Published in Radiat Res on May 01, 1967
Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro. Biophys J (1968) 2.87
Mechanism by which caffeine potentiates lethality of nitrogen mustard. Proc Natl Acad Sci U S A (1982) 1.86
Measurement of mutagenesis in mammalian cells. Proc Natl Acad Sci U S A (1979) 1.69
Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells. Biophys J (1974) 1.56
The enigmatic effects of caffeine in cell cycle and cancer. Cancer Lett (2006) 1.43
Deoxyribonucleic acid synthesis in ultraviolet-light-irradiated Chinese hamster cells. Biophys J (1971) 1.40
The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design. Br J Clin Pharmacol (2013) 1.19
Repair replication and degradation of bromouracil-substituted DNA in mammalian cells after irradiation with ultraviolet light. Biophys J (1968) 1.06
Sensitivity of synchronized Chinese hamster cells to ultraviolet light. Biophys J (1969) 1.06
Analysis of minimal functions of simian virus 40. 3. Evidence for "host cell repair" of oncogenicity and infectivity of UV-irradiated simian virus 40. J Virol (1974) 0.99
Ultraviolet irradiation of the vegetative cells of Dictyostelium discoideum. J Bacteriol (1970) 0.89
Effects of ultraviolet irradiation on the rate and sequence of DNA replication in synchronized Chinese hamster cells. Biophys J (1976) 0.89
A test for mutation theory of cancer: carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide. Br J Cancer (1977) 0.88
Mice, men, mustard and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents. Br J Cancer (1981) 0.81
Caffeine potentiates the lethality of tumour necrosis factor in cancer cells. Br J Cancer (1993) 0.80
The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells. Biophys J (1981) 0.77
Characterization of excision repair in Neurospora crassa. J Bacteriol (1973) 0.75
Principles and applications of ultrasound backscatter microscopy. IEEE Trans Ultrason Ferroelectr Freq Control (1993) 2.98
An in vitro assay to measure the viability of KHT tumor cells not previously exposed to culture conditions. Radiat Res (1974) 2.62
Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells. Cancer Res (1976) 2.26
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique. Br J Radiol (1975) 1.86
The Physical State of Viral Nucleic Acid and the Sensitivity of Viruses to Ultraviolet Light. Biophys J (1965) 1.29
Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233). Biochem Pharmacol (1988) 1.28
Presence of a heterozygous substitution and its relationship to DT-diaphorase activity. Br J Cancer (1995) 1.28
The interaction of caffeine with ultra-violet-light-irradiated DNA. Int J Radiat Biol Relat Stud Phys Chem Med (1970) 1.27
Differences in the toxicity and metabolism of the 2-nitroimidazole misonidazole (Ro-07-0582) in HeLa and Chinese hamster ovary cells. Cancer Res (1978) 1.19
A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity. Br J Cancer (1996) 1.19
An experimental and analytical study of oxygen depletion in stirred cell suspensions. Radiat Res (1980) 1.18
Testing of hypoxic cell radiosensitizers in vivo. Br J Cancer Suppl (1978) 1.16
Nascent DNA synthesis in ultraviolet light-irradiated mouse L cells. Biochim Biophys Acta (1972) 1.15
Ultraviolet irradiation of mouse L cells: effects on DNA synthesis and progression through the cell cycle. Radiat Res (1968) 1.14
Effects of caffeine on ultraviolet-irradiated mouse L cells. Radiat Res (1969) 1.10
Pharmacology and toxicology of sensitizers: mechanism studies. Int J Radiat Oncol Biol Phys (1984) 1.08
A study of doxorubicin loading onto and release from sulfopropyl dextran ion-exchange microspheres. J Control Release (2001) 1.07
DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family. Carcinogenesis (1991) 1.05
Activity of mitomycin C for aerobic and hypoxic cells in vitro and in vivo. Cancer Res (1983) 1.05
Effects of dimethyl sulfoxide and hypoxic cell radiosensitizers on the radiation response of the KHT murine tumor in vivo. Radiat Res (1977) 1.04
Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions. Br J Cancer (1989) 1.03
The metabolism and pharmacokinetics of the hypoxic cell radiosensitizer and cytotoxic agent, misonidazole, in C3H mice. Radiat Res (1981) 0.97
Nascent DNA synthesis in ultraviolet light-irradiated mouse, human and Chinese hamster cells. Biophys J (1974) 0.96
Screening for the mutagenicity of nitro-group containing hypoxic cell radiosensitizers using Salmonella typhimurium strains TA 100 and TA98. Mutat Res (1978) 0.93
Targeting radiosensitizers to DNA by attachment of an intercalating group: nitroimidazole-linked phenanthridines. Radiat Res (1991) 0.93
