Why do viruses cause cancer? Highlights of the first century of human tumour virology.

PubWeight™: 2.68‹?› | Rank: Top 1%

🔗 View Article (PMC 3718018)

Published in Nat Rev Cancer on November 24, 2010

Authors

Patrick S Moore1, Yuan Chang

Author Affiliations

1: Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA. psm9@pitt.edu

Articles citing this

(truncated to the top 100)

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer (2013) 4.02

The microbiome and cancer. Nat Rev Cancer (2013) 2.86

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest (2011) 2.37

Cancer immunotherapy--revisited. Nat Rev Drug Discov (2011) 2.26

The landscape of viral expression and host gene fusion and adaptation in human cancer. Nat Commun (2013) 2.17

Consensus on the role of human cytomegalovirus in glioblastoma. Neuro Oncol (2012) 2.02

Exploiting the curative potential of adoptive T-cell therapy for cancer. Immunol Rev (2014) 1.86

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet (2015) 1.86

Virus-encoded microRNAs: an overview and a look to the future. PLoS Pathog (2012) 1.80

Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest (2013) 1.68

Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med (2012) 1.61

Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol (2011) 1.56

Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol (2011) 1.46

Human viral oncogenesis: a cancer hallmarks analysis. Cell Host Microbe (2014) 1.42

An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe (2012) 1.38

Exposure to Bovine Leukemia Virus Is Associated with Breast Cancer: A Case-Control Study. PLoS One (2015) 1.37

Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors. J Natl Cancer Inst (2012) 1.30

Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology (2013) 1.27

Cancer research: past, present and future. Nat Rev Cancer (2011) 1.24

Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One (2011) 1.21

Trial watch: Peptide vaccines in cancer therapy. Oncoimmunology (2012) 1.17

MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol (2012) 1.14

Keeping it quiet: chromatin control of gammaherpesvirus latency. Nat Rev Microbiol (2013) 1.13

The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology. PLoS Pathog (2013) 1.10

KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways. PLoS Pathog (2013) 1.08

New insights into human papillomavirus-associated head and neck squamous cell carcinoma. Acta Otorhinolaryngol Ital (2013) 1.07

An updated overview of HPV-associated head and neck carcinomas. Oncotarget (2014) 1.06

The price of immunity. Nat Immunol (2012) 1.04

Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. PLoS Comput Biol (2013) 1.04

The prevention of infection-associated cancers. Carcinogenesis (2011) 1.03

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer. Curr Oncol Rep (2011) 1.03

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

What's the damage? The impact of pathogens on pathways that maintain host genome integrity. Cell Host Microbe (2014) 1.00

Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis (2011) 0.99

Roles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications. World J Virol (2012) 0.98

Exposure to raccoon polyomavirus (RacPyV) in free-ranging North American raccoons (Procyon lotor). Virology (2016) 0.98

A review of bacteria-animal lateral gene transfer may inform our understanding of diseases like cancer. PLoS Genet (2013) 0.97

Endogenous retroviruses and the development of cancer. J Immunol (2014) 0.97

Review of the clinical and biologic aspects of human papillomavirus-positive squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys (2014) 0.97

Ubiquitin-independent proteasomal degradation during oncogenic viral infections. Biochim Biophys Acta (2011) 0.96

A new role for microRNAs, as ligands of Toll-like receptors. RNA Biol (2013) 0.96

Urinary human polyomavirus and papillomavirus infection and bladder cancer risk. Br J Cancer (2011) 0.94

Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol (2015) 0.93

Human viruses and cancer. Viruses (2014) 0.92

Unusual space-time patterning of the Fallon, Nevada leukemia cluster: Evidence of an infectious etiology. Chem Biol Interact (2011) 0.92

Chronic inflammation and immunologic-based constraints in malignant disease. Immunotherapy (2011) 0.91

Is virology dead? MBio (2014) 0.91

Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIβ for latent DNA replication of the terminal repeats. J Virol (2012) 0.91

Sensitive detection of viral transcripts in human tumor transcriptomes. PLoS Comput Biol (2013) 0.90

Epigenetic regulation of EBV and KSHV latency. Curr Opin Virol (2013) 0.90

Human tumour viruses and the deregulation of cell polarity in cancer. Nat Rev Cancer (2012) 0.90

Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen. J Virol (2015) 0.89

The conundrum of causality in tumor virology: the cases of KSHV and MCV. Semin Cancer Biol (2013) 0.89

Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go? Purinergic Signal (2012) 0.88

Implication of human herpesviruses in oncogenesis through immune evasion and supression. Infect Agent Cancer (2014) 0.87

Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus. Cancers (Basel) (2014) 0.87

The tumor virus landscape of AIDS-related lymphomas. Blood (2015) 0.87

Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons. Anal Chem (2013) 0.87

PDZ domains and viral infection: versatile potentials of HPV-PDZ interactions in relation to malignancy. Biomed Res Int (2013) 0.86

Using antimicrobial adjuvant therapy in cancer treatment: a review. Infect Agent Cancer (2012) 0.86

The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer. Viruses (2015) 0.85

No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with breast cancer in Mexican women. Sci Rep (2013) 0.85

Modulation of autophagy-like processes by tumor viruses. Cells (2012) 0.85

Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. PLoS One (2015) 0.84

Landscape of gene fusions in epithelial cancers: seq and ye shall find. Genome Med (2015) 0.84

Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J Virol (2013) 0.84

Macaque homologs of EBV and KSHV show uniquely different associations with simian AIDS-related lymphomas. PLoS Pathog (2012) 0.84

Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells. J Virol (2014) 0.83

The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor. Nucleic Acids Res (2013) 0.83

TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. Drugs Future (2011) 0.83

The host STING pathway at the interface of cancer and immunity. J Clin Invest (2016) 0.83

Immediate Antiretroviral Therapy Reduces Risk of Infection-Related Cancer During Early HIV Infection. Clin Infect Dis (2016) 0.83

Milestones in the staging, classification, and biology of Merkel cell carcinoma. J Natl Compr Canc Netw (2014) 0.82

Necroptosis: an alternative cell death program defending against cancer. Biochim Biophys Acta (2016) 0.82

The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation. BMC Genomics (2013) 0.82

An association between membranoproliferative glomerulonephritis and metastatic colorectal carcinoma: a case report. J Med Case Rep (2016) 0.80

Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection. Oncogenesis (2012) 0.80

The Microbiome and Cancer: Is the 'Oncobiome' Mirage Real? Trends Cancer (2015) 0.80

Detection of Epstein-Barr virus (EBV) in human lymphoma tissue by a novel microbial detection array. Biomark Res (2014) 0.79

Epigenetics and Genetics of Viral Latency. Cell Host Microbe (2016) 0.79

Leukaemia 'firsts' in cancer research and treatment. Nat Rev Cancer (2016) 0.79

Full-length single-cell RNA-seq applied to a viral human cancer: applications to HPV expression and splicing analysis in HeLa S3 cells. Gigascience (2015) 0.79

Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen. Cancer Lett (2014) 0.79

How to develop viruses into anticancer weapons. PLoS Pathog (2017) 0.78

Perspective: The Promise of Proteomics in the Study of Oncogenic Viruses. Mol Cell Proteomics (2017) 0.78

Preclinical evaluation of PI3K inhibitor BYL719 as a single agent and its synergism in combination with cisplatin or MEK inhibitor in nasopharyngeal carcinoma (NPC). Am J Cancer Res (2015) 0.78

Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus. Viruses (2015) 0.78

Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97. J Biol Chem (2015) 0.78

Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy. J Biol Chem (2014) 0.78

Epigenetic impact of infection on carcinogenesis: mechanisms and applications. Genome Med (2016) 0.78

Antiviral antibody profiling by high-density protein arrays. Proteomics (2015) 0.78

KSHV Genome Replication and Maintenance. Front Microbiol (2016) 0.78

Pathogen-driven cancers and emerging immune therapeutic strategies. Cancer Immunol Res (2014) 0.78

Tissue-specific tumorigenesis: context matters. Nat Rev Cancer (2017) 0.77

Proteomics and Transcriptomics of BJAB Cells Expressing the Epstein-Barr Virus Noncoding RNAs EBER1 and EBER2. PLoS One (2015) 0.77

Prior human polyomavirus and papillomavirus infection and incident lung cancer: a nested case-control study. Cancer Causes Control (2015) 0.77

The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma. AIDS Res Treat (2012) 0.77

