Published in J Clin Invest on December 01, 1971
Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest (1974) 2.40
Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest (1976) 2.27
Glucose metabolism during leg exercise in man. J Clin Invest (1971) 2.27
Isolation and metabolic characteristics of rat and chicken enterocytes. Biochem J (1979) 2.25
Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest (1972) 2.11
Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest (1973) 2.04
Effect of ketone infusions on amino acid and nitrogen metabolism in man. J Clin Invest (1975) 1.87
Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest (1974) 1.73
Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J (1977) 1.69
Evidence of inter-organ amino-acid transport by blood cells in humans. Proc Natl Acad Sci U S A (1973) 1.60
L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol (1998) 1.39
Hepatic ketogenesis and gluconeogenesis in humans. J Clin Invest (1974) 1.37
Glucagon release induced by pancreatic nerve stimulation in the dog. J Clin Invest (1973) 1.35
Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest (1980) 1.33
Glucagon-stimulating activity of 20 amino acids in dogs. J Clin Invest (1972) 1.26
The variable hyponatremic response to hyperglycemia. West J Med (1985) 1.20
Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance. J Appl Physiol (1985) (2010) 1.09
Regulation of net hepatic glycogenolysis and gluconeogenesis during exercise: impact of type 1 diabetes. J Clin Endocrinol Metab (2004) 1.08
Leucine and protein metabolism in obese Zucker rats. PLoS One (2013) 1.07
Substrates for muscle glycogen synthesis in recovery from intense exercise in man. J Physiol (1991) 1.04
Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest (1995) 1.01
Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J Clin Invest (1976) 0.98
Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle. J Clin Invest (1995) 0.97
Effects of intravenously administered fructose and glucose on splanchnic amino acid and carbohydrate metabolism in hypertriglyceridemic men. J Clin Invest (1975) 0.96
Muscle and plasma amino acids after injury: the role of inactivity. Ann Surg (1978) 0.93
Mechanism of the hypolipemic effect of clofibrate in postabsorptive man. J Clin Invest (1973) 0.93
Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in muscle-free glutamine, and improves whole-body nitrogen economy after operation. Ann Surg (1992) 0.91
Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat. Br J Pharmacol (1985) 0.88
Effects of glucagon on plasma amino acids. J Clin Invest (1984) 0.88
Skeletal muscle is anabolically unresponsive to an amino acid infusion in pediatric burn patients 6 months postinjury. Ann Surg (2011) 0.87
Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxid Med Cell Longev (2016) 0.84
Effects of intrabrachial arterial infusion of pyruvate on forearm tissue metabolism. Interrelationships between pyruvate, lactate, and alanine. J Clin Invest (1972) 0.83
Alanyl-glutamine counteracts the depletion of free glutamine and the postoperative decline in protein synthesis in skeletal muscle. Ann Surg (1990) 0.81
Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. PLoS One (2012) 0.80
Myocardial amino acid metabolism in patients with chronic ischemic heart disease. Basic Res Cardiol (1978) 0.80
Effects of physical activity upon the liver. Eur J Appl Physiol (2014) 0.79
Exercise and the Regulation of Hepatic Metabolism. Prog Mol Biol Transl Sci (2015) 0.77
Alanine, glutamate, and ammonia exchanges in acutely ischemic swine myocardium. Basic Res Cardiol (1992) 0.77
Single sodium pyruvate ingestion modifies blood acid-base status and post-exercise lactate concentration in humans. Nutrients (2014) 0.75
[Animal experiment studies of chronic thiamine deficiency. Changes in carbohydrate and amino acid metabolism under resting and load conditions]. Z Ernahrungswiss (1984) 0.75
Influence of L-leucine on glutamate dehydrogenase activity in isolated rat diaphragm. Yale J Biol Med (1978) 0.75
Hormonal, metabolic and biochemical changes following thermal injury. J R Soc Med (1982) 0.75
Detection of Pancreatic Cancer-Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance. Cancer Res (2015) 0.75
Metal inhibitors of calcium uptake by the duodenum of the rat. J Physiol (1972) 0.75
Effect of exercise intensities on free fatty acid uptake in whole-body organs measured with (123)I-BMIPP-SPECT. Eur J Appl Physiol (2008) 0.75
The free amino acids of human blood plasma. J Biol Chem (1954) 8.89
The rate of gluconeogenesis from various precursors in the perfused rat liver. Biochem J (1967) 4.08
Amino acid metabolism during prolonged starvation. J Clin Invest (1969) 4.06
Alanine: key role in gluconeogenesis. Science (1970) 3.43
Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart. Biochem J (1970) 3.23
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J Clin Invest (1969) 2.94
Control of gluconeogenesis from amino acids in the perfused rat liver. J Biol Chem (1969) 2.64
The amino acid composition of action, myosin, tropomyosin and the meromyosins. Arch Biochem Biophys (1954) 2.36
Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest (1971) 2.29
Glucose metabolism during leg exercise in man. J Clin Invest (1971) 2.27
Muscle and splanchnic glutmine and glutamate metabolism in postabsorptive andstarved man. J Clin Invest (1971) 2.10
Effects of ischaemia on metabolite concentrations in rat liver. Biochem J (1970) 2.07
Hyperornithinemia, hyperammonemia, and homocitrullinuria. A new disorder of amino acid metabolism associated with myoclonic seizures and mental retardation. Am J Dis Child (1969) 1.65
Splanchnic removal of lactate and pyruvate during prolonged exercise in man. J Appl Physiol (1966) 1.51
Effects of diabetes, fatty acids, and ketone bodies on tricarboxylic acid cycle metabolism in the perfused rat heart. J Biol Chem (1966) 1.43
Arterio-hepatic venous differences of free fatty acids and amino acids. Studies in patients with diabetes or essential hypercholesterolemia, and in healthy individuals. Acta Med Scand (1967) 1.34
Myocardial metabolism of glucose, lactic acid, amino acids and fatty acids in healthy human individuals at rest and at different work loads. Scand J Clin Lab Invest (1961) 1.27
Intermittent cerebellar ataxia associated with hyperpyruvic acidemia, hyperalaninemia, and hyperalaninuria. Pediatrics (1969) 1.11
Ammonia production in muscle: the purine nucleotide cycle. Science (1971) 1.02
Elevation of peripheral blood ammonia following muscular exercise. Proc Soc Exp Biol Med (1958) 1.01
Familial protein intolerance. Possible nature of enzyme defect. N Engl J Med (1971) 0.96
Biochemical investigations of hyperammonaemia. Lancet (1969) 0.96
Studies on amino acid metabolism in citrullinuria. Am J Dis Child (1967) 0.88
Arterial concentrations of free fatty acids and free amino acids in healthy human individuals at rest and at different work loads. Scand J Clin Lab Invest (1962) 0.87
[ON THE METABOLISM OF THE HEART. THE BEHAVIOR OF ARTERIAL AND CORONARY VEIN DIFFERENCES IN AMINO ACIDS AND AMMONIA IN HEALTHY HUMAN HEARTS DURING REST AND DURING AND AFTER BODILY EFFORT]. Dtsch Arch Klin Med (1964) 0.83
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes (1981) 7.28
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest (1985) 4.38
Plasma amino acid levels and insulin secretion in obesity. N Engl J Med (1969) 4.18
Amino acid metabolism during prolonged starvation. J Clin Invest (1969) 4.06
Liver and kidney metabolism during prolonged starvation. J Clin Invest (1969) 3.47
The glucose-alanine cycle. Metabolism (1973) 3.43
Alanine: key role in gluconeogenesis. Science (1970) 3.43
Leg blood flow during exercise in man. Clin Sci (1971) 2.97
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J Clin Invest (1969) 2.94
Amino acid metabolism in man. Annu Rev Biochem (1975) 2.88
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes (1983) 2.45
Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest (1974) 2.40
Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest (1996) 2.33
Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest (1971) 2.29
Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest (1976) 2.27
Glucose metabolism during leg exercise in man. J Clin Invest (1971) 2.27
Is skin preparation necessary before insulin injection? Lancet (1978) 2.15
Nonproductive exchanges: the use of isotopes gone astray. Metabolism (1992) 2.12
Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest (1972) 2.11
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci U S A (1978) 2.08
Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest (1973) 2.04
Increased 24-hour energy expenditure in cigarette smokers. N Engl J Med (1986) 2.01
Insulin resistance in uremia. J Clin Invest (1981) 1.98
Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients. Ann Intern Med (1980) 1.96
Retracted Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes. J Clin Invest (1979) 1.94
Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res (1998) 1.92
Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci U S A (1999) 1.91
The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes (1985) 1.88
Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med (1979) 1.88
Effect of ketone infusions on amino acid and nitrogen metabolism in man. J Clin Invest (1975) 1.87
Plasma amino acid levels in diabetic ketoacidosis. Diabetes (1970) 1.76
Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state. J Clin Invest (1995) 1.76
