mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 2229485)

Published in J Gen Physiol on November 01, 2000

Authors

S C Dudley1, N Chang, J Hall, G Lipkind, H A Fozzard, R J French

Author Affiliations

1: Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. sdudley@emory.edu

Articles citing this

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J (2004) 1.40

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin. J Gen Physiol (2002) 1.33

Molecular biology of insect sodium channels and pyrethroid resistance. Insect Biochem Mol Biol (2014) 1.28

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin. J Neurophysiol (2010) 1.14

Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J Gen Physiol (2004) 1.14

Energetic localization of saxitoxin in its channel binding site. Biophys J (2002) 1.14

Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block. J Physiol (2002) 1.12

Sodium channels: ionic model of slow inactivation and state-dependent drug binding. Biophys J (2007) 1.10

Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels (Austin) (2007) 1.07

Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule. Biophys J (2003) 1.05

The tetrodotoxin binding site is within the outer vestibule of the sodium channel. Mar Drugs (2010) 1.04

The hitchhiker's guide to the voltage-gated sodium channel galaxy. J Gen Physiol (2016) 1.03

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel. Nat Commun (2012) 0.93

Structural model for phenylalkylamine binding to L-type calcium channels. J Biol Chem (2009) 0.93

Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry. Biophys J (2003) 0.92

Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2. J Biol Chem (2009) 0.90

Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels. J Biol Chem (2010) 0.90

A homology model of the pore domain of a voltage-gated calcium channel is consistent with available SCAM data. J Gen Physiol (2010) 0.86

Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door? Biophys J (2007) 0.85

Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4. PLoS One (2014) 0.85

The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins. Mar Drugs (2010) 0.84

Computational studies of marine toxins targeting ion channels. Mar Drugs (2013) 0.84

Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4. PLoS One (2014) 0.84

Structural modeling of calcium binding in the selectivity filter of the L-type calcium channel. Eur Biophys J (2010) 0.83

Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4. J Gen Physiol (2014) 0.83

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels. Toxicon (2004) 0.81

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels. Pflugers Arch (2014) 0.80

A new look at sodium channel β subunits. Open Biol (2015) 0.80

The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating. Mar Drugs (2010) 0.79

Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate. J Biol Chem (2013) 0.78

Modular organization of α-toxins from scorpion venom mirrors domain structure of their targets, sodium channels. J Biol Chem (2013) 0.78

Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br J Pharmacol (2012) 0.77

Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7. Proc Natl Acad Sci U S A (2016) 0.75

The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4. Mar Drugs (2016) 0.75

Network topology of NaV1.7 mutations in sodium channel-related painful disorders. BMC Syst Biol (2017) 0.75

Articles cited by this

The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding. J Mol Biol (1992) 6.10

Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science (1995) 3.82

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. J Mol Biol (1995) 3.76

Structural conservation in prokaryotic and eukaryotic potassium channels. Science (1998) 3.61

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett (1991) 3.29

Diversity of Conus neuropeptides. Science (1990) 2.78

Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (1989) 2.75

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J (1994) 2.64

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles. Biochemistry (1990) 2.59

Strength and co-operativity of contributions of surface salt bridges to protein stability. J Mol Biol (1990) 2.52

Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron (1996) 2.38

Conus geographus toxins that discriminate between neuronal and muscle sodium channels. J Biol Chem (1985) 2.38

Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron (1997) 2.35

Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation. Biochemistry (1983) 2.31

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron (1990) 2.14

Agitoxin footprinting the shaker potassium channel pore. Neuron (1996) 1.99

Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis. Neuron (1996) 1.98

Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins. Neuron (1995) 1.70

Structure of the sodium channel pore revealed by serial cysteine mutagenesis. Proc Natl Acad Sci U S A (1996) 1.67

A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel. Neuron (1996) 1.63

Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. Biochemistry (1992) 1.61

Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Proc Natl Acad Sci U S A (1986) 1.59

Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann N Y Acad Sci (1986) 1.57

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry (1998) 1.50

Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry. Neuron (1996) 1.44

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J (1995) 1.42

Molecular motions within the pore of voltage-dependent sodium channels. Biophys J (1997) 1.39

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry (1992) 1.39

Pore properties of rat brain II sodium channels mutated in the selectivity filter domain. Eur Biophys J (1996) 1.34

Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule. Biophys J (1999) 1.33

Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis. Biophys J (1997) 1.30

Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels. J Biol Chem (1991) 1.21

Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification. Biophys J (1997) 1.17

Chimeric study of sodium channels from rat skeletal and cardiac muscle. FEBS Lett (1992) 1.16

Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations. Biochemistry (1992) 1.13

The signature sequence of voltage-gated potassium channels projects into the external vestibule. J Biol Chem (1996) 1.13

Tertiary structure of conotoxin GIIIA in aqueous solution. Biochemistry (1991) 1.12

The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB. J Membr Biol (1994) 1.09

P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements. J Gen Physiol (1997) 1.07

Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site. Biophys J (1998) 1.06

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis. Biophys J (1997) 1.02

On the choice of reference mutant states in the application of the double-mutant cycle method. Protein Eng (1996) 1.02

Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channel. Biophys J (1994) 1.00

Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations. Receptors Channels (1995) 0.97

Probing a potassium channel pore with an engineered protonatable site. Biochemistry (1995) 0.95

Synthesis and characterization of mu-conotoxin IIIa. Eur J Biochem (1989) 0.82

Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations. FEBS Lett (1991) 0.81

Synthesis and characterization of an N-terminal-specific 125I-photoaffinity derivative of mu-Conotoxin GIIIA which binds to the voltage-dependent sodium channel. FEBS Lett (1990) 0.77

Articles by these authors

Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis (1981) 7.00

Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment. BMJ (1993) 6.14

Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87

Pulsed-field gel electrophoresis of Campylobacter jejuni and Campylobacter coli genomic DNA and its epidemiologic application. J Infect Dis (1991) 4.87

Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of 'open' and 'closed' formats. JAMA (1996) 4.71

A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization. Nature (2000) 4.36

Development of a Canadian standardized protocol for subtyping methicillin-resistant Staphylococcus aureus using pulsed-field gel electrophoresis. J Clin Microbiol (2001) 4.05

Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axon. J Gen Physiol (1977) 4.00

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75

Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry (2000) 3.67

Membrane capacity of the cardiac Purkinje fibre. J Physiol (1966) 3.65

Rapid active transport of immunoglobulin A from blood to bile. J Exp Med (1978) 3.62

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science (1992) 3.47

Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med (1992) 3.23

Transmembrane Na+ and Ca2+ electrochemical gradients in cardiac muscle and their relationship to force development. J Gen Physiol (1982) 3.20

Sex differences in brain maturation during childhood and adolescence. Cereb Cortex (2001) 3.17

Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level. J Bacteriol (1992) 3.16

Comparison of potency of inhaled beclomethasone and budesonide in New Zealand: retrospective study of computerised general practice records. BMJ (1998) 3.15

Blocking of the squid axon potassium channel by external caesium ions. J Physiol (1978) 3.10

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet (1999) 2.88

Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81

The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.74

Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed (2000) 2.70

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J (1994) 2.64

Improved survival in ARDS patients associated with a reduction in pulmonary capillary wedge pressure. Chest (1990) 2.61

Evaluation of anticoagulant control in a pharmacist operated anticoagulant clinic. J Clin Pathol (1995) 2.58

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58

Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes. Biophys J (1981) 2.53

Occurrence of specific antibodies of the IgA class in the bile of rats. Int Arch Allergy Appl Immunol (1979) 2.46

Genome maps of Campylobacter jejuni and Campylobacter coli. J Bacteriol (1992) 2.42

Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect (2003) 2.40

Activities of potassium and sodium ions in rabbit heart muscle. J Gen Physiol (1975) 2.38

Single sodium channels from rat brain incorporated into planar lipid bilayer membranes. Nature (1983) 2.28

Optimizing planar lipid bilayer single-channel recordings for high resolution with rapid voltage steps. Biophys J (1990) 2.26

The positive dynamic current and its inactivation properties in cardiac Purkinje fibres. J Physiol (1973) 2.23

An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions. J Gen Physiol (1985) 2.19

Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle. Circ Res (1982) 2.14

The impact of course attendance on the practice of dentists. Br Dent J (2004) 2.08

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther (2006) 2.07

Septicemia caused by Pseudomonas paucimobilis. Am J Clin Pathol (1979) 2.06

The management of oesophageal carcinoma: radiotherapy or surgery? Cost considerations. Eur J Cancer Clin Oncol (1989) 2.00

Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase. Biochem J (1990) 1.93

Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol (1995) 1.79

Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells. Circ Res (1988) 1.78

KcsA crystal structure as framework for a molecular model of the Na(+) channel pore. Biochemistry (2000) 1.76

Sodium channel gating: models, mimics, and modifiers. Annu Rev Biophys Bioeng (1983) 1.76

The N-terminal region of an endoglucanase from Pseudomonas fluorescens subspecies cellulosa constitutes a cellulose-binding domain that is distinct from the catalytic centre. Mol Microbiol (1990) 1.76

