Published in Mol Cell Endocrinol on November 01, 1981
Inositol trisphosphate and diacylglycerol as second messengers. Biochem J (1984) 14.37
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J (1983) 10.35
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J (1982) 8.16
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J (1983) 6.17
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem J (1983) 4.11
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. Biochem J (1984) 3.07
Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands. Biochem J (1983) 2.47
Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate. Biochem J (1984) 1.92
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem J (1985) 1.83
Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism. Proc Natl Acad Sci U S A (1984) 1.58
Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli. Biochem J (1984) 1.49
Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium. Biochem J (1984) 1.39
Inositol 1,4,5-trisphosphate-induced release of sequestered Ca2+ from highly purified human platelet intracellular membranes. Biochem J (1985) 1.33
The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation. Biochem J (1984) 1.31
Histamine-induced inositol phospholipid breakdown in the longitudinal smooth muscle of guinea-pig ileum. Br J Pharmacol (1985) 1.28
Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation. Biochem J (1984) 1.27
Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites. Proc Natl Acad Sci U S A (1983) 1.18
Requirements for hormone release from permeabilized nerve endings isolated from the rat neurohypophysis. J Physiol (1987) 1.16
Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents. Biochem J (1983) 1.13
Receptor-mediated metabolism of the phosphoinositides and phosphatidic acid in rat lacrimal acinar cells. Biochem J (1984) 1.11
Phospholipid turnover in isolated rat pancreatic acini. Consideration of the relative roles of phospholipase A2 and phospholipase C. Biochem J (1982) 1.06
Voltage dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in peeled skeletal muscle fibers. Proc Natl Acad Sci U S A (1988) 1.03
The spasmogenic action of oxytocin in the rat uterus--comparison with other agonists. Br J Pharmacol (1986) 1.00
Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase. Proc Natl Acad Sci U S A (1984) 0.96
Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets. J Clin Invest (1983) 0.96
Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets. Biochem J (1984) 0.91
Gonadotropin-releasing hormone (GnRH) stimulates phosphatidylinositol metabolism in rat granulosa cells: mechanism of action of GnRH. Proc Natl Acad Sci U S A (1983) 0.88
Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters. Biochem J (1985) 0.87
Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels. Front Pharmacol (2012) 0.86
Alpha- and beta-adrenergic receptor subtypes properties, distribution and regulation. Drugs (1984) 0.86
Modulation of active Ca2+ uptake by the islet-cell endoplasmic reticulum. Biochem J (1983) 0.85
Phorbol diesters inhibit enzymatic hydrolysis of diacylglycerols in vitro. Proc Natl Acad Sci U S A (1986) 0.83
Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog thyroid cells. Biochem J (1989) 0.81
Role of retinoic acid and platelet-derived growth factor receptor cross talk in the regulation of neonatal gonocyte and embryonal carcinoma cell differentiation. Endocrinology (2015) 0.79
Plasma from uninephrectomized rats stimulates production of inositol trisphosphates and inositol tetrakisphosphate in renal cortical slices. Biochem J (1988) 0.79
Lypopolysaccharide downregulates the expression of selected phospholipase C genes in cultured endothelial cells. Inflammation (2013) 0.78
Depletion of arachidonic acid from GH3 cells. Effects on inositol phospholipid turnover and cellular activation. Biochem J (1987) 0.78
Monoclonal antibodies to purified muscarinic receptor display agonist-like activity. Proc Natl Acad Sci U S A (1984) 0.77
Complex interactions of agonists with alpha 1-adrenoceptors in intact cells. Br J Pharmacol (1988) 0.77
Chemiluminescence in neutrophils and Lettré cells induced by myxoviruses. Biochem J (1985) 0.75
Impairment of relaxations to acetylcholine and nitric oxide by a phorbol ester in rat isolated aorta. Br J Pharmacol (1990) 0.75
Proceedings of the British Pharmacological Society 8th-10th September, 1982. Abstracts. Br J Pharmacol (1982) 0.75
Different expression and subcellular localization of Phosphoinositide-specific Phospholipase C enzymes in differently polarized macrophages. J Cell Commun Signal (2016) 0.75
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Inositol trisphosphate and diacylglycerol as second messengers. Biochem J (1984) 14.37
Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu Rev Biochem (1987) 12.04
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature (1983) 10.90
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J (1983) 10.35
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J (1982) 8.16
Calcium--a life and death signal. Nature (1998) 6.35
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J (1983) 6.17
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues. Nature (1986) 5.41
