Published in Nature on October 04, 1969
Immunity in cutaneous leishmaniasis of the guinea-pig. Clin Exp Immunol (1970) 4.50
Lymphocyte-mediated modification of blood-derived macrophage function in vitro; inhibition of growth of intracellular mycobacteria with lymphokines. Clin Exp Immunol (1971) 3.74
Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes. Clin Exp Immunol (1971) 3.69
Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol (1973) 3.33
Mycobacterium. Bacteriol Rev (1977) 3.20
Lymphokine stimulation of collagen accumulation. J Clin Invest (1976) 2.94
Preparation and characterization of the plasma membrane of pig lymphocytes. Biochem J (1970) 2.71
Cytokines in context. J Cell Biol (1991) 2.65
The biological activities of soluble lymphocyte products. Clin Exp Immunol (1972) 2.58
Experimental cutaneous leishmaniasis. II. Effects of immunosuppression and antigenic competition on the course of infection with Leishmania enriettii in the guinea-pig. Clin Exp Immunol (1972) 2.15
'Lymphokines': molecular mediators of cellular immune responses in animals and man. Proc R Soc Med (1970) 2.13
Acute inflammation. A review. Am J Pathol (1977) 2.06
The role of immunoglobulins in lymphocyte-mediated cell damage, in vitro. II. The mechanism of target cell damage by lymphoid cells from immunized rats. Immunology (1970) 1.96
Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol (1984) 1.95
Role of lymphocyte activation products (LAP) in cell-mediated immunity. II. Effects of lymphocyte activation products on lymph node architecture and evidence for peripheral release of LAP following antigenic stimulation. Clin Exp Immunol (1972) 1.94
Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells. Proc Natl Acad Sci U S A (1986) 1.91
Cell cooperation in the immune response. Clin Exp Immunol (1971) 1.91
Cell-mediated immunity in mice vaccinated against malaria. Clin Exp Immunol (1978) 1.82
Concomitant synthesis, in separate cells, of non-reactive immunoglobulins and specific antibodies after immunization with tobacco mosaic virus. Immunology (1970) 1.61
In vitro studies of cell-mediated immunity. I. Induction of lymphocyte transformation by a soluble "mitogenic" factor derived from interaction of sensitized guinea-pig lymphoid cells with specific antigen. Immunology (1970) 1.60
Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP. Clin Exp Immunol (1972) 1.51
Immunological control of macrophage proliferation in vivo. Infect Immun (1973) 1.46
Identification by density separation of antigen-specific surface receptors on the progenitors of antibody-producing cells. Immunology (1971) 1.35
Relationship of antimicrobial cellular immunity to delayed hypersensitivity in Listeriosis. Infect Immun (1974) 1.34
Immunocompetent cells in resistance to bacterial infections. Bacteriol Rev (1976) 1.31
Contact sensitivity in the pig. Immunology (1973) 1.30
Cytokines in radiobiological responses: a review. Radiat Res (2012) 1.29
Growth of Mycobacterium lepraemurium in nonstimulated and stimulated mouse peritoneal-derived and bone marrrow-derived macrophages in vitro. Infect Immun (1978) 1.23
Sequential cell-mediated immune responses in experimental gingivitis in man. Clin Exp Immunol (1974) 1.22
Immunological aspects of clinical leishmaniasis. Proc R Soc Med (1970) 1.20
Cellular response to alpha-gliadin in untreated coeliac disease. Gut (1982) 1.18
The effect of T and B lymphocyte depletion on the protection of mice vaccinated with a Gal E mutant of Salmonella typhimurium. Br J Exp Pathol (1976) 1.17
Production of colony-stimulating factor in mixed leucocyte cultures. Immunology (1974) 1.16
Production of macrophage migration inhibition factors by virus-infected cell cultures. Infect Immun (1973) 1.15
Cellular immunity in congestive cardiomyopathy. The normal cellular immune response. Br Heart J (1985) 1.15
