Published in J Biol Chem on April 25, 1971
Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes. J Cell Biol (1978) 4.33
Externally disposed plasma membrane proteins. II. Metabolic fate of iodinated polypeptides of mouse L cells. J Cell Biol (1975) 2.39
Selective release of content from microsomal vesicles without membrane disassembly. II. Electrophoretic and immunological characterization of microsomal subfractions. J Cell Biol (1974) 1.69
Relationship between in vivo degradative rates and isoelectric points of proteins. Proc Natl Acad Sci U S A (1975) 1.59
Structure, composition, physical properties, and turnover of proliferated peroxisomes. A study of the trophic effects of Su-13437 on rat liver. J Cell Biol (1975) 1.58
Studies on lipid synthesis and degradation in developing soybean cotyledons. Plant Physiol (1976) 1.25
Identification and characterization of a bile acid receptor in isolated liver surface membranes. J Clin Invest (1976) 1.22
Phospholipid turnover in soybean tissue cultures. Plant Physiol (1977) 1.21
Synthesis of chloroplast membrane polypeptides during synchronous growth of Chlamydomonas reinhardtii. J Cell Biol (1974) 1.18
The relation of size to the relative rates of degradation of intestinal brush border proteins. J Clin Invest (1972) 1.13
Synthesis and turnover of plasma-membrane proteins and glycoproteins in a neuroblastoma cell line. Biochem J (1976) 1.08
Stimulation of hepatic sodium and potassium-activated adenosine triphosphatase activity by phenobarbital. Its possible role in regulation of bile flow. J Clin Invest (1977) 1.08
Structure and metabolism of rat liver heparan sulphate. Biochem J (1977) 1.07
Production of membrane whorls in rat liver by some inhibitors of protein synthesis. J Cell Biol (1974) 1.04
Rapid cell surface appearance of endocytic membrane proteins in Chinese hamster ovary cells. Mol Cell Biol (1981) 1.01
Soluble neutral and acid maltases in the suckling-rat intestine. The effect of cortisol and development. Biochem J (1974) 0.99
Protein degradation during terminal cytodifferentiation. Studies on mammary gland in organ culture. Biochem J (1980) 0.92
A releationship between protein-degradation rates in vivo, isoelectric points, and molecular weights obtained by using density labelling. Biochem J (1979) 0.90
Degradation of transplanted rat liver mitochondrial-outer-membrane proteins in hepatoma cells. Biochem J (1983) 0.89
The degradation and turnover of fucosylated glycoproteins in the plasma membrane of a neuroblastoma-cell line. Biochem J (1977) 0.87
General characteristics of normal and stress-enhanced protein degradation in Lemna minor (duckweed). Biochem J (1980) 0.83
Relative rates of turnover of subunits of mitochondrial proteins. Biochem J (1978) 0.82
Relative stability of membrane proteins in Escherichia coli. J Bacteriol (1981) 0.82
Growth and metabolism of fucosylated plasma-membrane glycoproteins in mouse neuroblastoma N2a cells. Biochem J (1978) 0.82
Regeneration of cilia in starved Tetrahymena thermophila involves induced synthesis of ciliary proteins but not synthesis of membrane lipids. Biochem J (1980) 0.81
Regulation of hepatic transport of bile salt. Effect of protein synthesis inhibition on excretion of bile salts and their binding to liver surface membrane fractions. J Clin Invest (1979) 0.80
Modeling the electric potential across neuronal membranes: the effect of fixed charges on spinal ganglion neurons and neuroblastoma cells. PLoS One (2014) 0.75
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem (1978) 9.13
Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature (1978) 8.76
Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. J Biol Chem (1978) 8.20
Gene amplification in cultured animal cells. Cell (1984) 5.43
Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proc Natl Acad Sci U S A (1978) 4.60
Control of enzyme levels in animal tissues. Annu Rev Biochem (1970) 4.59
Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell (1980) 4.25
Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25
Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells. Cell (1980) 4.23
Synthesis of full length cDNAs from four partially purified oviduct mRNAs. J Biol Chem (1978) 3.92
Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci U S A (1979) 3.68
Multiple hexokinases of rat tissues. Purification and comparison of soluble forms. J Biol Chem (1966) 3.56