Multitask learning of signaling and regulatory networks with application to studying human response to flu. PLoS Comput Biol (2014) 0.77

Thank You, Edward. Merci, Louis. PLoS Pathog (2016) 0.77

Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies. J Diabetes Res (2015) 0.77

Articles cited by this

(truncated to the top 100)

A genetic model for colorectal tumorigenesis. Cell (1990) 44.37

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science (1983) 43.61

THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Proc R Soc Med (1965) 40.52

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science (1994) 39.60

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08

A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS. J Exp Med (1911) 29.44

DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature (1984) 27.05

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med (1995) 21.16

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60

RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature (1970) 19.89

RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature (1970) 19.38

T antigen is bound to a host protein in SV40-transformed cells. Nature (1979) 17.78

Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science (2008) 16.60

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54

Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47

Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med (2007) 16.39

Cancer. p53, guardian of the genome. Nature (1992) 16.36

INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med (1933) 15.65

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci U S A (1983) 14.73

VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet (1964) 14.21

Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell (1979) 14.05

A review of human carcinogens--Part B: biological agents. Lancet Oncol (2009) 13.85

The global health burden of infection-associated cancers in the year 2002. Int J Cancer (2006) 13.57

Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet (1981) 13.54

Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat (2004) 13.18

Identification of microRNAs of the herpesvirus family. Nat Methods (2005) 12.98

Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89

Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science (1990) 12.88

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell (1988) 12.69

Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet (2007) 11.06

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature (1996) 10.81

Cloning the differences between two complex genomes. Science (1993) 10.60

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J (1984) 10.28

The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol (2006) 10.21

Retracted Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog (2006) 10.08

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81

Epstein-Barr virus: 40 years on. Nat Rev Cancer (2004) 9.70

Interferon-inducible antiviral effectors. Nat Rev Immunol (2008) 9.68

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature (1981) 9.25

Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet (1990) 9.11

Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells. Science (1967) 8.62

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE. Science (1936) 8.23

Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog (2007) 8.01

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J (1989) 7.69

Hepatitis B virus biology. Microbiol Mol Biol Rev (2000) 7.58

The quest for human cancer viruses. Science (1962) 7.44

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature (2005) 7.18

Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS (2006) 7.08

Identification of a third human polyomavirus. J Virol (2007) 7.06

In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood (1995) 6.91

A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA (1965) 6.21

Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev (1996) 6.12

Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med (1997) 6.03

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell (1995) 5.97

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (1996) 5.97

KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med (1996) 5.96

The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med (1996) 5.56

Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science (1999) 5.55

Primary structure of the herpesvirus saimiri genome. J Virol (1992) 5.26

"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos. Proc Soc Exp Biol Med (1951) 5.18

The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell (1986) 5.13

A viral microRNA functions as an orthologue of cellular miR-155. Nature (2007) 5.09

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A (1984) 4.97

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature (2003) 4.80

Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77

MORPHOLOGICAL AND BIOLOGICAL STUDIES ON A VIRUS IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. J Exp Med (1965) 4.76

Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc Natl Acad Sci U S A (2008) 4.75

p53 inhibition by the LANA protein of KSHV protects against cell death. Nature (2000) 4.74

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A (2008) 4.74

Merkel cell carcinoma and HIV infection. Lancet (2002) 4.72

Helicobacter pylori: gastric cancer and beyond. Nat Rev Cancer (2010) 4.64

Seroepidemiology of human polyomaviruses. PLoS Pathog (2009) 4.62

Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in a body cavity-based lymphoma cell line (BC-1). J Virol (1998) 4.62

Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture. Virology (1958) 4.36

Herpesvirus latency confers symbiotic protection from bacterial infection. Nature (2007) 4.27

The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med (2000) 4.20

Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med (1996) 4.13

Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. Retrovirology (2009) 4.11

Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet (1996) 4.05

A TRANSMISSIBLE AVIAN NEOPLASM. (SARCOMA OF THE COMMON FOWL.). J Exp Med (1910) 3.99

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature (2002) 3.99

Part I: Cancer in Indigenous Africans--burden, distribution, and trends. Lancet Oncol (2008) 3.91

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (1996) 3.88

Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe (2010) 3.78

Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City and California. MMWR Morb Mortal Wkly Rep (1981) 3.78

