| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement.
|
Science
|
1968
|
3.69
|
|
2
|
A COMPARISON OF HUMAN AND GUINEA PIG COMPLEMENTS AND THEIR COMPONENT FRACTIONS.
|
J Exp Med
|
1945
|
2.96
|
|
3
|
Mechanism of cytolysis by complement.
|
Proc Natl Acad Sci U S A
|
1972
|
2.71
|
|
4
|
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a.
|
Immunochemistry
|
1966
|
2.37
|
|
5
|
An alternate complement pathway: C-3 cleaving activity, not due to C4,2a, on endotoxic lipopolysaccharide after treatment with guinea pig serum; relation to properdin.
|
Proc Natl Acad Sci U S A
|
1971
|
1.89
|
|
6
|
The reaction of zymosan with the properdin system in normal and C4-deficienct guinea pig serum. Demonstration of C3- and C5-cleaving multi-unit enzymes, both containing factor B, and acceleration of their formation by the classical complement pathway.
|
J Immunol
|
1973
|
1.87
|
|
7
|
Kinetic studies of the formation of the properdin system enzymes on zymosan: evidence that nascent C3b controls the rate of assembly.
|
J Immunol
|
1974
|
1.82
|
|
8
|
Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism.
|
Exp Cell Res
|
1998
|
1.79
|
|
9
|
Studies of complement complex C5b,6 eluted from--EAC-6: reaction of C5b,6 with EAC4b,3b and evidence on the role of C2a and C3b in the activation of C5.
|
J Immunol
|
1974
|
1.73
|
|
10
|
The third component of the guinea pig complement system. II. Kinetic study of the reaction of EAC'4,2a with guinea pig C'3. Enzymatic nature of C'3 comsumption, multiphasic character of fixation, and hemolytic titration of C'3.
|
Biochemistry
|
1968
|
1.71
|
|
11
|
Increased ion permeability of planar lipid bilayer membranes after treatment with the C5b-9 cytolytic attack mechanism of complement.
|
Proc Natl Acad Sci U S A
|
1976
|
1.69
|
|
12
|
On the mechanism of cytolysis by complement: evidence on insertion of C5b and C7 subunits of the C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes.
|
Proc Natl Acad Sci U S A
|
1975
|
1.57
|
|
13
|
Antibody-complement complexes.
|
Science
|
1965
|
1.42
|
|
14
|
On the mechanism of cell membrane damage by complement: evidence on insertion of polypeptide chains from C8 and C9 into the lipid bilayer of erythrocytes.
|
J Immunol
|
1977
|
1.41
|
|
15
|
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency.
|
Immunochemistry
|
1966
|
1.41
|
|
16
|
Synthesis of the ninth component of complement by a clonal strain of rat hepatoma cells.
|
J Immunol
|
1970
|
1.38
|
|
17
|
Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics.
|
Proc Natl Acad Sci U S A
|
1983
|
1.35
|
|
18
|
On the mechanism of membrane damage by C: exposure of hydrophobic sites on activated C proteins.
|
J Immunol
|
1977
|
1.35
|
|
19
|
The fifth component of the guinea pig complement system. II. Mechanism of SAC1,4,2,3,5b formation and C5 consumption by EAC1,4,2,3.
|
J Immunol
|
1971
|
1.34
|
|
20
|
Elimination of complement channels from the plasma membranes of U937, a nucleated mammalian cell line: temperature dependence of the elimination rate.
|
J Immunol
|
1983
|
1.30
|
|
21
|
Transmembrane channel formation by complement: functional analysis of the number of C5b6, C7, C8, and C9 molecules required for a single channel.
|
Proc Natl Acad Sci U S A
|
1982
|
1.29
|
|
22
|
C3 split products inhibit the binding of antigen-antibody-complement complexes to B lymphocytes.
|
J Immunol
|
1973
|
1.28
|
|
23
|
Consequences of cell membrane attack by complement: release of arachidonate and formation of inflammatory derivatives.
|
Proc Natl Acad Sci U S A
|
1983
|
1.27
|
|
24
|
The reaction of zymosan with the properdin system: isolation of purified factor D from guinea pig serum and study of its reaction characteristics.