The second messenger linking receptor activation to internal Ca release in liver. Nature (1984) 3.73
The interaction of cyclic nucleotides and calcium in the control of cellular activity. Adv Cyclic Nucleotide Res (1975) 3.38
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate. Nature (1984) 3.35
The elemental principles of calcium signaling. Cell (1995) 3.18
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. Biochem J (1984) 3.07
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. Proc Natl Acad Sci U S A (1990) 2.97
Cooking with calcium: the recipes for composing global signals from elementary events. Cell (1997) 2.89
Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland. Biochem J (1979) 2.70
The organisation and functions of local Ca(2+) signals. J Cell Sci (2001) 2.38
Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells. Biochem J (1986) 2.30
The AM and FM of calcium signalling. Nature (1997) 2.26
Localization and heterogeneity of agonist-induced changes in cytosolic calcium concentration in single bovine adrenal chromaffin cells from video imaging of fura-2. EMBO J (1989) 2.24
A comparison of fluorescent Ca2+ indicator properties and their use in measuring elementary and global Ca2+ signals. Cell Calcium (2000) 2.21
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells. Biochem J (1984) 2.18
Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores. Nature (1991) 2.16
Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate. Nature (1984) 2.11
Calcium signalling--an overview. Semin Cell Dev Biol (2001) 2.06
Inositol tetrakis- and pentakisphosphates in GH4 cells. J Exp Biol (1985) 2.02
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes. Biochem J (1984) 2.01
myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors. Nature (1984) 1.96
Cell signalling. A tale of two messengers. Nature (1993) 1.88
Inositol lipids and cell proliferation. Biochim Biophys Acta (1987) 1.84
Reduction of epidermal growth factor receptor affinity by heterologous ligands: evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C. Biochem Biophys Res Commun (1984) 1.83
Distribution of two distinct Ca2+-ATPase-like proteins and their relationships to the agonist-sensitive calcium store in adrenal chromaffin cells. Nature (1989) 1.81
Subcellular Ca2+ signals underlying waves and graded responses in HeLa cells. Curr Biol (1996) 1.70
Functional InsP3 receptors that may modulate excitation-contraction coupling in the heart. Curr Biol (2000) 1.68
Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. Biochem J (1984) 1.67
Mitochondrial Ca(2+) uptake depends on the spatial and temporal profile of cytosolic Ca(2+) signals. J Biol Chem (2001) 1.64
Nuclear calcium signalling by individual cytoplasmic calcium puffs. EMBO J (1997) 1.63
Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol (2001) 1.62
Hormone-evoked elementary Ca2+ signals are not stereotypic, but reflect activation of different size channel clusters and variable recruitment of channels within a cluster. J Biol Chem (1998) 1.59
Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine. Biochem J (1979) 1.57
Effects of bombesin and insulin on inositol (1,4,5)trisphosphate and inositol (1,3,4)trisphosphate formation in Swiss 3T3 cells. Cell (1986) 1.55
The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes. J Biol Chem (1994) 1.54
Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion. Proc Natl Acad Sci U S A (1972) 1.51
A comparative survey of the function, mechanism and control of cellular oscillators. J Exp Biol (1979) 1.50
All-or-nothing Ca2+ mobilization from the intracellular stores of single histamine-stimulated HeLa cells. J Physiol (1992) 1.49
Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells. J Biol Chem (1985) 1.45
The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor. J Biol Chem (1992) 1.44
Smoothly graded Ca2+ release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores. J Biol Chem (1994) 1.44
Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses. J Cell Sci (2001) 1.42
Microscopic properties of elementary Ca2+ release sites in non-excitable cells. Curr Biol (2000) 1.42
Characterization of elementary Ca2+ release signals in NGF-differentiated PC12 cells and hippocampal neurons. Neuron (1999) 1.39
Expression and function of ryanodine receptors in nonexcitable cells. J Biol Chem (1996) 1.38
The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands. J Exp Biol (1970) 1.36
Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate-sensitive stores in rat hepatocytes. J Physiol (1992) 1.35
Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands. Biochem J (1979) 1.34
Excitation and adaptation of Limulus ventral photoreceptors by inositol 1,4,5 triphosphate result from a rise in intracellular calcium. J Gen Physiol (1986) 1.34
Relationship of polyphosphoinositide metabolism to the hormonal activation of the inset salivary gland by 5-hydroxytryptamine. Mol Cell Endocrinol (1984) 1.31
The role of calcium in fly salivary gland secretion analyzed with the ionophore A-23187. Biochim Biophys Acta (1973) 1.30
Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release. Cell Calcium (1991) 1.29
