Published in Nature on March 29, 1969
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Purification of large quantities of influenza virus by density gradient centrifugation. J Virol (1967) 3.84
Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector. Proc Natl Acad Sci U S A (1981) 3.38
Australia antigen: large-scale purification from human serum and biochemical studies of its proteins. J Virol (1971) 3.28
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An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol (1982) 2.94
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Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure. N Engl J Med (1976) 2.67
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Analytical techniques for cell fractions. XXI. Two-dimensional analysis of serum and tissue proteins: multiple isoelectric focusing. Anal Biochem (1978) 2.65
Immunochemical identification of viral and nonviral proteins of the respiratory syncytial virus virion. Infect Immun (1982) 2.61
The hepatitis B virus-associated delta antigen: isolation from liver, development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen. J Immunol (1980) 2.57
Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA. J Virol (1995) 2.54
Separation of subcellular components and viruses by combined rate- and isopycnic-zonal centrifugation. Natl Cancer Inst Monogr (1966) 2.50
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K-series centrifuges. I. Development of the K-II continuous-sample-flow-with-banding centrifuge system for vaccine purification. Anal Biochem (1969) 2.18
Epidemiology of HBV-associated delta agent: geographical distribution of anti-delta and prevalence in polytransfused HBsAg carriers. Lancet (1980) 2.17
Analytical techniques for cell fractions. XXII. Two-dimensional analysis of serum and tissue proteins: multiple gradient-slab gel electrophoresis. Anal Biochem (1978) 2.16
Demonstration of subpopulations of Dane particles. J Virol (1976) 2.14
Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication. Antiviral Res (1992) 2.08
Radioimmunoassay for the detection of the core of the Dane particle and antibody to it. Intervirology (1974) 2.02
Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees. Proc Natl Acad Sci U S A (1983) 2.00
Analytical techniques for cell fractions. V. Characteristics of the B-XIV and B-XV zonal centrifuge rotors. Anal Biochem (1967) 1.99
Core antigen and antibody in woodchucks after infection with woodchuck hepatitis virus. J Virol (1984) 1.97
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Viral hepatitis, type B, DNA polymerase activity and antibody to hepatitis B core antigen. N Engl J Med (1974) 1.92
Structural requirements for RNA editing in hepatitis delta virus: evidence for a uridine-to-cytidine editing mechanism. Proc Natl Acad Sci U S A (1992) 1.87
Monoclonal antibodies to respiratory syncytial virus: detection of virus neutralization and other antigen-antibody systems using infected human and murine cells. J Virol Methods (1981) 1.78
Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-r sera in rabbits. J Immunol (1975) 1.75
Density in cesium chloride of the 27 nm "8FIIa" particle associated with acute infectious nonbacterial gastroenteritis: determination by ultra-centrifugation and immune electron microscopy. Proc Soc Exp Biol Med (1973) 1.73
Separation of Treponema pallidum from tissue substances by continuous-flow zonal centrifugation. Appl Microbiol (1972) 1.72
Proteins of hepatitis B surface antigen. J Virol (1977) 1.71
Woodchuck hepatitis and hepatocellular carcinoma: correlation of histologic with virologic observations. Hepatology (1981) 1.67
The stabilization and purification of respiratory syncytial virus using MgSO4. Virology (1980) 1.63
Non-specificity of anti-HCV test for seroepidemiological analysis. Lancet (1990) 1.62
Preparation and characterization of complement-fixing hepatitis-associated antigen and antiserum. J Infect Dis (1970) 1.62
Proteins of human urine. I. Concentration and analysis by two-dimensional electrophoresis. Clin Chem (1979) 1.61
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The development of Balb/c cells persistently infected with respiratory syncytial virus: presence of ribonucleoprotein on the cell surface. Proc Soc Exp Biol Med (1981) 1.56
Improved continuous flow centrifugation with banding. Nature (1966) 1.53
Immunochemistry of hepatitis B surface antigen (HBsAg): preparation and characterization of antibodies to the constituent polypeptides. J Immunol (1975) 1.52
The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host. J Virol (1992) 1.52
The delta agent: HBsAg particles with delta antigen and RNA in the serum of an HBV carrier. Hepatology (1981) 1.47
Enzyme-linked immunosorbent assay for detection of antibody to the hepatitis B surface antigen-associated delta antigen. J Clin Microbiol (1981) 1.47