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ (2011) 1.74

Predisposition to and late onset of upper airway obstruction following angiotensin-converting enzyme inhibitor therapy. Chest (1992) 1.70

Biogeography and ecological setting of Indian Ocean hydrothermal vents. Science (2001) 1.69

The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry (2007) 1.68

Spontaneous remission of primary hyperparathyroidism from parathyroid apoplexy. J Clin Endocrinol Metab (1996) 1.66

Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria. Biochem J (1995) 1.64

Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. Am J Obstet Gynecol (1995) 1.62

Sodium channel selectivity filter regulates antiarrhythmic drug binding. Proc Natl Acad Sci U S A (1997) 1.61

Voltage-dependent block by saxitoxin of sodium channels incorporated into planar lipid bilayers. Biophys J (1984) 1.60

Strength-duration curves in cardiac Purkinje fibres: effects of liminal length and charge distribution. J Physiol (1972) 1.60

Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biol Psychiatry (2001) 1.57

Dark matter search results from the CDMS II experiment. Science (2010) 1.57

Voltage dependence and time dependence of contraction in sheep cardiac Purkinje fibers. Circ Res (1971) 1.56

Using graded motor imagery for complex regional pain syndrome in clinical practice: failure to improve pain. Eur J Pain (2011) 1.56

Hydrocephalus in achondroplasia: the possible role of intracranial venous hypertension. J Neurosurg (1989) 1.55

Molecular cloning of multiple xylanase genes from Pseudomonas fluorescens subsp. cellulosa. J Gen Microbiol (1988) 1.53

Incremental change in the Australian health care system. Health Aff (Millwood) (1999) 1.52

Trimethyloxonium modification of single batrachotoxin-activated sodium channels in planar bilayers. Changes in unit conductance and in block by saxitoxin and calcium. J Gen Physiol (1986) 1.52

Slow inward current and contraction of sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.52

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis. Biochemistry (1998) 1.50

Effects of membrane surface charge and calcium on the gating of rat brain sodium channels in planar bilayers. J Gen Physiol (1988) 1.50

Use of the muscle flap in chronic osteomyelitis: experimental and clinical correlation. Plast Reconstr Surg (1982) 1.49

The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes. J Immunol (1984) 1.48

Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells. Biophys J (1987) 1.47

Comparison of the effect of bacterial inoculation in musculocutaneous and random-pattern flaps. Plast Reconstr Surg (1982) 1.46

A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry (2001) 1.46

Lumbar spine surgery in the obese patient. J Spinal Disord (1997) 1.45

In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation. J Biol Chem (1976) 1.45

Accuracy of a portable interpretive ECG machine in diagnosis of acute evolving myocardial infarction. Aust N Z J Med (1992) 1.44

Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol (1990) 1.44

Mutations in the follicle-stimulating hormone receptor and familial dizygotic twinning. Lancet (2001) 1.43

Utilisation as a measure of equity: weighing heat? J Health Econ (1991) 1.43

Membrane response to current pulses in spheroidal aggregates of embryonic heart cells. J Gen Physiol (1975) 1.42

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. Biophys J (1995) 1.42

A general-practitioner survey of the Abortion Act 1967. Practitioner (1971) 1.42

Influence of changes in external potassium and chloride ions on membrane potential and intracellular potassium ion activity in rabbit ventricular muscle. J Physiol (1976) 1.41

A cost-utility approach to the use of 5-fluorouracil and levamisole as adjuvant chemotherapy for Dukes' C colonic carcinoma. Med J Aust (1993) 1.41

Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle. Biophys J (1993) 1.40

Heparin concentrations in neonates during cardiopulmonary bypass. J Thromb Haemost (2012) 1.40

N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD. Am J Psychiatry (2000) 1.40

Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. J Hosp Infect (2004) 1.40

An unusual complication of central venous catheterization. Chest (1994) 1.39

Reflections on the recommendations of the EWMA Patient Outcome Group document. J Wound Care (2010) 1.39

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. Biochemistry (1992) 1.39

Amylin innocent in essential hypertension? Diabetologia (1999) 1.39

Whither private health insurance? Aust N Z J Public Health (1997) 1.39

Counting the costs of mammography screening: first year results from the Sydney study. Med J Aust (1990) 1.39

Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels. Proc Natl Acad Sci U S A (2000) 1.39

Relationships between voltage and tension in sheep cardiac Purkinje fibers. J Gen Physiol (1975) 1.38

Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics. Circ Res (1993) 1.38

The double 'tails-up' capnograph. Anaesthesia (2004) 1.38