|
J Immunol
|
1974
|
1.24
|
|
25
|
Inhibition of guinea pig C'2 by rabbit antibody. Quantitative measurement of inhibition, discrimination between immune inhibition and complement fixation, specificity of inhibition and demonstration of uptake of C'2 by EAC'1a,4.
|
Immunochemistry
|
1965
|
1.23
|
|
26
|
A specific method for purification of the second component of guinea pig complement and a chemical evaluation of the one-hit theory.
|
J Immunol
|
1970
|
1.21
|
|
27
|
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates.
|
Immunochemistry
|
1965
|
1.20
|
|
28
|
The fifth component of the guinea pig complement system. 3. Dissociation and transfer of C5b, and the probable site of C5b fixation.
|
J Immunol
|
1971
|
1.18
|
|
29
|
Presidential address to the American Association of Immunologists, delivered in Chicago, Illinois, April 6, 1977. Mechanism of cytolysis by lymphocytes: A comparison with complement.
|
J Immunol
|
1977
|
1.17
|
|
30
|
Life-span and size of the trans-membrane channel formed by large doses of complement.
|
J Immunol
|
1980
|
1.16
|
|
31
|
The third component of the guinea pig complement system. I. Purification and characterization.
|
Biochemistry
|
1968
|
1.16
|
|
32
|
The kinetics of release of 86rubidium and hemoglobin from erythrocytes damaged by antibody and complement.
|
Immunochemistry
|
1969
|
1.12
|
|
33
|
Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for two pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells.
|
Cell Immunol
|
1976
|
1.09
|
|
34
|
Immunologically mediated membrane damage: the mechanism of complement action and the similarity of lymphocyte-mediated cytoxicity.
|
Immunochemistry
|
1978
|
1.08
|
|
35
|
Studies on the properdin system: isolation of a heat-labile factor from guinea pig serum related to a human glycine rich beta-glycoprotein (GBG or factor B).
|
J Immunol
|
1972
|
1.07
|
|
36
|
Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.
|
Proc Natl Acad Sci U S A
|
1983
|
1.07
|
|
37
|
The complement system.
|
Sci Am
|
1973
|
1.04
|
|
38
|
A new activity of complement component C3: cell-bound C3b potentiates lysis of erythrocytes by C5b,6 and terminal components.
|
J Immunol
|
1976
|
1.02
|
|
39
|
The fifth component of the guinea pig complement system. I. Purification and characterization.
|
J Immunol
|
1971
|
1.01
|
|
40
|
Complement, past and present.
|
Harvey Lect
|
1978
|
0.99
|
|
41
|
On the lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by complement: dual role of C3b.
|
Blut
|
1982
|
0.98
|
|
42
|
The third component of the guinea pig complement system. 3. Effect of inhibitors.
|
Biochemistry
|
1968
|
0.97
|
|
43
|
Studies of guinea pig complement component C9: reaction kinetics and evidence that lysis of EAC1-8 results from a single membrane lesion caused by one molecule of C9.
|
J Immunol
|
1973
|
0.97
|
|
44
|
On the mechanism of membrane damage by complement: the effect of length and unsaturation of the acyl chains in liposomal bilayers and the effect of cholesterol concentration in sheep erythrocyte and liposomal membranes.
|
J Immunol
|
1978
|
0.94
|
|
45
|
Studies on lymphokines: the production of antibody to guinea pig lymphotoxin and its use to distinguish lymphotoxin from migration inhibitory factor and mitogenic factor.
|
J Immunol
|
1975
|
0.94
|
|
46
|
Highlights of complement research during the past twenty-five years.
|
Immunochemistry
|
1970
|
0.93
|
|
47
|
Size of the transmembrane channels produced by complement proteins C5b-8.
|
J Immunol
|
1982
|
0.93
|
|
48
|
On the cleavage of C'2 by C'la: immunological and physical comparisons of C'2ad and C'2a-i.
|
Proc Soc Exp Biol Med
|
1968
|
0.92
|
|
49
|
Studies on the mechanism of action of guinea pig lymphotoxin. II. Increase of calcium uptake rate in LT-damaged target cells.
|
J Immunol
|
1978
|
0.90
|
|
50
|
Purification and characterization of lymphokines: an approach to the study of molecular mechanisms of cell-mediated immunity.