The role of endoplasmic reticulum calcium pumps during cytosolic calcium spiking in pancreatic acinar cells. J Biol Chem (1993) 1.28
Fine-structural changes in relation to ion and water transport in the rectal papillae of the blowfly, Calliphora. J Cell Sci (1967) 1.27
Simultaneous measurements of cytosolic calcium and secretion in single bovine adrenal chromaffin cells by fluorescent imaging of fura-2 in cocultured cells. J Cell Biol (1989) 1.27
Membrane permeability changes during stimulation of isolated salivary glands of Calliphora by 5-hydroxytryptamine. J Physiol (1975) 1.26
Inositol(3,4)bisphosphate and inositol(1,3)bisphosphate in GH4 cells--evidence for complex breakdown of inositol(1,3,4)trisphosphate. Biochem Biophys Res Commun (1987) 1.26
Spatial localization of the stimulus-induced rise in cytosolic Ca2+ in bovine adrenal chromaffin cells. Distinct nicotinic and muscarinic patterns. FEBS Lett (1989) 1.25
Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem J (1995) 1.21
Insect salivary glands: stimulation of fluid secretion by 5-hydroxytryptamine and adenosine-3',5'-monophosphate. Science (1968) 1.20
G-protein regulation of capacitative calcium entry may be mediated by protein kinases A and C in Xenopus oocytes. Biochem J (1995) 1.18
Ca2+ entry into PC12 cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors. Biochem J (1998) 1.18
Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium. Biochem J (1989) 1.17
Bovine adrenal chromaffin cells contain an inositol 1,4,5-trisphosphate-insensitive but caffeine-sensitive Ca2+ store that can be regulated by intraluminal free Ca2+. Biochem J (1991) 1.15
Transepithelial potential changes during stimulation of isolated salivary glands with 5-hydroxytryptamine and cyclic AMP. J Exp Biol (1972) 1.15
Extracellular calcium concentration controls the frequency of intracellular calcium spiking independently of inositol 1,4,5-trisphosphate production in HeLa cells. Biochem J (1996) 1.08
The caffeine-sensitive Ca2+ store in bovine adrenal chromaffin cells; an examination of its role in triggering secretion and Ca2+ homeostasis. FEBS Lett (1990) 1.06
DL-myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes. Biochem Biophys Res Commun (1988) 1.05
Inositol 1,4,5-trisphosphate may be a signal for f-Met-Leu-Phe-induced intracellular Ca mobilisation in human leucocytes (HL-60 cells). FEBS Lett (1984) 1.03
5-Hydroxytryptamine stimulation of phosphatidylinositol hydrolysis and calcium signalling in the blowfly salivary gland. Cell Calcium (1982) 1.03
Regulation of ion channels by inositol trisphosphate and diacylglycerol. J Exp Biol (1986) 1.02
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization. Biochem J (2000) 1.02
Quantal Ca2+ release from caffeine-sensitive stores in adrenal chromaffin cells. J Biol Chem (1993) 1.01
Ernst Klenk Lecture, November 1985. Intracellular signalling through inositol trisphosphate and diacylglycerol. Biol Chem Hoppe Seyler (1986) 1.01
Oscillations in calcium-cyclic AMP control loops form the basis of pacemaker activity and other high frequency biological rhythms. J Theor Biol (1977) 1.01
Phosphatidylinositol-hydrolysing enzymes in blowfly salivary glands. Biochem J (1982) 1.01
Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: evidence against a highly diffusible calcium influx factor. Pflugers Arch (1996) 0.99
The effects of 5-hydroxytryptamine and cyclic AMP on the potential profile across isolated salivary glands. J Exp Biol (1972) 0.98
Regulation of ryanodine receptor opening by lumenal Ca(2+) underlies quantal Ca(2+) release in PC12 cells. J Biol Chem (1999) 0.98
Changes in cyclic AMP and cyclic GMP concentrations during the action of 5-hydroxytryptamine on an insect salivary gland. Biochem J (1980) 0.97
The molecular basis of communication within the cell. Sci Am (1985) 0.97
Separate 5-hydroxytryptamine receptors on the salivary gland of the blowfly are linked to the generation of either cyclic adenosine 3',5'-monophosphate or calcium signals. Br J Pharmacol (1981) 0.96
Cell signalling through phospholipid metabolism. J Cell Sci Suppl (1986) 0.96
Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking. Biochem J (1996) 0.95
Subsecond and second changes in inositol polyphosphates in GH4C1 cells induced by thyrotropin-releasing hormone. Biochem J (1987) 0.94
Quantal Ca2+ mobilization by ryanodine receptors is due to all-or-none release from functionally discrete intracellular stores. Biochem J (1994) 0.94
Relationship between 5-hydroxytryptamine activation of phosphatidylinositol hydrolysis and calcium-ion entry in Calliphora salivary glands. Biochem Soc Trans (1978) 0.93
Phosphoinositides and signal transductions. Rev Clin Basic Pharm (1985) 0.93
A coat of repeating subunits on the cytoplasmic surface of the plasma membrane in the rectal papillae of the blowfly, Calliphora erythrocephala (Meig.), studied in situ by electron microscopy. J Cell Biol (1966) 0.93
Fertilisation and thimerosal stimulate similar calcium spiking patterns in mouse oocytes but by separate mechanisms. Development (1993) 0.92
Structural and functional aspects of salivary fluid section in Calliphora. Tissue Cell (1970) 0.92
Inositol lipids and cell proliferation. Biochem Soc Trans (1985) 0.92