Published in Science on July 05, 1968
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
A gene expression database for the molecular pharmacology of cancer. Nat Genet (2000) 13.31
Low back pain. N Engl J Med (2001) 9.70
Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51
EDGAR: extraction of drugs, genes and relations from the biomedical literature. Pac Symp Biocomput (2000) 6.64
MedMiner: an Internet text-mining tool for biomedical information, with application to gene expression profiling. Biotechniques (1999) 5.56
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res (1997) 4.34
A characteristic of self-regulated linear energy converters. The Hill force-velocity relation for muscle. J Theor Biol (1966) 4.11
Fishing expeditions. Science (1998) 4.09
Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis (1981) 3.74
Interactions of liposomes with mammalian cells. Annu Rev Biophys Bioeng (1978) 3.42
Helping patients decide about back surgery: a randomized trial of an interactive video program. Spine (Phila Pa 1976) (2001) 3.32
Liposome-cell interaction: transfer and intracellular release of a trapped fluorescent marker. Science (1977) 2.89
Dynamics of a tightly coupled mechanism for flagellar rotation. Bacterial motility, chemiosmotic coupling, protonmotive force. Biophys J (1989) 2.86
Primary bone tumors of the spine. Terminology and surgical staging. Spine (Phila Pa 1976) (1997) 2.80
Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents. J Natl Cancer Inst (1994) 2.78
The impact of spinal problems on the health status of patients: have we underestimated the effect? Spine (Phila Pa 1976) (2000) 2.51
Thoracolumbar burst fractures. The clinical efficacy and outcome of nonoperative management. Spine (Phila Pa 1976) (1993) 2.43
The coupling of an enzymatic reaction to transmembrane flow of electric current in a synthetic "active transport" system. Biophys J (2008) 2.27
Design of liposomes for enhanced local release of drugs by hyperthermia. Science (1978) 2.17
An estimation of the light-induced electrochemical potential difference of protons across the membrane of Halobacterium halobium. Biochim Biophys Acta (1976) 2.11
Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. Cancer Res (1989) 2.04
Orthopaedic workforce in the next millennium. J Bone Joint Surg Am (1998) 2.04
Lumbar laminectomy alone or with instrumented or noninstrumented arthrodesis in degenerative lumbar spinal stenosis. Patient selection, costs, and surgical outcomes. Spine (Phila Pa 1976) (1997) 2.01
Long-term follow-up of lower lumbar fusion patients. Spine (Phila Pa 1976) (1987) 2.01
Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol (1999) 1.97
Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science (1994) 1.96
Predictors of surgical outcome in degenerative lumbar spinal stenosis. Spine (Phila Pa 1976) (1999) 1.92
Artificial neural networks improve the accuracy of cancer survival prediction. Cancer (1997) 1.91
Charge clusters and the orientation of membrane proteins. J Membr Biol (1982) 1.87
Voltage-dependent trans-bilayer orientation of melittin. J Biol Chem (1982) 1.86
A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J Nucl Med (1990) 1.85
Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A. Nature (1980) 1.82
Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res (1992) 1.81
The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy. Spine (Phila Pa 1976) (1998) 1.77
Chordoma of the spine above the sacrum. Treatment and outcome in 21 cases. Spine (Phila Pa 1976) (1996) 1.74
Energetics of active transport processes. Biophys J (1968) 1.73
Cost-effectiveness of fusion with and without instrumentation for patients with degenerative spondylolisthesis and spinal stenosis. Spine (Phila Pa 1976) (2000) 1.68
Effects of rigidity of an internal fixation device. A comprehensive biomechanical investigation. Spine (Phila Pa 1976) (1991) 1.65
Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data. Pharmacogenomics J (2002) 1.63
A system for surgical staging and management of spine tumors. A clinical outcome study of giant cell tumors of the spine. Spine (Phila Pa 1976) (1997) 1.56
Kinetic studies of phototransients in bacteriorhodopsin. Biochim Biophys Acta (1976) 1.53
Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Science (1979) 1.53
Papain-collodion membranes. I. Preparation and properties. Biochemistry (1968) 1.51
The effectiveness of psychological interventions for the rehabilitation of low back pain: a randomized controlled trial evaluation. Pain (1992) 1.51
Pausing, switching and speed fluctuation of the bacterial flagellar motor and their relation to motility and chemotaxis. J Mol Biol (1990) 1.49
Isolated L4-L5 fusions using the variable screw placement system: unilateral versus bilateral. J Spinal Disord (1992) 1.45
Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine (Phila Pa 1976) (2000) 1.45
Energetics and chronology of phototransients in the light response of the purple membrane of Halobacterium halobium. Biochim Biophys Acta (1976) 1.43
Interaction of tubulin with phospholipid vesicles. I. Association with vesicles at the phase transition. J Biol Chem (1981) 1.40
Clinical correlates of patient satisfaction after laminectomy for degenerative lumbar spinal stenosis. Spine (Phila Pa 1976) (1995) 1.39