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science (1997) 3.73

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73

Intracellular DNA recognition. Nat Rev Immunol (2010) 3.70

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science (1996) 3.70

Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature (1996) 3.61

Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N Engl J Med (1996) 3.61

Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Engl J Med (1999) 3.38

Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. Infect Agent Cancer (2009) 3.33

Cyclin encoded by KS herpesvirus. Nature (1996) 3.32

Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40. Virology (1962) 3.22

Projected clinical benefits and cost-effectiveness of a human papillomavirus 16/18 vaccine. J Natl Cancer Inst (2004) 3.11

A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med (2003) 3.10

Articles by these authors

Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science (2008) 16.60

T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A (2008) 4.74

Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol (2010) 2.88

Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer (2009) 2.78

Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer (2009) 2.77

Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol (2007) 2.68

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest (2011) 2.37

Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog (2009) 2.08

Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin? Annu Rev Microbiol (2003) 2.07

Viral IL-6-induced cell proliferation and immune evasion of interferon activity. Science (2002) 1.97

A sensitive non-radioactive northern blot method to detect small RNAs. Nucleic Acids Res (2010) 1.81

Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Pathol (2009) 1.79

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res (2012) 1.66

Survivin is a therapeutic target in Merkel cell carcinoma. Sci Transl Med (2012) 1.61

The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication. J Virol (2009) 1.52

Update on human polyomaviruses and cancer. Adv Cancer Res (2010) 1.40

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J Virol (2007) 1.28

Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7. Cell Host Microbe (2013) 1.27

Characterization of viral and human RNAs smaller than canonical MicroRNAs. J Virol (2009) 1.23

Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One (2011) 1.21

Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol (2006) 1.21

The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication. J Gen Virol (2003) 1.17

Multicolor microRNA FISH effectively differentiates tumor types. J Clin Invest (2013) 1.16

MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol (2012) 1.14

Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes. BMC Genomics (2011) 1.09

Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma. J Am Acad Dermatol (2010) 1.03

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus. J Biol Chem (2011) 1.01

Transcriptional analysis of latent and inducible Kaposi's sarcoma-associated herpesvirus transcripts in the K4 to K7 region. J Virol (2005) 1.00

Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerg Infect Dis (2011) 0.99

Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice. J Virol Methods (2012) 0.96

The T antigen locus of Merkel cell polyomavirus downregulates human Toll-like receptor 9 expression. J Virol (2013) 0.94

Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. PLoS One (2012) 0.94

Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol (2011) 0.92

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation. Virology (2011) 0.92

KSHV: forgotten but not gone. Blood (2011) 0.89

Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiation. J Virol (2012) 0.87

The role of connective tissue growth factor, transforming growth factor beta1 and Smad signaling pathway in cornea wound healing. Chin Med J (Engl) (2006) 0.87

Kaposi sarcoma-associated herpesvirus and primary and secondary pulmonary hypertension. Chest (2005) 0.86

Low Expression of Mucin-4 Predicts Poor Prognosis in Patients With Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) (2016) 0.85

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells. Blood (2005) 0.84

Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood (2009) 0.84

Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor. PLoS One (2013) 0.83

Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood (2010) 0.82

Durable remission of HIV-negative, Kaposi's sarcoma herpes virus-associated multicentric Castleman disease in patient with rheumatoid arthritis treated with methotrexate. Clin Rheumatol (2006) 0.81

John Snow's legacy: epidemiology without borders. Lancet (2013) 0.80

Clinicopathological review: primary angiitis of the central nervous system in association with cerebral amyloid angiopathy. Neurosurgery (2003) 0.79

Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) (2015) 0.79

The role of NF-kappaB activation in lipopolysaccharide induced keratitis in rats. Chin Med J (Engl) (2005) 0.79

Seroprevalence of Kaposi's sarcoma-associated herpesvirus in various populations in Cuba. Rev Panam Salud Publica (2004) 0.78

Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression. J Gen Virol (2015) 0.78

The anti-angiogenic role of discoidin domain receptor 2 (DDR2) in laser-induced choroidal neovascularization. J Mol Med (Berl) (2014) 0.77

Studies on the PEGylation of Protein at a Specific Site: Sulfhydryl-PEGylation of 97Cys-IFN-gamma. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) (1996) 0.75

Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med (2007) 0.75