PubRank

M J Hitchcock

Author PubWeight™ 41.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus. Antimicrob Agents Chemother 1989 1.66
2 Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Mol Pharmacol 1992 1.65
3 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo. Antimicrob Agents Chemother 1994 1.39
4 Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 1995 1.32
5 In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine. Antimicrob Agents Chemother 1993 1.23
6 Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine. Antiviral Res 1992 1.20
7 High-frequency fusion of Streptomyces parvulus or Streptomyces antibioticus protoplasts induced by polyethylene glycol. J Bacteriol 1979 1.19
8 Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys. Antiviral Res 1991 1.17
9 Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug. Drug Metab Dispos 1996 1.17
10 Biochemical pharmacology of acyclic nucleotide analogues. Ann N Y Acad Sci 1990 1.17
11 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent. J Med Chem 1989 1.17
12 Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. J Med Chem 1989 1.10
13 Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol Sci 1998 1.09
14 Susceptibility of human cytomegalovirus to cidofovir is unchanged after limited in vivo exposure to various regimens of drug. J Infect Dis 1996 1.04
15 Affinity purification of renal dipeptidase solubilized with detergent. Anal Biochem 1987 1.01
16 Cellular pharmacology of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) in human peripheral blood mononuclear cells. Biochem Pharmacol 1990 1.01
17 (S)-1-(3-hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): a potent antiherpesvirus agent. Adv Exp Med Biol 1990 0.98
18 Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. J Med Chem 1992 0.97
19 Actinomycin biosynthesis by protoplasts derived from Streptomyces parvulus. Antimicrob Agents Chemother 1978 0.97
20 Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). J Med Chem 1994 0.93
21 Distinct kynureninase and hydroxykynureninase enzymes in an actinomycin-producing strain of Streptomyces parvulus. Biochim Biophys Acta 1980 0.93
22 Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits. Curr Eye Res 1996 0.91
23 Preparation of oocytes for microinjection of RNA and DNA. Methods Enzymol 1987 0.90
24 Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus. Antimicrob Agents Chemother 1990 0.90
25 Preparation of interferon messenger RNAs with the use of ribonucleoside--vanadyl complexes. Methods Enzymol 1981 0.90
26 Metabolism and DNA interaction of 2',3'-didehydro-2',3'-dideoxythymidine in human bone marrow cells. Mol Pharmacol 1991 0.89
27 Characterization of interferon messenger RNA synthesis in Namalva cells. J Biol Chem 1980 0.89
28 Evidence for a constitutive and inducible form of kynurenine formamidase in an actinomycin-producing strain of Streptomyces parvulus. Arch Biochem Biophys 1980 0.88
29 Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships. J Med Chem 1990 0.87
30 Synthesis and in vitro activity of C-2 quaternary heterocyclic alkylthio carbapenems. J Antibiot (Tokyo) 1987 0.86
31 Regulation of lysine- and lysine-plus-threonine-inhibitable aspartokinases in Bacillus brevis. J Bacteriol 1980 0.86
32 Phosphonomethylether compounds as antiviral agents. Transplant Proc 1991 0.83
33 Purification and characterization of kynurenine formamidase activities from Streptomyces parvulus. Can J Microbiol 1986 0.83
34 Comparative studies of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) with other pyrimidine nucleoside analogues. Ann N Y Acad Sci 1990 0.81
35 Microinjection into Xenopus oocytes: equipment. Methods Enzymol 1987 0.80
36 Effect of cephalosporins on organic ion transport in renal membrane vesicles from rat and rabbit kidney cortex. Res Commun Chem Pathol Pharmacol 1985 0.80
37 Translation of human immune interferon messenger RNA in Xenopus laevis oocytes. Biochem Biophys Res Commun 1981 0.79
38 Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues. J Med Chem 1993 0.78
39 A preclinical and clinical overview of the nucleotide-based antiviral agent cidofovir (HPMPC). Adv Exp Med Biol 1996 0.77
40 Microinjection of Xenopus oocytes. An automated device for volume control in the nanoliter range. Anal Biochem 1980 0.77
41 Arylformamidase from Streptomyces parvulus. Methods Enzymol 1987 0.77
42 Radiolabeled quaternary carbapenems and their interactions with human serum albumin. Antimicrob Agents Chemother 1988 0.75
43 Food service: more training programs recommended. Hospitals 1973 0.75
44 Chilled food systems. Effects of chilled holding on quality of beef loaves. J Am Diet Assoc 1975 0.75
45 Effect of holding on broccoli prepared in volume. J Am Diet Assoc 1966 0.75
46 Prodrugs of 2',3'-didehydro-3'-deoxythymidine (D4T): synthesis, antiviral activity, and rapid pharmacokinetic evaluation. J Pharm Sci 1994 0.75
47 Cellular metabolism and enzymatic phosphorylation of 9-(2-phosphonylmethoxyethyl) guanine (PMEG), a potent antiviral agent. Adv Exp Med Biol 1992 0.75
48 Personnel training needs. Hospitals 1971 0.75
49 Cilastatin-sensitive dehydropeptidase I enzymes from three sources all catalyze carbapenem hydrolysis and conversion of leukotriene D4 to leukotriene E4. Arch Biochem Biophys 1987 0.75
50 A new class of acyclic phosphonate nucleotide analogues: phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents. J Med Chem 1991 0.75
51 A new approach to the limiting dilution assay. J Biopharm Stat 1994 0.75