Retracted Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding. J Clin Invest (1978) 1.73
Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest (1974) 1.73
Fuel homeostasis in exercise. N Engl J Med (1975) 1.73
Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes (1975) 1.68
Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest (1972) 1.63
Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus. Diabet Med (2000) 1.63
Evidence of inter-organ amino-acid transport by blood cells in humans. Proc Natl Acad Sci U S A (1973) 1.60
Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest (1981) 1.59
Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes (1978) 1.58
Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest (1995) 1.58
Simulation and evaluation of nicotine intake during passive smoking: cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine. Clin Pharmacol Ther (1990) 1.52
The effect of local anaesthetics on the central circulation and respiration in man and dog. Acta Anaesthesiol Scand (1968) 1.50
Infusion of ornithine-alpha-ketoglutarate in healthy subjects: effects on protein metabolism. Clin Nutr (1985) 1.47
The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia (1992) 1.47
Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med (1976) 1.46
Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J Clin Invest (1975) 1.46
Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J Clin Endocrinol Metab (1994) 1.44
Noninvasive tracing of Krebs cycle metabolism in liver. J Biol Chem (1991) 1.43
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol (1983) 1.43
Influence of age on the local circulatory adaptation to leg exercise. Scand J Clin Lab Invest (1974) 1.43
Hypoglycemia during prolonged exercise in normal men. N Engl J Med (1982) 1.42
Very-low-calorie protein diets. N Engl J Med (1984) 1.40
Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J Biol Chem (1991) 1.38
Beta-adrenergic blockade does not influence the thermogenic response to a mixed meal in man. Clin Physiol (1989) 1.38
Proinsulin C-peptide--a consensus statement. Int J Exp Diabetes Res (2001) 1.38
[Starvation in human pregnancy: hypoglycemia, hypoinsulinemia, and hyperketonemia]. Science (1970) 1.36
Long-term improvement of metabolic control with the insulin pump does not reverse diabetic microangiopathy. Diabetes Care (1984) 1.36
Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proc Natl Acad Sci U S A (1977) 1.35
Influence of somatostatin on carbohydrate disposal and absorption in diabetes mellitus. Lancet (1976) 1.33
Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med (1979) 1.33
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol (1980) 1.32
Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J Clin Endocrinol Metab (1993) 1.29
Hyperglucagonemia in Laennec's cirrhosis. The role of portal-systemic shunting. N Engl J Med (1974) 1.29
Human forearm muscle metabolism during exercise. II. Uptake, release and oxidation of individual FFA and glycerol. Scand J Clin Lab Invest (1968) 1.28
Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest (1976) 1.28
Substance P: a pioneer amongst neuropeptides. J Intern Med (2001) 1.28
Effects of leg exercise on insulin absorption in diabetic patients. N Engl J Med (1978) 1.27
Amino acid metabolism in lactic acidosis. Am J Med (1972) 1.26
Restoration of normal lipid and aminoacid metabolism in diabetic patients treated with a portable insulin-infusion pump. Lancet (1979) 1.23
Substrate utilization by the inactive leg during one-leg or arm exercise. J Appl Physiol (1975) 1.23
Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. Diabetes (1999) 1.22
Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients. Diabetologia (1992) 1.22
Kinetics of glucagon in man: effects of starvation. Proc Natl Acad Sci U S A (1976) 1.22
Insulin-infusion-pump treatment of diabetes: influence of improved metabolic control on plasma somatomedin levels. N Engl J Med (1981) 1.21
Cerebral effects of nicotine during cognition in smokers and non-smokers. Psychopharmacology (Berl) (1998) 1.20
Determination of leg blood flow during exercise in man: an indicator-dilution technique based on femoral venous dye infusion. Clin Sci Mol Med (1973) 1.17
Quantitative aspects of blood flow and oxygen uptake in the human forearm during rhythmic exercise. Acta Physiol Scand Suppl (1966) 1.17
Augmented thermic effect of amino acids under general anaesthesia: a mechanism useful for prevention of anaesthesia-induced hypothermia. Clin Sci (Lond) (1994) 1.15
Glucose homeostasis in viral hepatitis. N Engl J Med (1970) 1.15
Nitrogen and sodium balance and sympathetic-nervous-system activity in obese subjects treated with a low-calorie protein or mixed diet. N Engl J Med (1980) 1.14