Published in J Am Chem Soc on April 09, 1969
The synthesis and enzymatic polymerization of nucleotides containing mercury: potential tools for nucleic acid sequencing and structural analysis. Proc Natl Acad Sci U S A (1973) 2.02
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs. PLoS One (2016) 1.38
Total synthesis of certain 2-, 6-mono- and 2,6-disubstituted-tubercidin derivatives. Synthesis of tubercidin via the sodium salt glycosylation procedure. Nucleic Acids Res (1984) 0.86
Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells. ChemMedChem (2014) 0.77
Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors. Bioorg Med Chem Lett (2013) 0.75
Synthesis of 8-(1,2,3-triazol-1-yl)-7-deazapurine nucleosides by azide-alkyne click reactions and direct C-H bond functionalization. Tetrahedron Lett (2016) 0.75
Purine nucleosides. XIV. Unsaturated furanosyl adenine nucleosides prepared via base-catalyzed elimination reactions of 2'-deoxyadenosine derivatives. J Am Chem Soc (1966) 57.26
Purine nucleosides. XII. The preparation of 2',3'-dideoxyadenosine, 2',5'-dideoxyadenosine, and 2',3',5'-trideoxyadenosine from 2'-deoxyadenosine. Biochemistry (1966) 56.84
Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science (1972) 7.74
Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc Natl Acad Sci U S A (1973) 4.36
Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides. J Med Chem (1972) 4.12
In vitro effect of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses. Antimicrob Agents Chemother (1973) 4.04
9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci U S A (1983) 3.03
Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product. J Virol (1998) 2.53
Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56. J Virol (1998) 2.41
Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett (2000) 2.10
Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides. J Med Chem (2000) 2.07
Suppression by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) of influenza virus-induced infections in mice. Antimicrob Agents Chemother (1973) 1.87
Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG). Biochem Biophys Res Commun (1982) 1.83
The relationship between the metabolism of ribavirin and its proposed mechanism of action. Ann N Y Acad Sci (1977) 1.79
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem (1999) 1.65
Chemical synthesis and biological activity of 8-substituted adenosine 3',5'-cyclic monophosphate derivatives. Biochemistry (1971) 1.63
Purine nucleosides. XI. The synthesis of 2'-deoxy-9-alpha- and-beta-D-ribofuranosylpurines and the correlation of their anomeric structure with proton magnetic resonance spectra. J Am Chem Soc (1965) 1.63
Identification of HIV vaccine candidate peptides by screening random phage epitope libraries. Virology (1993) 1.60
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives. J Med Chem (1983) 1.57
Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles. J Med Chem (2000) 1.54
Effect of 1-beta-D-ribofuranosyl1-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) on herpes and vaccinia keratitis and encephalitis in laboratory animals. Antimicrob Agents Chemother (1973) 1.42
Ivermectin, a new broad-spectrum antiparasitic agent. J Med Chem (1980) 1.42
Growth inhibition and induction of cellular differentiation of human myeloid leukemia cells in culture by carbamoyl congeners of ribavirin. J Med Chem (1990) 1.37
Benzimidazole nucleosides, nucleotides, and related derivatives. Chem Rev (1970) 1.35
Carbon-13 magnetic resonance. XVII. Pyrimidine and purine nucleosides. J Am Chem Soc (1970) 1.34
Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent. Antimicrob Agents Chemother (1983) 1.33
Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antimicrob Agents Chemother (1987) 1.30
Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc Natl Acad Sci U S A (1980) 1.26
Effect of selenazofurin on influenza A and B virus infections of mice. Antiviral Res (1986) 1.25
A comparison of the antiviral agents 2'-nor-2'-deoxyguanosine and acyclovir: uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates. Biochem Biophys Res Commun (1983) 1.24
Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer Res (1985) 1.22
Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts. Science (1981) 1.21
Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. J Med Chem (1998) 1.21
Synthesis and antiherpetic activity of (S)-, (R)-, and (+/-)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine. J Med Chem (1985) 1.18
Synthesis and biochemical studies of various 8-substituted derivatives of guanosine 3',5'-cyclic phosphate, inosine 3',5'-cyclic phosphate, and xanthosine 3',5'-cyclic phosphate. Biochemistry (1973) 1.18
Optical rotatory dispersion, circular dichroism, and absorption studies on some naturally occurring ribonucleosides and related derivatives. Proc Natl Acad Sci U S A (1967) 1.17
Inhibition of RNA virus replication in vitro by 3-deazacytidine and 3-deazauridine. Proc Soc Exp Biol Med (1972) 1.16
Ribavirin: an antiviral agent. Pharmacol Ther (1979) 1.16
Nuclear magnetic resonance determination of syn and anti conformations in pyrimidine nucleosides. J Am Chem Soc (1971) 1.14
2' Derivatives of guanosine and inosine cyclic 3',5'-phosphates. Synthesis, enzymic activity, and the effect of 8-substituents. Biochemistry (1976) 1.13
The chemistry and biological properties of nucleotides related to nucleoside 3',5'-cyclic phosphates. Adv Cyclic Nucleotide Res (1973) 1.13
Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles. J Med Chem (1998) 1.12
Purine nucleosides. XV. The synthesis of 8-aminoand 8-substituted aminopurine nucleosides. J Org Chem (1967) 1.11
Activity of purine analogs against Leishmania tropica within human macrophages in vitro. Antimicrob Agents Chemother (1983) 1.09
