Published in Infect Immun on December 01, 1979
Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. J Clin Invest (1984) 1.68
Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates. J Exp Med (1980) 1.44
Oxidant injury of lung parenchymal cells. J Clin Invest (1981) 1.44
Iron metabolism in the lower respiratory tract. Thorax (1998) 1.11
Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation. J Clin Invest (1993) 0.92
Mononuclear phagocytes have the potential for sustained hydroxyl radical production. Use of spin-trapping techniques to investigate mononuclear phagocyte free radical production. J Exp Med (1988) 0.87
Changes in permeability of the alveolar-capillary barrier in firefighters. Br J Ind Med (1985) 0.81
Modulation of pulmonary clearance of bacteria by antioxidants. Infect Immun (1985) 0.77
Stimulation of pulmonary rapidly adapting receptors by inhaled wood smoke in rats. J Physiol (1998) 0.76
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest (1967) 9.01
Metabolic patterns in three types of phagocytizing cells. J Cell Biol (1963) 8.92
Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity. Biochem Biophys Res Commun (1972) 7.50
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest (1975) 7.40
Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Semin Hematol (1975) 6.19
A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem (1970) 5.26
Superoxide production by phagocytic leukocytes. J Exp Med (1975) 3.43
Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G. J Exp Med (1976) 3.19
Free radicals and inflammation. Protection of phagocytosine leukocytes by superoxide dismutase. J Clin Invest (1975) 3.04
Human granulocyte generation of hydroxyl radical. J Exp Med (1978) 2.54
Evidence for hydroxyl radical production by human neutrophils. J Clin Invest (1977) 2.15
Singlet excited oxygen as a mediator of the antibacterial action of leukocytes. Science (1974) 2.12
Monocyte function in children with neutropenia and chronic infections. Blood (1972) 1.98
Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease. J Clin Invest (1974) 1.92
Evidence for hydroxyl radical generation by human Monocytes. J Clin Invest (1977) 1.85
Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis. J Clin Invest (1970) 1.82
Iodinating ability of various leukocytes and their bactericidal activity. J Exp Med (1973) 1.67
Hemolysis and iodination of erythrocyte components by a myeloperoxidase-mediated system. Blood (1975) 1.56
Stimulation of the hexose monophosphate shunt independent of hydrogen peroxide and superoxide production in rabbit alveolar macrophages during phagocytosis. Blood (1977) 1.06
Influence of surface proteins and separation techniques on neutrophil unstimulated and stimulated locomotion in vitro. J Reticuloendothel Soc (1978) 1.05
Evidence for production of oxidizing radicals by the particulate O-2-forming system from human neutrophils. Blood (1979) 1.01
The generation of superoxide anion by various types of phagocyte. J Infect Dis (1975) 1.01
Hydroxyl radical formation in phagocytic cells of the rat. J Appl Physiol Respir Environ Exerc Physiol (1979) 0.97
Defective oxidative metabolic responses in vitro of alveolar macrophages in chronic granulomatous disease. Am Rev Respir Dis (1979) 0.89
Comparison of the metabolism of alveolar macrophages from humans, rats, and rabbits: phorbol myristate acetate. J Lab Clin Med (1978) 0.89
Hydrogen peroxide release by rat alveolar macrophages: comparison with blood neutrophils. Infect Immun (1978) 0.84
Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest (1984) 2.88
Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis (1983) 2.63
Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J Clin Invest (1988) 2.54
Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. J Clin Invest (1979) 2.40
Pathogenesis of Campylobacter fetus infections. Failure of encapsulated Campylobacter fetus to bind C3b explains serum and phagocytosis resistance. J Clin Invest (1988) 2.38
Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J Biol Chem (1981) 2.16
Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical. Proc Natl Acad Sci U S A (1981) 2.13
Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity. Proc Natl Acad Sci U S A (1982) 1.99
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem (1988) 1.98