Cloned fragment of the hepatitis delta virus RNA genome: sequence and diagnostic application. Science (1986) 1.46
A case-control study of Nocardia mastitis in Ontario dairy herds. Can Vet J (1990) 1.46
Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells. J Immunol (1970) 1.45
Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults. Gastroenterology (1987) 1.44
Hepatitis B subunit vaccine: a preliminary report of safety and efficacy tests in chimpanzees. Am J Med Sci (1977) 1.43
Production of monoclonal antibodies against hepatitis B surface antigen (HBsAg) by somatic cell hybrids. J Virol Methods (1980) 1.43
Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis. J Virol (1986) 1.43
Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host. Proc Natl Acad Sci U S A (1989) 1.41
Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections. Hepatology (1989) 1.39
Successful passive and active immunization of cynomolgus monkeys against hepatitis E. Proc Natl Acad Sci U S A (1994) 1.38
Cancer, differentiation and embryonic antigens: some central problems. Adv Cancer Res (1974) 1.38
Continuous-flow centrifugation combined with isopycnic banding: rotors B-8 and B-IX. Natl Cancer Inst Monogr (1966) 1.38
Lymphoid cells in the spleens of woodchuck hepatitis virus-infected woodchucks are a site of active viral replication. J Virol (1987) 1.36
Inactivated whole-virus vaccine derived from a proviral DNA clone of simian immunodeficiency virus induces high levels of neutralizing antibodies and confers protection against heterologous challenge. Proc Natl Acad Sci U S A (1992) 1.35
Biochemical characterization of Australia antigen. Evidence for defective particles of hepatitis B virus. Am J Pathol (1975) 1.35
Properties of delta-associated ribonucleic acid. Prog Clin Biol Res (1983) 1.34
An evaluation of the B-V (continuous-flow) and B-IV (density gradient) rotors by use of live polio virus. Natl Cancer Inst Monogr (1966) 1.32
A human monoclonal antibody that recognizes viral polypeptides and in vitro translation products of the genome of the hepatitis D virus. J Infect Dis (1987) 1.32
Measures of herd health and productivity in Ontario cow-calf herds. Can Vet J (1991) 1.32
Use of zonal ultracentrifuge systems for biophysical studies of rhinoviruses. J Virol (1968) 1.32
The isoform-specific regulation of apoptosis by protein kinase C. Cell Mol Life Sci (2003) 1.32
Classification of hybridomas to respiratory syncytial virus glycoproteins. Proc Soc Exp Biol Med (1982) 1.32
The TYCHO system for computer analysis of two-dimensional gel electrophoresis patterns. Clin Chem (1981) 1.31
An ultraviolet-sensitive RNA structural element in a viroid-like domain of the hepatitis delta virus. Science (1989) 1.31
The demonstration of subtype (D or Y)-specific determinants on the surface of the presumed hepatitis B virus. J Immunol (1977) 1.29
Survival in trisomy 18. Life tables for use in genetic counselling and clinical paediatrics. Clin Genet (1985) 1.28
Hepatitis B vaccines. On the threshold. Am J Clin Pathol (1978) 1.28
The design and operation of the B-IV zonal centrifuge system. Natl Cancer Inst Monogr (1966) 1.28
Lipid class and fatty acid composition of rat liver plasma membranes isolated by zonal centrifugation. Biochemistry (1968) 1.28
DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc Natl Acad Sci U S A (1996) 1.28
Buoyant density of the hepatitis A virus-like particle in cesium chloride. J Virol (1974) 1.27
Characterization of antibodies to the structural polypeptides of HGSAg: evidence for subtype-specific determinants. J Immunol (1976) 1.27
Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection. Hepatology (2000) 1.27
Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. Hepatology (1998) 1.26
Natural and experimental infection of woodchucks with woodchuck hepatitis virus, as measured by new, specific assays for woodchuck surface antigen and antibody. J Clin Microbiol (1982) 1.26
Hepatitis B virus (HBV)/hepatitis D virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon basin: the roles of HDV genotype III and HBV genotype F. J Infect Dis (1996) 1.26
Hepatitis delta virus (HDV) and woodchuck hepatitis virus (WHV) nucleic acids in tissues of HDV-infected chronic WHV carrier woodchucks. J Virol (1989) 1.26
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Geographic distribution and genetic variability of hepatitis delta virus genotype I. Virology (1997) 1.22
Intrahepatic markers of hepatitis delta virus infection: a study by in situ hybridization. Hepatology (1989) 1.22
Hepatitis B virus infection in the acquired immunodeficiency syndrome. Ann Intern Med (1984) 1.22
Transmission of hepatitis B to chimpanzees by hepatitis B surface antigen-positive saliva and semen. Infect Immun (1977) 1.22