Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 6131695)

Published in Biochim Biophys Acta on January 25, 1983

Authors

D Häussinger, W Gerok, H Sies

Articles citing this

Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. J Clin Invest (1986) 1.78

Nitrogen metabolism in liver: structural and functional organization and physiological relevance. Biochem J (1990) 1.76

Cell swelling inhibits proteolysis in perfused rat liver. Biochem J (1990) 1.27

Glutamine metabolism and cycling in Neurospora crassa. Microbiol Rev (1990) 1.00

Breath ammonia measurement in Helicobacter pylori infection. Dig Dis Sci (2002) 0.99

A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells. Biochem J (1993) 0.95

Bidirectional transport of glutamine across the cell membrane in rat liver. Biochem J (1983) 0.90

Inborn error of amino acid synthesis: human glutamine synthetase deficiency. J Inherit Metab Dis (2006) 0.90

Effect of phenylephrine on glutamate and glutamine metabolism in isolated perfused rat liver. Biochem J (1984) 0.88

The effect of urea synthesis on extracellular pH in isolated perfused rat liver. Biochem J (1986) 0.87

Bidirectional substrate fluxes through the system N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver. J Physiol (2004) 0.84

Inhibition of intracellular protein degradation by ethanol in perfused rat liver. Biochem J (1987) 0.83

Substrate and pH effects on glutamine synthesis in rat liver. Consequences for acid-base regulation. Biochem J (1991) 0.81

Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver. Int J Exp Pathol (2003) 0.78

Benzoate stimulates glutamate release from perfused rat liver. Biochem J (1989) 0.76

Activation of hepatic glutaminase by spermine. Biochem J (1995) 0.75

Articles by these authors

Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13

Functional significance of cell volume regulatory mechanisms. Physiol Rev (1998) 4.59

Long-term survival in patients with hereditary hemochromatosis. Gastroenterology (1996) 4.00

Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med (1996) 3.41

Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys (1989) 3.33

Prognosis of chronic hepatitis C: results of a large, prospective cohort study. Hepatology (1998) 3.00

Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol (1981) 2.85

Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J (1989) 2.85

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation. Experientia (1981) 2.71

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc Natl Acad Sci U S A (1987) 2.51

Chemistry of biologically important synthetic organoselenium compounds. Chem Rev (2001) 2.41

Prior cytomegalovirus infection and the risk of restenosis after percutaneous transluminal coronary balloon angioplasty. Circulation (1999) 2.13

[Demonstration of HFE polymorphism in German patients with hereditary hemochromatosis]. Dtsch Med Wochenschr (1999) 2.03

A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochem Pharmacol (1984) 1.90

Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Proc Natl Acad Sci U S A (1991) 1.87

Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology (1999) 1.87

The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems. Methods Enzymol (1978) 1.86

The role of H 2 O 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Arch Biochem Biophys (1973) 1.81

Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood (1988) 1.76

Effects of cytokines on the liver. Hepatology (1991) 1.76

Proton magnetic resonance spectroscopy of the brain in symptomatic and asymptomatic patients with liver cirrhosis. Gastroenterology (1997) 1.70

Evidence for a vasoconstriction-mediating receptor for UTP, distinct from the P2 purinoceptor, in rabbit ear artery. Naunyn Schmiedebergs Arch Pharmacol (1987) 1.68

Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells. Gastroenterology (2001) 1.66

Transjugular intrahepatic portosystemic stent-shunt (TIPS) in the treatment of Budd-Chiari syndrome. J Hepatol (1993) 1.63

Hepatorenal reflex regulating kidney function. Hepatology (1991) 1.61

Oxidative stress: damage to intact cells and organs. Philos Trans R Soc Lond B Biol Sci (1985) 1.55

Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr (1991) 1.54

Control of the levels of free amino acids in plasma by the liver. Biochem Z (1965) 1.54

Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen. Biochemistry (1991) 1.53

Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease. J Hepatol (1994) 1.52

Plasmodium knowlesi infection imported to Germany, January 2013. Euro Surveill (2013) 1.50

Cortical origin of mini-asterixis in hepatic encephalopathy. Neurology (2002) 1.50

Exocytosis in secretory cells of rat lacrimal gland. Peroxidase release from lobules and isolated cells upon cholinergic stimulation. J Cell Biol (1976) 1.50

Reduced and oxidized glutathione efflux from liver. FEBS Lett (1978) 1.49

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett (1999) 1.46

Anal endosonography and manometry: comparison in patients with defecation problems. Dis Colon Rectum (1997) 1.46

Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem (1983) 1.43

Cardiotoxicity of the antiproliferative compound fluorouracil. Drugs (1999) 1.42

Vitamin E in humans: demand and delivery. Annu Rev Nutr (1996) 1.42

Actions of extracellular UTP and ATP in perfused rat liver. A comparative study. Eur J Biochem (1987) 1.40

Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet (1993) 1.38

Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys (1996) 1.38

Low-level chemiluminescence as an indicator of singlet molecular oxygen in biological systems. Methods Enzymol (1984) 1.37

Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label. Gastroenterology (1988) 1.35

Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr (1992) 1.35

Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart. J Biol Chem (1986) 1.33

Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr (1997) 1.31

Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver. Pflugers Arch (1989) 1.31

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem Pharmacol (1983) 1.31

Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem (1999) 1.31

Increased biliary glutathione disulfide release in chronically ethanol-treated rats. FEBS Lett (1979) 1.30

Hydroperoxide-metabolizing systems in rat liver. Eur J Biochem (1975) 1.29

Characterization and natural course of cardiac autonomic nervous dysfunction in HIV-infected patients. AIDS (1997) 1.29

Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D. Gut (2005) 1.28

The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver. J Biol Chem (1982) 1.27

Cell swelling inhibits proteolysis in perfused rat liver. Biochem J (1990) 1.27

Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology (1994) 1.26

Interactions between glutamine metabolism and cell-volume regulation in perfused rat liver. Eur J Biochem (1990) 1.25

Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties--studies on isolated hepatocytes and lipid membrane vesicles. Hepatology (1984) 1.25

S-nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch Biochem Biophys (1999) 1.24

Mitochondrial and cytosolic NADPH systems and isocitrate dehydrogenase indicator metabolites during ureogensis from ammonia in isolated rat hepatocytes. Eur J Biochem (1977) 1.24

Singlet molecular oxygen causes loss of biological activity in plasmid and bacteriophage DNA and induces single-strand breaks. Biochim Biophys Acta (1989) 1.24

Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle. J Hepatol (1985) 1.22

Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B. Hepatology (2000) 1.22

Heme occupancy of catalase in hemoglobin-free perfused rat liver and of isolated rat liver catalase. Arch Biochem Biophys (1973) 1.22

Activation of pyruvate dehydrogenase during metabolism of ammonium ions in hemoglobin-free perfused rat liver. Eur J Biochem (1975) 1.21

Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, alpha-adrenergic agonists and the ionophore A23187 in perfused rat liver. Biochem J (1983) 1.20

Chemical depletion of glutathione in vivo. Methods Enzymol (1981) 1.20

Increased incidence of cancer in adult Gaucher disease in Western Europe. Blood Cells Mol Dis (2005) 1.19

State of oxidation-reduction and state of binding in the cytosolic NADH-system as disclosed by equilibration with extracellular lactate-pyruvate in hemoglobin-free perfused rat liver. Eur J Biochem (1972) 1.19

Transjugular intrahepatic portacaval stent shunt: preliminary clinical results. Radiology (1990) 1.19

Protection against peroxynitrite. FEBS Lett (1999) 1.19

Regulation of cell function by the cellular hydration state. Am J Physiol (1994) 1.19

Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo. Biochem J (1981) 1.19

Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc Natl Acad Sci U S A (1996) 1.19

Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S-transferases. FEBS Lett (1979) 1.18

ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver. J Biol Chem (1991) 1.16

Spot-blot hybridization assay for the detection of hepatitis B virus DNA in serum: factors determining its sensitivity and specificity. Hepatology (1987) 1.15

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes. Nat Chem (2012) 1.14

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies. Pharmacogenetics (1997) 1.14

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts. Biochem J (2000) 1.14

Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Arch Biochem Biophys (2001) 1.13

Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes. J Exp Med (1989) 1.13

Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA. Eur J Biochem (1999) 1.12

Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers. Biochem Soc Trans (1990) 1.12

A simple and rapid method for the detection of RNA in formalin-fixed, paraffin-embedded tissues by PCR amplification. Biochem Biophys Res Commun (1991) 1.12

Reactive oxygen species associated with cell differentiation in Neurospora crassa. Free Radic Biol Med (1993) 1.12

cis-trans isomers of lycopene and beta-carotene in human serum and tissues. Arch Biochem Biophys (1992) 1.11

Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock. J Biol Chem (1998) 1.11

Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med (2000) 1.11

The information needs and fears of patients with inflammatory bowel disease. Hepatogastroenterology (1987) 1.11

Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol (1984) 1.10

alpha-Amanitin uptake into hepatocytes. Identification of hepatic membrane transport systems used by amatoxins. J Biol Chem (1986) 1.10

Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen. Eur J Biochem (1983) 1.10

Liver cell volume and protein synthesis. Biochem J (1992) 1.10

Regulation of liver cell volume and proteolysis by glucagon and insulin. Biochem J (1991) 1.10