Published in J Biol Chem on January 25, 1983
Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus. J Virol (1986) 3.65
Interaction between proteins localized in membranes. Proc Natl Acad Sci U S A (1986) 2.74
Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes. J Cell Biol (1984) 2.71
Aggregation of complement receptors on human neutrophils in the absence of ligand. J Cell Biol (1987) 2.38
High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med (1986) 2.37
Diversification of TAM receptor tyrosine kinase function. Nat Immunol (2014) 2.12
Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding. Proc Natl Acad Sci U S A (1987) 2.10
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Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes. J Exp Med (1986) 1.91
A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation. Biochem J (1988) 1.59
Internalization of blocking antibodies against mannose-6-phosphate specific receptors. EMBO J (1985) 1.48
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. J Cell Biol (1987) 1.47
An angiogenic growth factor is expressed in human glioma cells. EMBO J (1987) 1.46
Preformed oligomeric epidermal growth factor receptors undergo an ectodomain structure change during signaling. Biophys J (2002) 1.44
Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells. J Cell Biol (1986) 1.43
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Properties of a monoclonal antibody to epidermal growth factor receptor with implications for the mechanism of action of EGF. EMBO J (1984) 1.34
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Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. J Gastroenterol (1997) 1.30
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Equilibrium theory for the clustering of bivalent cell surface receptors by trivalent ligands. Application to histamine release from basophils. Biophys J (1984) 1.21
Aspects of the metabolism of the epidermal growth factor receptor in A431 human epidermoid carcinoma cells. Mol Cell Biol (1984) 1.16
Dissociation of cellular responses to epidermal growth factor using anti-receptor monoclonal antibodies. EMBO J (1986) 1.15
Electron-spin resonance study of aggregation of gramicidin in dipalmitoylphosphatidylcholine bilayers and hydrophobic mismatch. Biophys J (1999) 1.15
Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells. J Cell Biol (1985) 1.14
The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2004) 1.14
Interaction of antibodies with ErbB receptor extracellular regions. Exp Cell Res (2008) 1.13
Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor. J Cell Biol (1985) 1.11
Cytosolic calcium regulates epidermal growth factor endocytosis in rat pancreas and cultured fibroblasts. Proc Natl Acad Sci U S A (1984) 1.10
Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor. Biochem J (1987) 1.09
The ErbB kinase domain: structural perspectives into kinase activation and inhibition. Exp Cell Res (2008) 1.08
Nerve growth factor- and epidermal growth factor-stimulated phosphorylation of a PC12 cytoskeletally associated protein in situ. J Cell Biol (1985) 1.07
Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis. Proc Natl Acad Sci U S A (1985) 1.06
Purification of human gamma interferon receptors by sequential affinity chromatography on immobilized monoclonal antireceptor antibodies and human gamma interferon. J Exp Med (1987) 1.06
Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules. EMBO J (1987) 1.03
A431 cell variants lacking the blood group A antigen display increased high affinity epidermal growth factor-receptor number, protein-tyrosine kinase activity, and receptor turnover. J Cell Biol (1988) 1.01
Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase. Proc Natl Acad Sci U S A (2013) 0.99
Silicon nitride windows for electron microscopy of whole cells. J Microsc (2011) 0.98
Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo. PLoS One (2011) 0.96
Recruitment of the adaptor protein Grb2 to EGFR tetramers. Biochemistry (2014) 0.95
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Quantifying aggregation of IgE-FcepsilonRI by multivalent antigen. Biophys J (1999) 0.93
Lipid-gramicidin interactions: dynamic structure of the boundary lipid by 2D-ELDOR. Biophys J (2003) 0.93
Blood group-active carbohydrate chains on the receptor for epidermal growth factor of A431 cells. EMBO J (1984) 0.92
Orientation of the v-erb-B gene product in the plasma membrane. Mol Cell Biol (1986) 0.90
Appearance of functional EGF receptor kinase during rodent embryogenesis. EMBO J (1983) 0.90
Antibody mimicking the action of RAS proteins on yeast adenylyl cyclase: implication for RAS-effector interaction. Mol Cell Biol (1993) 0.88
Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity. Biochem J (1993) 0.88
Three-dimensional locations of gold-labeled proteins in a whole mount eukaryotic cell obtained with 3nm precision using aberration-corrected scanning transmission electron microscopy. J Struct Biol (2011) 0.88
Recycling of epidermal growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sci U S A (1985) 0.88
Receptor dynamics of closely related ligands: "fast' and "slow' interferons. EMBO J (1985) 0.87
Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system. Proc Natl Acad Sci U S A (1984) 0.86
Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family. Elife (2013) 0.85
Receptor-bound somatostatin and epidermal growth factor are processed differently in GH4C1 rat pituitary cells. J Cell Biol (1986) 0.85
Epidermal growth factor receptor (EGFR) expression in operable non-small cell lung carcinoma. J Korean Med Sci (2004) 0.84
Mechanism of kinase activation in the receptor for colony-stimulating factor 1. Proc Natl Acad Sci U S A (1990) 0.81
neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation. Proc Natl Acad Sci U S A (1988) 0.81
