Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
|
Nature
|
1976
|
13.19
|
2
|
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
|
Prostaglandins
|
1976
|
4.54
|
3
|
Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.
|
Prostaglandins
|
1976
|
4.44
|
4
|
Modulation of human platelet adenylate cyclase by prostacyclin (PGX).
|
Prostaglandins
|
1977
|
3.80
|
5
|
The chemical structure of prostaglandin X (prostacyclin).
|
Prostaglandins
|
1976
|
3.63
|
6
|
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.
|
J Pharmacol Exp Ther
|
1990
|
3.55
|
7
|
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
|
J Clin Invest
|
1994
|
3.11
|
8
|
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides.
|
Nature
|
1976
|
2.83
|
9
|
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.
|
Proc Natl Acad Sci U S A
|
2001
|
2.77
|
10
|
Imidazole: a selective inhibitor of thromboxane synthetase.
|
Prostaglandins
|
1977
|
2.48
|
11
|
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.
|
Prostaglandins
|
1976
|
2.28
|
12
|
Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery.
|
Circulation
|
1995
|
2.07
|
13
|
The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].
|
Br J Pharmacol
|
1976
|
2.06
|
14
|
Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo.
|
Circulation
|
1995
|
1.92
|
15
|
Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic.
|
Thromb Haemost
|
2001
|
1.64
|
16
|
Effects of vascular endothelial growth factor on hemodynamics and cardiac performance.
|
J Cardiovasc Pharmacol
|
1996
|
1.63
|
17
|
Prostacyclin is a circulating hormone.
|
Nature
|
1978
|
1.60
|
18
|
Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition.
|
Prostaglandins
|
1976
|
1.56
|
19
|
Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.
|
Proc Natl Acad Sci U S A
|
1990
|
1.55
|
20
|
Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor.
|
Circulation
|
1995
|
1.51
|
21
|
Kistrin, a polypeptide platelet GPIIb/IIIa receptor antagonist, enhances and sustains coronary arterial thrombolysis with recombinant tissue-type plasminogen activator in a canine preparation.
|
Circulation
|
1991
|
1.44
|
22
|
Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis.
|
Prostaglandins
|
1976
|
1.40
|
23
|
The regulation of blood vessel growth by vascular endothelial growth factor.
|
Ann N Y Acad Sci
|
1995
|
1.34
|
24
|
Effects of intravenous infusion of prostacyclin (PGI2) in man.
|
Prostaglandins
|
1980
|
1.30
|
25
|
Inhibition of phospholipase C dependent processes by U-73, 122.
|
Adv Prostaglandin Thromboxane Leukot Res
|
1989
|
1.27
|
26
|
Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb.
|
Am J Physiol
|
1994
|
1.22
|
27
|
Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.
|
Circulation
|
1994
|
1.21
|
28
|
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
|
Circulation
|
1997
|
1.21
|
29
|
The prostacyclin--thromboxane A2 balance: pathophysiological and therapeutic implications.
|
Br Med Bull
|
1983
|
1.20
|
30
|
A monoclonal antibody that inhibits mouse tissue factor function.
|
J Thromb Haemost
|
2005
|
1.19
|
31
|
Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4.
|
J Biol Chem
|
1984
|
1.18
|
32
|
Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man.
|
Br J Clin Pharmacol
|
1979
|
1.16
|
33
|
Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo.
|
Am J Physiol
|
1996
|
1.14
|
34
|
Vascular endothelial growth factor, a specific regulator of angiogenesis.
|
Curr Opin Nephrol Hypertens
|
1996
|
1.12
|
35
|
Cyclic RGD peptide analogues as antiplatelet antithrombotics.
|
J Med Chem
|
1992
|
1.10
|
36
|
Synthesis and structure of the platelet aggregation factor thromboxane A2.
|
Nature
|
1985
|
1.09
|
37
|
Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor.
|
J Vasc Surg
|
1995
|
1.08
|
38
|
Hypertension and endothelial dysfunction in apolipoprotein E knockout mice.