Application of extracorporeal shock wave lithotripter (ECSWL) in orthopedics. I. Foundations and overview. J Appl Biomater (1991) 1.39
Mining and visualizing large anticancer drug discovery databases. J Chem Inf Comput Sci (2000) 1.38
Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice. Cancer Res (1986) 1.36
An experimental enzyme-membrane oscillator. Biochim Biophys Acta (1973) 1.34
A combined finite element and optimization investigation of lumbar spine mechanics with and without muscles. Spine (Phila Pa 1976) (1993) 1.33
Autonomic energy conversion. I. The input relation: phenomenological and mechanistic considerations. Biophys J (1968) 1.31
Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc Natl Acad Sci U S A (1995) 1.27
An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Res (1991) 1.23
Oscillatory enzymes. Annu Rev Biophys Bioeng (1976) 1.21
Proton and carbon-13 nuclear magnetic resonance studies of the polar lipids of Halobacterium halobium. Biochemistry (1980) 1.20
European Spine Society--the AcroMed Prize for Spinal Research 1995. Unexpected load and asymmetric posture as etiologic factors in low back pain. Eur Spine J (1996) 1.20
Phase transition release, a new approach to the interaction of proteins with lipid vesicles. Application to lipoproteins. Biochim Biophys Acta (1981) 1.19
Autonomic energy conversion. II. An approach to the energetics of muscular contraction. Biophys J (1968) 1.18
Kinetic isotope effects in the photochemical cycle of bacteriorhodopsin. Biophys Struct Mech (1976) 1.17
Modulation excitation spectro-photometry of purple membrane of Halobacterium halobium. Nature (1975) 1.16
Temperature-induced switching of the bacterial flagellar motor. Biophys J (1996) 1.15
Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition. Oncogene (2007) 1.15
Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes. Nature (1980) 1.14
Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. J Natl Cancer Inst (1994) 1.14
Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns. J Natl Cancer Inst (1997) 1.13
Reconstitution of the hepatic asialoglycoprotein receptor with phospholipid vesicles. Proc Natl Acad Sci U S A (1980) 1.13
In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations. Antimicrob Agents Chemother (1992) 1.13
A protein expression database for the molecular pharmacology of cancer. Electrophoresis (1997) 1.13
Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor. Science (1983) 1.12
Determination of the distribution of catalyst activity across a permeable membrane containing an immobilized enzyme. Indeterminacy of a functional approach to a structural problem. Biophys J (1984) 1.12
Solitary plasmacytomas of the spine: a review of 84 cases. J Spinal Disord (1989) 1.12
Pharmacogenomics--teaching old drugs new tricks. N Engl J Med (2000) 1.12
Congenital coxa vara. A retrospective review. J Pediatr Orthop (1984) 1.12
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J Med Chem (1998) 1.12
The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine (Phila Pa 1976) (1998) 1.12
Long-term follow-up of patients with chronic back pain treated in a multidisciplinary rehabilitation program. Spine (Phila Pa 1976) (1995) 1.11
Consensus summary of the diagnosis and treatment of lumbar disc herniation. Spine (Phila Pa 1976) (1996) 1.10
Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells. Proc Natl Acad Sci U S A (1980) 1.09
Lumbar discography in normal subjects. A controlled, prospective study. J Bone Joint Surg Am (1990) 1.09
Lumbar discectomy outcomes vary by herniation level in the Spine Patient Outcomes Research Trial. J Bone Joint Surg Am (2008) 1.09
The direction of light-induced pH changes in purple membrane suspensions. Influence of pH and temperature. FEBS Lett (1977) 1.09
High-density lipoprotein recombinants: evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Lett (1979) 1.09
Lumbar spinal stenosis and diabetes. Outcome of surgical decompression. J Bone Joint Surg Br (1994) 1.09
Bacteriorhodopsin-loaded charged synthetic membranes. Utilization of light energy to generate electrical current. FEBS Lett (1977) 1.08
Oxidative phosphorylation: thermodynamic criteria for the chemical and chemiosmotic hypotheses. Proc Natl Acad Sci U S A (1969) 1.08
Energetics of sodium transport in frog skin. I. Oxygen consumption in the short-circuited state. J Gen Physiol (1972) 1.08
Liposome--lymphocyte interaction: saturable sites for transfer and intracellular release of liposome contents. Proc Natl Acad Sci U S A (1977) 1.07
Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat. Spine (Phila Pa 1976) (1996) 1.07
Kinetic analysis of light-induced pH changes in bacteriorhodopsin-containing particles from Halobacterium halobium. Biochemistry (1978) 1.06
Epidural steroid injection: a procedure ideally performed with fluoroscopic control. Radiology (1988) 1.06
Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages. Proc Natl Acad Sci U S A (1989) 1.05
Light-driven sodium transport in sub-bacterial particles of Halobacterium halobium. Biochim Biophys Acta (1977) 1.04
Bacteriorhodopsin: biphasic kinetics of phototransients and of light-induced proton transfer by sub-bacterial Halobacterium halobium particles and by reconstituted liposomes. FEBS Lett (1976) 1.04
Factors that affect surgical rates in Iowa. Spine (Phila Pa 1976) (1994) 1.04