Immun (1994) 2.57
Erythema chronicum migrans and Lyme arthritis: epidemiologic evidence for a tick vector. Am J Epidemiol (1978) 2.53
Empiric parenteral antibiotic treatment of patients with fibromyalgia and fatigue and a positive serologic result for Lyme disease. A cost-effectiveness analysis. Ann Intern Med (1993) 2.52
Neurologic abnormalities of Lyme disease: successful treatment with high-dose intravenous penicillin. Ann Intern Med (1983) 2.50
The lupus autoantigens and the pathogenesis of systemic lupus erythematosus. Arthritis Rheum (1986) 2.49
Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med (1997) 2.48
Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction. J Immunol (1974) 2.45
Diagnosing early Lyme disease. Am J Med (1985) 2.41
Microtubule crystals: a new biophysical phenomenon induced by Vinca alkaloids. Nature (1968) 2.41
Handwashing practices for the prevention of nosocomial infections. Ann Intern Med (1975) 2.36
Intralaboratory reliability of serologic and urine testing for Lyme disease. Am J Med (2001) 2.34
Successful parenteral penicillin therapy of established Lyme arthritis. N Engl J Med (1985) 2.23
Possible nosocomial transmission of group B streptococci in a newborn nursery. J Pediatr (1975) 2.21
Vinblastine and griseofulvin reversibly disrupt the living mitotic spindle. Science (1968) 2.19
Treatment of early Lyme disease. Am J Med (1992) 2.18
Clinical pathologic correlations of Lyme disease by stage. Ann N Y Acad Sci (1988) 2.16
Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol (1987) 2.12
Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet (1993) 2.05
Fatal pancarditis in a patient with coexistent Lyme disease and babesiosis. Demonstration of spirochetes in the myocardium. Ann Intern Med (1985) 2.04
Lyme arthritis. Spirochetes found in synovial microangiopathic lesions. Am J Pathol (1985) 2.03
DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci U S A (1994) 2.01
Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi. Arthritis Rheum (1999) 2.01
Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi. J Clin Microbiol (1999) 1.95
Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c. J Immunol (1992) 1.89
Circulating Borrelia burgdorferi in patients with acute Lyme disease: results of blood cultures and serum DNA analysis. J Infect Dis (1993) 1.88
High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452. Am J Pathol (1988) 1.86
A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity. Arthritis Rheum (1999) 1.85
The mobilization and extracellular release of granular enzymes from human leukocytes during phagocytosis. J Cell Biol (1972) 1.84
Pathophysiology of small intestinal malabsorption in gerbils infected with Giardia lamblia. Gastroenterology (1992) 1.82
Practice guidelines for the treatment of Lyme disease. The Infectious Diseases Society of America. Clin Infect Dis (2000) 1.82
A simple rapid micromethod for detecting chronic granulomatous disease of childhood. J Lab Clin Med (1970) 1.81
Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use. Ann Intern Med (1979) 1.79
The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect Immun (1999) 1.79
Chronic Lyme arthritis. Clinical and immunogenetic differentiation from rheumatoid arthritis. Ann Intern Med (1979) 1.79
Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A. J Clin Invest (1973) 1.76
Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest (1991) 1.75
Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA. J Biol Chem (1992) 1.75
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. Proc Natl Acad Sci U S A (1990) 1.74
The T-cell proliferative assay in the diagnosis of Lyme disease. Ann Intern Med (1991) 1.70
Lyme arthritis: correlation of serum and cryoglobulin IgM with activity, and serum IgG with remission. Arthritis Rheum (1979) 1.70
The clinical spectrum and treatment of Lyme disease. Yale J Biol Med (1985) 1.70
The cytokineplast: purified, stable, and functional motile machinery from human blood polymorphonuclear leukocytes. J Cell Biol (1982) 1.68
Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease. Infect Immun (1995) 1.68