|
Arterioscler Thromb Vasc Biol
|
1999
|
1.02
|
39
|
Substantially attenuated hemodynamic responses to Escherichia coli-derived vascular endothelial growth factor given by intravenous infusion compared with bolus injection.
|
J Pharmacol Exp Ther
|
1998
|
1.01
|
40
|
VEGF administration in chronic myocardial ischemia in pigs.
|
Cardiovasc Res
|
1998
|
0.99
|
41
|
Voices and paradigms: perspectives on critical and feminist theory in nursing.
|
ANS Adv Nurs Sci
|
1991
|
0.98
|
42
|
Antithrombotic properties of vascular endothelium.
|
Lancet
|
1977
|
0.98
|
43
|
Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia.
|
J Am Coll Cardiol
|
2001
|
0.97
|
44
|
Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency.
|
Am J Pathol
|
1995
|
0.92
|
45
|
Protection against endotoxic shock by bactericidal/permeability-increasing protein in rats.
|
J Clin Invest
|
1995
|
0.91
|
46
|
Evidence that S-nitrosothiols are responsible for the smooth muscle relaxing activity of the bovine retractor penis inhibitory factor.
|
J Pharmacol Exp Ther
|
1992
|
0.91
|
47
|
Peripheral vascular stenosis in apolipoprotein E-deficient mice. Potential roles of lipid deposition, medial atrophy, and adventitial inflammation.
|
Arterioscler Thromb Vasc Biol
|
1997
|
0.90
|
48
|
Proceedings: Formation of prostaglandin endoperoxides and rabbit aorta contracting substance (RCS) by coupling two enzyme systems.
|
Br J Pharmacol
|
1976
|
0.90
|
49
|
Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response.
|
Am J Physiol
|
1997
|
0.89
|
50
|
Prostacyclin: a solution to some problems of extracorporeal circulation. Experiments in greyhounds.
|
Lancet
|
1979
|
0.89
|
51
|
Growth hormone improves cardiac performance in experimental heart failure.
|
Circulation
|
1995
|
0.88
|
52
|
Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice.
|
J Magn Reson Imaging
|
2001
|
0.86
|
53
|
Prostacyclin in physiology and pathophysiology.
|
Int Rev Exp Pathol
|
1982
|
0.86
|
54
|
Prostacyclin can replace heparin in haemodialysis in dogs.
|
Lancet
|
1978
|
0.85
|
55
|
Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
|
J Med Chem
|
1996
|
0.84
|
56
|
Resting blood pressure and thermal pain responses among females: effects on pain unpleasantness but not pain intensity.
|
Int J Psychophysiol
|
1998
|
0.83
|
57
|
Vascular endothelial growth factor augments muscle blood flow and function in a rabbit model of chronic hindlimb ischemia.
|
J Cardiovasc Pharmacol
|
1996
|
0.82
|
58
|
A soluble tissue factor mutant is a selective anticoagulant and antithrombotic agent.
|
Blood
|
1997
|
0.81
|
59
|
Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats.
|
J Pharmacol Exp Ther
|
2001
|
0.81
|
60
|
Leukotriene B4 and 20-hydroxyleukotriene B4 contract guinea-pig trachea strips in vitro.
|
J Pharmacol Exp Ther
|
1986
|
0.81
|
61
|
Generation of thromboxane A2-like activity from prostaglandin endoperoxides by polymorphonuclear leukocyte homogenates [proceedings].
|
Br J Pharmacol
|
1976
|
0.81
|
62
|
Inhibition of platelet activation by prostacyclin: possible consequences in coagulation and anticoagulation.
|
Thromb Res
|
1981
|
0.80
|
63
|
G4120, an Arg-Gly-Asp containing pentapeptide, enhances arterial eversion graft recanalization with recombinant tissue-type plasminogen activator in dogs.
|
Thromb Haemost
|
1992
|
0.79
|
64
|
Effects of gender and acute dental pain on thermal pain responses.
|
Clin J Pain
|
1999
|
0.79
|
65
|
In vivo characterization of synthetic thromboxane A2 in canine myocardium.
|
Circ Res
|
1987
|
0.79
|
66
|
Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model.
