Published in N Engl J Med on November 20, 1975
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell (2013) 2.55
Mammalian mitochondrial beta-oxidation. Biochem J (1996) 2.06
Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J (1977) 1.69
Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices. Diabetes Care (2014) 1.37
Infantile form of carnitine palmitoyltransferase II deficiency with hepatomuscular symptoms and sudden death. Physiopathological approach to carnitine palmitoyltransferase II deficiencies. J Clin Invest (1991) 1.28
Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J Clin Invest (1984) 1.12
Postprandial glucose fluxes and insulin sensitivity during exercise: a study in healthy individuals. Am J Physiol Endocrinol Metab (2013) 1.09
Role of changes in insulin and glucagon in glucose homeostasis in exercise. J Clin Invest (1986) 1.09
Regulation of net hepatic glycogenolysis and gluconeogenesis during exercise: impact of type 1 diabetes. J Clin Endocrinol Metab (2004) 1.08
Carnitine-acylcarnitine translocase deficiency with severe hypoglycemia and auriculo ventricular block. Translocase assay in permeabilized fibroblasts. J Clin Invest (1993) 1.02
Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection. Biochem J (1988) 1.00
Dynamic modeling of exercise effects on plasma glucose and insulin levels. J Diabetes Sci Technol (2007) 1.00
Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J Clin Invest (1976) 0.98
The effects of acute or chronic ingestion of propranolol or metoprolol on the metabolic and hormonal responses to prolonged, submaximal exercise in hypertensive men. Br J Clin Pharmacol (1984) 0.96
Exercise intensity modulation of hepatic lipid metabolism. J Nutr Metab (2012) 0.95
Exercise, hypoglycemia, and type 1 diabetes. Diabetes Technol Ther (2014) 0.91
Mechanism of exercise-induced hypoglycemia in depancreatized dogs maintained on long-acting insulin. J Clin Invest (1977) 0.88
Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach. Am J Physiol Endocrinol Metab (2015) 0.85
Flux control analysis of mitochondrial oxidative phosphorylation in rat skeletal muscle: pyruvate and palmitoyl-carnitine as substrates give different control patterns. Eur J Appl Physiol (2007) 0.84
Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression. Am J Hum Genet (1996) 0.84
Carbohydrate utilization during exercise after high-altitude acclimation: a new perspective. Proc Natl Acad Sci U S A (1998) 0.83
Splanchnic and peripheral glucose and lactate metabolism during and after prolonged arm exercise. J Clin Invest (1986) 0.82
The biochemical consequences of hypoxia. J Clin Pathol Suppl (R Coll Pathol) (1977) 0.80
Stair climbing/descending exercise for a short time decreases blood glucose levels after a meal in participants with type 2 diabetes. BMJ Open Diabetes Res Care (2016) 0.79
Characterisation of carnitine palmitoyltransferases in patients with a carnitine palmitoyltransferase deficiency: implications for diagnosis and therapy. J Neurol Neurosurg Psychiatry (1997) 0.79
Defects of fatty acid oxidation in skeletal muscle. J Inherit Metab Dis (1987) 0.78
Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics. J Clin Invest (1984) 0.78
Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. Br J Clin Pharmacol (1985) 0.77
A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex. J Physiol (2003) 0.77
Effectiveness of Intravenous Infusion Algorithms for Glucose Control in Diabetic Patients Using Different Simulation Models. Ind Eng Chem Res (2009) 0.75
Case-Based Reasoning for Insulin Bolus Advice. J Diabetes Sci Technol (2016) 0.75
[Effect of carbohydrate intake during a long distance run on work capacity and metabolism]. Z Ernahrungswiss (1992) 0.75
Physical exercise and the prevention of atherosclerosis and cholesterol gall stones. Postgrad Med J (1978) 0.75
Physiological responses of wheelchair athletes at percentages of top speed. Br J Sports Med (1997) 0.75
Competitive sport and the insulin-dependent diabetic patient. Postgrad Med J (1990) 0.75
The Effect of Energy Patches on Substrate Utilization in Collegiate Cross-Country Runners. Int J Exerc Sci (2011) 0.75
Effects of physical training on hormonal responses to exercise in asthmatic children. Arch Dis Child (1979) 0.75
A system model of the effects of exercise on plasma Interleukin-6 dynamics in healthy individuals: Role of skeletal muscle and adipose tissue. PLoS One (2017) 0.75
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes (1981) 7.28
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest (1985) 4.38
Plasma amino acid levels and insulin secretion in obesity. N Engl J Med (1969) 4.18
Amino acid metabolism during prolonged starvation. J Clin Invest (1969) 4.06
Liver and kidney metabolism during prolonged starvation. J Clin Invest (1969) 3.47
The glucose-alanine cycle. Metabolism (1973) 3.43
Alanine: key role in gluconeogenesis. Science (1970) 3.43
Leg blood flow during exercise in man. Clin Sci (1971) 2.97
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J Clin Invest (1969) 2.94
Amino acid metabolism in man. Annu Rev Biochem (1975) 2.88
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes (1983) 2.45
Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest (1974) 2.40
Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest (1996) 2.33
Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest (1971) 2.29
Amino acid metabolism in exercising man. J Clin Invest (1971) 2.29
Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest (1976) 2.27
Glucose metabolism during leg exercise in man. J Clin Invest (1971) 2.27
Is skin preparation necessary before insulin injection? Lancet (1978) 2.15
Nonproductive exchanges: the use of isotopes gone astray. Metabolism (1992) 2.12
Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest (1972) 2.11
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Acad Sci U S A (1978) 2.08
Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest (1973) 2.04
Increased 24-hour energy expenditure in cigarette smokers. N Engl J Med (1986) 2.01
Insulin resistance in uremia. J Clin Invest (1981) 1.98
Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients. Ann Intern Med (1980) 1.96
Retracted Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes. J Clin Invest (1979) 1.94
Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res (1998) 1.92
Specific binding of proinsulin C-peptide to human cell membranes. Proc Natl Acad Sci U S A (1999) 1.91
The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes (1985) 1.88
Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump. N Engl J Med (1979) 1.88
Effect of ketone infusions on amino acid and nitrogen metabolism in man. J Clin Invest (1975) 1.87
Plasma amino acid levels in diabetic ketoacidosis. Diabetes (1970) 1.76
Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state. J Clin Invest (1995) 1.76
Retracted Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding. J Clin Invest (1978) 1.73
Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest (1974) 1.73
Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes (1975) 1.68
Uptake of individual free fatty acids by skeletal muscle and liver in man. J Clin Invest (1972) 1.63
Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus. Diabet Med (2000) 1.63
Evidence of inter-organ amino-acid transport by blood cells in humans. Proc Natl Acad Sci U S A (1973) 1.60
Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest (1981) 1.59
Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes (1978) 1.58
Protein dynamics in whole body and in splanchnic and leg tissues in type I diabetic patients. J Clin Invest (1995) 1.58
Simulation and evaluation of nicotine intake during passive smoking: cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine. Clin Pharmacol Ther (1990) 1.52
The effect of local anaesthetics on the central circulation and respiration in man and dog. Acta Anaesthesiol Scand (1968) 1.50
The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia (1992) 1.47
Infusion of ornithine-alpha-ketoglutarate in healthy subjects: effects on protein metabolism. Clin Nutr (1985) 1.47
Hyperglucagonemia and blood glucose regulation in normal, obese and diabetic subjects. N Engl J Med (1976) 1.46
Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus. J Clin Invest (1975) 1.46
Effect of insulin on the hepatic production of insulin-like growth factor-binding protein-1 (IGFBP-1), IGFBP-3, and IGF-I in insulin-dependent diabetes. J Clin Endocrinol Metab (1994) 1.44
Influence of age on the local circulatory adaptation to leg exercise. Scand J Clin Lab Invest (1974) 1.43
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol (1983) 1.43
Noninvasive tracing of Krebs cycle metabolism in liver. J Biol Chem (1991) 1.43
Hypoglycemia during prolonged exercise in normal men. N Engl J Med (1982) 1.42
Very-low-calorie protein diets. N Engl J Med (1984) 1.40
Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis. J Biol Chem (1991) 1.38
Beta-adrenergic blockade does not influence the thermogenic response to a mixed meal in man. Clin Physiol (1989) 1.38
Proinsulin C-peptide--a consensus statement. Int J Exp Diabetes Res (2001) 1.38
[Starvation in human pregnancy: hypoglycemia, hypoinsulinemia, and hyperketonemia]. Science (1970) 1.36
Long-term improvement of metabolic control with the insulin pump does not reverse diabetic microangiopathy. Diabetes Care (1984) 1.36
Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin. Proc Natl Acad Sci U S A (1977) 1.35
Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med (1979) 1.33
Influence of somatostatin on carbohydrate disposal and absorption in diabetes mellitus. Lancet (1976) 1.33
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man. Am J Physiol (1980) 1.32
Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J Clin Endocrinol Metab (1993) 1.29
Hyperglucagonemia in Laennec's cirrhosis. The role of portal-systemic shunting. N Engl J Med (1974) 1.29
Human forearm muscle metabolism during exercise. II. Uptake, release and oxidation of individual FFA and glycerol. Scand J Clin Lab Invest (1968) 1.28
Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest (1976) 1.28
Substance P: a pioneer amongst neuropeptides. J Intern Med (2001) 1.28
Effects of leg exercise on insulin absorption in diabetic patients. N Engl J Med (1978) 1.27
Amino acid metabolism in lactic acidosis. Am J Med (1972) 1.26
Restoration of normal lipid and aminoacid metabolism in diabetic patients treated with a portable insulin-infusion pump. Lancet (1979) 1.23
Substrate utilization by the inactive leg during one-leg or arm exercise. J Appl Physiol (1975) 1.23
Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. Diabetes (1999) 1.22
Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients. Diabetologia (1992) 1.22
Kinetics of glucagon in man: effects of starvation. Proc Natl Acad Sci U S A (1976) 1.22
Insulin-infusion-pump treatment of diabetes: influence of improved metabolic control on plasma somatomedin levels. N Engl J Med (1981) 1.21
Cerebral effects of nicotine during cognition in smokers and non-smokers. Psychopharmacology (Berl) (1998) 1.20
Determination of leg blood flow during exercise in man: an indicator-dilution technique based on femoral venous dye infusion. Clin Sci Mol Med (1973) 1.17
Quantitative aspects of blood flow and oxygen uptake in the human forearm during rhythmic exercise. Acta Physiol Scand Suppl (1966) 1.17
Augmented thermic effect of amino acids under general anaesthesia: a mechanism useful for prevention of anaesthesia-induced hypothermia. Clin Sci (Lond) (1994) 1.15
Glucose homeostasis in viral hepatitis. N Engl J Med (1970) 1.15
Nitrogen and sodium balance and sympathetic-nervous-system activity in obese subjects treated with a low-calorie protein or mixed diet. N Engl J Med (1980) 1.14