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro. Br J Cancer (1980) 0.92
Ultraviolet-light irradiation of mouse L cells: effects on cells in the DNA synthesis phase. Radiat Res (1969) 0.91
Mechanism of ultrasound enhanced porphyrin cytotoxicity. Part I: A search for free radical effects. Ultrasound Med Biol (1997) 0.88
DNA-targeted 2-nitroimidazoles: in vitro and in vivo studies. Br J Cancer (1994) 0.88
Constitutive expression of P-glycoprotein as a determinant of loading with fluorescent calcium probes. Cytometry (1994) 0.88
5-Fluorouracil infusions and fractionated doses of radiation: studies with a murine squamous cell carcinoma. Int J Radiat Oncol Biol Phys (1987) 0.88
Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant. Cancer Res (1986) 0.87
The survival of synchronized L cells after ultraviolet irradiation. Radiat Res (1966) 0.87
Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual. Biochem Pharmacol (1991) 0.87
Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation. Int J Radiat Oncol Biol Phys (1992) 0.86
Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide. Biochem Pharmacol (1986) 0.86
Measurement of low levels of oxygen and their effect on respiration in cell suspensions maintained in an open system. Radiat Res (1986) 0.85
Spontaneous phenotypic and karyotypic progression in the SV40 transfected cell line SVG during prolonged passage in vitro. J Neurooncol (1990) 0.85
Growth delay in a murine squamous cell tumor after local radiation and concurrent infusional 5-fluorouracil treatment. Int J Radiat Oncol Biol Phys (1986) 0.85
Effect of 1-methyl-2-nitrosoimidazole on intracellular thiols and calcium levels in Chinese hamster ovary cells. Biochem Pharmacol (1991) 0.84
Mechanism of the selective hypoxic cytotoxicity of 1-methyl-2-nitroimidazole. Biochem Pharmacol (1994) 0.84
Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole. A toxic 2-nitroimidazole reduction product. Biochem Pharmacol (1988) 0.84
Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells. Cancer Res (1988) 0.83
A toxicity study of daily dose metronidazole with pelvic irradiation. Cancer Clin Trials (1980) 0.83
Use of a high frequency ultrasound microscope to image the action of 2-nitroimidazoles in multicellular spheroids. Br J Cancer (1992) 0.83
The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system. Int J Radiat Oncol Biol Phys (1984) 0.82
NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Int J Radiat Oncol Biol Phys (1989) 0.81
Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C. Oncol Res (1993) 0.81
Effects of caffeine on L-cells exposed to mitomycin C. Cancer Res (1970) 0.81
The effects of phleomycin on mouse L-cells. Cancer Res (1971) 0.80
Assessment of the relationship between genotypic status of a DT-diaphorase point mutation and enzymatic activity. Br J Cancer (2000) 0.80
An analysis of changes in oxygen tension in stirred cellular suspensions under conditions of radiolytic and cellular consumption. Cancer Clin Trials (1980) 0.80
Effect of hypoxia on the accumulation of technetium-99m-glucarate and technetium-99m-gluconate by Chinese hamster ovary cells in vitro. J Nucl Med (1993) 0.80
Differential cell death in immortalized and non-immortalized cells at confluency. Oncogene (1996) 0.80
Oxygen tension, cellular respiration, and redox state as variables influencing the cytotoxicity of the radiosensitizer misonidazole. Radiat Res (1982) 0.80
BRU59-21, a second-generation 99mTc-labeled 2-nitroimidazole for imaging hypoxia in tumors. J Nucl Med (2000) 0.80
Cell cycle specific recovery from fractionated exposures of ultraviolet light. Radiat Res (1973) 0.79
Isolation and characterization of revertants of the mammalian temperature sensitive leucyl-tRNA synthetase mutant tsHl. J Cell Physiol (1979) 0.79
Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. Int J Radiat Oncol Biol Phys (1998) 0.79
Studies of 99mTc-BnAO (HL-91): a non-nitroaromatic compound for hypoxic cell detection. Int J Radiat Oncol Biol Phys (1998) 0.79
Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models. Nucl Med Commun (2003) 0.79
In vitro and in vivo evaluation of a technetium-99m-labeled 2-nitroimidazole (BMS181321) as a marker of tumor hypoxia. J Nucl Med (1996) 0.79
2-Hydroxylaminoimidazoles--unstable intermediates in the reduction of 2-nitroimidazoles. Biochem Pharmacol (1984) 0.79
Transfection of COS-1 cells with DT-diaphorase cDNA: role of a base change at position 609. Br J Cancer (1998) 0.79
