Published in J Biol Chem on February 10, 1984
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest (1987) 2.70
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci U S A (1996) 1.65
Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci U S A (1985) 1.62
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A (1986) 1.57
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol Pharmacol (1998) 1.27
Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochem J (1988) 1.03
Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures. Environ Health Perspect (1996) 1.01
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A (1992) 0.99
Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase. Biochem J (1989) 0.97
Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc Natl Acad Sci U S A (1996) 0.95
Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochem J (1990) 0.92
Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat. Biochem J (1987) 0.88
Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos (2015) 0.84
Genotype-guided tacrolimus dosing in African-American kidney transplant recipients. Pharmacogenomics J (2015) 0.82
Individualizing therapy - in search of approaches to maximize the benefit of drug treatment (II). Curr Control Trials Cardiovasc Med (2004) 0.77
Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222. J Bacteriol (1991) 0.75
Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells. Toxicol In Vitro (2011) 0.75
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet (2001) 5.80
Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (2000) 3.41
Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther (2001) 2.79
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest (1987) 2.70
Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J (2010) 2.43
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. Pharmacogenetics (2001) 2.29
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol (2000) 2.25
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev (2000) 2.15
Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann N Y Acad Sci (1980) 1.96
Use of human hepatocytes to study P450 gene induction. Methods Enzymol (1996) 1.79
Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol (1988) 1.76
CYP3A gene expression in human gut epithelium. Pharmacogenetics (1994) 1.66
Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci U S A (1985) 1.62
Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest (1989) 1.59
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry (1985) 1.57
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A (1986) 1.57
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol (1996) 1.55
Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther (2008) 1.54
Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial. N Engl J Med (1978) 1.47
Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. Drug Metab Dispos (1995) 1.46
Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Annu Rev Pharmacol Toxicol (1982) 1.45
Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. J Biol Chem (1984) 1.37
In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metab Dispos (2000) 1.36
Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenterology (1977) 1.35
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile. J Biol Chem (1980) 1.31
The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab Dispos (1999) 1.30
Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther (1998) 1.29
Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer. Endocrinology (1978) 1.27
The human CYP3A subfamily: practical considerations. Drug Metab Rev (2001) 1.26
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol (1994) 1.26
The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism. Drug Metab Rev (2001) 1.26
6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther (1999) 1.25
Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos (1992) 1.24
Effect of cobalt on synthesis of heme and cytochrome P-450 in the liver. Studies of adult rat hepatocytes in primary monolayer culture and in vivo. J Biol Chem (1976) 1.24
Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450. J Pharmacol Exp Ther (1993) 1.24
Variability in human cytochrome P450 paclitaxel metabolism. J Pharmacol Exp Ther (1995) 1.23
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci U S A (1997) 1.23
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. Biochemistry (1990) 1.21
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemia. Lancet (2000) 1.21
Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture. J Clin Invest (1980) 1.21
A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J Biol Chem (1995) 1.21
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc Natl Acad Sci U S A (1997) 1.21
Collagen formation by the hepatocyte in primary monolayer culture and in vivo. Science (1983) 1.21
Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. J Biol Chem (1986) 1.20
Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos (1995) 1.19
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. Mol Pharmacol (1985) 1.17
Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. Biochem Pharmacol (1995) 1.17
Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents. Mol Pharmacol (1982) 1.16
O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol Pharmacol (1994) 1.16
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys (1992) 1.16
Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Clin Pharmacol Ther (2008) 1.15
Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J Pharmacol Exp Ther (1999) 1.15
The role of CYP2B6 in human xenobiotic metabolism. Drug Metab Rev (1999) 1.14
Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. Pharmacogenetics (1994) 1.14
Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology (1993) 1.11
Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. Biochemistry (1986) 1.10
Molecular and physical mechanisms of first-pass extraction. Drug Metab Dispos (1999) 1.09
Progress in predicting human ADME parameters in silico. J Pharmacol Toxicol Methods (2001) 1.09
Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol Pharmacol (1985) 1.07
Distribution and excretion of chlordecone (Kepone) in the rat. Drug Metab Dispos (1978) 1.06
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. Toxicol Appl Pharmacol (1993) 1.04
Bimodal distribution of renal cytochrome P450 3A activity in humans. Mol Pharmacol (1996) 1.04
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents. Mol Pharmacol (1989) 1.04
Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase. Biochemistry (1986) 1.04
Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos (2001) 1.03
Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. Mol Pharmacol (1986) 1.03
Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide. Chem Res Toxicol (1992) 1.03
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrob Agents Chemother (1990) 1.03
Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol (1996) 1.02
Present and future in vitro approaches for drug metabolism. J Pharmacol Toxicol Methods (2001) 1.02
Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity. Clin Pharmacol Ther (1992) 1.00
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A (1992) 0.99
Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A (1982) 0.98
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. Proc Natl Acad Sci U S A (1990) 0.98
Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol (1994) 0.98
Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem (1990) 0.96