Synthesis of 2-amino-5-cyano-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one. An important precursor for the synthesis of nucleoside Q and Q. J Am Chem Soc (1976) 1.09
2'-Nor-cGMP: a seco-cyclic nucleotide with powerful anti-DNA-viral activity. Biochem Biophys Res Commun (1985) 1.08
Carbon-13 nuclear magnetic resonance: naturally occurring nucleosides. Proc Natl Acad Sci U S A (1970) 1.08
Purine nucleosides. XVI. Synthesis of the naturally occurring 2 -O-methylpurine ribonucleosides and related derivatives. J Am Chem Soc (1966) 1.07
Purine nucleosides. 8. The synthesis of 2-fluoro- and 2-chloroinosine and certain derived purine nucleosides. J Org Chem (1966) 1.05
Circular dichroism of nucleoside derivatives. IV. Uracil derivatives. J Am Chem Soc (1969) 1.04
Optical and conformational properties of the 7-(beta-D-ribofuranosyl)purines. Biopolymers (1972) 1.03
Pseudomonas exotoxin A: toxoid preparation by photoaffinity inactivation. Proc Natl Acad Sci U S A (1983) 1.02
Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity. Antimicrob Agents Chemother (1987) 1.02
tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1. Biochemistry (1995) 1.02
Efficacy of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate in therapy of equine abortion virus-induced hepatitis in hamsters. Antimicrob Agents Chemother (1975) 1.01
Circular dichroism of nucleoside derivatives. IX. Vicinal effects on the circular dichroism of pyrimidine nucleosides. J Am Chem Soc (1970) 1.01
Carbon-13 magnetic resonance. XXVI. A quantitative determination of the tautomeric populations of certain purines. J Am Chem Soc (1975) 1.01
Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides. J Med Chem (1984) 1.01
Synthesis and antimicrobial activity of some novel heterocycles. Azolo-as-triazines. J Med Chem (1976) 1.01
Immunogenicity of conjugate vaccines consisting of pneumococcal capsular polysaccharide types 6B, 14, 19F, and 23F and a meningococcal outer membrane protein complex. Infect Immun (1992) 1.00
Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus. Antimicrob Agents Chemother (1991) 1.00
Antiviral activity of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid. Antimicrob Agents Chemother (1977) 1.00
Circular dichroism of nucleoside derivatives. V. Cytosine derivatives. J Am Chem Soc (1969) 1.00
Synthesis and antischistosomal activity of certain pyrazolo[1,5-a]pyrimidines. J Med Chem (1981) 0.99
Synthesis and antiviral activity of certain 5'-monophosphates of 9-D-arabinofuranosyladenine and 9-D-arabinofuranosylhypoxanthine. J Med Chem (1975) 0.99
Antiviral mechanisms of action. Annu Rev Pharmacol Toxicol (1980) 0.99
The phosphorylation of ribavirin by deoxyadenosine kinase from rat liver. Differentiation between adenosine and deoxyadenosine kinase. Biochemistry (1974) 0.99
Effect of 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate on genital lesions and encephalitis induced by Herpesvirus hominis type 2 in female mice. J Infect Dis (1976) 0.98
A general synthesis of 4-substituted 1-(beta-D-ribofuranosyl) imidazo-[4, 5-c] pyridines. J Chem Soc Perkin 1 (1975) 0.98
Synthesis and antiviral activity of 1,2,4-triazole-3-thiocarboxamide and 1,2,4-triazole-3-carboxamidine ribonucleosides. J Med Chem (1973) 0.98
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193). Biochem Pharmacol (1982) 0.98
Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses. Antimicrob Agents Chemother (1984) 0.98
Pyrimidine nucleosides. I. The synthesis of 6-methylcytidine, 6-methyluridine, and related 6-methylpyrimidine nucleosides. J Org Chem (1968) 0.97
Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. Antimicrob Agents Chemother (1989) 0.97
Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-beta-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents. J Med Chem (1990) 0.96
Vicinal effects on the optical activity of some adenine nucleosides. J Phys Chem (1968) 0.96
Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides. Proc Natl Acad Sci U S A (1976) 0.96
Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines. J Med Chem (1993) 0.96
Synthesis and evaluation of a series of 2'-deoxy analogues of the antiviral agent 5,6-dichloro-2-isopropylamino-1-(beta-L-ribofuranosyl)-1H-benzimidazole (1263W94). Nucleosides Nucleotides Nucleic Acids (2000) 0.96
Synthesis and antifungal properties of certain 7-alkylaminopyrazolo[1,5-a]pyrimidines. J Med Chem (1977) 0.96
2-beta-D-Ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases. J Med Chem (1982) 0.94
Toxoids of Pseudomonas aeruginosa exotoxin-A: photoaffinity inactivation of purified toxin and purified toxin derivatives. Infect Immun (1984) 0.94
Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth. FEBS Lett (1987) 0.94
Synthesis of 3-deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors. J Am Chem Soc (1976) 0.94
Synthesis and antiviral evaluation of certain disubstituted benzimidazole ribonucleosides. J Med Chem (1996) 0.93
Anti-DNA virus activity of the 5'-nucleotide and 3',5'-cyclic nucleotide of 9-beta-D-arabinofuranosyladenine. Chemotherapy (1973) 0.93
Inhibition of purine beta-ribosidases by certain urine nucleosides and nucleoside antibiotics. Arch Biochem Biophys (1968) 0.93
Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells. Br J Haematol (1996) 0.93
Synthesis and biological activity of some 2' derivatives of adenosine 3',5'-cyclic phosphate. Biochemistry (1973) 0.92
Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. J Med Chem (1997) 0.92
Calf intestine adenosine deaminase. Substrate specificity. Biochemistry (1970) 0.92
Synthesis and antiviral and enzymatic studies of certain 3-deazaguanines and their imidazolecarboxamide precursors. J Med Chem (1978) 0.92
Azapurine nucleosides. 2. Synthesis and antiviral activity of 7-amino-3- -D-arabinofuranosyl-v-triazolo (4,5-d)pyrimidine and related nucleosides. J Med Chem (1972) 0.91