Cytokines. 3. Cytokines in asthma. Thorax (1993) 1.12
In vitro delayed hypersensitivity in normal and hyporeactive patients. Immunology (1971) 1.11
The production of lymphocyte mitogenic factor and migration-inhibition factor by antigen-stimulated lymphocytes of subjects with grass pollen allergy. Clin Exp Immunol (1971) 1.09
Lymphocyte transformation in vitro. IV. Recruitment in antigen-stimulated cultures. Clin Exp Immunol (1971) 1.08
A study of histamine release from human basophils and lung mast cells by products of lymphocyte stimulation. Agents Actions (1983) 1.06
Lymphocyte--target cell interaction in vitro. Ultrastructural and cinematographic studies. Am J Pathol (1970) 1.06
Germinal centre proliferation in response to mitogenic lymphokines. Clin Exp Immunol (1974) 1.05
In vitro demonstration of microbial cellular hypersensitivity in man. Proc R Soc Med (1970) 1.04
In vitro correlates of delayed hypersensitivity in man: ambiguity of polymorphonuclear neutrophils as indicator cells in leukocyte migration test. Infect Immun (1973) 1.04
Expulsion of Nippostrongylus brasiliensis from the intestine of rats. Collaboration between humoral and cellular components of the immune response. Immunology (1973) 1.03
Macrophage migration inhibition induced by tissue antigen in guinea-pigs. Clin Exp Immunol (1971) 1.02
Inhibition of guinea-pig lymphocyte activation by histamine and histamine analogues. Br J Pharmacol (1979) 1.00
Macrophages and cytokines in the early defence against herpes simplex virus. Virol J (2005) 1.00
Albumin associated with purified pig lymphocyte plasma membrane. Biochem J (1980) 1.00
Studies of an inhibitor of DNA synthesis and a nonspecific mitogen elaborated by human lymphoblasts. Am J Pathol (1970) 0.97
Inhibition of in vitro lymphocyte blastogenesis by inhibitor produced by cultured human lymphoblasts. Clin Exp Immunol (1974) 0.94
Experimental myocarditis: in vitro and in vivo studies of lymphocytes sensitized to heart extracts and group A streptococci. Immunology (1971) 0.93
Mechanisms of lymphocyte-induced cell and tissue destruction in vitro. Am J Pathol (1970) 0.92
Cytotoxicity of immune guinea-pig cells. I. Investigation of a correlation with delayed hypersensitivity and a comparison of cytotoxicity of spleen, lymph node and peritoneal exudate cells. Immunology (1972) 0.91
The enhancement of eosinophil function by lymphocyte supernatants. Clin Exp Immunol (1983) 0.90
Detachment of L cells in the presence of normal mouse spleen cells in vitro; a quantitative study. Clin Exp Immunol (1970) 0.89
Cytokine research: the interferon paradigm. J Clin Pathol (1997) 0.89
Cellular immunity of mice to Leishmania donovani in vitro: lymphokine-mediated killing of intracellular parasites in macrophages. Proc Natl Acad Sci U S A (1981) 0.88
Immunosuppressive factors released by transforming lymphocytes in the delayed hypersensitivity skin response to tuberculin. Immunology (1973) 0.87
Alteratons in RNA synthesis in lymphotoxin-treated target cells. Am J Pathol (1975) 0.87
Modulation of the effect of histamine-releasing lymphokine on human basophils. Agents Actions (1984) 0.86
Blood-nerve barrier studies in experimental allergic neuritis. Acta Neuropathol (1985) 0.86
In vitro tests for cell-mediated immunity in thyroid disease. Proc R Soc Med (1974) 0.83
Macrophage cytophilic antibody in mice: mechanism of action of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells. Infect Immun (1971) 0.82
Production of mitogenic factor by concanavalin A stimulated lymphocytes. Clin Exp Immunol (1972) 0.81
An analysis of the effects of skin reactive factor released from lymphoid cells by concanavalin A in vivo. Am J Pathol (1971) 0.81
Determination of lymphokine induced histamine release in vitro [proceedings]. Br J Pharmacol (1980) 0.81
