Published in Am J Physiol on April 01, 1967
Excitation-concentration coupling in frog ventricle: evidence from voltage clamp studies. J Physiol (1971) 2.42
Reconstruction of the repolarization process in cardiac Purkinje fibres based on voltage clamp measurements of membrane current. J Physiol (1969) 2.37
High potassium and low sodium contractures in sheep cardiac muscle. J Gen Physiol (1971) 1.19
Effect of formaldehyde and glutaraldehyde on electrical properties of cardiac Purkinje fibers. J Gen Physiol (1969) 0.99
Actions of adrenaline on the potassium balance of the isolated heart. Br J Pharmacol (1969) 0.75
Membrane capacity of the cardiac Purkinje fibre. J Physiol (1966) 3.65
A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science (1992) 3.47
Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol (1982) 3.20
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J (1994) 2.64
Activities of potassium and sodium ions in rabbit heart muscle. J Gen Physiol (1975) 2.38
The positive dynamic current and its inactivation properties in cardiac Purkinje fibres. J Physiol (1973) 2.23
Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circ Res (1982) 2.14
Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res (1988) 1.78
KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry (2000) 1.76
Sodium channel selectivity filter regulates antiarrhythmic drug binding. Proc Natl Acad Sci U S A (1997) 1.61
Strength-duration curves in cardiac Purkinje fibres: effects of liminal length and charge distribution. J Physiol (1972) 1.60
Voltage dependence and time dependence of contraction in sheep cardiac Purkinje fibers. Circ Res (1971) 1.56
Slow inward current and contraction of sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.52
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry (1998) 1.50
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. Biophys J (1987) 1.47
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol (1990) 1.44
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J (1995) 1.42
Membrane response to current pulses in spheroidal aggregates of embryonic heart cells. J Gen Physiol (1975) 1.42
Influence of changes in external potassium and chloride ions on membrane potential and intracellular potassium ion activity in rabbit ventricular muscle. J Physiol (1976) 1.41
Relationships between voltage and tension in sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.38
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res (1993) 1.38
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. Biophys J (1998) 1.35
New studies of the excitatory sodium currents in heart muscle. Circ Res (1985) 1.35
Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells. J Physiol (1992) 1.33
Characteristics of L- and T-type Ca2+ currents in canine cardiac Purkinje cells. Am J Physiol (1989) 1.33
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule. Biophys J (1999) 1.33
Delayed afterdepolarizations in heart muscle: mechanisms and relevance. Pharmacol Rev (1988) 1.31
Open sodium channel properties of single canine cardiac Purkinje cells. Biophys J (1987) 1.30
mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains. J Gen Physiol (2000) 1.30
Is there a second external lidocaine binding site on mammalian cardiac cells? Am J Physiol (1989) 1.29
Sarcolemmal evaginations with knob-like or stalked projections in Purkinje fibers of the sheep's heart. J Ultrastruct Res (1969) 1.27
Changes in intracellular Ca2+ activity with stimulation in sheep cardiac Purkinje strands. Am J Physiol (1982) 1.26
Isolation and characterization of single canine cardiac purkinje cells. Circ Res (1983) 1.24
Surgical treatment of recurrent primary malignant tumor of the left atrium. J Thorac Cardiovasc Surg (1979) 1.23
Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction. J Gen Physiol (1993) 1.23
Heart: excitation-contraction coupling. Annu Rev Physiol (1977) 1.22
High potassium and low sodium contractures in sheep cardiac muscle. J Gen Physiol (1971) 1.19
Effect of diameter on membrane capacity and conductance of sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.18
Relationship between membrane voltage and tension in voltage-clamped cardiac purkinje fibres. Nature (1968) 1.18
The voltage clamp and cardiac electrophysiology. Circ Res (1975) 1.17
The selectivity filter of the voltage-gated sodium channel is involved in channel activation. J Biol Chem (2001) 1.16
Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels. FEBS Lett (1990) 1.15
Gating currents associated with Na channels in canine cardiac Purkinje cells. J Gen Physiol (1990) 1.15
Two phosphatase sites on the Ca2+ channel affecting different kinetic functions. J Physiol (1993) 1.14
Relation between intracellular sodium and twitch tension in sheep cardiac Purkinje strands exposed to cardiac glycosides. Circ Res (1983) 1.13
Electrophysiology of Cl secretion in canine trachea. J Membr Biol (1983) 1.12
Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block. J Physiol (2002) 1.12
The effects of membrane potential, extracellular potassium, and tetrodotoxin on the intracellular sodium ion activity of sheep cardiac muscle. Circ Res (1984) 1.11
