Published in Proc Soc Exp Biol Med on June 01, 1966
Identification of a putative second T-cell receptor. Nature (1986) 7.90
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annu Rev Biochem (1985) 2.30
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man. Drug Metab Dispos (1978) 1.61
Immunoglobulin subclasses in normal children. Pediatr Res (1979) 1.42
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine. J Med Chem (1980) 1.41
Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci U S A (1998) 1.33
Evidence for a defect in "switch" T cells in patients with immunodeficiency and hyperimmunoglobulinemia M. N Engl J Med (1986) 1.29
Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. Proc Natl Acad Sci U S A (1983) 1.27
Primary immunodeficiency diseases: an update. Clin Exp Immunol (2003) 1.27
Use of nude mouse xenografts as preclinical drug screens: in vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts. Cancer Treat Rep (1987) 1.25
Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels. Ann Oncol (2008) 1.25
Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. J Immunol (1989) 1.21
Identification of a closely linked DNA marker, DXS178, to further refine the X-linked agammaglobulinemia locus. Genomics (1990) 1.21
Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J Clin Oncol (2001) 1.18
Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex. Science (1981) 1.13
A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal. Life Sci (1986) 1.12
Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species. Life Sci (1984) 1.12
Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay. J Infect Dis (1973) 1.09
Allescheria boydii--unique systemic dissemination to thyroid and brain. Can Med Assoc J (1965) 1.06
Stereospecific glucocorticoid binding to subcellular fractions of the sensitive and resistant lymphosarcoma P1798. Nat New Biol (1971) 1.05
Luminescent immobilized enzyme test systems for inorganic pyrophosphate: assays using firefly luciferase and nicotinamide-mononucleotide adenylyl transferase or adenosine-5'-triphosphate sulfurylase. Anal Biochem (1991) 1.05
Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad Sci U S A (1995) 1.04
Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW 301U), a novel lipid-soluble inhibitor of dihydrofolate reductase. Cancer Res (1982) 1.03
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol (2001) 1.01
Micro procedure for determination of pyrophosphate and orthophosphate. Anal Biochem (1970) 0.98
The effect of endotoxin and thorotrast on inducible enzymes in the isolated, perfused rat liver. Biochim Biophys Acta (1969) 0.95
Analysis of folate cofactor levels in tissues using high-performance liquid chromatography. Anal Biochem (1983) 0.94
Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun (1986) 0.94
Glucocorticoid receptors in rat thymocytes. Interactions with the antiglucocorticoid cortexolone and mechanism of its action. J Biol Chem (1974) 0.94
Pseudohypoparathyroidism with osteitis fibrosa cystica: direct demonstration of skeletal responsiveness to parathyroid hormone in cells cultured from bone. J Bone Miner Res (1993) 0.93
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. J Immunol (1990) 0.92
Inhibition of glucose uptake in lymphosarcoma P1798 by cortisol and its relationship to the biosynthesis of deoxyribonucleic acid. J Biol Chem (1970) 0.91
Utilization of dihydroflavin mononucleotide and superoxide anion for the decyclization of L-tryptophan by murine epididymal indoleamine 2,3-dioxygenase. Arch Biochem Biophys (1987) 0.91
Estrogen and progesterone receptors and tamoxifen in malignant melanoma. Cancer Treat Rep (1981) 0.91
Interaction of glucocorticoids and androgens with skeletal muscle. Metabolism (1977) 0.90
High incidence and characterization of glucocorticoid receptors in human malignant melanoma. J Natl Cancer Inst (1981) 0.89
Spermiogenesis in the brush-tailed possum, Trichosurus vulpecula (Marsupialia). The development of the acrosome. Cell Tissue Res (1976) 0.89
Cortexolone: binding to glucocorticoid receptors in rat thymocytes and mechanism of its antiglucocorticoid action. Biochem Biophys Res Commun (1972) 0.89
Specific glucocorticoid binding in human hemopoietic cell lines and neoplastic tissue. Cancer Res (1973) 0.88
Ileal adenocarcinoma in a mild phenotype of abetalipoproteinemia. Clin Genet (2003) 0.87
Nivazol: a glucocorticoid in rats with only hypothalamic-pituitary-adrenal-inhibiting activity in primates. Endocrinology (1984) 0.87
Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase. Biochem Pharmacol (1978) 0.87
Interaction of drugs inhibiting different steps in the synthesis of DNA. Cancer Res (1972) 0.87
Studies on dihydrofolate reductase related to the drug sensitivity of microbial and neoplastic cells. Adv Enzyme Regul (1968) 0.87
Ultrastructural changes in spermatozoa of the brush-tailed possum, Trichosurus vulpecula (Marsupialia), during epididymal transit. Part II: The acrosome. Cell Tissue Res (1976) 0.87
Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists. Mol Pharmacol (1980) 0.86
On the mode of action of 7-deaza-adenosine (tubercidin). Biochim Biophys Acta (1967) 0.85
Effects of casein hydrolysate on the induction and regulation of tyrosine-alpha-ketoglutarate transaminase in rat liver. J Biol Chem (1968) 0.85
Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and RNA and protein metabolism in lymphosarcoma P1798. Cancer Res (1972) 0.85
Cortisol binding in rat skeletal muscle. J Biol Chem (1975) 0.85