|
Blood
|
1992
|
0.79
|
67
|
Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.
|
Circulation
|
2001
|
0.78
|
68
|
Effects of VEGF on hemodynamics and cardiac function: characterization and mechanisms.
|
IDrugs
|
2000
|
0.78
|
69
|
Hemodynamic effects of scatter factor in conscious rats.
|
J Cardiovasc Pharmacol
|
1997
|
0.77
|
70
|
Pressor and bradycardic effects of centrally administered relaxin in conscious rats.
|
Am J Hypertens
|
1995
|
0.77
|
71
|
Peripheral neuropathy in patients with HIV infection: consider dual pathology.
|
Sex Transm Infect
|
2002
|
0.76
|
72
|
Pulmonary pharmacology of synthetic thromboxane A2.
|
Adv Prostaglandin Thromboxane Leukot Res
|
1987
|
0.75
|
73
|
Antithrombotic drugs in relation to prostaglandin metabolism.
|
Clin Haematol
|
1980
|
0.75
|
74
|
An antiserum to 5,6-dihydro prostacyclin (PGI1) which also binds prostacyclin.
|
Prostaglandins
|
1978
|
0.75
|
75
|
Antithrombotic effects and bleeding time prolongation with synthetic platelet GPIIb/IIIa inhibitors in animal models of platelet-mediated thrombosis.
|
Thromb Haemost
|
1994
|
0.75
|
76
|
Comparison of VEGF delivery techniques on collateral-dependent microvascular reactivity.
|
Microvasc Res
|
1998
|
0.75
|
77
|
Support for the terminally ill: letting conscience by the guide.
|
Volunt Leader
|
1983
|
0.75
|
78
|
RGD-containing peptides inhibit adhesion of 293 cells transfected with GpIIb/IIIa to fibrinogen: comparison to inhibition of platelet aggregation.
|
Blood Coagul Fibrinolysis
|
1993
|
0.75
|
79
|
Triangulation research among culturally diverse populations.
|
J Allied Health
|
2000
|
0.75
|
80
|
The effect of cyclo-oxygenase and thromboxane synthetase inhibitors on shock induced by injection of heterologous blood in cats.
|
Thromb Res
|
1983
|
0.75
|
81
|
Effects of growth hormone in rats with postinfarction left ventricular dysfunction.
|
Cardiovasc Drugs Ther
|
1995
|
0.75
|
82
|
Pharmacokinetics, pharmacodynamics and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administrations of a prodrug form.
|
Thromb Haemost
|
1998
|
0.75
|
83
|
Prostacyclin eliminates the thrombocytopenia associated with charcoal hemoperfusion and minimizes heparin and fibrinogen consumption.
|
Artif Organs
|
1980
|
0.75
|
84
|
Ethical decision making by nurses in HIV/AIDS situations.
|
J Assoc Nurses AIDS Care
|
1992
|
0.75
|
85
|
An experimental model of intracranial hemorrhage during thrombolytic therapy with t-PA.
|
Thromb Haemost
|
1996
|
0.75
|
86
|
[Clinical study of prostacyclin in extracorporeal circulation. Effects on hemodynamics and coagulation].
|
Arch Mal Coeur Vaiss
|
1982
|
0.75
|
87
|
Electrophoretic study of genetic variation in British Myzus persicae (Sulz.) (Hemiptera, Aphididae).
|
Biochem Genet
|
1978
|
0.75
|
88
|
Haemodialysis without heparin.
|
Proc Eur Dial Transplant Assoc
|
1978
|
0.75
|
89
|
Prostacyclin eliminates the bioincompatibility of charcoal haemoperfusion.
|
Proc Eur Dial Transplant Assoc
|
1979
|
0.75
|
90
|
Intravenous and endobronchial administration of G4120, a cyclic Arg-Gly-Asp-containing platelet GPIIb/IIIa receptor-blocking pentapeptide, enhances and sustains coronary arterial thrombolysis with rt-PA in a canine preparation.
|
Arterioscler Thromb
|
1993
|
0.75
|