Published in Biochim Biophys Acta on December 04, 1979
Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures. J Cell Biol (1986) 2.51
Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI. Nat Protoc (2008) 2.29
The concept of lipid domains in membranes. J Cell Biol (1982) 2.26
Lateral diffusion of membrane lipids and proteins during the cell cycle of neuroblastoma cells. Proc Natl Acad Sci U S A (1980) 1.04
Components of the plasma membrane of growing axons. II. Diffusion of membrane protein complexes. J Cell Biol (1984) 1.04
Mapping of collision frequencies for stearic acid spin labels by saturation-recovery electron paramagnetic resonance. Biophys J (1990) 0.99
Lateral diffusion of lipid probes in the surface membrane of human platelets. An electron-electron double resonance (ELDOR) study. Biophys J (1986) 0.97
Analysis of lateral diffusion from a spherical cell surface to a tubular projection. Biophys J (1992) 0.96
Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys J (1976) 25.12
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature (1984) 17.70
Fluorescence correlation spectroscopy. II. An experimental realization. Biopolymers (1974) 17.35
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (1984) 14.21
Dynamics of fluorescence marker concentration as a probe of mobility. Biophys J (1976) 9.67
Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology (1998) 9.57
Single particle tracking. Analysis of diffusion and flow in two-dimensional systems. Biophys J (1991) 9.39
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (1985) 9.12
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature (1985) 8.23
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J (1987) 7.32
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sci U S A (1978) 6.59
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (1993) 6.38
Lateral transport on cell membranes: mobility of concanavalin A receptors on myoblasts. Proc Natl Acad Sci U S A (1976) 6.27
Nanometre-level analysis demonstrates that lipid flow does not drive membrane glycoprotein movements. Nature (1989) 6.18
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature (1995) 6.16
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J (1992) 5.84
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell (1987) 5.80
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell (1989) 5.68
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell (1991) 5.65
Concentration correlation spectroscopy: a new biophysical probe based on occupation number fluctuations. Annu Rev Biophys Bioeng (1975) 5.56
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (1993) 5.02
Mobility of microinjected rhodamine actin within living chicken gizzard cells determined by fluorescence photobleaching recovery. Cell (1982) 4.87
Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers. Proc Natl Acad Sci U S A (1976) 4.86
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science (1997) 4.70
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (1993) 4.54
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell (1997) 4.43
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature (1996) 4.23
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J (1998) 4.14
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc Natl Acad Sci U S A (1995) 4.10
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell (1985) 4.02
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell (1991) 3.95
Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry (1987) 3.94
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell (1978) 3.90
Allosteric regulation of the epidermal growth factor receptor kinase. J Cell Biol (1986) 3.78
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell (1995) 3.65
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell (1990) 3.65
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A (1987) 3.64
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science (1993) 3.57
Lateral transport of a lipid probe and labeled proteins on a cell membrane. Science (1977) 3.50
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature (1983) 3.47
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell (1994) 3.44
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol Cell Biol (1992) 3.42
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol (1994) 3.42
Dependence of locally measured cellular deformability on position on the cell, temperature, and cytochalasin B. Proc Natl Acad Sci U S A (1982) 3.38
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell (1996) 3.35
Forward transport of glycoproteins on leading lamellipodia in locomoting cells. Nature (1989) 3.34
Distribution of molecular aggregation by analysis of fluctuation moments. Proc Natl Acad Sci U S A (1990) 3.30
Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature (1989) 3.24
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry (1987) 3.20
Structural basis for FGF receptor dimerization and activation. Cell (1999) 3.19
On the analysis of high order moments of fluorescence fluctuations. Biophys J (1990) 3.15
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature (1992) 3.13
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol (1990) 3.12
Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science (1989) 3.12
The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science (1993) 3.12
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J (1997) 3.11
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J (1990) 3.10
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J (1998) 3.09
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature (1992) 3.02
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell (2000) 2.99
Helix formation by dAT oligomers. I. Hairpin and straight-chain helices. J Mol Biol (1968) 2.99
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med (1997) 2.99
Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem (1983) 2.94
Intercellular adhesion molecule-1. J Mol Med (Berl) (1996) 2.94
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell (1993) 2.92
BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. Oncogene (1991) 2.89
Growth factor-like action of phosphatidic acid. Nature (1986) 2.87
Expression of epidermal growth factor receptors in human brain tumors. Cancer Res (1984) 2.83
Signal transduction by allosteric receptor oligomerization. Trends Biochem Sci (1988) 2.82
Lateral diffusion in planar lipid bilayers. Science (1977) 2.82
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol (1996) 2.80
Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells. J Biol Chem (1986) 2.78
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A (1992) 2.75
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell (1996) 2.75
A mechanical function of myosin II in cell motility. J Cell Sci (1995) 2.74
Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci (2001) 2.74
SH3 domains direct cellular localization of signaling molecules. Cell (1993) 2.73
Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature (1976) 2.69
Mechanical function of dystrophin in muscle cells. J Cell Biol (1995) 2.67
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol (1994) 2.66
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell (1994) 2.61
Analysis of cell surface interactions by measurements of lateral mobility. J Supramol Struct (1979) 2.59