Shape of the hydrophobic barrier of phospholipid bilayers (evidence for water penetration in biological membranes). J Membr Biol (1974) 3.43
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. J Biol Chem (1982) 3.25
Studies on the synthesis and degradation of proteins of the endoplasmic reticulum of rat liver. J Biol Chem (1969) 3.24
Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature (1986) 3.18
Methylmercury hydroxide enhancement of translation and transcription of ovalbumin and conalbumin mRNA's. J Biol Chem (1979) 3.08
Influence of turnover rates on the responses of enzymes to cortisone. Mol Pharmacol (1965) 3.05
Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. J Biol Chem (1972) 2.96
Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. J Biol Chem (1971) 2.73
The generation of energy by the arginine dihydrolase pathway in Mycoplasma hominis 07. J Biol Chem (1966) 2.70
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol Cell Biol (1983) 2.68
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A (1983) 2.59
Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene. J Biol Chem (1982) 2.59
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell (1979) 2.55
Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct. J Biol Chem (1976) 2.55
Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proc Natl Acad Sci U S A (1982) 2.45
Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. J Biol Chem (1976) 2.36
Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proc Natl Acad Sci U S A (1986) 2.33
Gene amplification in a single cell cycle in Chinese hamster ovary cells. J Biol Chem (1984) 2.32
Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle. J Biol Chem (1985) 2.31
Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1985) 2.30
Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions. J Biol Chem (1985) 2.29
Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell (1984) 2.28
Isolation of hen oviduct ovalbumin and rat live albumin polysomes by indirect immunoprecipitation. J Biol Chem (1974) 2.20
Quantitative measurement of ovalbumin messenger ribonucleic acid activity. Localization in polysomes, induction by estrogen, and effect of actinomycin D. J Biol Chem (1973) 2.17
Synthesis of rat liver albumin in a rabbit reticulocyte cell-free protein-synthesizing system. J Biol Chem (1973) 2.13
Studies of the stability in vivo and in vitro of rat liver tryptophan pyrrolase. J Biol Chem (1965) 2.13
Organization of polysomes from pre-existing ribosomes in chick oviduct by a secondary administration of either estradiol or progesterone. J Biol Chem (1970) 2.12
Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc Natl Acad Sci U S A (1990) 2.10
Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. J Cell Biol (1979) 2.09
An analysis of the kinetics of rat liver tryptophan pyrrolase induction: the significance of both enzyme synthesis and degradation. Biochem Biophys Res Commun (1964) 2.06
Synthesis of a deoxyribonucleic acid sequence complementary to ovalbumin messenger ribonucleic acid and quantification of ovalbumin genes. J Biol Chem (1973) 2.05
Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. J Biol Chem (1978) 2.00
Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc Natl Acad Sci U S A (1988) 1.99
Studies on the correlation between size and relative degradation rate of soluble proteins. J Biol Chem (1973) 1.96
Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta (1974) 1.93
Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. J Biol Chem (1979) 1.92
A re-examination of the 5' termini of mouse dihydrofolate reductase RNA. J Biol Chem (1986) 1.92
Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties. Proc Natl Acad Sci U S A (1965) 1.91
Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. J Biol Chem (1984) 1.86
Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines. Mol Cell Biol (1981) 1.83
Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harb Symp Quant Biol (1978) 1.81
Presence of the arginine dihydrolase pathway in Mycoplasma. J Bacteriol (1966) 1.81
Gene amplification, drug resistance, and cancer. Cancer Res (1984) 1.79
Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. J Biol Chem (1976) 1.79
Synthesis of ovalbumin in a rabbit reticulocyte cell-free system programmed with hen oviduct ribonucleic acid. J Biol Chem (1971) 1.71
Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. J Biol Chem (1981) 1.71
2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature (1979) 1.71
Ovalbumin messenger RNA: evidence that the initial product of transcription is the same size as polysomal ovalbumin messenger. Proc Natl Acad Sci U S A (1974) 1.69
Control of enzyme levels in mammalian tissues. Adv Enzymol Relat Areas Mol Biol (1973) 1.67
S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1981) 1.65
In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene. Mol Cell Biol (1986) 1.64
Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line. Mol Cell Biol (1981) 1.63
Independent genetic control of the catalytic activity and the rate of degradation of catalase in mice. J Biol Chem (1969) 1.63
Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1986) 1.61
The structural gene for alpha-mannosidase-1 in Dictyostellium discoideum. Genetics (1976) 1.60
Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes. Cell (1981) 1.59
Induction of ovalbumin mRNA sequences by estrogen and progesterone in chick oviduct as measured by hybridization to complementary DNA. J Biol Chem (1975) 1.56
Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression. Anal Biochem (1996) 1.56
UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Mol Cell Biol (1984) 1.55
Regulation of protein turnover in mammalian tissues. Fed Proc (1968) 1.55
Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. Cold Spring Harb Symp Quant Biol (1981) 1.54
Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence. Proc Natl Acad Sci U S A (1980) 1.51
Preparation of electrocompetent E. coli using salt-free growth medium. Biotechniques (1996) 1.46
Murine dihydrofolate reductase transcripts through the cell cycle. Mol Cell Biol (1986) 1.43
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Mol Cell Biol (1981) 1.42
Identification and isolation of ovalbumin-synthesizing polysomes. II. Quantification and immunoprecipitation of polysomes. J Biol Chem (1972) 1.41
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Proc Natl Acad Sci U S A (1979) 1.40
Interaction of estrogen and progesterone in chick oviduct development. II. Effects of estrogen and progesterone on tubular gland cell function. J Cell Biol (1969) 1.40
Methods for analysis of enzyme synthesis and degradation in animal tissues. Methods Enzymol (1975) 1.39
Two RFLPs for the human dihydrofolate reductase gene (DHFR). Nucleic Acids Res (1987) 1.39
Regulation of protein synthesis in chick oviduct. 3. Mechanism of ovalbumin "superinduction" by actinomycin D. J Biol Chem (1973) 1.38
Post-transcriptional regulation in higher eukaryotes: the role of the reporter gene in controlling expression. Mol Gen Genet (1991) 1.38
Purification of ovalbumin messenger ribonucleic acid by specific immunoadsorption of ovalbumin-synthesizing polysomes and millipore partition of ribonucleic acid. J Biol Chem (1973) 1.34
Interaction of estrogen and progesterone in chick oviduct development. I. Antagonistic effect of progesterone on estrogen-induced proliferation and differentiation of tubular gland cells. J Cell Biol (1969) 1.30
Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proc Natl Acad Sci U S A (1983) 1.30
Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harb Symp Quant Biol (1979) 1.27
Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs. J Biol Chem (1976) 1.27
Methotrexate resistance and gene amplification. Mechanisms and implications. Cancer (1986) 1.25
Immunochemical isolation and characterization of ovalbumin messenger ribonucleic acid. J Biol Chem (1975) 1.25
In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc Natl Acad Sci U S A (1993) 1.21
Improvements in immunoprecipitation of specific messenger RNA. Isolation of highly purified conalbumin mRNA in high yield. Eur J Biochem (1979) 1.20
BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Cancer Res (1995) 1.20
Characterization and genetic mapping of modA. A mutation in the post-translational modification of the glycosidases of Dictyostelium discoideum. J Biol Chem (1978) 1.19
Cell cycle analysis of apoptosis using flow cytometry. Methods Cell Biol (1995) 1.18
Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. Cancer Res (1985) 1.16
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. Exp Cell Res (1995) 1.15
Specific binding of albumin antibody to rat liver polysomes. J Biol Chem (1974) 1.15