Human fibronectin binding to staphylococcal surface protein and its relative inefficiency in promoting phagocytosis by human polymorphonuclear leukocytes, monocytes, and alveolar macrophages. Infect Immun (1981) 1.97
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties. J Biol Chem (1991) 1.96
Pulmonary strategies of antioxidant defense. Am Rev Respir Dis (1989) 1.94
The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes. J Lab Clin Med (1974) 1.92
Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease. J Clin Invest (1974) 1.92
Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3. Blood (1990) 1.71
Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Respir Dis (1982) 1.70
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med (2000) 1.70
Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers. Am Rev Respir Dis (1981) 1.64
Alveolar hemorrhage syndromes: diffuse microvascular lung hemorrhage in immune and idiopathic disorders. Medicine (Baltimore) (1984) 1.62
Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin. FEBS Lett (2000) 1.57
Quantitation of maximal bactericidal capability in human neutrophils. J Lab Clin Med (1976) 1.52
Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A (1989) 1.50
Opsonic requirements for the uptake of Cryptococcus neoformans by human polymorphonuclear leukocytes and monocytes. J Infect Dis (1982) 1.47
Phagocytosis, bacterial killing, and metabolism by purified human lung phagocytes. J Infect Dis (1981) 1.46
Influence of a deficiency of the second component of complement on the bactericidal activity of neutrophils in vitro. J Clin Invest (1977) 1.44
Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages. J Clin Invest (1987) 1.43
Natural mycobacteriostatic activity in human monocyte-derived adherent cells. Am Rev Respir Dis (1986) 1.42
Dusts causing pneumoconiosis generate .OH and produce hemolysis by acting as Fenton catalysts. Arch Biochem Biophys (1989) 1.41
Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cytokine (1991) 1.37
Alterations in leukocyte oxidative metabolism in cigarette smokers. Am Rev Respir Dis (1982) 1.36
Phagocytosis by polymorphonuclear leukocytes of Staphylococcus aureus and Pseudomonas aeruginosa adherent to plastic, agar, or glass. J Immunol Methods (1983) 1.36
Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. Am J Physiol (1992) 1.36
Human dipeptidyl-peptidase I. Gene characterization, localization, and expression. J Biol Chem (1997) 1.35
Peritoneal macrophages and opsonins: antibacterial defense in patients undergoing chronic peritoneal dialysis. J Infect Dis (1983) 1.35
Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity. Proc Natl Acad Sci U S A (1992) 1.34
Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells. J Clin Invest (1984) 1.33
Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. Role of thromboxane A2. J Clin Invest (1983) 1.33
Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes. Am Rev Respir Dis (1981) 1.33
Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J Clin Invest (1987) 1.32
Effect of tumor necrosis factor-alpha and interleukin-1 alpha on heme oxygenase-1 expression in human endothelial cells. Am J Physiol (1998) 1.31
Copper-dependent inflammation and nuclear factor-kappaB activation by particulate air pollution. Am J Respir Cell Mol Biol (1998) 1.30
Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts. J Clin Invest (1988) 1.29
Alcohol-induced breast cancer: a proposed mechanism. Free Radic Biol Med (1999) 1.27
Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Respir Dis (1982) 1.25
Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest (1992) 1.25
Hydrogen peroxide mediated killing of bacteria. Mol Cell Biochem (1982) 1.23
Pathogenesis of emphysema. Chest (1983) 1.22
Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. J Clin Invest (1984) 1.20
Increased leucocyte oxidative metabolism in hyperlipoproteinaemia. Lancet (1982) 1.20
Interleukin 1 pretreatment decreases ischemia/reperfusion injury. Proc Natl Acad Sci U S A (1990) 1.20
Lung phagocyte recruitment and metabolic alterations induced by cigarette smoke in humans and in hamsters. Am Rev Respir Dis (1982) 1.19
Lung fibrosis and emphysema: divergent responses to a common injury? Science (1982) 1.18