|
Prog Allergy
|
1978
|
0.89
|
|
51
|
Activation of the fifth and sixth component of the complement system: similarities between C5b6 and C(56)a with respect to lytic enhancement by cell-bound C3b or A2C, and species preferences of target cell.
|
J Immunol
|
1981
|
0.89
|
|
52
|
Penetration of C8 and C9 in the C5b-9 complex across the erythrocyte membrane into the cytoplasmic space.
|
J Biol Chem
|
1985
|
0.88
|
|
53
|
The molecular dimensions of mitogenic factor from guinea pig lymph node cells.
|
J Immunol
|
1975
|
0.88
|
|
54
|
Size distribution and stability of the trans-membrane channels formed by complement complex C5b-9.
|
Mol Immunol
|
1983
|
0.88
|
|
55
|
Membrane damage by complement.
|
Johns Hopkins Med J
|
1981
|
0.87
|
|
56
|
The relationship between channel size and the number of C9 molecules in the C5b-9 complex.
|
J Immunol
|
1985
|
0.87
|
|
57
|
Release of arachidonic acid and formation of oxygenated derivatives after complement attack on macrophages: role of channel formation.
|
J Immunol
|
1986
|
0.87
|
|
58
|
NORMAL HUMAN STROMATA AS ANTIGENS FOR COMPLEMENT FIXATION IN THE SERA OF PATIENTS WITH RELAPSING VIVAX MALARIA.
|
Science
|
1944
|
0.86
|
|
59
|
Complement. Historical perspectives and some current issues.
|
Complement
|
1984
|
0.85
|
|
60
|
Photometric analysis of proteins and peptides at 191-194 millimicrons.
|
Anal Biochem
|
1970
|
0.85
|
|
61
|
Immunologically mediated membrane damage: the mechanism of complement action and the similarity of lymphocyte-mediated cytotoxicity.
|
Transplant Proc
|
1978
|
0.80
|
|
62
|
The molecular dimensions of guinea pig lymphotoxin.
|
J Immunol
|
1974
|
0.79
|
|
63
|
Membrane damage by a toxin from the sea anemone Stoichactis helianthus. II. Effect of membrane lipid composition in a liposome system.
|
Biochim Biophys Acta
|
1979
|
0.79
|
|
64
|
Separation of lymphocyte mitogen from lymphotoxin and experiments on the production of lymphotoxin by lymphoid cells stimulated with the partially purified mitogen: a possible amplification mechanism of cellular immunity and allergy.
|
J Immunol
|
1976
|
0.79
|
|
65
|
Specific cytolytic activity of lymphocytes: effect of antibodies against complement components C2, C3, and C5.
|
Cell Immunol
|
1971
|
0.79
|
|
66
|
The cytolytic attack mechanism of complement.
|
Monogr Allergy
|
1977
|
0.77
|
|
67
|
Complement lysis of nucleated cells: effect of temperature and puromycin on the number of channels required for cytolysis.
|
Mol Immunol
|
1984
|
0.77
|
|
68
|
Effect of agents that produce membrane disorder on lysis of erythrocytes by complement.
|
Proc Natl Acad Sci U S A
|
1981
|
0.77
|
|
69
|
Studies on the mechanism of action of guinea pig lymphotoxin. I. Membrane active substances prevent target cell lysis by lymphotoxin.
|
J Immunol
|
1978
|
0.77
|
|
70
|
The effect of antibodies to complement components C2, C3 and C5 on the production and action of lymphotoxin.
|
J Immunol
|
1972
|
0.76
|
|
71
|
Membrane attack by complement (with comments on cell-mediated cytotoxicity).
|
Adv Exp Med Biol
|
1982
|
0.75
|
|
72
|
Two mechanisms of cell-mediated cytotoxicity: Ca++ transport modulation by lymphotoxin and transmembrane channel formation by antibody and nonadherent spleen cells.
|
Ann N Y Acad Sci
|
1979
|
0.75
|
|
73
|
Revised nomenclature.
|
J Immunol
|
1980
|
0.75
|
|
74
|
Transmembrane channels produced by complement proteins.
|
Ann N Y Acad Sci
|
1980
|
0.75
|