Major histocompatibility restriction of antigen recognition by T cells in a recipient of haplotype mismatched human bone marrow transplantation. J Clin Invest (1983) 0.85
Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol. Am J Physiol (1975) 0.84
Possible significance of myofibrillar protease in muscle catabolism. Enzyme activity in dystrophic, tumor-bearing, and glucocorticoid-treated animals. Exp Mol Pathol (1976) 0.84
Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors. Cancer Res (1978) 0.84
Mammalian deoxyuridine 5'-triphosphate pyrophosphatase. Biochim Biophys Acta (1971) 0.84
Anaplastic carcinoma of the thyroid with abnormal circulating iodoprotein: a case simulating subacute thyroiditis. Can Med Assoc J (1966) 0.83
A sensitive high-performance liquid chromatographic-fluorometric assay for dihydrofolate reductase in adult rat brain, using 7,8-dihydrobiopterin as substrate. Anal Biochem (1984) 0.83
Effects of pregnancy on several cortisol-responsive enzymes in rat liver. Am J Physiol (1966) 0.83
Glucocorticoid receptors and mechanism of resistance in the cortisol-sensitive and -resistant lines of lymphosarcoma P1798. Cancer Res (1974) 0.82
Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections. Am J Trop Med Hyg (1984) 0.82
Effect of estrogen on the growth of B-16 melanoma. Surg Forum (1978) 0.82
Quantitative thin-layer chromatography of pyrimethamine and related diaminopyrimidines in body fluids and tissues. J Chromatogr (1975) 0.82
Iodide metabolism in Ontario. Acta Endocrinol (Copenh) (1967) 0.82
Spermatogenesis and synaptonemal complexes of hybrid Petrogale (Marsupialia). J Hered (1996) 0.82
Studies on the antiglucocorticoid action of progesterone in rat thymocytes: early in vitro effects. J Steroid Biochem (1979) 0.82
Human graft versus host disease. J Invest Dermatol (1980) 0.82
Glucocorticoid-binding macromolecules in normal tissues and tumors. Stabilization of the specific binding component. J Biol Chem (1972) 0.81
Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin. Biochem Biophys Res Commun (1984) 0.81
Glucocorticoid-binding macromolecules in rat and mouse thymocytes. J Biol Chem (1973) 0.80
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. J Neurochem (1986) 0.80
Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth. Cancer Res (1979) 0.80
A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798. Biochim Biophys Acta (1970) 0.80
Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate. Endocrinology (1986) 0.80
Inhibition of ribosephosphate pyrophosphokinase activity by decoinine, an adenine nucleoside. Biochem Biophys Res Commun (1964) 0.80
Interaction of glucocorticoid hormones with rat skeletal muscle: catabolic effects and hormone binding. Metabolism (1976) 0.80
The binding of dexamethasone and triamcinolone acetonide to glucocorticoid receptors in rat skeletal muscle. J Biol Chem (1974) 0.80
Synthesis, utilization, and structure of the tetrahydropterin intermediates in the bovine adrenal medullary de novo biosynthesis of tetrahydrobiopterin. J Biol Chem (1986) 0.79
Pharmacokinetics: selectivity of action related to physicochemical properties and kinetic patterns of anticancer drugs. Cancer (1977) 0.79
Glucocorticoid activity of various progesterone analogs: correlation between specific binding in thymus and liver and biologic activity. Ann N Y Acad Sci (1977) 0.79
Crystalloid inclusions in the Sertoli cell of the koala, Phascolarctos cinereus (Marsupialia). Cell Tissue Res (1982) 0.79
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations. Arch Biochem Biophys (1983) 0.79
Antiglucocorticoids: in vivo assay and evaluation of cortexolone, progesterone, and 6-beta-bromoprogesterone. Endocrinology (1980) 0.79
Differences in the metabolism of the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in mutant mice with neurological and immunological defects. Biochem Genet (1986) 0.79
The manipulation of metabolism by drugs and nutrients. Cancer Res (1969) 0.79
Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity. Biochem Pharmacol (1984) 0.79
Embryology of the thyrotroph. J Clin Endocrinol Metab (1966) 0.78
Effect of temperature on glucocorticoid uptake and glucocorticoid-receptor translocation in rat thymocytes. Arch Biochem Biophys (1976) 0.78
Evaluation of combination chemotherapy in vivo and in culture with l- -D-arabinofuranosylcytosine and 1-formylisoquinoline thiosemicarbazone. Cancer Res (1972) 0.78
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice. Biochem Pharmacol (1981) 0.78
Phase II trial of aminocamptothecin (9-AC/DMA) in patients with advanced squamous cell head and neck cancer. Invest New Drugs (2000) 0.77
Sex differences in the concentrations of glucocorticoid receptors in rat liver and thymus. J Endocrinol (1979) 0.77
Mammary cancer: selective action of the estrogen receptor complex. Science (1979) 0.77
Comparison of the antitumor activity and toxicity of 2,4-diamino-5-(1-adamantyl)-6-methylpyrimidine and 2,4-diamino-5-(1-adamantyl)-6-ethylpyrimidine. J Natl Cancer Inst (1978) 0.77
Radiotherapy alone compared with radiotherapy and chemotherapy in patients with squamous cell carcinoma of the esophagus. Am J Clin Oncol (1995) 0.77
Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex. Endocrinology (1983) 0.77
Synthesis and biological activity of some new N6-substituted purine nucleosides. J Med Chem (1969) 0.77
Studies on the nature and specificity of the induction of several adaptive enzymes responsive to cortisol. Adv Enzyme Regul (1964) 0.76