Bacillus Calmette-Guérin-stimulated neutrophils release chemotaxins for monocytes in rabbit pleural spaces and in vitro. J Clin Invest (1985) 1.18
Deficiency of the second component of complement (C2) with chronic vasculitis. Ann Intern Med (1975) 1.17
Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea. Circulation (1987) 1.17
Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation. J Immunol (1994) 1.17
Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism. J Clin Invest (1990) 1.15
Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.14
Influence of subinhibitory concentrations of penicillin, cephalothin, and clindamycin on Staphylococcus aureus growth in human phagocytic cells. Antimicrob Agents Chemother (1982) 1.14
Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. Am J Physiol Lung Cell Mol Physiol (2000) 1.13
Influence of cationic local anesthetics on the metabolism and ultrastructure of human alveolar macrophages. J Lab Clin Med (1979) 1.12
Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys. Am J Physiol (1988) 1.12
Circulating IL-1ra and IL-10 levels are increased but do not predict the development of acute respiratory distress syndrome in at-risk patients. Am J Respir Crit Care Med (1997) 1.11
Mechanism of free radical production in exhaustive exercise in humans and rats; role of xanthine oxidase and protection by allopurinol. IUBMB Life (2000) 1.10
Hyperoxia damages cultured endothelial cells causing increased neutrophil adherence. Am Rev Respir Dis (1983) 1.10
Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin. J Appl Physiol (1985) (1987) 1.10
An improved nitroblue tetrazolium test using phorbol myristate acetate-coated coverslips. Am J Clin Pathol (1979) 1.10
Clearance of neutrophil-derived myeloperoxidase by the macrophage mannose receptor. Am J Respir Cell Mol Biol (1990) 1.10
TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am J Physiol (1999) 1.10
Radiation therapy for tracheobronchial amyloidosis. Chest (1998) 1.10
The role of platelets in the adult respiratory distress syndrome. Culprits or bystanders? Am Rev Respir Dis (1987) 1.09
Phagocytosis by human alveolar macrophages and neutrophils: qualitative differences in the opsonic requirements for uptake of Staphylococcus aureus and Streptococcus pneumoniae in vitro. Am Rev Respir Dis (1980) 1.07
Ischemia increases neutrophil retention and worsens acute renal failure: role of oxygen metabolites and ICAM 1. Kidney Int (1995) 1.07
Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. J Biol Chem (1999) 1.06
Influence of surface proteins and separation techniques on neutrophil unstimulated and stimulated locomotion in vitro. J Reticuloendothel Soc (1978) 1.05
Endothelial activation in ARDS. Chest (1999) 1.04
Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J Appl Physiol (1985) (1988) 1.04
Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium. J Appl Physiol (1985) (1987) 1.04
Opsonin-independent phagocytosis of surface-adherent bacteria by human alveolar macrophages. J Leukoc Biol (1984) 1.04
Production of C2 by human alveolar macrophages. Immunology (1978) 1.04
O2 metabolites and neutrophil elastase synergistically cause edematous injury in isolated rat lungs. J Appl Physiol (1985) (1986) 1.04
Chemiluminescence by human alveolar macrophages: stimulation with heat-killed bacteria or phorobol myristate acetate. Infect Immun (1977) 1.03
Inflammatory responses in experimental tuberculosis pleurisy. Acta Cytol (1983) 1.03
Cellularity of the alveolar walls in smokers and its relation to alveolar destruction. Functional implications. Am Rev Respir Dis (1990) 1.03
Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics (1996) 1.02
Role of reactive oxygen species in reperfusion injury of the rabbit lung. J Clin Invest (1989) 1.01
Expression and regulation of tumor necrosis factor in macrophages from cystic fibrosis patients. Am J Respir Cell Mol Biol (1993) 1.01
Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury. Am J Physiol Heart Circ Physiol (2000) 1.01
Hydroxyl radical scavengers produce similar decreases in the chemiluminescence responses and bactericidal activities of neutrophils. Infect Immun (1984) 1.01
Role of cytochrome P-450 in reperfusion injury of the rabbit lung. J Clin Invest (1990) 1.00
Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia. Am J Physiol (1996) 1.00