Sensitivity of non-human cells to human lymphocyte 'proliferation inhibitory factor' (PIF) in vitro. Clin Exp Immunol (1973) 0.81
Cytotoxic effects of activated lymphocytes and their supernatants. Clin Exp Immunol (1973) 0.80
Cells binding the antigen keyhole limpet haemocyanin in the peripheral blood and in the lymphocyte cultures of non-immune and immunized human subjects. Clin Exp Immunol (1974) 0.80
Migration inhibition factor-like activity in inflammatory synovial fluids might be due to proteases. Clin Exp Immunol (1976) 0.79
The effect of lymphocytes from sufferers from recurrent aphthous ulceration upon colon cells in tissue culture. Gut (1972) 0.79
Lymphocyte tissue culture studies on human heart transplant recipients. I. Screening recipients for serum factors which inhibit the mixed lymphocyte reaction. Ann Surg (1974) 0.79
A comparison of the hematogenous cell infiltrate evoked by lymphokine injection with that of delayed hypersensitivity reactions. Am J Pathol (1978) 0.79
Cell-mediated hypersensitivity to Pasteurella hemolytica in normal and cold-stressed mice. Can J Comp Med (1974) 0.79
Specific inactivation of sensitized lymphocytes in vitro using antigens labelled with astatine-211. Clin Exp Immunol (1973) 0.76
The meteorology of cytokine storms, and the clinical usefulness of this knowledge. Semin Immunopathol (2017) 0.76
Growing points of immunology. Postgrad Med J (1970) 0.75
Lymphokines: an increasing repertoire. Br Med J (1978) 0.75
Proceedings: Mitogenic and inflammatory activities produced by antigen activation of guinea-pig lymphocytes. Br J Pharmacol (1972) 0.75
Cartilage antigen dependent lymphotoxin release. Immunopathological significance in articular destructive disorders. Ann Rheum Dis (1974) 0.75
Lysosomal enzyme changes in mouse spleen cells after antigenic stimulation. Immunology (1971) 0.75
[Skin tests with phytohaemagglutinin (PHA). Correlation with other parameters of cell-mediated immunity (author's transl)]. Arch Dermatol Res (1976) 0.75
Mediation of macrophage effector function by lymphokine. Agents Actions (1976) 0.75
Tumour growth inhibition in mice by glycosylated recombinant human lymphotoxin: analysis of tumour-regional mononuclear cells involved with its action. Br J Cancer (1993) 0.75
Unified concept of cell-mediated immune reactions. Br Med J (1970) 0.75
Antigen release from insoluble polymer complexes by lymphocyte cell suspensions. Clin Exp Immunol (1971) 0.75
Modern immunology in clinical paediatrics. Proc R Soc Med (1971) 0.75
The beta-lactamases of gram-negative bacteria and their role in resistance to beta-lactam antibiotics. J Antimicrob Chemother (1976) 18.58
Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med (2001) 7.41
Plasmid-mediated beta-lactamases of Gram-negative bacteria: properties and distribution. J Antimicrob Chemother (1979) 7.39
Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature (1973) 6.34
Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility. J Bacteriol (1976) 5.07
Immunity in cutaneous leishmaniasis of the guinea-pig. Clin Exp Immunol (1970) 4.50
Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J (1978) 4.29
Types of beta-lactamase determined by plasmids in gram-negative bacteria. J Bacteriol (1979) 4.01
Rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic, and serologic study. Arthritis Rheum (1992) 3.92
Identification of beta-lactamases by analytical isoelectric focusing: correlation with bacterial taxonomy. J Gen Microbiol (1976) 3.54
A micro-method for peripheral leucocyte migration in tuberculin sensitivity. J Clin Pathol (1971) 3.45
Control of lymphokine secretion by prostaglandins. Nature (1976) 3.34
Delayed hypersensitivity in the guinea-pig to a protein-hapten conjugate and its relationship to in vitro transformation of lymph node, spleen, thymus and peripheral blood lymphocytes. Immunology (1967) 3.33
Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica. Clin Exp Immunol (1972) 3.08
An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies. Clin Exp Immunol (1982) 3.05
R-factor mediated beta-lactamase production by Haemophilus influenzae. J Med Microbiol (1975) 2.75
Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum (2002) 2.75
The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum (1992) 2.68
The sensitivity and specificity of reduced CD8 lymphocyte levels in the diagnosis of polymyalgia rheumatica/giant cell arteritis. Clin Exp Rheumatol (1994) 2.61
HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci U S A (1989) 2.60
A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide. J Immunol (1990) 2.55
HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. N Engl J Med (1980) 2.52
Carcinoma of the Stomach. Br Med J (1937) 2.34
Acquisition by Escherichia coli of plasmid-borne beta-lactamases normally confined to Pseudomonas spp. Plasmid (1979) 2.32
Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum (1992) 2.31
Properties of the beta-lactamase specified by the Pseudomonas plasmid RPL11. J Bacteriol (1977) 2.29
Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum (1995) 2.25
Experimental cutaneous leishmaniasis. V. Protective immunity in subclinical and self-healing infection in the mouse. Clin Exp Immunol (1976) 2.20
Interleukin 1 in Crohn's disease. Clin Exp Immunol (1987) 2.18
Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin Exp Immunol (1984) 2.17
Experimental cutaneous leishmaniasis. II. Effects of immunosuppression and antigenic competition on the course of infection with Leishmania enriettii in the guinea-pig. Clin Exp Immunol (1972) 2.15
A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism. Lancet (1978) 2.15
Tissue-specific antigens. Adv Immunol (1966) 2.15
'Lymphokines': molecular mediators of cellular immune responses in animals and man. Proc R Soc Med (1970) 2.13
Vasodilatation in the submaxillary gland of the cat. J Physiol (1965) 2.12
The role of the macrophage in delayed hypersensitivity. Br Med Bull (1967) 2.07
The clinical significance of mediators of cellular immunity. Clin Allergy (1971) 2.03
Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis (1993) 2.01
Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids. Clin Exp Immunol (1984) 1.95
Role of lymphocyte activation products (LAP) in cell-mediated immunity. II. Effects of lymphocyte activation products on lymph node architecture and evidence for peripheral release of LAP following antigenic stimulation. Clin Exp Immunol (1972) 1.94
Visceral Pain. Br Med J (1937) 1.89
D-Penicillamine induced toxicity in rheumatoid arthritis: the role of sulphoxidation status and HLA-DR3. J Rheumatol (1984) 1.69
Plasmid-determined beta-lactamase indistinguishable from the chromosomal beta-lactamase of Escherichia coli. J Bacteriol (1976) 1.69
Selective depletion and activation of CD8+ lymphocytes from peripheral blood of patients with polymyalgia rheumatica and giant cell arteritis. Ann Rheum Dis (1989) 1.68
Anti-retinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. Lancet (1982) 1.68
IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol (1983) 1.67
Proceedings: Role of prostaglandins in reactions of cellular immunity. Br J Pharmacol (1974) 1.67
B lymphocyte alloantigens in the study of the genetic basis of rheumatoid arthritis. Ann Rheum Dis (1977) 1.65
Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies. Ann Rheum Dis (1983) 1.64
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. J Immunol (2001) 1.62
In vitro studies of cell-mediated immunity. I. Induction of lymphocyte transformation by a soluble "mitogenic" factor derived from interaction of sensitized guinea-pig lymphoid cells with specific antigen. Immunology (1970) 1.60