1-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabilities. Int J Radiat Oncol Biol Phys (1989) 0.78
Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line. Eur J Nucl Med (2000) 0.78
Failure of 2-deoxy-D-glucose and 5-thio-D-glucose to kill hypoxic cells of two murine tumors. Cancer Res (1983) 0.78
Depletion of intracellular glutathione by 1-methyl-2-nitrosoimidazole. Int J Radiat Oncol Biol Phys (1992) 0.78
Isolation and characterization of a cell line resistant to 5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide (2-NLP-3), a DNA-intercalating hypoxic cell radiosensitizer and cytotoxin. Biochem Pharmacol (1995) 0.78
Differential cytotoxicity of diaziquone toward Chinese hamster ovary cells under hypoxic and aerobic exposure conditions. Cancer Res (1990) 0.78
Hyperresistance to 4-nitroquinoline 1-oxide cytotoxicity and reduced DNA damage formation in dermal fibroblast strains derived from five members of a cancer-prone family. Br J Cancer (1993) 0.77
Radiosensitizing and cytotoxic properties of DNA targeted phenanthridine-linked nitroheterocycles of varying electron affinities. Int J Radiat Biol (1994) 0.77
Oxidative stress and 1-methyl-2-nitroimidazole cytotoxicity. Biochem Pharmacol (1998) 0.77
Cellular accumulation and retention of the technetium-99m-labelled hypoxia markers BRU59-21 and butylene amine oxime. Nucl Med Biol (2001) 0.76
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro. Cancer Gene Ther (2002) 0.76
Targeting hypoxia in tumors using 2-nitroimidazoles with peptidic chelators for technetium-99m: effect of lipophilicity. Bioconjug Chem (2000) 0.76
BMS181321 accumulation in rodent and human cells: the role of P-glycoprotein. Br J Cancer Suppl (1996) 0.75
Nitropyrrole radiosensitizers: structure function relationships. Br J Cancer Suppl (1978) 0.75
Immortalisation of a human diploid fibroblast cell strain: a DT-diaphorase paradox. Br J Cancer Suppl (1996) 0.75
Apoptosis and 1-methyl-2-nitroimidazole toxicity in CHO cells. Br J Cancer (1997) 0.75
A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix. Br J Cancer (1982) 0.75
Selective toxicity of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide toward hypoxic mammalian cells. Cancer Res (1981) 0.75
The effect of amino acids on the temperature sensitive phenotype of the mammalian leucyl-tRNA synthetase mutant tsHl and its revertants. J Cell Physiol (1979) 0.75
Some biological applications of an electric heating tape. Lab Pract (1974) 0.75
Ultraviolet photochemistry of DNA in mouse spermatozoa. Mutat Res (1972) 0.75
The production of strand breaks in DNA in the presence of the hydroxylamine of SR-2508 (1-[N-(2-hydroxyethyl)acetamido]-2-nitroimidazole) at neutral pH. Int J Radiat Oncol Biol Phys (1986) 0.75
Effect of leucine on the temperature sensitive phenotype of a mammalian leucyl-tRNA synthetase mutant. J Cell Physiol (1975) 0.75
Mitomycin C pharmacokinetics in patients with recurrent or metastatic colorectal carcinoma. Can J Physiol Pharmacol (1987) 0.75
An investigation into the potential of a mammalian temperature sensitive leucyl-tRNA synthetase mutant for mutagenesis studies. Mutat Res (1976) 0.75
A bioassay to measure cytotoxicity of plasma from patients treated with mitomycin C. Cancer Res (1985) 0.75
Synthesis and evaluation of two technetium-99m-labeled peptidic 2-nitroimidazoles for imaging hypoxia. Bioconjug Chem (1999) 0.75
A comparison of the effectiveness of NF-167 and metronidazole as hypoxic cell sensitizers of KHT tumor cells in vitro. Radiat Res (1974) 0.75
A novel amine-dioxime chelator for technetium-99m: synthesis and evaluation of 2-nitroimidazole-containing analogues as markers for hypoxic cells. Bioconjug Chem (2000) 0.75
Mode of interaction of 5-fluorouracil, radiation, and mitomycin C: in vitro studies. Int J Radiat Oncol Biol Phys (1992) 0.75
Modifying the in vitro accumulation of BMS181321, a technetium-99m-nitroimidazole, with unlabelled nitroaromatics. Biochem Pharmacol (1997) 0.75
Potentiation of ultra -violet light damage in mouse L cells by 1-cyclohexyl-3-(2-morpholinyl-4-ethyl) carbodiimide metho-p-toluene sulphonate (CMEC). Int J Radiat Biol Relat Stud Phys Chem Med (1973) 0.75
Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia. Biochem Pharmacol (2000) 0.75
Prostate-specific antigen induction by a steroid hormone in T47D cells growing in SCID mice. Breast Cancer Res Treat (1998) 0.75
Stable reduction product of misonidazole. Int J Radiat Oncol Biol Phys (1986) 0.75
A comparison of the sensitivity to ultraviolet light of mouse L cells and mouse bone marrow cells assayed in vitro. Radiat Res (1971) 0.75