Published in Proc Natl Acad Sci U S A on October 01, 1983
Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages. Proc Natl Acad Sci U S A (1986) 2.63
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide. Proc Natl Acad Sci U S A (1985) 1.29
Necrosin: purification and properties of a cytotoxin derived from a murine macrophage-like cell line. Proc Natl Acad Sci U S A (1984) 1.19
Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization. Proc Natl Acad Sci U S A (1989) 1.09
Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2. Mol Cell Biol (1994) 1.07
A protective role of platelet-activating factor in murine candidiasis. Infect Immun (1997) 0.87
Analysis of endotoxin fever in rabbits by using a monoclonal antibody to tumor necrosis factor (cachectin). Infect Immun (1989) 0.85
Macrophage functions in Biozzi mice. Immunology (1985) 0.83
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An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A (1975) 23.42
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. J Exp Med (1979) 5.38
Purification and physico-chemical characterization of rabbit tumor necrosis factor. J Immunol (1980) 4.98
Activated macrophages kill tumour cells by releasing arginase. Nature (1978) 3.63
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Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells. Infect Immun (1980) 2.12
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The in vitro induction and release of a cell toxin by immune C57B1-6 mouse peritoneal macrophages. Cell Immunol (1972) 1.73
Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum. J Immunol (1981) 1.64
Production of the complement cleavage product, C3a, by activated macrophages and its tumorolytic effects. Clin Exp Immunol (1978) 1.46
Factors in delayed sensitivity: lymphocyte and macrophage cytotoxins in the tuberculin reaction. J Immunol (1969) 1.32
Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum. Cancer Res (1981) 1.30
Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor. Infect Immun (1981) 1.24
Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for two pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells. Cell Immunol (1976) 1.09
Effect of human monocyte killing of tumour cells of antibody raised against an extracellular monocyte cytotoxin. Immunology (1983) 1.07
Inability of the C3a anaphylatoxin to promote cellular lysis. Nature (1980) 1.07
Lymphotoxin. A review and analysis. Am J Pathol (1976) 1.05
Mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. J Immunol (1978) 1.05
Active and passive immunity against Pseudomonas aeruginosa with a ribosomal vaccine and antiserum in C3H/HeJ mice. J Immunol (1983) 0.97
Studies on lymphokines: the production of antibody to guinea pig lymphotoxin and its use to distinguish lymphotoxin from migration inhibitory factor and mitogenic factor. J Immunol (1975) 0.94
Role of soluble cytotoxins in cell-mediated immunity. Transplant Proc (1973) 0.92
Activation of macrophages for tumor cell cytotoxicity: identification of indomethacin sensitive and insensitive pathways. J Immunol (1981) 0.91
Purification and characterization of guinea pig lymphotoxin produced by lymph node cells stimulated by phytohemagglutinin. Transplantation (1975) 0.90
Mechanisms of lymphocyte-mediated cytotoxicity. I. The effects of anti-human lymphotoxin antisera on the cytolysis of allogeneic B cell lines by MLC-sensitized human lymphocytes in vitro. J Immunol (1981) 0.87
Cellular cytotoxicity induced by various lectins and mitogens. Transplantation (1978) 0.85
Inhibition of human lymphocyte-mediated mitogen-induced cytotoxicity of murine L-929 cells by heterologous anti-human lymphotoxin antisera in vitro. J Immunol (1977) 0.80
The LT system in experimental animals. III. Physicochemical characteristics and relationships of lymphotoxin (LT) molecules released in vitro by activated lymphoid cells from several animal species. J Immunol (1979) 0.79
The molecular dimensions of guinea pig lymphotoxin. J Immunol (1974) 0.79
Functional heterogeneity among peritoneal macrophages. III. No evidence for the role of arginase in the inhibition of tumor cell growth by supernatants from macrophages or macrophage subpopulation cultures. Cell Immunol (1980) 0.78
Human T-cell mediated cytotoxicity: role of subsets and neutralization of cytotoxicity by anti-alpha-lymphotoxin serum. Cell Immunol (1982) 0.78
Studies on the mechanism of action of guinea pig lymphotoxin. I. Membrane active substances prevent target cell lysis by lymphotoxin. J Immunol (1978) 0.77
A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53
