Published in Science on September 21, 1984
Diverse molecular functions of Hu proteins. Cell Mol Life Sci (2008) 4.09
Factors influencing alternative splice site utilization in vivo. Mol Cell Biol (1987) 2.39
Regulation of alternative polyadenylation by U1 snRNPs and SRp20. Mol Cell Biol (1998) 2.26
Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1986) 2.19
Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol (1999) 2.05
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J (1986) 1.98
Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements. Mol Cell Biol (1993) 1.76
Alternative RNA splicing generates transcripts encoding a thorax-specific isoform of Drosophila melanogaster myosin heavy chain. Mol Cell Biol (1986) 1.69
An intron enhancer containing a 5' splice site sequence in the human calcitonin/calcitonin gene-related peptide gene. Mol Cell Biol (1995) 1.67
Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse. EMBO J (1988) 1.50
Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. Mol Cell Biol (2006) 1.41
U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Mol Cell Biol (2003) 1.40
Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. EMBO J (1985) 1.39
Molecular analysis of the locus elav in Drosophila melanogaster: a gene whose embryonic expression is neural specific. EMBO J (1987) 1.32
Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP. Nucleic Acids Res (1992) 1.31
Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. Proc Natl Acad Sci U S A (1987) 1.20
Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1. J Exp Med (1988) 1.16
A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin. Br J Pharmacol (1991) 1.16
Rat amylin: cloning and tissue-specific expression in pancreatic islets. Proc Natl Acad Sci U S A (1989) 1.14
Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem J (1988) 1.14
The memory gene dunce+ encodes a remarkable set of RNAs with internal heterogeneity. Mol Cell Biol (1986) 1.10
Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J (2001) 1.05
Structure and methylation of the human calcitonin/alpha-CGRP gene. Nucleic Acids Res (1989) 1.03
Calcitonin and calcitonin receptors: bone and beyond. Int J Exp Pathol (2000) 0.97
Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A (1988) 0.97
Validation of an in vitro RNA processing system for CT/CGRP precursor mRNA. Nucleic Acids Res (1991) 0.97
Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev (2014) 0.96
Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II. Proc Natl Acad Sci U S A (1986) 0.96
Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis. J Clin Invest (1991) 0.92
Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor. Biochem J (2000) 0.90
Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone. Proc Natl Acad Sci U S A (1987) 0.90
Alternative processing and developmental control of the transcripts of the Drosophila abl oncogene homologue. EMBO J (1985) 0.89
Transduction of c-src coding and intron sequences by a transformation-defective deletion mutant of Rous sarcoma virus. J Virol (1986) 0.88
Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock. Mol Cell Biol (1993) 0.88
A genetic polymorphism within the third poly(A) signal of the DHFR gene alters the polyadenylation pattern of DHFR transcripts in CHL cells. Nucleic Acids Res (1994) 0.88
Mouse brain CD4 transcripts encode only the COOH-terminal half of the protein. Mol Cell Biol (1988) 0.86
Two Drosophila chorion genes terminate transcription in discrete regions near their poly(A) sites. EMBO J (1986) 0.84
cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene. Mol Cell Biol (1994) 0.84
Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature. Br J Clin Pharmacol (1988) 0.84
Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene-related peptides (CGRP). Br J Pharmacol (1986) 0.83
Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig Dis Sci (2007) 0.82
Calcitonin and calcitonin receptors. Clin Cases Miner Bone Metab (2007) 0.81
Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. Peptides (2012) 0.79
Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin gene. Nucleic Acids Res (1993) 0.79
Epigenetic regulation of the calcitonin gene-related peptide gene in trigeminal glia. Cephalalgia (2011) 0.79
Two molecular weight forms of muscarinic acetylcholine receptors in the avian central nervous system: switch in predominant form during differentiation of synapses. Proc Natl Acad Sci U S A (1985) 0.79
Analysis of the proteolysis of bioactive peptides using a peptidomics approach. Nat Protoc (2013) 0.78
Transcription of a cloned rainbow trout protamine gene is accurately initiated following transfection into HeLa cells but the majority of the transcripts fail to polyadenylate at the correct site. Nucleic Acids Res (1985) 0.77
Effects of endurance and resistance training on calcitonin gene-related Peptide and acetylcholine receptor at slow and fast twitch skeletal muscles and sciatic nerve in male wistar rats. Int J Pept (2012) 0.77
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
The RXR heterodimers and orphan receptors. Cell (1995) 12.33
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature (1995) 11.18
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02
The c-erb-A gene encodes a thyroid hormone receptor. Nature (1987) 10.53
PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell (1999) 10.08
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
Coincidence of the promoter and capped 5' terminus of RNA from the adenovirus 2 major late transcription unit. Cell (1978) 9.60