Lhermitte-Duclos disease. An immunohistochemical study of the cerebellar cortex. Acta Neuropathol (1988) 0.81
Inhibiting the growth of pancreatic adenocarcinoma in vitro and in vivo through targeted treatment with designer gold nanotherapeutics. PLoS One (2013) 0.80
Epithelial impedance analysis in experimentally induced colon cancer. Biophys J (1987) 0.79
Visualization of Cell-Cell Interaction Contacts: Synapses and Kinapses. Self Nonself (2011) 0.78
Co-conserved features associated with cis regulation of ErbB tyrosine kinases. PLoS One (2010) 0.78
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3). Proc Natl Acad Sci U S A (1983) 0.77
Monoclonal antibodies to purified muscarinic receptor display agonist-like activity. Proc Natl Acad Sci U S A (1984) 0.77
Histone H4 stimulates glucose transport activity in rat skeletal muscle. Biochem J (1993) 0.76
Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma. Int J Oncol (2015) 0.75
Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells. J Control Release (2016) 0.75
HER2 Pro1170Ala polymorphism is associated with decreased survival rate in HER2-negative breast cancer. Oncol Lett (2017) 0.75
Single particle tracking-based reaction progress kinetic analysis reveals a series of molecular mechanisms of cetuximab-induced EGFR processes in a single living cell. Chem Sci (2017) 0.75
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Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature (1984) 17.70
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (1984) 14.21
Dynamics of fluorescence marker concentration as a probe of mobility. Biophys J (1976) 9.67
Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science (1985) 9.12
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature (1985) 8.23
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (1986) 7.90
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J (1987) 7.32
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sci U S A (1978) 6.59
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature (1993) 6.38
Lateral transport on cell membranes: mobility of concanavalin A receptors on myoblasts. Proc Natl Acad Sci U S A (1976) 6.27
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature (1995) 6.16
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J (1992) 5.84
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell (1987) 5.80
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell (1989) 5.68
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell (1991) 5.65
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (1993) 5.02
Mobility of microinjected rhodamine actin within living chicken gizzard cells determined by fluorescence photobleaching recovery. Cell (1982) 4.87
Lateral motion of fluorescently labeled acetylcholine receptors in membranes of developing muscle fibers. Proc Natl Acad Sci U S A (1976) 4.86
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science (1997) 4.70
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (1993) 4.54
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol (1996) 4.47
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell (1997) 4.43
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature (1996) 4.23
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J (1998) 4.14
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc Natl Acad Sci U S A (1995) 4.10
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein. Cell (1985) 4.02
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell (1991) 3.95
Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor. Biochemistry (1987) 3.94
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell (1993) 3.94
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell (1978) 3.90
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Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell (1990) 3.65
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A (1987) 3.64
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science (1993) 3.57
Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science (1986) 3.52
Lateral transport of a lipid probe and labeled proteins on a cell membrane. Science (1977) 3.50
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell (1994) 3.44
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Mol Cell Biol (1992) 3.42
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol (1994) 3.42
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell (1996) 3.35
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett (1997) 3.23
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J (1996) 3.22
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation. Biochemistry (1987) 3.20
Structural basis for FGF receptor dimerization and activation. Cell (1999) 3.19
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature (1992) 3.13
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
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Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol (1990) 3.12
The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science (1993) 3.12
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. EMBO J (1997) 3.11
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J (1990) 3.10
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J (1998) 3.09
Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol (1995) 3.08
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The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature (1992) 3.02
Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain. Science (1984) 3.00
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell (2000) 2.99
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Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood (1996) 2.98
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Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell (1992) 2.62