Na,K pump stimulation by intracellular Na in isolated, intact sheep cardiac Purkinje fibers. J Gen Physiol (1988) 1.10
The relation of Vmax to INa, GNa, and h infinity in a model of the cardiac Purkinje fiber. Biophys J (1979) 1.09
ST-segment potentials and mapping. Theory and experiments. Circulation (1976) 1.08
Low conductance sodium channels in canine cardiac Purkinje cells. Biophys J (1987) 1.06
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A (2000) 1.05
Intracellular potassium and sodium activities of chick ventricular muscle during embryonic development. J Physiol (1980) 1.04
Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids. Biophys J (1994) 1.03
A structural motif for the voltage-gated potassium channel pore. Proc Natl Acad Sci U S A (1995) 1.02
Influence of extracellular K+ concentration on cable properties and excitability of sheep cardiac Purkinje fibers. Circ Res (1970) 1.02
Action potential and contraction of heart muscle. Am J Cardiol (1973) 1.02
Intra- and extracellular K+ and Na+ activities and resting membrane potential in sheep cardiac purkinje strands. Circ Res (1980) 1.01
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics. Mol Pharmacol (2001) 1.00
The influence of intercellular clefts on the electrical properties of sheep cardiac Purkinje fibers. Biophys J (1979) 1.00
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis. Biophys J (2001) 1.00
The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels. J Membr Biol (1992) 1.00
Intracellular chloride activity in mammalian ventricular muscle. Am J Physiol (1981) 1.00
Fab fragments of digoxin-specific antibodies used to reverse ventricular fibrillation induced by digoxin ingestion in a child. Pediatrics (1982) 0.99
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII. Circ Res (1992) 0.99
Effect of formaldehyde and glutaraldehyde on electrical properties of cardiac Purkinje fibers. J Gen Physiol (1969) 0.99
Catecholamine effects on intracellular sodium activity and tension in dog heart. Am J Physiol (1982) 0.98
Regulation of intracellular sodium concentrations in rat diaphragm muscle. Science (1967) 0.98
Relationship between lipid fluidity and water permeability of bovine tracheal epithelial cell apical membranes. Biochemistry (1986) 0.98
Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block. Circ Res (2001) 0.97
Modeling of the outer vestibule and selectivity filter of the L-type Ca2+ channel. Biochemistry (2001) 0.97
Electrochemical properties of hydrated cation-selective glass membrane. A model of K+ and Na+ transport. Biophys J (1974) 0.97
Adrenergic modulation of the transient outward current in isolated canine Purkinje cells. Circ Res (1988) 0.96
A real-time pressure algorithm. Comput Biol Med (1981) 0.95
The electrophysiology of acute myocardial ischemia. Annu Rev Med (1985) 0.95
External site for local anesthetic block of cardiac Na+ channels. J Mol Cell Cardiol (1991) 0.93
A cleft model for cardiac Purkinje strands. Biophys J (1981) 0.93
Validity of myocardial infarction models. Circulation (1975) 0.92
Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit. Biophys J (1996) 0.92
The cellular mechanism of active chloride secretion in vertebrate epithelia: studies in intestine and trachea. Philos Trans R Soc Lond B Biol Sci (1982) 0.92
Na/Ca exchange in the intact cardiac cell. J Gen Physiol (1985) 0.92
Effects of Ca2+/Mg2+ removal on aiNa, aiK, and tension in cardiac Purkinje fibers. Am J Physiol (1986) 0.92
Therapeutic uses of calcium-blocking agents:verapamil, nifedipine, and diltiazem. Compr Ther (1981) 0.91
Intra- and extracellular potassium activities, acetylcholine and resting potential in guinea pig atria. Circ Res (1984) 0.91
Isoform-dependent interaction of voltage-gated sodium channels with protons. J Physiol (2006) 0.90
Modulation of the cardiac transient outward current by catecholamines. J Mol Cell Cardiol (1989) 0.90
Experimental study of the conducted action potential in cardiac Purkinje strands. Biophys J (1983) 0.89
The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field. Biophys J (1994) 0.88
The conducted action potential. Models and comparison to experiments. Biophys J (1983) 0.88
Sources of Error in Oximetry. Ann Surg (1949) 0.88
AZTEC, a preprocessing program for real-time ECG rhythm analysis. IEEE Trans Biomed Eng (1968) 0.87
Inactivation properties of T-type calcium current in canine cardiac Purkinje cells. Biophys J (1989) 0.87
Ca and Na selectivity of the active membrane of rabbit AV nodal cells. Am J Physiol (1979) 0.87
Effects of tonicity on tension and intracellular sodium and calcium activities in sheep heart. Circ Res (1984) 0.87
The inhibitory effects of K+ channel-blocking agents on T lymphocyte proliferation and lymphokine production are "nonspecific". J Immunol (1987) 0.87
Effect of stretch on conduction velocity and cable properties of cardiac Purkinje fibers. Am J Physiol (1979) 0.86
Excitation-contraction coupling and digitalis. Circulation (1973) 0.86
A model of scorpion toxin binding to voltage-gated K+ channels. J Membr Biol (1997) 0.85