Published in Proc Natl Acad Sci U S A on December 01, 1984
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J (1991) 11.86
Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest (1993) 4.70
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J (1992) 3.98
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29
Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol (1991) 2.59
Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci U S A (1988) 2.34
Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Proc Natl Acad Sci U S A (1991) 1.87
On the spin trapping and ESR detection of oxygen-derived radicals generated inside cells. Proc Natl Acad Sci U S A (1986) 1.72
Peroxynitrite-induced luminol chemiluminescence. Biochem J (1993) 1.63
A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc Natl Acad Sci U S A (1989) 1.62
Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury. J Clin Invest (1992) 1.44
MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One (2010) 1.31
Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase. J Biol Chem (2008) 1.26
The capsule supports survival but not traversal of Escherichia coli K1 across the blood-brain barrier. Infect Immun (1999) 1.21
Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A (1993) 1.16
Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol (2007) 1.14
Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. Arch Biochem Biophys (2003) 1.13
Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase. Br J Pharmacol (1999) 1.10
Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport. J Clin Invest (1993) 1.05
Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci U S A (1996) 1.04
Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery. Br J Pharmacol (2005) 1.03
Release of endothelium-derived relaxing factor from pig cultured aortic endothelial cells, as assessed by changes in endothelial cell cyclic GMP content, is inhibited by a phorbol ester. Br J Pharmacol (1990) 1.02
Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol (2009) 1.02
Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem (2010) 1.00
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA. Nucleic Acids Res (1993) 1.00
Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils. Am J Pathol (1989) 0.99
Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J Clin Invest (1994) 0.98
Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation, a novel mechanism regulating eNOS function and coupling. J Biol Chem (2011) 0.97
Endothelial-derived superoxide anions in pig coronary arteries: evidence from lucigenin chemiluminescence and histochemical techniques. J Physiol (1997) 0.97
Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe. Free Radic Biol Med (2012) 0.96
Detection of oxygen-derived radicals in biological systems using electron spin resonance. Environ Health Perspect (1994) 0.96
Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation. Biochemistry (2014) 0.94
Protein thiyl radical mediates S-glutathionylation of complex I. Free Radic Biol Med (2012) 0.94
Free radicals and chemiluminescence as products of the spontaneous oxidation of sulfide in seawater, and their biological implications. Biol Bull (1999) 0.93
Oxidative Stress and Lung Ischemia-Reperfusion Injury. Oxid Med Cell Longev (2015) 0.91
The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J Biol Chem (2010) 0.90
Modulation of arterial endothelial permeability: studies on an in vitro model. Br J Pharmacol (1989) 0.90
Endothelial superoxide production in the isolated rat heart during early reperfusion after ischemia. A histochemical study. Am J Pathol (1991) 0.88
Direct measurement of nitroxide pharmacokinetics in isolated hearts situated in a low-frequency electron spin resonance spectrometer: implications for spin trapping and in vivo oxymetry. Proc Natl Acad Sci U S A (1988) 0.87
Bang-bang model for regulation of local blood flow. Microcirculation (2013) 0.87
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86
Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium. Biochem J (1998) 0.85
Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors. J Cell Biochem (2010) 0.83
Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.83
Perivascular demyelination and intramyelinic oedema in reperfusion nerve injury. J Anat (1994) 0.82
Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. Biochem J (1987) 0.81
Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells. J Clin Invest (1989) 0.80
Neutrophil-oxidized low density lipoprotein: generation in and clearance from the plasma. Int J Exp Pathol (1992) 0.79
The effect of NG-nitro-L-arginine methyl ester upon basal blood flow and endothelium-dependent vasodilatation in the dog hindlimb. Br J Pharmacol (1993) 0.79
Inhibition of peripheral blood neutrophil oxidative burst in periodontitis patients with a homeopathic medication Traumeel S. Med Sci Monit (2011) 0.75
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem (1969) 43.83
Superoxide dismutases. Annu Rev Biochem (1975) 8.00
The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem (1968) 4.72
Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems? FEBS Lett (1978) 3.14
Paraquat and Escherichia coli. Mechanism of production of extracellular superoxide radical. J Biol Chem (1979) 2.82
The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J Biol Chem (1982) 2.81
Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography. J Biol Chem (1976) 2.63
Spin trapping of superoxide and hydroxyl radical: practical aspects. Arch Biochem Biophys (1980) 2.30
The univalent reduction of oxygen by reduced flavins and quinones. J Biol Chem (1972) 2.07
Considerations in the spin trapping of superoxide and hydroxyl radical in aqueous systems using 5,5-dimethyl-1-pyrroline-1-oxide. Biochem Biophys Res Commun (1978) 1.82
Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts. Mol Pharmacol (1982) 1.80
Spin trapping of superoxide. Mol Pharmacol (1979) 1.73
The effect of iron on the distribution of superoxide and hydroxyl radicals as seen by spin trapping and on the superoxide dismutase assay. Photochem Photobiol (1979) 1.58
Reduced triphosphopyridine nucleotide oxidase-catalyzed alterations of membrane phospholipids. IV. Dependence on Fe3+. J Biol Chem (1971) 1.41
Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem (1983) 1.28
A quantitative test for superoxide radicals produced in biological systems. Biochem J (1982) 1.22
Chemical evidence for production of hydroxyl radicals during microsomal electron transfer. Science (1979) 1.15
A method for the detection of superoxide in biological systems. Arch Biochem Biophys (1982) 1.09
Current concepts concerning radioprotective and cryoprotective properties of dimethyl sulfoxide in cellular systems. Ann N Y Acad Sci (1975) 1.09
Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane. Biochim Biophys Acta (1978) 1.07
In vivo spin-trapping of trichloromethyl radicals formed from CCl4. Biochem Pharmacol (1979) 1.03
Hyperoxia enhances lung and liver nuclear superoxide generation. Biochim Biophys Acta (1984) 0.97
Not all aromatic nitro compounds form free radicals. Toxicol Lett (1984) 0.86
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest (1996) 6.38
Biology of disease: free radicals and tissue injury. Lab Invest (1982) 6.09
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J Biol Chem (1991) 5.84
Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys (1991) 4.71
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature (1998) 4.34
Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem (1994) 3.64
Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation (2001) 3.54
Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation (1997) 3.28
Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem (1992) 3.21
Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest (1995) 2.94
Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res (2000) 2.62
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem (1981) 2.60
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci U S A (2001) 2.48
The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys (1982) 2.37
Superoxide and peroxynitrite in atherosclerosis. Proc Natl Acad Sci U S A (1994) 2.32
Spin trapping of superoxide and hydroxyl radical: practical aspects. Arch Biochem Biophys (1980) 2.30
Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration. J Clin Invest (2001) 2.16
Behavioral bibliotherapy: a review of self-help behavior therapy manuals. Psychol Bull (1978) 2.13
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem (1988) 1.98
Detection of catalase in rat heart mitochondria. J Biol Chem (1991) 1.90
Lipid composition and lipid metabolism of Spiroplasma citri. J Bacteriol (1976) 1.87
Oxygen reduction by nitric-oxide synthases. J Biol Chem (2001) 1.86
Production of hydroxyl radical by decomposition of superoxide spin-trapped adducts. Mol Pharmacol (1982) 1.80
Spin trapping of superoxide. Mol Pharmacol (1979) 1.73
Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion. Chem Res Toxicol (1999) 1.72
GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.70
Assessment of diagnostic technologies. Science (1979) 1.68
Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations. Arch Biochem Biophys (1996) 1.67
Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. J Biol Chem (1999) 1.64
Peroxynitrite-induced luminol chemiluminescence. Biochem J (1993) 1.63
Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. Proc Natl Acad Sci U S A (1999) 1.55
Feasibility of using unattended polysomnography in children for research--report of the Tucson Children's Assessment of Sleep Apnea study (TuCASA). Sleep (2001) 1.54
Cytochrome c nitration by peroxynitrite. J Biol Chem (2000) 1.53
Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy. Free Radic Biol Med (1988) 1.53
Spin trapping of superoxide and hydroxyl radicals. Methods Enzymol (1984) 1.52
Hyperoxia increases H2O2 release by lung mitochondria and microsomes. Arch Biochem Biophys (1982) 1.51
Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J Biol Chem (2000) 1.49
Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug. J Clin Invest (1996) 1.46
Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury. Anesthesiology (1998) 1.45
Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits. Proc Natl Acad Sci U S A (1996) 1.41
Mechanism of superoxide generation by neuronal nitric-oxide synthase. J Biol Chem (1999) 1.41
Nitric oxide inhibition of lipid peroxidation: kinetics of reaction with lipid peroxyl radicals and comparison with alpha-tocopherol. Biochemistry (1997) 1.38
Biological aspects of reactive nitrogen species. Biochim Biophys Acta (1999) 1.37
Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes. J Biol Chem (1992) 1.36
Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease. Circ Res (2001) 1.36
Separation of type 2 toxins of Vibrio cholerae. Science (1969) 1.35
Xanthine oxidase-mediated decomposition of S-nitrosothiols. J Biol Chem (1998) 1.34
Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. Arch Biochem Biophys (1995) 1.34
Reactive species in sickle cell disease. Ann N Y Acad Sci (2000) 1.32
Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives. Free Radic Biol Med (2009) 1.32
Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am Rev Respir Dis (1992) 1.31
Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest (1984) 1.30
A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. Free Radic Biol Med (1989) 1.29
Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem (1983) 1.28
Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability. Am J Physiol (1989) 1.27
Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol (1989) 1.25
Intracellular localization of the copper-zinc and manganese superoxide dismutases in rat liver parenchymal cells. Lab Invest (1986) 1.25
Bacteria form intracellular free radicals in response to paraquat and streptonigrin. Demonstration of the potency of hydroxyl radical. J Biol Chem (1987) 1.25
Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry. J Biol Chem (1986) 1.24
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. Circ Res (1999) 1.24
Reaction of peroxynitrite with Mn-superoxide dismutase. Role of the metal center in decomposition kinetics and nitration. J Biol Chem (2001) 1.24
Nitric oxide regulation of tissue free radical injury. Chem Res Toxicol (1996) 1.24
Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol (1985) (1987) 1.20
Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate. J Biol Chem (2000) 1.20
Reactive oxygen species in human health and disease. Nutrition (2001) 1.18
Circulating xanthine oxidase: potential mediator of ischemic injury. Am J Physiol (1990) 1.17
Detection of H2O2 release from vascular endothelial cells. Free Radic Biol Med (1993) 1.17
Kinetics of peroxynitrite reaction with amino acids and human serum albumin. J Biol Chem (1999) 1.16
Hyperoxia increases oxygen radical production in rat lung homogenates. Arch Biochem Biophys (1982) 1.16
Spin trapping of the primary radical involved in the activation of the carcinogen N-hydroxy-2-acetylaminofluorene by cumene hydroperoxide-hematin. Mol Pharmacol (1980) 1.15
Oxidant-mediated impairment of nitric oxide signaling in sickle cell disease--mechanisms and consequences. Cell Mol Biol (Noisy-le-grand) (2004) 1.15
Nitroxides as potential contrast enhancing agents for MRI application: influence of structure on the rate of reduction by rat hepatocytes, whole liver homogenate, subcellular fractions, and ascorbate. Magn Reson Med (1987) 1.11
A method for the detection of superoxide in biological systems. Arch Biochem Biophys (1982) 1.09
Antigenic structure of Brucella suis spheroplasts. J Bacteriol (1966) 1.09
Peroxynitrite reactions with carbon dioxide-bicarbonate. Methods Enzymol (1999) 1.08
Osmotically sensitive Brucella in infected normal and immune macrophages. Infect Immun (1970) 1.07
Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes. Arch Biochem Biophys (1997) 1.07
15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase. J Biol Chem (1999) 1.07
Peroxynitrite-dependent tryptophan nitration. Chem Res Toxicol (1996) 1.06
Fractionation of Phenol Extracts from Brucella suis: Separation of Multiple Biologically Active Components. Infect Immun (1970) 1.04
Partial monosomy 21, diminished activity of superoxide dismutase, and pulmonary oxygen toxicity. N Engl J Med (1988) 1.04
Purification of flagellar cores of Vibrio cholerae. J Bacteriol (1977) 1.04
Cytochrome c-catalyzed membrane lipid peroxidation by hydrogen peroxide. Arch Biochem Biophys (1991) 1.04
Science and pseudoscience in the development of eye movement desensitization and reprocessing: implications for clinical psychology. Clin Psychol Rev (2000) 1.04
In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging. Biophys J (1996) 1.03
Some physical, chemical, and taxonomic features of the soluble antigens of the Brucellae. J Infect Dis (1970) 1.03
Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function. J Biol Chem (2000) 1.02
Nitration of unsaturated fatty acids by nitric oxide-derived reactive species. Methods Enzymol (1999) 1.02
Xanthine oxidase reaction with nitric oxide and peroxynitrite. Arch Biochem Biophys (1998) 1.01
Reaction of xanthine oxidase-derived oxidants with lipid and protein of human plasma. Arch Biochem Biophys (1991) 1.00
Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques. J Biol Chem (1986) 1.00
Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia. Am J Physiol (1996) 1.00
Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proc Natl Acad Sci U S A (2001) 0.99
Sulfenic acid in human serum albumin. Amino Acids (2006) 0.99
Binding of myeloperoxidase to bacteria: effect on hydroxyl radical formation and susceptibility to oxidant-mediated killing. Biochim Biophys Acta (1996) 0.99
Pharmacokinetics of nitroxide NMR contrast agents. Invest Radiol (1985) 0.98
Problems associated with spin trapping oxygen-centered free radicals in biological systems. Anal Biochem (1989) 0.98