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell (1991) 9.40
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell (1997) 8.99
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell (1991) 8.85
Nuclear receptors and lipid physiology: opening the X-files. Science (2001) 8.76
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell (1997) 8.72
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature (1997) 8.38
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature (1998) 8.33
Identification of a receptor for the morphogen retinoic acid. Nature (1988) 8.32
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell (1998) 7.91
Primary structure and expression of a functional human glucocorticoid receptor cDNA. Nature (1986) 7.81
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A (1997) 7.52
Role of CBP/P300 in nuclear receptor signalling. Nature (1996) 7.36
9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell (1992) 6.75
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (1992) 6.69
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature (1982) 6.56
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell (1994) 6.52
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A (1994) 6.46
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
Nuclear receptor that identifies a novel retinoic acid response pathway. Nature (1990) 6.23
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med (2001) 6.09
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell (1991) 5.89
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell (1998) 5.78
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature (1992) 5.76
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell (2001) 5.76
Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature (1989) 5.68
Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature (1998) 5.63
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell (1990) 5.59
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell (1999) 5.23
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature (1983) 5.20
Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature (1990) 5.20
LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev (1995) 4.93
Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev (1999) 4.92
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev (1998) 4.78
The initiation sites for RNA transcription in Ad2 DNA. Cell (1977) 4.76
Complex transcriptional units: diversity in gene expression by alternative RNA processing. Annu Rev Biochem (1986) 4.73
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev (1992) 4.69
Functional domains of the human glucocorticoid receptor. Cell (1986) 4.68
A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell (1988) 4.57
Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell (1989) 4.56
Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science (1998) 4.55
Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature (1989) 4.47
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32
A transcriptional switch mediated by cofactor methylation. Science (2001) 4.32
Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature (1982) 4.30
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell (1991) 4.27
SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev (1998) 4.19
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (1995) 4.14
Regulation of neuronal traits by a novel transcriptional complex. Neuron (2001) 4.02
Multiple and cooperative trans-activation domains of the human glucocorticoid receptor. Cell (1988) 4.00
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev (2000) 4.00
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements. Cell (1988) 3.91
Polarity-specific activities of retinoic acid receptors determined by a co-repressor. Nature (1995) 3.90
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR. Cell (1991) 3.87
Identification of a new class of steroid hormone receptors. Nature (1988) 3.83
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev (1998) 3.79
Ion fluxes associated with excitatory amino acid transport. Neuron (1995) 3.76
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature (1987) 3.75
Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell (1998) 3.71
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature (1993) 3.71
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67
Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure. Genes Dev (1996) 3.63
Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor. Cell (1987) 3.62
Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A (1996) 3.57
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev (1994) 3.54
Co-activators and co-repressors in the integration of transcriptional responses. Curr Opin Cell Biol (1998) 3.51
Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell (2000) 3.47
Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence. Nucleic Acids Res (1978) 3.46
Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature (1991) 3.46
Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature (1988) 3.42
Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (2000) 3.41
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev (1999) 3.41
A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell (1999) 3.36
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci (1994) 3.34
Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature (1995) 3.32
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer. Cell (1989) 3.24
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci U S A (1997) 3.22
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature (1996) 3.21