Disease activity in rheumatoid arthritis: preliminary report of the Consensus Study Group of the European Workshop for Rheumatology Research. Clin Exp Rheumatol (1993) 1.57
Antibodies to intermediate filaments in polymyalgia rheumatica and giant cell arteritis: a sequential study. Ann Rheum Dis (1987) 1.54
Inflammatory actions of platelet activating factor (Pafacether) in guinea-pig skin. Br J Pharmacol (1983) 1.53
Prostaglandins and lymphokines in arthritis. Prostaglandins (1974) 1.52
Lymphocyte mitogenic factor in man. Nature (1969) 1.51
Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP. Clin Exp Immunol (1972) 1.51
The platelet in asthma. Lancet (1984) 1.50
The therapeutic effects of an engineered human anti-tumour necrosis factor alpha antibody (CDP571) in rheumatoid arthritis. Br J Rheumatol (1995) 1.49
Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group. J Trauma (2003) 1.46
Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma. Lancet (1982) 1.45
Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of anti-asthma drugs. Br J Pharmacol (1990) 1.45
Platelet-activating factor: a possible mediator of the dual response to allergen? Clin Allergy (1984) 1.45
Intramuscular gold decreases cytokine expression and macrophage numbers in the rheumatoid synovial membrane. Ann Rheum Dis (1994) 1.44
Cytokines in human intraocular inflammation. Curr Eye Res (1992) 1.44
The distribution of beta-lactamase genes on plasmids found in Pseudomonas. Plasmid (1979) 1.43
Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol (1996) 1.43
Standardization of the leucocyte migration test. Int Arch Allergy Appl Immunol (1973) 1.39
Interleukin-6 in serum of patients with polymyalgia rheumatica and giant cell arteritis. Br J Rheumatol (1990) 1.38
Antiasthma drugs and airway hyperreactivity. Am Rev Respir Dis (1992) 1.38
Influence of pregnancy on disease activity in a patient with palindromic rheumatism. J Rheumatol (1992) 1.38
ELISA assays for IgM and IgG rheumatoid factors. J Immunol Methods (1982) 1.37
Selective migration of the human helper-inducer memory T cell subset: confirmation by in vivo cellular kinetic studies. Eur J Immunol (1991) 1.34
An in vivo model for studying platelet aggregation and disaggregation. Thromb Haemost (1982) 1.33
Circadian variation in disease activity in rheumatoid arthritis. Br Med J (Clin Res Ed) (1982) 1.30
Human pregnancy serum inhibits interleukin-2 production. Clin Exp Immunol (1984) 1.29
HLA-DRw4 and rheumatoid arthritis. Lancet (1979) 1.29
An evaluation of cusum analysis in asthma. Br J Dis Chest (1980) 1.29
Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome. Hum Immunol (1991) 1.27
Cytokines in proliferative vitreoretinopathy. Eye (Lond) (1991) 1.26
Measurement of rate of extravasation of plasma protein in inflammatory responses in guinea-pig skin using a continuous recording method. Br J Exp Pathol (1974) 1.26
Immunity to malaria. 3. Possible occurrence of a cell-mediated immunity to Plasmodium knowlesi in chronically infected and Freund's complete adjuvant-sensitized monkeys. Exp Parasitol (1970) 1.24
Letter: An anti-inflammatory peptide from bee venom. Nature (1973) 1.23
Histocompatibility antigens in psoriasis, psoriatic arthropathy, and ankylosing spondylitis. Ann Rheum Dis (1983) 1.23
Macrophages on intrauterine contraceptive devices produce prostaglandins. Nature (1975) 1.23
Evidence for the continuous recruitment and activation of T cells into the joints of patients with rheumatoid arthritis. Eur J Immunol (1994) 1.22
Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun (2000) 1.21
Experimental cutaneous leishmaniasis: VI: anergy and allergy in the cellular immune response during non-healing infection in different strains of mice. J Clin Lab Immunol (1978) 1.20
Disease activity and pregnancy associated alpha 2-glycoprotein in rheumatoid arthritis during pregnancy. Br Med J (Clin Res Ed) (1983) 1.20