Interactions of the complement system with endotoxic lipopolysaccharide: consumption of each of the six terminal complement components. J Exp Med (1968) 4.19
Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. Science (1968) 3.69
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron (2001) 3.37
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Heat labile opsonins to Pneumococcus. 3. The participation of immunoglobulin and of the alternate pathway of C3 activation. J Immunol (1972) 2.89
Reaction of a cobra venom factor with guinea pig complement and generation of an activity chemotactic for polymorphonuclear leukocytes. Proc Soc Exp Biol Med (1969) 2.76
Mechanism of cytolysis by complement. Proc Natl Acad Sci U S A (1972) 2.71
The biologic activities of guinea pig antibodies. II. Modes of complement interaction with gamma 1 and gamma 2-immunoglobulins. J Immunol (1970) 2.70
Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci U S A (1989) 2.56
A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. J Immunol (1969) 2.54
Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5. J Exp Med (1969) 2.38
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. Immunochemistry (1966) 2.37
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates. Nature (1985) 2.25
Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc Natl Acad Sci U S A (1999) 2.23
Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes. J Immunol (1987) 2.22
A chemotactic factor for mononuclear leukocytes. Proc Soc Exp Biol Med (1971) 2.18
Significance of complement to the mechanism of action of endotoxin. Curr Top Microbiol Immunol (1969) 2.18
The antifungal drug clotrimazole. Acta Crystallogr C (1998) 1.98
Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood (1983) 1.95
An alternate complement pathway: C-3 cleaving activity, not due to C4,2a, on endotoxic lipopolysaccharide after treatment with guinea pig serum; relation to properdin. Proc Natl Acad Sci U S A (1971) 1.89
Kinetic studies of the formation of the properdin system enzymes on zymosan: evidence that nascent C3b controls the rate of assembly. J Immunol (1974) 1.82
Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res (1998) 1.79
Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. J Exp Med (1996) 1.75
Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes. Cell (1982) 1.73
Studies of complement complex C5b,6 eluted from--EAC-6: reaction of C5b,6 with EAC4b,3b and evidence on the role of C2a and C3b in the activation of C5. J Immunol (1974) 1.73
The role of immunoglobulin in the interaction of pneumococci and the properdin pathway: evidence for its specificity and lack of requirement for the Fc portion of the molecule. J Immunol (1974) 1.73
Increased ion permeability of planar lipid bilayer membranes after treatment with the C5b-9 cytolytic attack mechanism of complement. Proc Natl Acad Sci U S A (1976) 1.69
Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor. J Biol Chem (1988) 1.66
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature (1997) 1.66
On the mechanism of cytolysis by complement: evidence on insertion of C5b and C7 subunits of the C5b,6,7 complex into phospholipid bilayers of erythrocyte membranes. Proc Natl Acad Sci U S A (1975) 1.57
Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases. Immunity (1997) 1.55
The fixation of guinea pig complement by gamma 1 and gamma 2 immunoglobulins. J Immunol (1969) 1.52
Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J Immunol (1995) 1.50
Regulation of mitochondrial biogenesis: enzymatic changes in cytochrome-deficient yeast mutants requiring delta-aminolevulinic acid. J Biol Chem (1975) 1.48
Frequency dependence of impedances at the acupuncture point Quze (PC3). IEEE Eng Med Biol Mag (2002) 1.46
Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation. J Clin Invest (2001) 1.46
Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus. Mol Cell Biol (1992) 1.46
Identification of an endotoxin and IFN-inducible cDNA: possible identification of a novel protein family. J Leukoc Biol (1995) 1.45
Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol Cell Biol (1997) 1.42
Antibody-complement complexes. Science (1965) 1.42
Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells. Proc Natl Acad Sci U S A (1992) 1.42
On the mechanism of cell membrane damage by complement: evidence on insertion of polypeptide chains from C8 and C9 into the lipid bilayer of erythrocytes. J Immunol (1977) 1.41
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. Immunochemistry (1966) 1.41
Synthesis of the ninth component of complement by a clonal strain of rat hepatoma cells. J Immunol (1970) 1.38
The role of C3 as an opsonin in the early stages of infection. Proc Soc Exp Biol Med (1975) 1.38
Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2. J Biol Chem (2000) 1.35
Cytolysis of nucleated cells by complement: cell death displays multi-hit characteristics. Proc Natl Acad Sci U S A (1983) 1.35
On the mechanism of membrane damage by C: exposure of hydrophobic sites on activated C proteins. J Immunol (1977) 1.35
The fifth component of the guinea pig complement system. II. Mechanism of SAC1,4,2,3,5b formation and C5 consumption by EAC1,4,2,3. J Immunol (1971) 1.34
Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system. J Exp Med (1975) 1.34
Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J Immunol (1994) 1.34
Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones. Cell (1986) 1.32
Elimination of complement channels from the plasma membranes of U937, a nucleated mammalian cell line: temperature dependence of the elimination rate. J Immunol (1983) 1.30
Transmembrane channel formation by complement: functional analysis of the number of C5b6, C7, C8, and C9 molecules required for a single channel. Proc Natl Acad Sci U S A (1982) 1.29
Antibody-mediated suppression of grafted lymphoma cells. I. Participation of a host factor(s) other than complement. Proc Soc Exp Biol Med (1972) 1.29
C3 split products inhibit the binding of antigen-antibody-complement complexes to B lymphocytes. J Immunol (1973) 1.28
Consequences of cell membrane attack by complement: release of arachidonate and formation of inflammatory derivatives. Proc Natl Acad Sci U S A (1983) 1.27
The reaction of zymosan with the properdin system: isolation of purified factor D from guinea pig serum and study of its reaction characteristics. J Immunol (1974) 1.24
Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation. J Immunol (1988) 1.24
The antimorphic nature of the Tc allele at the mouse T locus. Genetics (1988) 1.24
A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene (1995) 1.23
Inhibition of guinea pig C'2 by rabbit antibody. Quantitative measurement of inhibition, discrimination between immune inhibition and complement fixation, specificity of inhibition and demonstration of uptake of C'2 by EAC'1a,4. Immunochemistry (1965) 1.23
PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nat Neurosci (2001) 1.22
A specific method for purification of the second component of guinea pig complement and a chemical evaluation of the one-hit theory. J Immunol (1970) 1.21
Catalysis of C'2 fixation by C'la. Reaction kinetics, competitive inhibition by TAMe, and transferase hypothesis of the enzymatic action of C'la on C'2, one of its natural substrates. Immunochemistry (1965) 1.20
Inversion in the H-2 complex of t-haplotypes in mice. Nature (1984) 1.19
The fifth component of the guinea pig complement system. 3. Dissociation and transfer of C5b, and the probable site of C5b fixation. J Immunol (1971) 1.18
Presidential address to the American Association of Immunologists, delivered in Chicago, Illinois, April 6, 1977. Mechanism of cytolysis by lymphocytes: A comparison with complement. J Immunol (1977) 1.17
The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones. J Immunol (1985) 1.17
Life-span and size of the trans-membrane channel formed by large doses of complement. J Immunol (1980) 1.16
The third component of the guinea pig complement system. I. Purification and characterization. Biochemistry (1968) 1.16
Lymphocyte-activating factor. I. Generation and physicochemical characterization. J Immunol (1978) 1.12
The kinetics of release of 86rubidium and hemoglobin from erythrocytes damaged by antibody and complement. Immunochemistry (1969) 1.12
A novel function of IL-12p40 as a chemotactic molecule for macrophages. J Immunol (1999) 1.12
Natural immunity to bacterial infections: the relation of complement to heat-labile opsonins. Proc Natl Acad Sci U S A (1969) 1.10
Foregut duplication cyst of the stomach. Pathol Int (2000) 1.10
Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for two pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells. Cell Immunol (1976) 1.09
Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. Learn Mem (1999) 1.09
Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc Natl Acad Sci U S A (1998) 1.09
Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability. J Biol Chem (1994) 1.09
Immunologically mediated membrane damage: the mechanism of complement action and the similarity of lymphocyte-mediated cytoxicity. Immunochemistry (1978) 1.08
Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel. Mol Cell Neurosci (2001) 1.08
Mechanism of macrophage-mediated cytotoxicity: production of a soluble cytotoxic factor. J Immunol (1983) 1.07